Apoptotic cell death in disease—Current understanding of the NCCD 2023

SARS-CoV-2 membrane protein causes the mitochondrial apoptosis and pulmonary edema via targeting BOK

(2022) Yang Yang et al.   CELL DEATH AND DIFFERENTIATION

The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner

(2022) Anna-Lena Meinhardt et al.   ONCOGENE

Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state

(2022) Farzaneh Ghazavi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell cycle regulation: p53-p21-RB signaling

(2022) Kurt Engeland   CELL DEATH AND DIFFERENTIATION

Caspase‐8 in endothelial cells maintains gut homeostasis and prevents small bowel inflammation in mice

(2022) Nathalie Tisch et al.   EMBO Molecular Medicine

Genetic and pharmacological PARP inhibition reduces axonal degeneration in C. elegans models of ALS

(2022) Gilles Tossing et al.   HUMAN MOLECULAR GENETICS

Blocking site-specific cleavage of human tau delays progression of disease-related phenotypes in genetically matched tau-transgenic mice modeling frontotemporal dementia

(2022) Elizabeth L. Steuer et al.   JOURNAL OF NEUROSCIENCE

Bacterial inhibition of Fas-mediated killing promotes neuroinvasion and persistence

(2022) Claire Maudet et al.   NATURE

Stem cell architecture drives myelodysplastic syndrome progression and predicts response to venetoclax-based therapy

(2022) Irene Ganan-Gomez et al.   NATURE MEDICINE

Copper induces cell death by targeting lipoylated TCA cycle proteins

(2022) Peter Tsvetkov et al.   SCIENCE

Live cell tracking of macrophage efferocytosis during Drosophila embryo development in vivo

(2022) Michael H. Raymond et al.   SCIENCE

Caspases and Their Substrates

(2022) Douglas R. Green   Cold Spring Harbor Perspectives in Biology

Some mice lacking intrinsic, as well as death receptor induced apoptosis and necroptosis, can survive to adulthood

(2022) Francine F. S. Ke et al.   Cell Death & Disease

Deregulation and epigenetic modification of BCL2-family genes cause resistance to venetoclax in hematologic malignancies

(2022) Daniel Thomalla et al.   BLOOD

The BCL ‐2 family member BID plays a role during embryonic development in addition to its BH3 ‐only protein function by acting in parallel to BAX , BAK and BOK

(2022) Francine S Ke et al.   EMBO JOURNAL

Caspase-7 activates ASM to repair gasdermin and perforin pores

(2022) Kengo Nozaki et al.   NATURE

PANoptosis: A Unique Innate Immune Inflammatory Cell Death Modality

(2022) Nagakannan Pandian et al.   JOURNAL OF IMMUNOLOGY

Selective ablation of P53 in pancreatic beta cells fails to ameliorate glucose metabolism in genetic, dietary and pharmacological models of diabetes mellitus

(2022) Celina Uhlemeyer et al.   Molecular Metabolism

Apoptotic Ablation of Platelets Reduces Atherosclerosis in Mice With Diabetes

(2021) Man K.S. Lee et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Effects of selective TNFR1 inhibition or TNFR2 stimulation, compared to non-selective TNF inhibition, on (neuro)inflammation and behavior after myocardial infarction in male mice

(2021) L. Gouweleeuw et al.   BRAIN BEHAVIOR AND IMMUNITY

Cell death pathways: intricate connections and disease implications

(2021) Matthias Kist et al.   EMBO JOURNAL

TNF-mediated alveolar macrophage necroptosis drives disease pathogenesis during Respiratory Syncytial Virus infection

(2021) Leonardo Duarte Santos et al.   EUROPEAN RESPIRATORY JOURNAL

Tumor necrosis factor-α small interfering RNA alveolar epithelial cell-targeting nanoparticles reduce lung injury in C57BL/6J mice with sepsis

(2021) Like Qian et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Pharmacological inhibition of soluble tumor necrosis factor-alpha (sTNFα) 2 weeks after high thoracic spinal cord injury does not affect sympathetic hyperreflexia

(2021) Micaela O'Reilly et al.   JOURNAL OF NEUROTRAUMA

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Evidence for the involvement of caspases in establishing proper cerebrospinal fluid hydrodynamics

(2021) Ayako Yoshida et al.   NEUROSCIENCE RESEARCH

GABAergic neurons are susceptible to BAX-dependent apoptosis following isoflurane exposure in the neonatal period

(2021) Andrew M. Slupe et al.   PLoS One

Efficacy of novel bispecific antibody targeting TNF-α/CXCL10 in the treatment of experimental arthritis

(2021) Shin Eui Kang et al.   Translational Research

Mechanisms of mitochondrial cell death

(2021) Shashank Dadsena et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Puma- and Caspase9-mediated apoptosis is dispensable for p53-driven neural crest-based developmental defects

(2021) Margot E. Bowen et al.   CELL DEATH AND DIFFERENTIATION

Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition

(2021) Sergio Crespo-Garcia et al.   Cell Metabolism

Regulation of distinct caspase-8 functions in retinal ganglion cells and astroglia in experimental glaucoma

(2021) Xiangjun Yang et al.   NEUROBIOLOGY OF DISEASE

Cellular FADD-like IL-1β-converting enzyme-inhibitory protein attenuates myocardial ischemia/reperfusion injury via suppressing apoptosis and autophagy simultaneously

(2021) Di Liu et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Neurotrophin‐3 contributes to benefits of human embryonic stem cell‐derived cardiovascular progenitor cells against reperfused myocardial infarction

(2021) Wei Bi et al.   Stem Cells Translational Medicine

Influence of TRAIL Deficiency on Th17 Cells and Colonic Microbiota in Experimental Colitis Mouse Model

(2021) Dao-po Lin et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Intact TP53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

(2021) Rachel Thijssen et al.   BLOOD

Requirement for antiapoptotic MCL-1 during early erythropoiesis

(2021) Meghan E. Turnis et al.   BLOOD

Mitophagy protein PINK1 suppresses colon tumor growth by metabolic reprogramming via p53 activation and reducing acetyl-CoA production

(2021) Kunlun Yin et al.   CELL DEATH AND DIFFERENTIATION

Necroptosis, pyroptosis and apoptosis: an intricate game of cell death

(2021) Damien Bertheloot et al.   Cellular & Molecular Immunology

Mechanistic connections between mitochondrial biology and regulated cell death

(2021) Jerry Edward Chipuk et al.   DEVELOPMENTAL CELL

Tumor Necrosis Factor Alpha-Mediated Inflammation and Remodeling of the Extracellular Matrix Underlies Aortic Stiffening Induced by the Common Chemotherapeutic Agent Doxorubicin

(2021) Zachary S. Clayton et al.   HYPERTENSION

Loss of BOK Has a Minor Impact on Acetaminophen Overdose-Induced Liver Damage in Mice

(2021) Samara Naim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Viral dosing of influenza A infection reveals involvement of RIPK3 and FADD, but not MLKL

(2021) Teodora Oltean et al.   Cell Death & Disease

Fas/FasL mediates NF-κBp65/PUMA-modulated hepatocytes apoptosis via autophagy to drive liver fibrosis

(2021) Siwei Tan et al.   Cell Death & Disease

XIAP Knockdown in Alcohol-Associated Liver Disease Models Exhibits Divergent in vitro and in vivo Phenotypes Owing to a Potential Zonal Inhibitory Role of SMAC

(2021) Li He et al.   Frontiers in Physiology

Etanercept Ameliorates Cardiac Fibrosis in Rats with Diet-Induced Obesity

(2021) Chia-Chen Hsu et al.   Pharmaceuticals

Selective inhibition of soluble TNF using XPro1595 relieves pain and attenuates cerulein-induced pathology in mice

(2021) Rajasa Randhi et al.   BMC GASTROENTEROLOGY

Molecular mechanisms of cell death in neurological diseases

(2021) Diane Moujalled et al.   CELL DEATH AND DIFFERENTIATION

Absence of pro-survival A1 has no impact on inflammatory cell survival in vivo during acute lung inflammation and peritonitis

(2021) Lahiru Gangoda et al.   CELL DEATH AND DIFFERENTIATION

BCL-XL is crucial for progression through the adenoma-to-carcinoma sequence of colorectal cancer

(2021) Prashanthi Ramesh et al.   CELL DEATH AND DIFFERENTIATION

Potent pro-apoptotic combination therapy is highly effective in a broad range of cancers

(2021) Antonella Montinaro et al.   CELL DEATH AND DIFFERENTIATION

Targeting Cpt1a-Bcl-2 interaction modulates apoptosis resistance and fibrotic remodeling

(2021) Linlin Gu et al.   CELL DEATH AND DIFFERENTIATION

Ki-67 gene expression

(2021) Sigrid Uxa et al.   CELL DEATH AND DIFFERENTIATION

Too much death can kill you: inhibiting intrinsic apoptosis to treat disease

(2021) Kaiming Li et al.   EMBO JOURNAL

Dependence receptors: new targets for cancer therapy

(2021) Morgan Brisset et al.   EMBO Molecular Medicine

The anti‐apoptotic Bcl‐2 protein regulates hair follicle stem cell function

(2021) Anna Geueke et al.   EMBO REPORTS

XIAP gene therapy effects on retinal ganglion cell structure and function in a mouse model of glaucoma

(2021) Shagana Visuvanathan et al.   GENE THERAPY

Differential role of TNFR1 and TNFR2 in the development of imiquimod‐induced mouse psoriasis

(2021) Shaokui Chen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Microbes exploit death-induced nutrient release by gut epithelial cells

(2021) Christopher J. Anderson et al.   NATURE

E-type prostanoid receptor 4 drives resolution of intestinal inflammation by blocking epithelial necroptosis

(2021) Jay V. Patankar et al.   NATURE CELL BIOLOGY

Cell death in pancreatic cancer: from pathogenesis to therapy

(2021) Xin Chen et al.   Nature Reviews Gastroenterology & Hepatology

Hierarchical Cell Death Program Disrupts the Intracellular Niche Required for Burkholderia thailandensis Pathogenesis

(2021) David E. Place et al.   mBio

Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis

(2021) Jun Wang et al.   Cell Death & Disease

BCLXL gene therapy moderates neuropathology in the DBA/2J mouse model of inherited glaucoma

(2021) Ryan J. Donahue et al.   Cell Death & Disease

The TNFR1 Antagonist Atrosimab Is Therapeutic in Mouse Models of Acute and Chronic Inflammation

(2021) Fabian Richter et al.   Frontiers in Immunology

TNF-α Receptor Inhibitor Alleviates Metabolic and Inflammatory Changes in a Rat Model of Ischemic Stroke

(2021) Shih-Yi Lin et al.   Antioxidants

BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology

(2021) Liansheng Zhang et al.   iScience

A Dual Role for Death Receptor 5 in Regulating Cardiac Fibroblast Function

(2021) Miles A. Tanner et al.   Frontiers in Cardiovascular Medicine

The role of caspases as executioners of apoptosis

(2021) Sharad Kumar et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

BCL‐2‐family protein tBID can act as a BAX‐like effector of apoptosis

(2021) Hector Flores‐Romero et al.   EMBO JOURNAL

Overexpression of Transmembrane TNF Drives Development of Ectopic Lymphoid Structures in the Bone Marrow and B Cell Lineage Alterations in Experimental Spondyloarthritis

(2021) Merlijn H. Kaaij et al.   JOURNAL OF IMMUNOLOGY

Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice

(2021) Irini Papazian et al.   Journal of Neuroinflammation

Molecular mechanisms and consequences of mitochondrial permeability transition

(2021) Massimo Bonora et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

BAP1 forms a trimer with HMGB1 and HDAC1 that modulates gene × environment interaction with asbestos

(2021) Flavia Novelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the miRNA-155/TNFSF10 network restrains inflammatory response in the retina in a mouse model of Alzheimer’s disease

(2021) Chiara Burgaletto et al.   Cell Death & Disease

sTNFRII-Fc modification protects human UC-MSCs against apoptosis/autophagy induced by TNF-α and enhances their efficacy in alleviating inflammatory arthritis

(2021) Yingjie Zhao et al.   Stem Cell Research & Therapy

Suppression of Transmembrane Tumor Necrosis Factor Alpha Processing by a Specific Antibody Protects Against Colitis-Associated Cancer

(2021) Hongping Ba et al.   Frontiers in Immunology

TNF-mediated neuroinflammation is linked to neuronal necroptosis in Alzheimer's disease hippocampus

(2021) Anusha Jayaraman et al.   Acta Neuropathologica Communications

TNFα Signaling Is Increased in Progressing Oral Potentially Malignant Disorders and Regulates Malignant Transformation in an Oral Carcinogenesis Model

(2021) Jeffrey W. Chadwick et al.   Frontiers in Oncology

XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells

(2021) Adam Wahida et al.   Science Immunology

Caspases in Cell Death, Inflammation, and Gasdermin-Induced Pyroptosis

(2020) Sannula Kesavardhana et al.   Annual Review of Immunology

Loss of BIM in T cells results in BCL-2 family BH3-member compensation but incomplete cell death sensitivity normalization

(2020) Lindsey M. Ludwig et al.   APOPTOSIS

Venetoclax in acute myeloid leukemia – current and future directions

(2020) Curtis Lachowiez et al.   LEUKEMIA & LYMPHOMA

Future Therapeutic Directions for Smac-Mimetics

(2020) Emma Morrish et al.   Cells

Caspase-3 Promotes Diabetic Kidney Disease Through Gasdermin E-Mediated Progression to Secondary Necrosis During Apoptosis

(2020) Si Wen et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Pharmacological Inhibition of Caspase-8 Suppresses Inflammation-Induced Angiogenesis in the Cornea

(2020) Yunzhe Tian et al.   Biomolecules

Gasdermin E-derived caspase-3 inhibitors effectively protect mice from acute hepatic failure

(2020) Wan-feng Xu et al.   ACTA PHARMACOLOGICA SINICA

Tofacitinib for ulcerative colitis: results of the prospective Dutch Initiative on Crohn and Colitis (ICC) registry

(2020) Vince B. C. Biemans et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Inhibitory effects of JQ1 on listeria monocytogenes-induced acute liver injury by blocking BRD4/RIPK1 axis

(2020) Zhao Qian et al.   BIOMEDICINE & PHARMACOTHERAPY

Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis

(2020) Ting Zhang et al.   CELL

MCL1 is Required for Maintenance of Intestinal Homeostasis and Prevention of Carcinogenesis in Mice

(2020) Marc E. Healy et al.   GASTROENTEROLOGY

FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells

(2020) Robin Schwarzer et al.   IMMUNITY

Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis

(2020) Bart Tummers et al.   IMMUNITY

Novel Compound Heterozygote Variations in FADD Identified to Cause FAS-Associated Protein with Death Domain Deficiency

(2020) Lisa A. Kohn et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Targeting apoptosis in cancer therapy

(2020) Benedito A. Carneiro et al.   Nature Reviews Clinical Oncology

The clearance of dead cells by efferocytosis

(2020) Emilio Boada-Romero et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Blocking the death checkpoint protein TRAIL improves cardiac function after myocardial infarction in monkeys, pigs, and rats

(2020) Yaohui Wang et al.   Science Translational Medicine

Combined reduction in the expression of MCL-1 and BCL-2 reduces organismal size in mice

(2020) Francine Ke et al.   Cell Death & Disease

TNF-Receptor-1 inhibition reduces liver steatosis, hepatocellular injury and fibrosis in NAFLD mice

(2020) Franziska Wandrer et al.   Cell Death & Disease

Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation

(2020) Lucie Laurien et al.   Nature Communications

A 3′UTR modification of the TNF-α mouse gene increases peripheral TNF-α and modulates the Alzheimer-like phenotype in 5XFAD mice

(2020) Nikoleta Kalovyrna et al.   Scientific Reports

Targeting the Extrinsic Pathway of Hepatocyte Apoptosis Promotes Clearance of Plasmodium Liver Infection

(2020) Gregor Ebert et al.   Cell Reports

Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Receptor Deficiency Promotes the Ductular Reaction, Macrophage Accumulation, and Hepatic Fibrosis in the Abcb4 Mouse

(2020) Anuradha Krishnan et al.   AMERICAN JOURNAL OF PATHOLOGY

MCL-1 is essential for survival but dispensable for metabolic fitness of FOXP3+ regulatory T cells

(2020) Charis E. Teh et al.   CELL DEATH AND DIFFERENTIATION

Treatment of acute lung inflammation by pulmonary delivery of anti-TNF-α siRNA with PAMAM dendrimers in a murine model

(2020) Adam Bohr et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

(2020) Marcel Doerflinger et al.   IMMUNITY

Novel Orally Administered Recombinant Anti-TNF Alpha Fusion Protein for the Treatment of Ulcerative Colitis

(2020) Einat Almon et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease

(2020) Holly Anderton et al.   Nature Reviews Rheumatology

Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia

(2020) Courtney D. DiNardo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of tumor necrosis factor on viral replication and pulmonary inflammation during acute mouse adenovirus type 1 respiratory infection

(2020) Krittika Pant et al.   VIROLOGY

HIF-1α Mediates TRAIL-Induced Neuronal Apoptosis via Regulating DcR1 Expression Following Traumatic Brain Injury

(2020) Yuanjian Fang et al.   Frontiers in Cellular Neuroscience

The pro-survival Bcl-2 family member A1 delays spontaneous and FAS ligand-induced apoptosis of activated neutrophils

(2020) Robyn L. Schenk et al.   Cell Death & Disease

Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion

(2020) Maria I. Avrutsky et al.   Nature Communications

Biological Mechanisms and Clinical Significance of BAP1 Mutations in Human Cancer

(2020) Michele Carbone et al.   Cancer Discovery

Bax and Bak jointly control survival and dampen the early unfolded protein response in pancreatic β-cells under glucolipotoxic stress

(2020) Sarah A. White et al.   Scientific Reports

Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid β-Protein-Induced Synapse Loss in Alzheimer’s Disease

(2020) Goonho Park et al.   Cell Reports

TNF-α inhibition decreases MMP-2 activity, reactive oxygen species formation and improves hypertensive vascular hypertrophy independent of its effects on blood pressure

(2020) B.R. Mattos et al.   BIOCHEMICAL PHARMACOLOGY

TRAIL treatment prevents renal morphological changes and TGF-β-induced mesenchymal transition associated with diabetic nephropathy

(2020) Barbara Toffoli et al.   CLINICAL SCIENCE

Muscle-derived TRAIL negatively regulates myogenic differentiation

(2020) Dongwook Kim et al.   EXPERIMENTAL CELL RESEARCH

Proteins for increased surface expression of the α6β4 nicotinic acetylcholine receptor: Nothing but good news?

(2020) Stephen Grant et al.   JOURNAL OF CLINICAL INVESTIGATION

Emricasan to prevent new decompensation in patients with NASH-related decompensated cirrhosis

(2020) Catherine Frenette et al.   JOURNAL OF HEPATOLOGY

Necrostatin-1 Synergizes the Pan Caspase Inhibitor to Attenuate Lung Injury Induced by Ischemia Reperfusion in Rats

(2020) Liangrong Wang et al.   MEDIATORS OF INFLAMMATION

Modulating TRADD to restore cellular homeostasis and inhibit apoptosis

(2020) Daichao Xu et al.   NATURE

Emerging connectivity of programmed cell death pathways and its physiological implications

(2020) Sammy Bedoui et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tumor necrosis factor alpha receptor 1 deficiency in hepatocytes does not protect from non-alcoholic steatohepatitis, but attenuates insulin resistance in mice

(2020) Sena Bluemel et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Selective Blockade of TNFR1 Improves Clinical Disease and Bronchoconstriction in Experimental RSV Infection

(2020) Dorothea R. Morris et al.   Viruses-Basel

MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically

(2020) Enkhtsetseg Munkhbaatar et al.   Nature Communications

Anti-apoptotic peptide for long term cardioprotection in a mouse model of myocardial ischemia–reperfusion injury

(2020) Aurélie Covinhes et al.   Scientific Reports

TNF Receptor 1 Promotes Early-Life Immunity and Protects against Colitis in Mice

(2020) Cambrian Y. Liu et al.   Cell Reports

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

(2020) Rajendra Karki et al.   CELL

Antiapoptotic Bcl-2 family proteins BCL-xL and MCL-1 integrate neural progenitor survival and proliferation during postnatal cerebellar neurogenesis

(2020) Katherine A. Veleta et al.   CELL DEATH AND DIFFERENTIATION

Apoptosis is involved in maintaining the character of the midbrain and the diencephalon roof plate after neural tube closure

(2020) Yudai Matsumoto et al.   DEVELOPMENTAL BIOLOGY

Netrin‐1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson’s disease features

(2020) Mélissa Jasmin et al.   EMBO JOURNAL

BCL‐XL exerts a protective role against anemia caused by radiation‐induced kidney damage

(2020) Kerstin Brinkmann et al.   EMBO JOURNAL

TNF Is Partially Required for Cell-Death-Triggered Skin Inflammation upon Acute Loss of cFLIP

(2020) Maria Feoktistova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tumor necrosis factor alpha-receptor type 1 activation in the hypothalamic paraventricular nucleus contributes to glutamate signaling and angiotensin II-dependent hypertension

(2020) Clara Woods et al.   JOURNAL OF NEUROSCIENCE

Apoptosis in the fetal testis eliminates developmentally defective germ cell clones

(2020) Daniel H. Nguyen et al.   NATURE CELL BIOLOGY

Serine-70 phosphorylated Bcl-2 prevents oxidative stress-induced DNA damage by modulating the mitochondrial redox metabolism

(2020) Stephen Jun Fei Chong et al.   NUCLEIC ACIDS RESEARCH

Transmembrane tumor necrosis factor alpha attenuates pressure-overload cardiac hypertrophy via tumor necrosis factor receptor 2

(2020) Kun Miao et al.   PLOS BIOLOGY

BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages

(2020) Jie Li et al.   eLife

Loss of Fas signaling in fibroblasts impairs homeostatic fibrosis resolution and promotes persistent pulmonary fibrosis

(2020) Elizabeth F. Redente et al.   JCI Insight

Tumor necrosis factor receptor signaling modulates carcinogenesis in a mouse model of breast cancer

(2020) Ling He et al.   NEOPLASIA

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

(2019) Rumani Singh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TRAIL signals through the ubiquitin ligase MID1 to promote pulmonary fibrosis

(2019) Adam M. Collison et al.   BMC Pulmonary Medicine

Combined administration of PARP-1 and caspase-3 inhibitors alleviates neuronal apoptosis after spinal cord injury in rats

(2019) Wei Zhao et al.   World Neurosurgery

TRADD regulates perinatal development and adulthood survival in mice lacking RIPK1 and RIPK3

(2019) John P. Dowling et al.   Nature Communications

RIPK1 can mediate apoptosis in addition to necroptosis during embryonic development

(2019) Xuhua Zhang et al.   Cell Death & Disease

Serpin B1 defect and increased apoptosis of neutrophils in Cohen syndrome neutropenia

(2019) Laurence Duplomb et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Combined Blockade of TNF-α and IL-17A Alleviates Progression of Collagen-Induced Arthritis without Causing Serious Infections in Mice

(2019) Fang Shen et al.   JOURNAL OF IMMUNOLOGY

The Coming Decade of Cell Death Research: Five Riddles

(2019) Douglas R. Green   CELL

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology

(2019) Sho Morioka et al.   IMMUNITY

TRAIL suppresses gut inflammation and inhibits colitogeic T-cell activation in experimental colitis via an apoptosis-independent pathway

(2019) I. T. Chyuan et al.   Mucosal Immunology

Ibrutinib and Venetoclax for First-Line Treatment of CLL

(2019) Nitin Jain et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Neutrophil’s Role During Health and Disease

(2019) Pei Xiong Liew et al.   PHYSIOLOGICAL REVIEWS

The TP53 Apoptotic Network is a Primary Mediator of Resistance to BCL2 inhibition in AML Cells

(2019) Tamilla Nechiporuk et al.   Cancer Discovery

A novel therapeutic peptide targeting myocardial reperfusion injury

(2019) Prisca Boisguérin et al.   CARDIOVASCULAR RESEARCH

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold

(2019) David W. Vredevoogd et al.   CELL

Autophagy-Independent Functions of the Autophagy Machinery

(2019) Lorenzo Galluzzi et al.   CELL

Macrophages and Metabolism in the Tumor Microenvironment

(2019) Ilio Vitale et al.   Cell Metabolism

Environmental Microbial Factors Determine the Pattern of Inflammatory Lesions in a Murine Model of Crohn’s Disease–Like Inflammation

(2019) Iris Stolzer et al.   INFLAMMATORY BOWEL DISEASES

Venetoclax and Obinutuzumab in Patients with CLL and Coexisting Conditions

(2019) Kirsten Fischer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Caspase-8 promotes c-Rel–dependent inflammatory cytokine expression and resistance against Toxoplasma gondii

(2019) Alexandra A. DeLaney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient apoptosis requires feedback amplification of upstream apoptotic signals by effector caspase-3 or -7

(2019) Scott McComb et al.   Science Advances

Deletion of the Casp8 gene in mice results in ileocolitis, gut barrier dysfunction, and malassimilation, which can be partially attenuated by inulin or sodium butyrate

(2019) Valentina Kaden-Volynets et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

CFLAR is a critical regulator of cerebral ischaemia-reperfusion injury through regulating inflammation and endoplasmic reticulum (ER) stress

(2019) Wang Xiaohong et al.   BIOMEDICINE & PHARMACOTHERAPY

Immune-associated renal disease found in caspase 3-deficient mice

(2019) Takashi Suzuki et al.   CELL AND TISSUE RESEARCH

Functional analysis of a novel G87V TNFRSF1A mutation in patients with TNF receptor‐associated periodic syndrome

(2019) S. Tsuji et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis

(2019) Kim Newton et al.   NATURE

Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease

(2019) Dominic P. Del Re et al.   PHYSIOLOGICAL REVIEWS

BAX, BAK, and BOK: A Coming of Age for the BCL-2 Family Effector Proteins

(2019) Tudor Moldoveanu et al.   Cold Spring Harbor Perspectives in Biology

Topical Administration of a Soluble TNF Inhibitor Reduces Infarct Volume After Focal Cerebral Ischemia in Mice

(2019) Minna Yli-Karjanmaa et al.   Frontiers in Neuroscience

Apoptotic caspases inhibit abscopal responses to radiation and identify a new prognostic biomarker for breast cancer patients

(2019) Maria Esperanza Rodriguez-Ruiz et al.   OncoImmunology

Therapeutic Effects in a Transient Middle Cerebral Artery Occlusion Rat Model by Nose-To-Brain Delivery of Anti-TNF-Alpha siRNA with Cell-Penetrating Peptide-Modified Polymer Micelles

(2019) Takanori Kanazawa et al.   Pharmaceutics

Caspase-8 modulates physiological and pathological angiogenesis during retina development

(2019) Nathalie Tisch et al.   JOURNAL OF CLINICAL INVESTIGATION

Death receptor 5 contributes to cardiomyocyte hypertrophy through epidermal growth factor receptor transactivation

(2019) Miles A. Tanner et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A small peptide antagonist of the Fas receptor inhibits neuroinflammation and prevents axon degeneration and retinal ganglion cell death in an inducible mouse model of glaucoma

(2019) Anitha Krishnan et al.   Journal of Neuroinflammation

BAX-Depleted Retinal Ganglion Cells Survive and Become Quiescent Following Optic Nerve Damage

(2019) Ryan J. Donahue et al.   MOLECULAR NEUROBIOLOGY

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

(2019) Melanie Fritsch et al.   NATURE

Activity of caspase-8 determines plasticity between cell death pathways

(2019) Kim Newton et al.   NATURE

Mitochondria as multifaceted regulators of cell death

(2019) Florian J. Bock et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pan-caspase inhibitor F573 mitigates liver ischemia reperfusion injury in a murine model

(2019) Mariusz Bral et al.   PLoS One

Low human and murine Mcl-1 expression leads to a pro-apoptotic plaque phenotype enriched in giant-cells

(2019) Margaux A. C. Fontaine et al.   Scientific Reports

ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis)

(2019) R. K. Subbarao Malireddi et al.   Frontiers in Cellular and Infection Microbiology

Tumor necrosis factor-α blockade ameliorates diabetic nephropathy in rats

(2019) Dongsheng Cheng et al.   Clinical Kidney Journal

Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer’s disease

(2019) Marta J. Koper et al.   ACTA NEUROPATHOLOGICA

Effects of XIAP on high fat diet-induced hepatic steatosis: a mechanism involving NLRP3 inflammasome and oxidative stress

(2019) Shi Zilu et al.   Aging-US

Treatment of acetaminophen-induced liver failure by blocking the death checkpoint protein TRAIL

(2019) Qian Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Anti-TNF agent etanercept augments UV-induced skin cancer development in SKH-1 mice

(2019) Ercan Calıskan et al.   JOURNAL OF DERMATOLOGICAL TREATMENT

Randomized placebo-controlled trial of emricasan for non-alcoholic steatohepatitis-related cirrhosis with severe portal hypertension

(2019) Guadalupe Garcia-Tsao et al.   JOURNAL OF HEPATOLOGY

A randomized, placebo-controlled trial of emricasan in patients with NASH and F1-F3 fibrosis

(2019) Stephen A. Harrison et al.   JOURNAL OF HEPATOLOGY

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

(2019) Najoua Lalaoui et al.   NATURE

Targeting soluble tumor necrosis factor as a potential intervention to lower risk for late-onset Alzheimer’s disease associated with obesity, metabolic syndrome, and type 2 diabetes

(2019) Maria Elizabeth De Sousa Rodrigues et al.   Alzheimers Research & Therapy

Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide

(2019) Saskia D. Günther et al.   Nature Microbiology

Loss of cellular FLICE-inhibitory protein promotes acute cholestatic liver injury and inflammation from bile duct ligation

(2018) Nadine Gehrke et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion

(2018) Irina Pleines et al.   BLOOD

Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK

(2018) Francine F.S. Ke et al.   CELL

Caspase-8 deficiency in mouse embryos triggers chronic RIPK1-dependent activation of inflammatory genes, independently of RIPK3

(2018) Tae-Bong Kang et al.   CELL DEATH AND DIFFERENTIATION

New insights into apoptosome structure and function

(2018) Loretta Dorstyn et al.   CELL DEATH AND DIFFERENTIATION

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

The BH3-only protein BAD mediates TNFα cytotoxicity despite concurrent activation of IKK and NF-κB in septic shock

(2018) Jie Yan et al.   CELL RESEARCH

BCL-2 levels do not predict azathioprine treatment response in inflammatory bowel disease, but inhibition induces lymphocyte apoptosis and ameliorates colitis in mice

(2018) Bruce Weder et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Emricasan Improves Liver Function in Patients With Cirrhosis and High Model for End-stage Liver Disease Scores Compared With Placebo

(2018) Catherine T. Frenette et al.   Clinical Gastroenterology and Hepatology

Counteracting the effects of TNF receptor‐1 has therapeutic potential in Alzheimer's disease

(2018) Sophie Steeland et al.   EMBO Molecular Medicine

Key apoptotic genes APAF1 and CASP9 implicated in recurrent folate-resistant neural tube defects

(2018) Catherine J. Spellicy et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Dependence receptors - the dark side awakens

(2018) Ana-Maria Negulescu et al.   FEBS Journal

JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice

(2018) Xinxin Song et al.   GASTROENTEROLOGY

Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock

(2018) Pratyusha Mandal et al.   IMMUNITY

Loss of BID Delays FASL-Induced Cell Death of Mouse Neutrophils and Aggravates DSS-Induced Weight Loss

(2018) Simone Wicki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Autoimmune Lymphoproliferative Syndrome with Defective FAS or FAS-Ligand Functions

(2018) Frédéric Rieux-Laucat et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Emricasan, a pan-caspase inhibitor, improves survival and portal hypertension in a murine model of common bile-duct ligation

(2018) Akiko Eguchi et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Soluble TNFα Signaling within the Spinal Cord Contributes to the Development of Autonomic Dysreflexia and Ensuing Vascular and Immune Dysfunction after Spinal Cord Injury

(2018) Eugene Mironets et al.   JOURNAL OF NEUROSCIENCE

Disruption of tumor necrosis factor alpha receptor 1 signaling accelerates NAFLD progression in mice upon a high-fat diet

(2018) Flavia Lambertucci et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Caspase-3 Is a Pivotal Regulator of Microvascular Rarefaction and Renal Fibrosis after Ischemia-Reperfusion Injury

(2018) Bing Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The pro-apoptotic protein Bmf co-operates with Bim and Puma in neuron death induced by β-amyloid or NGF deprivation

(2018) Rumana Akhter et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The autophagic network and cancer

(2018) Marissa D. Rybstein et al.   NATURE CELL BIOLOGY

Venetoclax–Rituximab in Relapsed or Refractory Chronic Lymphocytic Leukemia

(2018) John F. Seymour et al.   NEW ENGLAND JOURNAL OF MEDICINE

Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of antigen-stimulated T cells

(2018) Honglian Tong et al.   PLoS One

Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury

(2018) Alastair Proudfoot et al.   THORAX

Fas activity mediates airway inflammation during mouse adenovirus type 1 respiratory infection

(2018) Laura J. Adkins et al.   VIROLOGY

Neutralization of CD95 ligand protects the liver against ischemia-reperfusion injury and prevents acute liver failure

(2018) Mohammed Al-Saeedi et al.   Cell Death & Disease

Rare mutations in apoptosis related genes APAF1, CASP9, and CASP3 contribute to human neural tube defects

(2018) Xiangyu Zhou et al.   Cell Death & Disease

IL-4 enhances survival of in vitro-differentiated mouse basophils through transcription-independent signaling downstream of PI3K

(2018) Ramona Reinhart et al.   Cell Death & Disease

Ablation of Bax and Bak protects skeletal muscle against pressure-induced injury

(2018) Bjorn T. Tam et al.   Scientific Reports

IAPs Regulate Distinct Innate Immune Pathways to Co-ordinate the Response to Bacterial Peptidoglycans

(2018) Che A. Stafford et al.   Cell Reports

Role of Caspase-8 and Fas in Cell Death After Spinal Cord Injury

(2018) Daniel Sobrido-Cameán et al.   Frontiers in Molecular Neuroscience

Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner

(2018) Rui Liu et al.   Frontiers in Immunology

TRAIL-Mediated Suppression of T Cell Receptor Signaling Inhibits T Cell Activation and Inflammation in Experimental Autoimmune Encephalomyelitis

(2018) I-Tsu Chyuan et al.   Frontiers in Immunology

Genetic deletion of muscle RANK or selective inhibition of RANKL is not as effective as full-length OPG-fc in mitigating muscular dystrophy

(2018) Sébastien S. Dufresne et al.   Acta Neuropathologica Communications

ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P

(2018) Ju Youn Kim et al.   CELL

RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development

(2018) Holly Anderton et al.   CELL DEATH AND DIFFERENTIATION

Emricasan (IDN-6556) Lowers Portal Pressure in Patients with Compensated Cirrhosis and Severe Portal Hypertension

(2018) Guadalupe Garcia-Tsao et al.   HEPATOLOGY

FcɛRI cross-linking and IL-3 protect human basophils from intrinsic apoptotic stress

(2018) Lionel Rohner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inactivation of Caspase 8 in liver parenchymal cells confers protection against murine obstructive cholestasis

(2018) Francisco Javier Cubero et al.   JOURNAL OF HEPATOLOGY

Ablation of Cytochrome c in Adult Forebrain Neurons Impairs Oxidative Phosphorylation Without Detectable Apoptosis

(2018) Milena Pinto et al.   MOLECULAR NEUROBIOLOGY

Loss of RIPK3 and Caspase-8 Augments Intrinsic Apoptosis in Tubular Epithelial Cell and promote Kidney Ischemia Reperfusion Injury

(2018) Baekjun Sung et al.   NEPHROLOGY

FADD (Fas-Associated Protein With Death Domain), Caspase-3, and Caspase-8 and Incidence of Ischemic Stroke

(2018) Iram Faqir Muhammad et al.   STROKE

LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L

(2018) Lucia Taraborrelli et al.   Nature Communications

Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis

(2018) Sarah K. Williams et al.   Scientific Reports

Intranasal delivery of a Fas-blocking peptide attenuates Fas-mediated apoptosis in brain ischemia

(2018) Irfan Ullah et al.   Scientific Reports

Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities

(2018) Stephanie Grabow et al.   Cell Reports

Infection with flaviviruses requires BCLXL for cell survival

(2018) Tatsuya Suzuki et al.   PLoS Pathogens

Unconventional Ways to Live and Die: Cell Death and Survival in Development, Homeostasis, and Disease

(2018) Swapna A. Gudipaty et al.   Annual Review of Cell and Developmental Biology

BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines

(2018) Delphine Merino et al.   CANCER CELL

CD95-ligand contributes to abdominal aortic aneurysm progression by modulating inflammation

(2018) Zhibo Liu et al.   CARDIOVASCULAR RESEARCH

Mcl-1 and Bcl-xL are essential for survival of the developing nervous system

(2018) Lauren C. Fogarty et al.   CELL DEATH AND DIFFERENTIATION

Impact of elevated anti-apoptotic MCL-1 and BCL-2 on the development and treatment of MLL-AF9 AML in mice

(2018) Natasha S. Anstee et al.   CELL DEATH AND DIFFERENTIATION

Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency

(2018) Anna S. Lehle et al.   GASTROENTEROLOGY

Lymphoproliferation, immunodeficiency and early-onset inflammatory bowel disease associated with a novel mutation in Caspase 8

(2018) Veronika Kanderova et al.   HAEMATOLOGICA

PUMA induction mediates acetaminophen‐induced necrosis and liver injury

(2018) Dongshi Chen et al.   HEPATOLOGY

FAS and RAS related Apoptosis defects: From autoimmunity to leukemia

(2018) Sonia Meynier et al.   IMMUNOLOGICAL REVIEWS

TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation

(2018) Cun-Jin Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Exclusive expression of transmembrane TNF aggravates acute glomerulonephritis despite reduced leukocyte infiltration and inflammation

(2018) Martin B. Müller et al.   KIDNEY INTERNATIONAL

RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation

(2018) Gianmaria Liccardi et al.   MOLECULAR CELL

Risk of hospitalization for heart failure in rheumatoid arthritis patients treated with etanercept and abatacept

(2018) Elena Generali et al.   RHEUMATOLOGY INTERNATIONAL

Bid maintains mitochondrial cristae structure and function and protects against cardiac disease in an integrative genomics study

(2018) Christi T Salisbury-Ruf et al.   eLife

Role and Regulation of Pro-survival BCL-2 Proteins in Multiple Myeloma

(2018) Anne Slomp et al.   Frontiers in Oncology

BAD knockout provides metabolic seizure resistance in a genetic model of epilepsy with sudden unexplained death in epilepsy

(2017) Jeannine Foley et al.   EPILEPSIA

Circulating proteins as predictors of incident heart failure in the elderly

(2017) Markus Stenemo et al.   EUROPEAN JOURNAL OF HEART FAILURE

The PIDDosome activates p53 in response to supernumerary centrosomes

(2017) Luca L. Fava et al.   GENES & DEVELOPMENT

Pivotal Role of TNF-α in the Development and Progression of Nonalcoholic Fatty Liver Disease in a Murine Model

(2017) Satomi Kakino et al.   HORMONE AND METABOLIC RESEARCH

Overexpression of the X-Linked Inhibitor of Apoptosis Protects Against Retinal Degeneration in a Feline Model of Retinal Detachment

(2017) Sarah J. Wassmer et al.   HUMAN GENE THERAPY

A constitutive BCL2 down-regulation aggravates the phenotype of PKD1-mutant-induced polycystic kidney disease

(2017) Laurence Duplomb et al.   HUMAN MOLECULAR GENETICS

Caspase-8: regulating life and death

(2017) Bart Tummers et al.   IMMUNOLOGICAL REVIEWS

Genetic Deletion of Tumor Necrosis Factor-α Attenuates Amyloid-β Production and Decreases Amyloid Plaque Formation and Glial Response in the 5XFAD Model of Alzheimer’s Disease

(2017) Evi Paouri et al.   JOURNAL OF ALZHEIMERS DISEASE

BCL-W has a fundamental role in B cell survival and lymphomagenesis

(2017) Clare M. Adams et al.   JOURNAL OF CLINICAL INVESTIGATION

TNF is required for TLR ligand–mediated but not protease-mediated allergic airway inflammation

(2017) Gregory S. Whitehead et al.   JOURNAL OF CLINICAL INVESTIGATION

PEGylated TRAIL ameliorates experimental inflammatory arthritis by regulation of Th17 cells and regulatory T cells

(2017) Jong-Sung Park et al.   JOURNAL OF CONTROLLED RELEASE

RIPK1-dependent apoptosis bypasses pathogen blockade of innate signaling to promote immune defense

(2017) Lance W. Peterson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation

(2017) Yochai Wolf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bim suppresses the development of SLE by limiting myeloid inflammatory responses

(2017) FuNien Tsai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflammasome and Fas-Mediated IL-1β Contributes to Th17/Th1 Cell Induction in Pathogenic Bacterial Infection In Vivo

(2017) Ryosuke Uchiyama et al.   JOURNAL OF IMMUNOLOGY

Peripheral Tumor Necrosis Factor-Alpha (TNF-α) Modulates Amyloid Pathology by Regulating Blood-Derived Immune Cells and Glial Response in the Brain of AD/TNF Transgenic Mice

(2017) Evi Paouri et al.   JOURNAL OF NEUROSCIENCE

The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2

(2017) Torsten Hartwig et al.   MOLECULAR CELL

Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory “FADDosome” Complex upon TRAIL Stimulation

(2017) Conor M. Henry et al.   MOLECULAR CELL

Caspase-3-dependent cleavage of Akt modulates tau phosphorylation via GSK3β kinase: implications for Alzheimer’s disease

(2017) J Chu et al.   MOLECULAR PSYCHIATRY

BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation

(2017) Angela Bononi et al.   NATURE

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

IRF3 and type I interferons fuel a fatal response to myocardial infarction

(2017) Kevin R King et al.   NATURE MEDICINE

Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates

(2017) Pi-Xiao Wang et al.   NATURE MEDICINE

Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice

(2017) Kathryn P. MacPherson et al.   NEUROBIOLOGY OF DISEASE

Skilled Movements Require Non-apoptotic Bax/Bak Pathway-Mediated Corticospinal Circuit Reorganization

(2017) Zirong Gu et al.   NEURON

Caspase-8, association with Alzheimer’s Disease and functional analysis of rare variants

(2017) Jan Rehker et al.   PLoS One

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis

(2017) David Lagares et al.   Science Translational Medicine

Physiological functions of non-apoptotic caspase activity in the nervous system

(2017) Emilie Hollville et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The BCL-2 family of proteins and mitochondrial outer membrane permeabilisation

(2017) Richard W. Birkinshaw et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Tumor Necrosis Factor Family: Family Conventions and Private Idiosyncrasies

(2017) David Wallach   Cold Spring Harbor Perspectives in Biology

Inhibition of Caspase-8 does not protect from alcohol-induced liver apoptosis but alleviates alcoholic hepatic steatosis in mice

(2017) Fengjie Hao et al.   Cell Death & Disease

Deletion of the BH3-only protein Noxa alters electrographic seizures but does not protect against hippocampal damage after status epilepticus in mice

(2017) Naoki Ichikawa et al.   Cell Death & Disease

Deletion Of XIAP reduces the severity of acute pancreatitis via regulation of cell death and nuclear factor-κB activity

(2017) Yong Liu et al.   Cell Death & Disease

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function

(2017) Flurin Item et al.   Nature Communications

Cancer preventive effect of recombinant TRAIL by ablation of oncogenic inflammation in colitis-associated cancer rather than anticancer effect

(2017) Joo-Young Kim et al.   Oncotarget

Double knockout of Bax and Bak from kidney proximal tubules reduces unilateral urethral obstruction associated apoptosis and renal interstitial fibrosis

(2017) Shuqin Mei et al.   Scientific Reports

Leukocyte Bim deficiency does not impact atherogenesis in ldlr −/− mice, despite a pronounced induction of autoimmune inflammation

(2017) Lieve Temmerman et al.   Scientific Reports

RIPK3 Mediates Necroptosis during Embryonic Development and Postnatal Inflammation in Fadd -Deficient Mice

(2017) Qun Zhao et al.   Cell Reports

Association of Increased F4/80high Macrophages With Suppression of Serum-Transfer Arthritis in Mice With Reduced FLIP in Myeloid Cells

(2017) Qi-Quan Huang et al.   Arthritis & Rheumatology

Inhibition of TNF Receptor p55 By a Domain Antibody Attenuates the Initial Phase of Acid-Induced Lung Injury in Mice

(2017) Michael R. Wilson et al.   Frontiers in Immunology

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

(2017) William Sealy Hambright et al.   Redox Biology

Elevated Markers of Death Receptor-Activated Apoptosis are Associated with Increased Risk for Development of Diabetes and Cardiovascular Disease

(2017) Ingrid Yao Mattisson et al.   EBioMedicine

Non-alcoholic fatty liver disease, vascular inflammation and insulin resistance are exacerbated by TRAIL deletion in mice

(2017) Siân P. Cartland et al.   Scientific Reports

TNFR1 inhibition with a Nanobody protects against EAE development in mice

(2017) Sophie Steeland et al.   Scientific Reports

Fas Regulates Macrophage Polarization and Fibrogenic Phenotype in a Model of Chronic Ethanol-Induced Hepatocellular Injury

(2016) Fuyumi Isayama et al.   AMERICAN JOURNAL OF PATHOLOGY

Caspase Inhibition Prevents Tumor Necrosis Factor-α–Induced Apoptosis and Promotes Necrotic Cell Death in Mouse Hepatocytes in Vivo and in Vitro

(2016) Hong-Min Ni et al.   AMERICAN JOURNAL OF PATHOLOGY

Absence of TNF-α enhances inflammatory response in the newborn lung undergoing mechanical ventilation

(2016) Harald Ehrhardt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Studies on the role of apoptosis after transient myocardial ischemia: genetic deletion of the executioner caspases-3 and -7 does not limit infarct size and ventricular remodeling

(2016) Javier Inserte et al.   BASIC RESEARCH IN CARDIOLOGY

Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers

(2016) Mélodie Grandin et al.   CANCER CELL

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

(2016) Fabien Llambi et al.   CELL

PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia

(2016) A A Guirguis et al.   CELL DEATH AND DIFFERENTIATION

Overexpression of Mcl-1 exacerbates lymphocyte accumulation and autoimmune kidney disease in lpr mice

(2016) Natasha S Anstee et al.   CELL DEATH AND DIFFERENTIATION

Caspase-2 deficiency accelerates chemically induced liver cancer in mice

(2016) S Shalini et al.   CELL DEATH AND DIFFERENTIATION

Endothelial cell survival during angiogenesis requires the pro-survival protein MCL1

(2016) E C Watson et al.   CELL DEATH AND DIFFERENTIATION

DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death

(2016) Roshan J. Thapa et al.   Cell Host & Microbe

RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus

(2016) Shoko Nogusa et al.   Cell Host & Microbe

Remote Limb Preconditioning Generates a Neuroprotective Effect by Modulating the Extrinsic Apoptotic Pathway and TRAIL-Receptors Expression

(2016) Wei Xu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Neuronal Soluble Fas Ligand Drives M1-Microglia Polarization after Cerebral Ischemia

(2016) Hai-Lan Meng et al.   CNS Neuroscience & Therapeutics

Intratracheal Administration of Small Interfering RNA Targeting Fas Reduces Lung Ischemia-Reperfusion Injury*

(2016) Lorenzo Del Sorbo et al.   CRITICAL CARE MEDICINE

FADD is a key regulator of lipid metabolism

(2016) Hongqin Zhuang et al.   EMBO Molecular Medicine

Role of proapoptotic BH3-only proteins inListeria monocytogenesinfection

(2016) Camilla Margaroli et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Evaluation of Etanercept Treatment in Newborn Rat Model with Hyperoxic Lung Injury

(2016) Guven Kaya et al.   Fetal and Pediatric Pathology

Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane

(2016) Katelyn L. O'Neill et al.   GENES & DEVELOPMENT

Chronic lymphocytic leukemia development is accelerated in mice with deficiency of the pro-apoptotic regulator NOXA

(2016) E. Slinger et al.   HAEMATOLOGICA

Opposing role of tumor necrosis factor receptor 1 signaling in T cell-mediated hepatitis and bacterial infection in mice

(2016) Raluca Wroblewski et al.   HEPATOLOGY

The human-specificCASP4gene product contributes to Alzheimer-related synaptic and behavioural deficits

(2016) Yuji Kajiwara et al.   HUMAN MOLECULAR GENETICS

Caspases Connect Cell-Death Signaling to Organismal Homeostasis

(2016) Lorenzo Galluzzi et al.   IMMUNITY

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis

(2016) Silvia Alvarez-Diaz et al.   IMMUNITY

Autoimmune lymphoproliferative syndrome due to somatic FAS mutation (ALPS-sFAS) combined with a germline caspase-10 (CASP10) variation

(2016) Ana Martínez-Feito et al.   IMMUNOBIOLOGY

Pancreatic β-Cell Death due to Pdx-1 Deficiency Requires Multi-BH Domain Protein Bax but Not Bak

(2016) Juan Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cleavage by Caspase 8 and Mitochondrial Membrane Association Activate the BH3-only Protein Bid during TRAIL-induced Apoptosis

(2016) Kai Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic ablation of soluble tumor necrosis factor with preservation of membrane tumor necrosis factor is associated with neuroprotection after focal cerebral ischemia

(2016) Pernille M Madsen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice

(2016) Alex R.D. Delbridge et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles

(2016) Vikas K. Verma et al.   JOURNAL OF HEPATOLOGY

Liver Bid suppression for treatment of fibrosis associated with non-alcoholic steatohepatitis

(2016) Akiko Eguchi et al.   JOURNAL OF HEPATOLOGY

Small interfering RNA targeting TNF-α gene significantly attenuates renal ischemia-reperfusion injury in mice

(2016) Ling Hou et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

TNF-α and Macrophages Are Critical for Respiratory Syncytial Virus–Induced Exacerbations in a Mouse Model of Allergic Airways Disease

(2016) Thi Hiep Nguyen et al.   JOURNAL OF IMMUNOLOGY

Bcl-xL Is Essential for the Survival and Function of Differentiated Neurons in the Cortex That Control Complex Behaviors

(2016) A. Nakamura et al.   JOURNAL OF NEUROSCIENCE

Re-activation of mitochondrial apoptosis inhibits T-cell lymphoma survival and treatment resistance

(2016) S Spinner et al.   LEUKEMIA

Pre-administration of BAX-inhibiting peptides decrease the loss of the nigral dopaminergic neurons in rats

(2016) Chi Ma et al.   LIFE SCIENCES

Genetic Ablation of Soluble TNF Does Not Affect Lesion Size and Functional Recovery after Moderate Spinal Cord Injury in Mice

(2016) Ditte Gry Ellman et al.   MEDIATORS OF INFLAMMATION

Bcl-xL dependency coincides with the onset of neurogenesis in the developing mammalian spinal cord

(2016) Lauren C. Fogarty et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor

(2016) Qingshan Fu et al.   MOLECULAR CELL

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

(2016) András Kotschy et al.   NATURE

Caspase-2 and tau—a toxic partnership?

(2016) Carol M Troy et al.   NATURE MEDICINE

Caspase-2 cleavage of tau reversibly impairs memory

(2016) Xiaohui Zhao et al.   NATURE MEDICINE

Necroptosis in development, inflammation and disease

(2016) Ricardo Weinlich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia

(2016) Andrew W. Roberts et al.   NEW ENGLAND JOURNAL OF MEDICINE

Caspase-3 Deletion Promotes Necrosis in Atherosclerotic Plaques of ApoE Knockout Mice

(2016) Mandy O. J. Grootaert et al.   Oxidative Medicine and Cellular Longevity

Caspase inhibitor zVAD-fmk protects against acute pancreatitis-associated lung injury via inhibiting inflammation and apoptosis

(2016) Mingdong Liu et al.   PANCREATOLOGY

Inhibition of Acute Lung Injury by TNFR-Fc through Regulation of an Inflammation-Oxidative Stress Pathway

(2016) Yuan Weifeng et al.   PLoS One

Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration

(2016) Yun Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the TNF-α receptor type 1 on prostate carcinogenesis in knockout mice

(2016) Maria Raquel Unterkircher Galheigo et al.   PROSTATE

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

(2016) Gabriela Brumatti et al.   Science Translational Medicine

Infliximab does not increase colonic cancer risk associated to murine chronic colitis

(2016) Loris R Lopetuso et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Oral administration of a non-absorbable plant cell-expressed recombinant anti-TNF fusion protein induces immunomodulatory effects and alleviates nonalcoholic steatohepatitis

(2016) Yaron Ilan et al.   WORLD JOURNAL OF GASTROENTEROLOGY

BID Mediates Oxygen-Glucose Deprivation-Induced Neuronal Injury in Organotypic Hippocampal Slice Cultures and Modulates Tissue Inflammation in a Transient Focal Cerebral Ischemia Model without Changing Lesion Volume

(2016) Nellie Anne Martin et al.   Frontiers in Cellular Neuroscience

Bcl-xL is an oncogenic driver in colorectal cancer

(2016) Anna-Lena Scherr et al.   Cell Death & Disease

Critical B-lymphoid cell intrinsic role of endogenous MCL-1 in c-MYC-induced lymphomagenesis

(2016) S Grabow et al.   Cell Death & Disease

Lack of FADD in Tie-2 expressing cells causes RIPK3-mediated embryonic lethality

(2016) Cunxian Fan et al.   Cell Death & Disease

Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease

(2016) M V Machado et al.   Cell Death & Disease

MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL

(2016) Ingela B Vikström et al.   Cell Death & Disease

Bcl-2 is a critical mediator of intestinal transformation

(2016) Maartje van der Heijden et al.   Nature Communications

Loss of a Single Mcl-1 Allele Inhibits MYC-Driven Lymphomagenesis by Sensitizing Pro-B Cells to Apoptosis

(2016) Stephanie Grabow et al.   Cell Reports

Chronic lymphocytic leukemia development is accelerated in mice with deficiency of the pro-apoptotic regulator NOXA

(2016) E. Slinger et al.   HAEMATOLOGICA

Loss of Caspase‐Activated DNase Protects Against Atherosclerosis in Apolipoprotein E–Deficient Mice

(2016) Meng‐Lin Chao et al.   Journal of the American Heart Association

Inhibition of Soluble Tumor Necrosis Factor Prevents Chemically Induced Carcinogenesis in Mice

(2016) A. Sobo-Vujanovic et al.   Cancer Immunology Research

Tumor necrosis factor links chronic obstructive pulmonary disease and K-ras mutant lung cancer through induction of an immunosuppressive pro-tumor microenvironment

(2016) Lei Gong et al.   OncoImmunology

Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis

(2016) Mary Speir et al.   Nature Microbiology

Spatio-temporal activation of caspase-8 in myeloid cells upon ischemic stroke

(2016) Johanna Rodhe et al.   Acta Neuropathologica Communications

Characterization of Social Behaviors in caspase-3 deficient mice

(2016) Shih-Ching Lo et al.   Scientific Reports

Conditional ablation of myeloid TNF increases lesion volume after experimental stroke in mice, possibly via altered ERK1/2 signaling

(2016) Bettina Hjelm Clausen et al.   Scientific Reports

Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model

(2015) Edel Kavanagh et al.   Aging-US

Antagonism between MCL-1 and PUMA governs stem/progenitor cell survival during hematopoietic recovery from stress

(2015) A. R. D. Delbridge et al.   BLOOD

Hyperactivity and depression-like traits in Bax KO mice

(2015) Thomas E. Krahe et al.   BRAIN RESEARCH

NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis

(2015) Vangelis Kondylis et al.   CANCER CELL

Cancer Cell-Autonomous TRAIL-R Signaling Promotes KRAS-Driven Cancer Progression, Invasion, and Metastasis

(2015) Silvia von Karstedt et al.   CANCER CELL

Dependence Receptors and Cancer: Addiction to Trophic Ligands

(2015) B. Gibert et al.   CANCER RESEARCH

Genetic deletion of TNFα inhibits ultraviolet radiation-induced development of cutaneous squamous cell carcinomas in PKCε transgenic mice via inhibition of cell survival signals

(2015) Ashok Singh et al.   CARCINOGENESIS

The BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland

(2015) F Schuler et al.   CELL DEATH AND DIFFERENTIATION

Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival

(2015) M Sochalska et al.   CELL DEATH AND DIFFERENTIATION

Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation

(2015) A Wree et al.   CELL DEATH AND DIFFERENTIATION

Combined loss of the BH3-only proteins Bim and Bmf restores B-cell development and function in TACI-Ig transgenic mice

(2015) C Woess et al.   CELL DEATH AND DIFFERENTIATION

Increased lymphocyte apoptosis in mouse models of colitis upon ABT-737 treatment is dependent upon BIM expression

(2015) C. Lutz et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells

(2015) Balasubramanian Krishnamurthy et al.   DIABETES

cIAP2 supports viability of mice lacking cIAP1 and XIAP

(2015) K. N. Heard et al.   EMBO JOURNAL

Transient activation of microglia following acute alcohol exposure in developing mouse neocortex is primarily driven by BAX-dependent neurodegeneration

(2015) Katelin E. Ahlers et al.   GLIA

The BH3-only protein BID impairs the p38-mediated stress response and promotes hepatocarcinogenesis during chronic liver injury in mice

(2015) Johanna Orlik et al.   HEPATOLOGY

Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice

(2015) Tom Vanden Berghe et al.   IMMUNITY

Effect of Genetic Deletion or Pharmacological Antagonism of Tumor Necrosis Factor Alpha on Colitis-associated Carcinogenesis in Mice

(2015) Brian Craven et al.   INFLAMMATORY BOWEL DISEASES

A new case of Fas-associated death domain protein deficiency and update on treatment outcomes

(2015) Sinisa Savic et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Caspase-8 Deficiency Presenting as Late-Onset Multi-Organ Lymphocytic Infiltration with Granulomas in two Adult Siblings

(2015) Julie Niemela et al.   JOURNAL OF CLINICAL IMMUNOLOGY

TNF-α antagonist may not be suitable for severe rituximab-induced interstitial lung disease

(2015) J. Tan et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice

(2015) Liang Gao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cellular FLIP Inhibits Myeloid Cell Activation by Suppressing Selective Innate Signaling

(2015) Yu-Jung Wu et al.   JOURNAL OF IMMUNOLOGY

ROS generated during early reperfusion contribute to intermittent hypobaric hypoxia-afforded cardioprotection against postischemia-induced Ca2+ overload and contractile dysfunction via the JAK2/STAT3 pathway

(2015) Lan Wu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Lack of TNF-alpha receptor type 2 protects motor neurons in a cellular model of amyotrophic lateral sclerosis and in mutant SOD1 mice but does not affect disease progression

(2015) Massimo Tortarolo et al.   JOURNAL OF NEUROCHEMISTRY

Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism

(2015) Nikenza Viceconte et al.   Journal of Neuroinflammation

Transiently lowering tumor necrosis factor-α synthesis ameliorates neuronal cell loss and cognitive impairments induced by minimal traumatic brain injury in mice

(2015) Renana Baratz et al.   Journal of Neuroinflammation

Caspase-3 Deficiency Results in Disrupted Synaptic Homeostasis and Impaired Attention Control

(2015) S.-C. Lo et al.   JOURNAL OF NEUROSCIENCE

Soluble Tumor Necrosis Factor Alpha Promotes Retinal Ganglion Cell Death in Glaucoma via Calcium-Permeable AMPA Receptor Activation

(2015) J. L. Cueva Vargas et al.   JOURNAL OF NEUROSCIENCE

Bax Regulates Neuronal Ca2+ Homeostasis

(2015) B. D'Orsi et al.   JOURNAL OF NEUROSCIENCE

BH3-only proteins contribute to steatotic liver ischemia–reperfusion injury

(2015) Bernard J. DuBray et al.   JOURNAL OF SURGICAL RESEARCH

Macrophage-derived tumor necrosis factor-α mediates diabetic renal injury

(2015) Alaa S. Awad et al.   KIDNEY INTERNATIONAL

Blockade of BCL-2 proteins efficiently induces apoptosis in progenitor cells of high-risk myelodysplastic syndromes patients

(2015) S Jilg et al.   LEUKEMIA

Mice lacking functional CD95-ligand display reduced proliferation of the intestinal epithelium without gross homeostatic alterations

(2015) Kari Trumpi et al.   Medical Molecular Morphology

Inhibition of Peripheral TNF-α and Downregulation of Microglial Activation by Alpha-Lipoic Acid and Etanercept Protect Rat Brain Against Ischemic Stroke

(2015) Ming-Hsiu Wu et al.   MOLECULAR NEUROBIOLOGY

Caspase-7: a critical mediator of optic nerve injury-induced retinal ganglion cell death

(2015) Shreyasi Choudhury et al.   Molecular Neurodegeneration

A pathogenic role for tumor necrosis factor-related apoptosis-inducing ligand in chronic obstructive pulmonary disease

(2015) T J Haw et al.   Mucosal Immunology

EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival

(2015) Nai Yang Fu et al.   NATURE CELL BIOLOGY

An interconnected hierarchical model of cell death regulation by the BCL-2 family

(2015) Hui-Chen Chen et al.   NATURE CELL BIOLOGY

Tumor necrosis factor-α confers cardioprotection through ectopic expression of keratins K8 and K18

(2015) Stamatis Papathanasiou et al.   NATURE MEDICINE

Combined loss of PUMA and p21 accelerates c-MYC-driven lymphoma development considerably less than loss of one allele of p53

(2015) L J Valente et al.   ONCOGENE

Spontaneous retrotransposon insertion intoTNF3′UTR causes heart valve disease and chronic polyarthritis

(2015) Derek Lacey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus

(2015) Gregor Ebert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis

(2015) Gregor Ebert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Attenuation of Nitrogen Mustard-Induced Pulmonary Injury and Fibrosis by Anti-Tumor Necrosis Factor-α Antibody

(2015) Rama Malaviya et al.   TOXICOLOGICAL SCIENCES

Intestinal genetic inactivation of caspase-8 diminishes migration of enterocytes

(2015) Elke Kaemmerer et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Conditional deletion of caspase-8 in macrophages alters macrophage activation in a RIPK-dependent manner

(2015) Carla M. Cuda et al.   ARTHRITIS RESEARCH & THERAPY

BCL-2 is dispensable for thrombopoiesis and platelet survival

(2015) M A Debrincat et al.   Cell Death & Disease

The BH3-only protein Bad is dispensable for TNF-mediated cell death

(2015) E Ottina et al.   Cell Death & Disease

Targeting caspase-6 and caspase-8 to promote neuronal survival following ischemic stroke

(2015) A P Shabanzadeh et al.   Cell Death & Disease

Impact of the combined loss of BOK, BAX and BAK on the hematopoietic system is slightly more severe than compound loss of BAX and BAK

(2015) F Ke et al.   Cell Death & Disease

Caspase-3 inhibitor prevents the apoptosis of brain tissue in rats with acute cerebral infarction

(2015) YUHUA SUN et al.   Experimental and Therapeutic Medicine

CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis

(2015) Qi-Quan Huang et al.   Nature Communications

Caspase inhibition impaired the neural stem/progenitor cell response after cortical ischemia in mice

(2015) Ahmed M. Osman et al.   Oncotarget

Preserved otolith organ function in caspase-3-deficient mice with impaired horizontal semicircular canal function

(2015) Patrick A. Armstrong et al.   EXPERIMENTAL BRAIN RESEARCH

Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Promotes Angiogenesis and Ischemia-Induced Neovascularization Via NADPH Oxidase 4 (NOX4) and Nitric Oxide-Dependent Mechanisms

(2015) B. A. Di Bartolo et al.   Journal of the American Heart Association

TRAIL Modulates the Immune System and Protects against the Development of Diabetes

(2015) Fleur Bossi et al.   Journal of Immunology Research

Fas-Associated Protein with Death Domain Regulates Notch Signaling during Muscle Regeneration

(2015) Rong Zhang et al.   CELLS TISSUES ORGANS

Deletion of FADD in Macrophages and Granulocytes Results in RIP3- and MyD88-Dependent Systemic Inflammation

(2015) Suruchi N. Schock et al.   PLoS One

Executioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart

(2015) Maria Cardona et al.   PLoS One

Oral TNFα Modulation Alters Neutrophil Infiltration, Improves Cognition and Diminishes Tau and Amyloid Pathology in the 3xTgAD Mouse Model

(2015) S. Prasad Gabbita et al.   PLoS One

Neutralization of Tumor Necrosis Factor Bioactivity Ameliorates Urethane-Induced Pulmonary Oncogenesis in Mice

(2015) Sophia P. Karabela et al.   NEOPLASIA

Tumor Necrosis Factor-α Accelerates the Resolution of Established Pulmonary Fibrosis in Mice by Targeting Profibrotic Lung Macrophages

(2014) Elizabeth F. Redente et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

BAX channel activity mediates lysosomal disruption linked to Parkinson disease

(2014) Jordi Bové et al.   Autophagy

FADD is essential for glucose uptake and survival of thymocytes

(2014) Xiang-Yu Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inflammatory outcomes of apoptosis, necrosis and necroptosis

(2014) Pavel Davidovich et al.   BIOLOGICAL CHEMISTRY

Loss of the Proapoptotic BH3-Only Protein BCL-2 Modifying Factor Prolongs the Fertile Life Span in Female Mice1

(2014) Seng H. Liew et al.   BIOLOGY OF REPRODUCTION

Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56  stabilizes its antiapoptotic activity

(2014) I. C. C. Low et al.   BLOOD

Deregulated cell death and lymphocyte homeostasis cause premature lethality in mice lacking the BH3-only proteins Bim and Bmf

(2014) V. Labi et al.   BLOOD

Plasmacytomagenesis in E -v-abl transgenic mice is accelerated when apoptosis is restrained

(2014) C. J. Vandenberg et al.   BLOOD

Abnormally differentiated CD4+ or CD8+ T cells with phenotypic and genetic features of double negative T cells in human Fas deficiency

(2014) A. Rensing-Ehl et al.   BLOOD

Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice

(2014) E. P. Lu et al.   BLOOD

MCL-1 but not BCL-XL is critical for the development and sustained expansion of thymic lymphoma in p53-deficient mice

(2014) S. Grabow et al.   BLOOD

Inability to resolve specific infection generates innate immunodeficiency syndrome in Xiap-/- mice

(2014) W.-C. Hsieh et al.   BLOOD

Natural history of autoimmune lymphoproliferative syndrome associated withFASgene mutations

(2014) Susan Price et al.   BLOOD

Neutralization of TNFSF10 ameliorates functional outcome in a murine model of Alzheimer’s disease

(2014) Giuseppina Cantarella et al.   BRAIN

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

(2014) Michael J. White et al.   CELL

Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

(2014) Anthony Rongvaux et al.   CELL

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

(2014) James A. Rickard et al.   CELL

RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3

(2014) Christopher P. Dillon et al.   CELL

The transcription factor p53: Not a repressor, solely an activator

(2014) Martin Fischer et al.   CELL CYCLE

Caspase-2 impacts lung tumorigenesis and chemotherapy response in vivo

(2014) M R Terry et al.   CELL DEATH AND DIFFERENTIATION

Acute organ failure following the loss of anti-apoptotic cellular FLICE-inhibitory protein involves activation of innate immune receptors

(2014) N Gehrke et al.   CELL DEATH AND DIFFERENTIATION

Death receptor-independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO knockout

(2014) H Ehlken et al.   CELL DEATH AND DIFFERENTIATION

Elimination of quiescent/slow-proliferating cancer stem cells by Bcl-XL inhibition in non-small cell lung cancer

(2014) A Zeuner et al.   CELL DEATH AND DIFFERENTIATION

Decreased mitochondrial priming determines chemoresistance of colon cancer stem cells

(2014) S Colak et al.   CELL DEATH AND DIFFERENTIATION

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

(2014) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Old, new and emerging functions of caspases

(2014) S Shalini et al.   CELL DEATH AND DIFFERENTIATION

Cardiomyocyte apoptosis contributes to pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated mice

(2014) Soon Woo Nam et al.   CLINICAL SCIENCE

Role of BH3-Only Molecules Bim and Puma in  -Cell Death in Pdx1 Deficiency

(2014) D. Ren et al.   DIABETES

BH3-Only Molecule Bim Mediates  -Cell Death in IRS2 Deficiency

(2014) D. Ren et al.   DIABETES

Caspase 3 Inactivation Protects Against Hepatic Cell Death and Ameliorates Fibrogenesis in a Diet-Induced NASH Model

(2014) Samjhana Thapaliya et al.   DIGESTIVE DISEASES AND SCIENCES

BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella

(2014) M. Andree et al.   EMBO JOURNAL

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

(2014) G. L. Kelly et al.   GENES & DEVELOPMENT

Overexpression of Fas and FasL Is Associated with Infectious Complications and Severity of Experimental Severe Acute Pancreatitis by Promoting Apoptosis of Lymphocytes

(2014) Liao Pinhu et al.   INFLAMMATION

Soluble or soluble/membrane TNF-± inhibitors protect the brain from focal ischemic injury in rats

(2014) C. A. Arango-Dávila et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Association Between Tumor Necrosis Factor-α Antagonists and Risk of Cancer in Patients With Inflammatory Bowel Disease

(2014) Nynne Nyboe Andersen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Differential regulation of inflammation and apoptosis in Fas-resistant hepatocyte-specific Bid-deficient mice

(2014) Milos Lazic et al.   JOURNAL OF HEPATOLOGY

Mutation of a Self-Processing Site in Caspase-8 Compromises Its Apoptotic but Not Its Nonapoptotic Functions in Bacterial Artificial Chromosome-Transgenic Mice

(2014) T.-B. Kang et al.   JOURNAL OF IMMUNOLOGY

TRAIL Deficiency Does Not Rescue Impaired CD8+ T Cell Memory Generated in the Absence of CD4+ T Cell Help

(2014) J. A. Sacks et al.   JOURNAL OF IMMUNOLOGY

A Role for cFLIP in B Cell Proliferation and Stress MAPK Regulation

(2014) H. Zhang et al.   JOURNAL OF IMMUNOLOGY

The Anti-Apoptotic Bcl-2 Family Member Mcl-1 Promotes T Lymphocyte Survival at Multiple Stages

(2014) I. Dzhagalov et al.   JOURNAL OF IMMUNOLOGY

Caspase-8 Acts as a Molecular Rheostat To Limit RIPK1- and MyD88-Mediated Dendritic Cell Activation

(2014) C. M. Cuda et al.   JOURNAL OF IMMUNOLOGY

TRAIL–Receptor Costimulation Inhibits Proximal TCR Signaling and Suppresses Human T Cell Activation and Proliferation

(2014) Corinna Lehnert et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice

(2014) S. B. Berger et al.   JOURNAL OF IMMUNOLOGY

Fas regulates neutrophil lifespan during viral and bacterial infection

(2014) Joanne A. O’Donnell et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Systemically administered anti-TNF therapy ameliorates functional outcomes after focal cerebral ischemia

(2014) Bettina Hjelm Clausen et al.   Journal of Neuroinflammation

Collagen II antibody-induced arthritis in Tg1278TNFko mice: optimization of a novel model to assess treatments targeting human TNFα in rheumatoid arthritis

(2014) Adrian Richard Moore et al.   Journal of Translational Medicine

The pan-caspase inhibitor Emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis

(2014) Fernando J. Barreyro et al.   LIVER INTERNATIONAL

Renal atrophy after ischemia–reperfusion injury depends on massive tubular apoptosis induced by TNFα in the later phase

(2014) Takaomi Adachi et al.   Medical Molecular Morphology

The caspase-8 shRNA-modified mesenchymal stem cells improve the function of infarcted heart

(2014) Yeyou Liang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Mice Lacking Functional Fas Death Receptors Are Protected from Kainic Acid-Induced Apoptosis in the Hippocampus

(2014) Miren Ettcheto et al.   MOLECULAR NEUROBIOLOGY

Tumor necrosis factor-related apoptosis-inducing ligand mediates the resolution of allergic airway inflammation induced by chronic allergen inhalation

(2014) L Faustino et al.   Mucosal Immunology

HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia

(2014) Jean-Benoît Arlet et al.   NATURE

Functional antagonism between pro-apoptotic BIM and anti-apoptotic BCL-XL in MYC-induced lymphomagenesis

(2014) A R D Delbridge et al.   ONCOGENE

TRAIL Deficiency Contributes to Diabetic Nephropathy in Fat-Fed ApoE-/- Mice

(2014) Siân P. Cartland et al.   PLoS One

Antibody-Mediated Inhibition of TNFR1 Attenuates Disease in a Mouse Model of Multiple Sclerosis

(2014) Sarah K. Williams et al.   PLoS One

AAV-Dominant Negative Tumor Necrosis Factor (DN-TNF) Gene Transfer to the Striatum Does Not Rescue Medium Spiny Neurons in the YAC128 Mouse Model of Huntington's Disease

(2014) Laura Taylor Alto et al.   PLoS One

Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death

(2014) D. Weng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition

(2014) W. J. Kaiser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis

(2014) Justine E. Roderick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PUMA regulates germ cell loss and primordial follicle endowment in mice

(2014) Michelle Myers et al.   REPRODUCTION

Regulation of NF-κB by TNF family cytokines

(2014) Matthew S. Hayden et al.   SEMINARS IN IMMUNOLOGY

Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand on NK Cells Protects From Hepatic Ischemia-Reperfusion Injury

(2014) René Fahrner et al.   TRANSPLANTATION

Impact of conditional deletion of the pro-apoptotic BCL-2 family member BIM in mice

(2014) M J Herold et al.   Cell Death & Disease

PUMA mediates ER stress-induced apoptosis in portal hypertensive gastropathy

(2014) S Tan et al.   Cell Death & Disease

Analysis of BH3-only proteins upregulated in response to oxygen/glucose deprivation in cortical neurons identifies Bmf but not Noxa as potential mediator of neuronal injury

(2014) S Pfeiffer et al.   Cell Death & Disease

FADD regulates thymocyte development at the β-selection checkpoint by modulating Notch signaling

(2014) X Zhang et al.   Cell Death & Disease

Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells

(2014) Priyanka Sathe et al.   Nature Communications

BIM Is the Primary Mediator of MYC-Induced Apoptosis in Multiple Solid Tissues

(2014) Nathiya Muthalagu et al.   Cell Reports

XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation

(2014) Monica Yabal et al.   Cell Reports

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice

(2014) James A Rickard et al.   eLife

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis

(2014) Snehlata Kumari et al.   eLife

Blockade of Death Ligand TRAIL Inhibits Renal Ischemia Reperfusion Injury

(2013) Takaomi Adachi et al.   ACTA HISTOCHEMICA ET CYTOCHEMICA

Chronic Neuron- and Age-Selective Down-Regulation of TNF Receptor Expression in Triple-Transgenic Alzheimer Disease Mice Leads to Significant Modulation of Amyloid- and Tau-Related Pathologies

(2013) Sara L. Montgomery et al.   AMERICAN JOURNAL OF PATHOLOGY

BH3-only protein Noxa contributes to apoptotic control of stress-erythropoiesis

(2013) Felix M. Wensveen et al.   APOPTOSIS

MCL1 is critical for mitochondrial function and autophagy in the heart

(2013) Robert L Thomas et al.   Autophagy

Targeted therapy of brain ischaemia using Fas ligand antibody conjugated PEG-lipid nanoparticles

(2013) Ying-mei Lu et al.   BIOMATERIALS

Mechanistic Differences in the Membrane Activity of Bax and Bcl-xL Correlate with Their Opposing Roles in Apoptosis

(2013) Stephanie Bleicken et al.   BIOPHYSICAL JOURNAL

Mantle cell lymphoma in cyclin D1 transgenic mice with Bim-deficient B cells

(2013) S. G. Katz et al.   BLOOD

ABT-199, a new Bcl-2-specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia

(2013) C. J. Vandenberg et al.   BLOOD

Inhibition of apoptosis by the intrinsic but not the extrinsic apoptotic pathway in myocardial ischemia-reperfusion

(2013) Arnt V. Kristen et al.   CARDIOVASCULAR PATHOLOGY

Inactivation of BAD by IKK Inhibits TNFα-Induced Apoptosis Independently of NF-κB Activation

(2013) Jie Yan et al.   CELL

Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice

(2013) M J Parsons et al.   CELL DEATH AND DIFFERENTIATION

Apaf1 apoptotic function critically limits Sonic hedgehog signaling during craniofacial development

(2013) A B Long et al.   CELL DEATH AND DIFFERENTIATION

Mcl-1 antagonizes Bax/Bak to promote effector CD4+ and CD8+ T-cell responses

(2013) P Tripathi et al.   CELL DEATH AND DIFFERENTIATION

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

(2013) Mychael V. Lourenco et al.   Cell Metabolism

Blockade of tumour necrosis factor-α in experimental autoimmune encephalomyelitis reveals differential effects on the antigen-specific immune response and central nervous system histopathology

(2013) H. Batoulis et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Impaired removal of Vβ8+lymphocytes aggravates colitis in mice deficient for B cell lymphoma-2-interacting mediator of cell death (Bim)

(2013) K. Leucht et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Possible Protecting Role of TNF-α in Kainic Acid-induced Neurotoxicity Via Down-Regulation of NFκB Signaling Pathway

(2013) Xing-Mei Zhang et al.   Current Alzheimer Research

Local Apoptosis Modulates Early Mammalian Brain Development through the Elimination of Morphogen-Producing Cells

(2013) Keiko Nonomura et al.   DEVELOPMENTAL CELL

Disease-causing mutations in the XIAPBIR2 domain impair NOD2-dependent immune signalling

(2013) Rune Busk Damgaard et al.   EMBO Molecular Medicine

Fas receptor-deficient lpr mice are protected against acetaminophen hepatotoxicity due to higher glutathione synthesis and enhanced detoxification of oxidant stress

(2013) C. David Williams et al.   FOOD AND CHEMICAL TOXICOLOGY

Cellular FLICE-Like Inhibitory Protein Secures Intestinal Epithelial Cell Survival and Immune Homeostasis by Regulating Caspase-8

(2013) Nadine Wittkopf et al.   GASTROENTEROLOGY

Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction

(2013) X. Wang et al.   GENES & DEVELOPMENT

Hepatocyte caspase-8 is an essential modulator of steatohepatitis in rodents

(2013) Maximilian Hatting et al.   HEPATOLOGY

Loss of caspase-8 in hepatocytes accelerates the onset of liver regeneration in mice through premature nuclear factor kappa B activation

(2013) Julia Freimuth et al.   HEPATOLOGY

Selective inhibition of caspases in skeletal muscle reverses the apoptotic synaptic degeneration in slow-channel myasthenic syndrome

(2013) H. Zhu et al.   HUMAN MOLECULAR GENETICS

Accumulation of the parkin substrate, FAF1, plays a key role in the dopaminergic neurodegeneration

(2013) Jee-Won Sul et al.   HUMAN MOLECULAR GENETICS

Comparison of TNF antagonism by etanercept and dexamethasone on airway epithelium and remodeling in an experimental model of asthma

(2013) Ozge Yilmaz et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Tumor Necrosis Factor-alpha-mutant Mice Exhibit High Frequency Hearing Loss

(2013) Naoki Oishi et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

Combination of necroptosis and apoptosis inhibition enhances cardioprotection against myocardial ischemia–reperfusion injury

(2013) Shizuka Koshinuma et al.   Journal of Anesthesia

Calpain and caspase-3 play required roles in immobilization-induced limb muscle atrophy

(2013) Erin E. Talbert et al.   JOURNAL OF APPLIED PHYSIOLOGY

The Bcl-2 Homology Domain 3 (BH3)-only Proteins Bim and Bid Are Functionally Active and Restrained by Anti-apoptotic Bcl-2 Family Proteins in Healthy Liver

(2013) Takahiro Kodama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase Inhibitors Protect Neurons by Enabling Selective Necroptosis of Inflamed Microglia

(2013) Michael Fricker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proapoptotic Bax and Bak Proteins Form Stable Protein-permeable Pores of Tunable Size

(2013) Stephanie Bleicken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor Necrosis Factor in Traumatic Brain Injury: Effects of Genetic Deletion of p55 or p75 Receptor

(2013) Luca Longhi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Caspase 8 differentially controls hepatocytes and non-parenchymal liver cells during chronic cholestatic liver injury in mice

(2013) Kunal Chaudhary et al.   JOURNAL OF HEPATOLOGY

TNF-Induced Death Signaling Triggers Alveolar Epithelial Dysfunction in Acute Lung Injury

(2013) B. V. Patel et al.   JOURNAL OF IMMUNOLOGY

TNF receptor 1 signaling is critically involved in mediating angiotensin-II-induced cardiac fibrosis

(2013) Clemens Duerrschmid et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Tumor necrosis factor alpha antagonism improves neurological recovery in murine intracerebral hemorrhage

(2013) Beilei Lei et al.   Journal of Neuroinflammation

Tonic Activation of Bax Primes Neural Progenitors for Rapid Apoptosis through a Mechanism Preserved in Medulloblastoma

(2013) A. J. Crowther et al.   JOURNAL OF NEUROSCIENCE

The RIP1-Kinase Inhibitor Necrostatin-1 Prevents Osmotic Nephrosis and Contrast-Induced AKI in Mice

(2013) A. Linkermann et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Apoptotic and inflammatory signaling via Fas and tumor necrosis factor receptor I contribute to the development of chest trauma-induced septic acute lung injury

(2013) Sebastian Weckbach et al.   Journal of Trauma and Acute Care Surgery

Viral Inhibition of BAK Promotes Murine Cytomegalovirus Dissemination to Salivary Glands

(2013) W. Handke et al.   JOURNAL OF VIROLOGY

Bax and Bak have critical roles in ischemic acute kidney injury in global and proximal tubule–specific knockout mouse models

(2013) Qingqing Wei et al.   KIDNEY INTERNATIONAL

Possible pitfalls investigating cell death responses in genetically engineered mouse models and derived cell lines

(2013) Claudia Manzl et al.   METHODS

Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains

(2013) Shan Li et al.   NATURE

A type III effector antagonizes death receptor signalling during bacterial gut infection

(2013) Jaclyn S. Pearson et al.   NATURE

Mcl-1 is essential for the survival of plasma cells

(2013) Victor Peperzak et al.   NATURE IMMUNOLOGY

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cells

(2013) Wim Pierson et al.   NATURE IMMUNOLOGY

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events

(2013) Kiran Bhaskar et al.   NEUROBIOLOGY OF DISEASE

TNF-α/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells

(2013) H Oshima et al.   ONCOGENE

Targeting Caspase-3 as Dual Therapeutic Benefits by RNAi Facilitating Brain-Targeted Nanoparticles in a Rat Model of Parkinson’s Disease

(2013) Yang Liu et al.   PLoS One

Tumor Necrosis Factor-α and Lymphotoxin-α Mediate Myocardial Ischemic Injury via TNF Receptor 1, but Are Cardioprotective When Activating TNF Receptor 2

(2013) Yanqing Zhang et al.   PLoS One

Tumor Necrosis Factor-α Promotes Cholestasis-Induced Liver Fibrosis in the Mouse through Tissue Inhibitor of Metalloproteinase-1 Production in Hepatic Stellate Cells

(2013) Yosuke Osawa et al.   PLoS One

TRAIL-Deficiency Accelerates Vascular Calcification in Atherosclerosis via Modulation of RANKL

(2013) Belinda A. Di Bartolo et al.   PLoS One

P45 Forms a Complex with FADD and Promotes Neuronal Cell Survival Following Spinal Cord Injury

(2013) Tsung-Chang Sung et al.   PLoS One

Distinct Contributions of TNF Receptor 1 and 2 to TNF-Induced Glomerular Inflammation in Mice

(2013) Anela Taubitz et al.   PLoS One

HSV-2 Regulates Monocyte Inflammatory Response via the Fas/FasL Pathway

(2013) Malgorzata Krzyzowska et al.   PLoS One

Inhibition of Fas-Associated Death Domain-Containing Protein (FADD) Protects against Myocardial Ischemia/Reperfusion Injury in a Heart Failure Mouse Model

(2013) Qian Fan et al.   PLoS One

Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice

(2013) J. Puccini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease

(2013) K. D. Mason et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dependence receptor TrkC is a putative colon cancer tumor suppressor

(2013) A.-L. Genevois et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury

(2013) A. Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration

(2013) H. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?

(2013) L. M. Coussens et al.   SCIENCE

PUMA and BIM Are Required for Oncogene Inactivation-Induced Apoptosis

(2013) G. R. Bean et al.   Science Signaling

TNF-α blockade is ineffective in animal models of established polycystic kidney disease

(2013) Jeffrey Roix et al.   BMC Nephrology

Mechanisms of Action of Bcl-2 Family Proteins

(2013) A. Shamas-Din et al.   Cold Spring Harbor Perspectives in Biology

Bmf upregulation through the AMP-activated protein kinase pathway may protect the brain from seizure-induced cell death

(2013) C Moran et al.   Cell Death & Disease

Consequences of the combined loss of BOK and BAK or BOK and BAX

(2013) F Ke et al.   Cell Death & Disease

Mature neurons: equipped for survival

(2013) A J Kole et al.   Cell Death & Disease

Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice

(2013) Julio Pozueta et al.   Nature Communications

Protective Roles for Caspase-8 and cFLIP in Adult Homeostasis

(2013) Ricardo Weinlich et al.   Cell Reports

RIP3 Inhibits Inflammatory Hepatocarcinogenesis but Promotes Cholestasis by Controlling Caspase-8- and JNK-Dependent Compensatory Cell Proliferation

(2013) Mihael Vucur et al.   Cell Reports

cFLIP Regulates Skin Homeostasis and Protects against TNF-Induced Keratinocyte Apoptosis

(2013) Diana Panayotova-Dimitrova et al.   Cell Reports

XIAP Regulates Caspase Activity in Degenerating Axons

(2013) Nicolas Unsain et al.   Cell Reports

MCMV-mediated Inhibition of the Pro-apoptotic Bak Protein Is Required for Optimal In Vivo Replication

(2013) Peter Fleming et al.   PLoS Pathogens

Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice

(2013) Jason Karch et al.   eLife

Fas Signaling in Macrophages Promotes Chronicity in K/BxN Serum-Induced Arthritis

(2013) Qi-Quan Huang et al.   Arthritis & Rheumatology

Inhibition of Apoptosis Protects Mice from Ethanol-Mediated Acceleration of Early Markers of CCl4-Induced Fibrosis but not Steatosis or Inflammation

(2012) Sanjoy Roychowdhury et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Increased hepatic fibrosis and JNK2-dependent liver injury in mice exhibiting hepatocyte-specific deletion of cFLIP

(2012) Jörn M. Schattenberg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Altered anxiety and defensive behaviors in Bax knockout mice

(2012) Angela C. Luedke et al.   BEHAVIOURAL BRAIN RESEARCH

Caspase-8 is essential for maintaining chromosomal stability and suppressing B-cell lymphomagenesis

(2012) A. Hakem et al.   BLOOD

Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival

(2012) M. A. Debrincat et al.   BLOOD

Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function

(2012) M. J. White et al.   BLOOD

p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis

(2012) Angelina V. Vaseva et al.   CELL

Deficiency in Bim, Bid and Bbc3 (Puma) do not prevent axonal injury induced death

(2012) J M Harder et al.   CELL DEATH AND DIFFERENTIATION

Prophylactic treatment with the BH3 mimetic ABT-737 impedes Myc-driven lymphomagenesis in mice

(2012) P N Kelly et al.   CELL DEATH AND DIFFERENTIATION

BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice

(2012) F Ke et al.   CELL DEATH AND DIFFERENTIATION

Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages

(2012) T Kodama et al.   CELL DEATH AND DIFFERENTIATION

Neuroprotective Effect of Small Interfering RNA Targeted to Caspase-3 on Rat Retinal Ganglion Cell Loss Induced by Ischemia and Reperfusion Injury

(2012) Shinichiro Ishikawa et al.   CURRENT EYE RESEARCH

IAPs limit activation of RIP kinases by TNF receptor 1 during development

(2012) Maryline Moulin et al.   EMBO JOURNAL

Astrocytic Fas ligand expression is required to induce T-cell apoptosis and recovery from experimental autoimmune encephalomyelitis

(2012) Xu Wang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The ‘complexities’ of life and death: Death receptor signalling platforms

(2012) Laura S. Dickens et al.   EXPERIMENTAL CELL RESEARCH

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

(2012) S. P. Glaser et al.   GENES & DEVELOPMENT

The BH3-Only Proteins Bim and Puma Cooperate to Impose Deletional Tolerance of Organ-Specific Antigens

(2012) Daniel H.D. Gray et al.   IMMUNITY

Defective cell death signalling along the Bcl-2 regulated apoptosis pathway compromises Treg cell development and limits their functionality in mice

(2012) Denise Tischner et al.   JOURNAL OF AUTOIMMUNITY

Clinical and Genetic Characteristics of XIAP Deficiency in Japan

(2012) Xi Yang et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Bak deficiency inhibits liver carcinogenesis: A causal link between apoptosis and carcinogenesis

(2012) Hayato Hikita et al.   JOURNAL OF HEPATOLOGY

Early intervention with a small molecule inhibitor for tumor nefosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer’s disease

(2012) S Prasad Gabbita et al.   Journal of Neuroinflammation

Tumor necrosis factor-α synthesis inhibitor 3,6′-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer’s disease

(2012) David Tweedie et al.   Journal of Neuroinflammation

Reduced Calreticulin Levels Link Endoplasmic Reticulum Stress and Fas-Triggered Cell Death in Motoneurons Vulnerable to ALS

(2012) N. Bernard-Marissal et al.   JOURNAL OF NEUROSCIENCE

TNFα gene knockout differentially affects lipid deposition in liver and skeletal muscle of high-fat-diet mice

(2012) Jérôme Salles et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Rip1 (Receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury

(2012) Andreas Linkermann et al.   KIDNEY INTERNATIONAL

Caspase-3 Protects Stressed Organs against Cell Death

(2012) H. Khalil et al.   MOLECULAR AND CELLULAR BIOLOGY

Mcl-1 regulates the survival of adult neural precursor cells

(2012) Craig D. Malone et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

BCL2L1 (BCL-X) promotes survival of adult and developing retinal ganglion cells

(2012) Jeffrey M. Harder et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

DNA Damage-Induced Primordial Follicle Oocyte Apoptosis and Loss of Fertility Require TAp63-Mediated Induction of Puma and Noxa

(2012) Jeffrey B. Kerr et al.   MOLECULAR CELL

The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

(2012) Rune Busk Damgaard et al.   MOLECULAR CELL

Lack of caspase-3 attenuates immobilization-induced muscle atrophy and loss of tension generation along with mitigation of apoptosis and inflammation

(2012) Shimei Zhu et al.   MUSCLE & NERVE

Intrinsically determined cell death of developing cortical interneurons

(2012) Derek G. Southwell et al.   NATURE

TRADD contributes to tumour suppression by regulating ULF-dependent p19Arf ubiquitylation

(2012) Iok In Christine Chio et al.   NATURE CELL BIOLOGY

Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration

(2012) Rhonda M. Perciavalle et al.   NATURE CELL BIOLOGY

Inhibition of TNF-α protects against hepatic ischemia–reperfusion injury in rats via NF-κB dependent pathway

(2012) Mona F. Mahmoud et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Bid signal pathway components are identified in the temporal cortex with Parkinson disease

(2012) H. Jiang et al.   NEUROLOGY

Bax deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation

(2012) I Garcia et al.   ONCOGENE

Minor cell-death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf

(2012) F Baumgartner et al.   ONCOGENE

Inhibition of the Intrinsic but Not the Extrinsic Apoptosis Pathway Accelerates and Drives Myc-Driven Tumorigenesis Towards Acute Myeloid Leukemia

(2012) Kari Högstrand et al.   PLoS One

The Viral TRAF Protein (ORF111L) from Infectious Spleen and Kidney Necrosis Virus Interacts with TRADD and Induces Caspase 8-mediated Apoptosis

(2012) Bai-Liang He et al.   PLoS One

Etanercept, a Widely Used Inhibitor of Tumor Necrosis Factor-α (TNF- α), Prevents Retinal Ganglion Cell Loss in a Rat Model of Glaucoma

(2012) Miin Roh et al.   PLoS One

Bax regulates primary necrosis through mitochondrial dynamics

(2012) R. S. Whelan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

c-FLIP Maintains Tissue Homeostasis by Preventing Apoptosis and Programmed Necrosis

(2012) X. Piao et al.   Science Signaling

Silencing of Fas, FADD (Fas-Associated Via Death Domain) or Caspase-3 Differentially Affects Lung Inflammation, Apoptosis and Development of Trauma Induced Septic Acute Lung Injury (ALI)

(2012) Mirko Philipp Messer et al.   SHOCK

Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis

(2012) Emmet E McGrath et al.   THORAX

The pantheon of the fallen: why are there so many forms of cell death?

(2012) Douglas R. Green et al.   TRENDS IN CELL BIOLOGY

Prothrombotic effects of tumor necrosis factor alpha in vivo are amplified by the absence of TNF-alpha receptor subtype 1 and require TNF-alpha receptor subtype 2

(2012) Joachim Pircher et al.   ARTHRITIS RESEARCH & THERAPY

Anti-apoptotic gene Bcl2 is required for stapes development and hearing

(2012) M R Carpinelli et al.   Cell Death & Disease

Inhibition of Bax protects neuronal cells from oligomeric Aβ neurotoxicity

(2012) W Kudo et al.   Cell Death & Disease

Neither loss of Bik alone, nor combined loss of Bik and Noxa, accelerate murine lymphoma development or render lymphoma cells resistant to DNA damaging drugs

(2012) L Happo et al.   Cell Death & Disease

Survival Function of the FADD-CASPASE-8-cFLIPL Complex

(2012) Christopher P. Dillon et al.   Cell Reports

Fas/FasL-mediated apoptosis and inflammation are key features of acute human spinal cord injury: implications for translational, clinical application

(2011) Wen Ru Yu et al.   ACTA NEUROPATHOLOGICA

Systemic FasL neutralization increases eosinophilic inflammation in a mouse model of asthma

(2011) S. K. Sharma et al.   ALLERGY

Ablation of TNF-RI/RII Expression in Alzheimer's Disease Mice Leads to an Unexpected Enhancement of Pathology

(2011) Sara L. Montgomery et al.   AMERICAN JOURNAL OF PATHOLOGY

Tumor necrosis factor receptor 1 functions as a tumor suppressor

(2011) Fengqi Chang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Role of the Fas/FasL system in a model of RSV infection in mechanically ventilated mice

(2011) Elske van den Berg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Fas Determines Differential Fates of Resident and Recruited Macrophages during Resolution of Acute Lung Injury

(2011) William J Janssen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Allergic Lung Inflammation Is Mediated by Soluble Tumor Necrosis Factor (TNF) and Attenuated by Dominant-Negative TNF Biologics

(2011) Isabelle Maillet et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The pro-apoptotic BH3-only protein Bid is dispensable for development of insulitis and diabetes in the non-obese diabetic mouse

(2011) Zia U. A. Mollah et al.   APOPTOSIS

Inhibition of caspase mediated apoptosis restores muscle function after crush injury in rat skeletal muscle

(2011) Ioannis Stratos et al.   APOPTOSIS

The role of TRAIL in mediating autophagy in myositis skeletal muscle: A potential nonimmune mechanism of muscle damage

(2011) Heather M. Alger et al.   ARTHRITIS AND RHEUMATISM

TRAIL attenuates the development of atherosclerosis in apolipoprotein E deficient mice

(2011) Victoria Watt et al.   ATHEROSCLEROSIS

Cellular FLICE-inhibitory protein protects against cardiac remodelling after myocardial infarction

(2011) Jinfeng Xiao et al.   BASIC RESEARCH IN CARDIOLOGY

TRAIL and DR5 Promote Thyroid Follicular Cell Apoptosis in Iodine Excess-Induced Experimental Autoimmune Thyroiditis in NOD Mice

(2011) Xiujie Yu et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Regulation of memory B-cell survival by the BH3-only protein Puma

(2011) C. Clybouw et al.   BLOOD

BH3-only protein Noxa regulates apoptosis in activated B cells and controls high-affinity antibody formation

(2011) F. M. Wensveen et al.   BLOOD

Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice

(2011) J. N. Lilla et al.   BLOOD

Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey

(2011) B. B. Aggarwal et al.   BLOOD

Endogenous Bcl-xL is essential for Myc-driven lymphomagenesis in mice

(2011) P. N. Kelly et al.   BLOOD

Inner ear dysfunction in caspase-3 deficient mice

(2011) Tomoko Makishima et al.   BMC NEUROSCIENCE

Inhibition of soluble tumour necrosis factor is therapeutic in experimental autoimmune encephalomyelitis and promotes axon preservation and remyelination

(2011) Roberta Brambilla et al.   BRAIN

Human neuropathological and animal model evidence supporting a role for Fas-mediated apoptosis and inflammation in cervical spondylotic myelopathy

(2011) W. R. Yu et al.   BRAIN

Targeted mutation of Fas ligand gene attenuates brain inflammation in experimental stroke

(2011) Feng-nan Niu et al.   BRAIN BEHAVIOR AND IMMUNITY

Attenuated neurological deficit, cell death and lesion volume in Fas-mutant mice is associated with altered neuroinflammation following traumatic brain injury

(2011) Jenna M. Ziebell et al.   BRAIN RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Pharmacological blockade of Bcl-2, Bcl-xL and Bcl-w by the BH3 mimetic ABT-737 has only minor impact on tumour development in p53-deficient mice

(2011) S Grabow et al.   CELL DEATH AND DIFFERENTIATION

Caspase-3 deficiency reveals a physiologic role for Smac/DIABLO in regulating programmed cell death

(2011) K K W Hui et al.   CELL DEATH AND DIFFERENTIATION

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

TNF-related apoptosis-inducing ligand (TRAIL) protects against diabetes and atherosclerosis in Apoe −/− mice

(2011) B. A. Di Bartolo et al.   DIABETOLOGIA

Loss of Caspase-8 Protects Mice Against Inflammation-Related Hepatocarcinogenesis but Induces Non-Apoptotic Liver Injury

(2011) Christian Liedtke et al.   GASTROENTEROLOGY

p53 and PUMA Independently Regulate Apoptosis of Intestinal Epithelial Cells in Patients and Mice With Colitis

(2011) Ramanarao Dirisina et al.   GASTROENTEROLOGY

Delayed-onset caspase-dependent massive hepatocyte apoptosis upon fas activation in bak/bax-deficient mice

(2011) Hayato Hikita et al.   HEPATOLOGY

PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice

(2011) Wei Qiu et al.   HEPATOLOGY

Over-expression of BCL2 rescues muscle weakness in a mouse model of oculopharyngeal muscular dystrophy

(2011) Janet E. Davies et al.   HUMAN MOLECULAR GENETICS

The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation

(2011) Marion C. Bonnet et al.   IMMUNITY

RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome

(2011) Linde Duprez et al.   IMMUNITY

RIG-I RNA Helicase Activation of IRF3 Transcription Factor Is Negatively Regulated by Caspase-8-Mediated Cleavage of the RIP1 Protein

(2011) Akhil Rajput et al.   IMMUNITY

TRAIL shows potential cardioprotective activity

(2011) Barbara Toffoli et al.   INVESTIGATIONAL NEW DRUGS

Caspase-8 inactivation in T cells increases necroptosis and suppresses autoimmunity inBim−/−mice

(2011) Toshiyuki Bohgaki et al.   JOURNAL OF CELL BIOLOGY

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

(2011) Haiming Dai et al.   JOURNAL OF CELL BIOLOGY

PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice

(2011) Wei Qiu et al.   JOURNAL OF CLINICAL INVESTIGATION

Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets

(2011) Emma C. Josefsson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanisms of necroptosis in T cells

(2011) Irene L. Ch’en et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ablation of c-FLIP in hepatocytes enhances death-receptor mediated apoptosis and toxic liver injury in vivo

(2011) Jörn M. Schattenberg et al.   JOURNAL OF HEPATOLOGY

The Proapoptotic Bcl-2 Family Member Bim Plays a Central Role during the Development of Virus-Induced Hepatitis

(2011) C. Lauer et al.   JOURNAL OF IMMUNOLOGY

FAS Haploinsufficiency Is a Common Disease Mechanism in the Human Autoimmune Lymphoproliferative Syndrome

(2011) H. S. Kuehn et al.   JOURNAL OF IMMUNOLOGY

Defects in the Bcl-2-Regulated Apoptotic Pathway Lead to Preferential Increase of CD25lowFoxp3+ Anergic CD4+ T Cells

(2011) Y. Zhan et al.   JOURNAL OF IMMUNOLOGY

TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation

(2011) Emmet E. McGrath et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Involvement of Caspase-6 and Caspase-8 in Neuronal Apoptosis and the Regenerative Failure of Injured Retinal Ganglion Cells

(2011) P. P. Monnier et al.   JOURNAL OF NEUROSCIENCE

Intranasal Delivery of Caspase-9 Inhibitor Reduces Caspase-6-Dependent Axon/Neuron Loss and Improves Neurological Function after Stroke

(2011) N. Akpan et al.   JOURNAL OF NEUROSCIENCE

Protective effect of caspase inhibition on compression-induced muscle damage

(2011) Bee T. Teng et al.   JOURNAL OF PHYSIOLOGY-LONDON

Reduction of Liver Ischemia Reperfusion Injury by Silencing of TNF-α Gene with shRNA

(2011) Roberto Hernandez-Alejandro et al.   JOURNAL OF SURGICAL RESEARCH

COGNITIVE IMPROVEMENT WITH INTRATHECAL ADMINISTRATION OF INFLIXIMAB IN A WOMAN WITH ALZHEIMER'S DISEASE

(2011) Jian-Quan Shi et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Blocking Fas Ligand on Leukocytes Attenuates Kidney Ischemia-Reperfusion Injury

(2011) G. J. Ko et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mice with defective Fas ligand are protected from crescentic glomerulonephritis

(2011) Ruth M. Tarzi et al.   KIDNEY INTERNATIONAL

Targeted expression of tumor necrosis factor-related apoptosis-inducing ligand TRAIL in skin protects mice against chemical carcinogenesis

(2011) Valerie Kedinger et al.   Molecular Cancer

BBC3 (PUMA) regulates developmental apoptosis but not axonal injury induced death in the retina

(2011) Jeffrey M Harder et al.   Molecular Neurodegeneration

DCC constrains tumour progression via its dependence receptor activity

(2011) Marie Castets et al.   NATURE

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

(2011) Patrick-Simon Welz et al.   NATURE

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

(2011) William J. Kaiser et al.   NATURE

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Functional complementation between FADD and RIP1 in embryos and lymphocytes

(2011) Haibing Zhang et al.   NATURE

Caspase signalling controls microglia activation and neurotoxicity

(2011) Miguel A. Burguillos et al.   NATURE

Caspase 8 inhibits programmed necrosis by processing CYLD

(2011) Marie Anne O’Donnell et al.   NATURE CELL BIOLOGY

Inhibition of Cysteine Proteases in Acute and Chronic Spinal Cord Injury

(2011) Swapan K. Ray et al.   Neurotherapeutics

Bim must be able to engage all pro-survival Bcl-2 family members for efficient tumor suppression

(2011) D Mérino et al.   ONCOGENE

Neuronal Deletion of Caspase 8 Protects against Brain Injury in Mouse Models of Controlled Cortical Impact and Kainic Acid-Induced Excitotoxicity

(2011) Maryla Krajewska et al.   PLoS One

Dissociation of Progressive Dopaminergic Neuronal Death and Behavioral Impairments by Bax Deletion in a Mouse Model of Parkinson's Diseases

(2011) Tae Woo Kim et al.   PLoS One

B regulatory cells and the tumor-promoting actions of TNF-  during squamous carcinogenesis

(2011) T. Schioppa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ryanodine receptor leak mediated by caspase-8 activation leads to left ventricular injury after myocardial ischemia-reperfusion

(2011) Jérémy Fauconnier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dependence Receptors: From Basic Research to Drug Development

(2011) P. Mehlen et al.   Science Signaling

Local Tissue Expression of the Cell Death Ligand, Fas Ligand, Plays a Central Role in the Development of Extrapulmonary Acute Lung Injury

(2011) Rajan K. Thakkar et al.   SHOCK

Tumor Necrosis Factor-α Antagonist Reduces Apoptosis of Neurons and Oligodendroglia in Rat Spinal Cord Injury

(2011) Ke-Bing Chen et al.   SPINE

Role of TRAIL and the pro-apoptotic Bcl-2 homolog Bim in acetaminophen-induced liver damage

(2011) A Badmann et al.   Cell Death & Disease

Caspase deficiency alters the murine gut microbiome

(2011) B M Brinkman et al.   Cell Death & Disease

Whole-Exome-Sequencing-Based Discovery of Human FADD Deficiency

(2010) Alexandre Bolze et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Bcl-2 overexpression in type II epithelial cells does not prevent hyperoxia-induced acute lung injury in mice

(2010) Isabelle Métrailler-Ruchonnet et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Fas/Fas Ligand–mediated Apoptosis Promotes Hypersensitivity Pneumonitis in Mice by Enhancing Maturation of Dendritic Cells

(2010) Su Jin Hwang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Epithelial Cell Death Is an Important Contributor to Oxidant-mediated Acute Lung Injury

(2010) G. R. Scott Budinger et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Development of Disseminated Histiocytic Sarcoma in a Patient With Autoimmune Lymphoproliferative Syndrome and Associated Rosai-Dorfman Disease

(2010) Girish Venkataraman et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Bim-Bcl-2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosis

(2010) John C. Scatizzi et al.   ARTHRITIS AND RHEUMATISM

Gene disruption of caspase-3 prevents MPTP-induced Parkinson’s disease in mice

(2010) Marina Yamada et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A role for proapoptotic Bax and Bak in T-cell differentiation and transformation

(2010) S. Biswas et al.   BLOOD

Extreme lymphoproliferative disease and fatal autoimmune thrombocytopenia in FasL and TRAIL double-deficient mice

(2010) L. M. Sedger et al.   BLOOD

Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim

(2010) L. Happo et al.   BLOOD

Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance

(2010) K. J. Campbell et al.   BLOOD

Prevention of Colitis-Associated Carcinogenesis with Infliximab

(2010) Y. J. Kim et al.   Cancer Prevention Research

Oncogene-Driven Intrinsic Inflammation Induces Leukocyte Production of Tumor Necrosis Factor That Critically Contributes to Mammary Carcinogenesis

(2010) S. Sangaletti et al.   CANCER RESEARCH

Mcl-1 promotes survival of thymocytes by inhibition of Bak in a pathway separate from Bcl-2

(2010) A Dunkle et al.   CELL DEATH AND DIFFERENTIATION

Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development

(2010) P N Kelly et al.   CELL DEATH AND DIFFERENTIATION

Identification and Evaluation of Small Molecule Pan-Caspase Inhibitors in Huntington's Disease Models

(2010) Melissa J. Leyva et al.   CHEMISTRY & BIOLOGY

Manipulation of Death Pathways in Desmin-Related Cardiomyopathy

(2010) Alina Maloyan et al.   CIRCULATION RESEARCH

Bim is responsible for the inherent sensitivity of the developing retinal vasculature to hyperoxia

(2010) Shoujian Wang et al.   DEVELOPMENTAL BIOLOGY

MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner

(2010) Marc Germain et al.   EMBO JOURNAL

Systemic Delivery of TNF-Related Apoptosis-Inducing Ligand (TRAIL) Elevates Levels of Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) and Prevents Type 1 Diabetes in Nonobese Diabetic Mice

(2010) Soojeong Kang et al.   ENDOCRINOLOGY

Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice

(2010) Jin Hwan Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Oncogenic K-Ras Turns Death Receptors Into Metastasis-Promoting Receptors in Human and Mouse Colorectal Cancer Cells

(2010) Frederik J.H. Hoogwater et al.   GASTROENTEROLOGY

Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation

(2010) V. Labi et al.   GENES & DEVELOPMENT

Apoptosis-promoted tumorigenesis:  -irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death

(2010) E. M. Michalak et al.   GENES & DEVELOPMENT

Cellular FLICE-Inhibitory Protein Protects Against Cardiac Remodeling Induced by Angiotensin II in Mice

(2010) Hongliang Li et al.   HYPERTENSION

CD95-Ligand on Peripheral Myeloid Cells Activates Syk Kinase to Trigger Their Recruitment to the Inflammatory Site

(2010) Elisabeth Letellier et al.   IMMUNITY

CD95 is cytoprotective for intestinal epithelial cells in colitis

(2010) Sun-Mi Park et al.   INFLAMMATORY BOWEL DISEASES

Deficiency of XIAP Leads to Sensitization forChlamydophila pneumoniaePulmonary Infection and Dysregulation of Innate Immune Response in Mice

(2010) Hridayesh Prakash et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMP kinase–mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis

(2010) Caoimhín G. Concannon et al.   JOURNAL OF CELL BIOLOGY

Tumor Necrosis Factor Alpha and Fas Receptor Contribute to Cognitive Deficits Independent of Cell Death after Concussive Traumatic Brain Injury in Mice

(2010) Jugta Khuman et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia

(2010) Zhifu Xiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis

(2010) Nichole A. Reyes et al.   JOURNAL OF CLINICAL INVESTIGATION

Synergism between p53 and Mcl-1 in protecting from hepatic injury, fibrosis and cancer

(2010) Shih-Yen Weng et al.   JOURNAL OF HEPATOLOGY

Oligodendrocyte-Specific FADD Deletion Protects Mice from Autoimmune-Mediated Demyelination

(2010) C. Mc Guire et al.   JOURNAL OF IMMUNOLOGY

FADD Deficiency Impairs Early Hematopoiesis in the Bone Marrow

(2010) S. Rosenberg et al.   JOURNAL OF IMMUNOLOGY

Dual Effects of TRAIL in Suppression of Autoimmunity: The Inhibition of Th1 Cells and the Promotion of Regulatory T Cells

(2010) T. Ikeda et al.   JOURNAL OF IMMUNOLOGY

A Major Role for Bim in Regulatory T Cell Homeostasis

(2010) C. A. Chougnet et al.   JOURNAL OF IMMUNOLOGY

BH3-only protein Bid is dispensable for seizure-induced neuronal death and the associated nuclear accumulation of apoptosis-inducing factor

(2010) Tobias Engel et al.   JOURNAL OF NEUROCHEMISTRY

Tumor Necrosis Factor-  (TNF- ) Regulates Shedding of TNF-  Receptor 1 by the Metalloprotease-Disintegrin ADAM8: Evidence for a Protease-Regulated Feedback Loop in Neuroprotection

(2010) J. W. Bartsch et al.   JOURNAL OF NEUROSCIENCE

Genetic Analysis of the Role of Tumor Necrosis Factor Receptors in Functional Outcome after Traumatic Brain Injury in Mice

(2010) Jinsheng Yang et al.   JOURNAL OF NEUROTRAUMA

Caspase-3 activation is required for reovirus-induced encephalitisin vivo

(2010) J David Beckham et al.   JOURNAL OF NEUROVIROLOGY

Role of tumor necrosis factor α (TNFα) in the onset of fructose-induced nonalcoholic fatty liver disease in mice

(2010) Giridhar Kanuri et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

XIAP Reduces Muscle Proteolysis Induced by CKD

(2010) J. Hu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Overexpression of Bcl-2 in hepatocytes protects against injury but does not attenuate fibrosis in a mouse model of chronic cholestatic liver disease

(2010) Claudia Mitchell et al.   LABORATORY INVESTIGATION

Melody, an ENU mutation in Caspase 3, alters the catalytic cysteine residue and causes sensorineural hearing loss in mice

(2010) Andrew Parker et al.   MAMMALIAN GENOME

BH3-Triggered Structural Reorganization Drives the Activation of Proapoptotic BAX

(2010) Evripidis Gavathiotis et al.   MOLECULAR CELL

CD95 promotes tumour growth

(2010) Lina Chen et al.   NATURE

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

(2010) Marcello D'Amelio et al.   NATURE NEUROSCIENCE

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Blocking TRAIL-DR5 signaling with soluble DR5 reduces delayed neuronal damage after transient global cerebral ischemia

(2010) Min Cui et al.   NEUROBIOLOGY OF DISEASE

Neutralization of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Reduces Spinal Cord Injury Damage in Mice

(2010) Giuseppina Cantarella et al.   NEUROPSYCHOPHARMACOLOGY

Deletion of puma protects hippocampal neurons in a model of severe status epilepticus

(2010) T. Engel et al.   NEUROSCIENCE

Fas/CD95 Deficiency in ApcMin/+ Mice Increases Intestinal Tumor Burden

(2010) Hector Guillen-Ahlers et al.   PLoS One

Development of atopic dermatitis-like skin disease from the chronic loss of epidermal caspase-8

(2010) C. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity

(2010) S. Ohsawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis

(2010) S. L. Osborn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program

(2010) D. Ren et al.   SCIENCE

Mcl-1 Is Essential for Germinal Center Formation and B Cell Memory

(2010) I. Vikstrom et al.   SCIENCE

DEFICIENCY OF BID PROTEIN REDUCES SEPSIS-INDUCED APOPTOSIS AND INFLAMMATION, WHILE IMPROVING SEPTIC SURVIVAL

(2010) Chun-Shiang Chung et al.   SHOCK

TNF RECEPTOR 2, NOT TNF RECEPTOR 1, ENHANCES MESENCHYMAL STEM CELL-MEDIATED CARDIAC PROTECTION FOLLOWING ACUTE ISCHEMIA

(2010) Megan L. Kelly et al.   SHOCK

BH3-only proteins BIM and PUMA in the regulation of survival and neuronal differentiation of newly generated cells in the adult mouse hippocampus

(2010) E C Bunk et al.   Cell Death & Disease

The p53-Target Gene Puma Drives Neutrophil-Mediated Protection against Lethal Bacterial Sepsis

(2010) Sean P. Garrison et al.   PLoS Pathogens

Fn14-TRAIL, a Chimeric Intercellular Signal Exchanger, Attenuates Experimental Autoimmune Encephalomyelitis

(2009) Marjaneh Razmara et al.   AMERICAN JOURNAL OF PATHOLOGY

The BH3-Only Protein Bid Does Not Mediate Death-Receptor-Induced Liver Injury in Obstructive Cholestasis

(2009) Padmavathi devi Nalapareddy et al.   AMERICAN JOURNAL OF PATHOLOGY

Decrease in Tumor Necrosis Factor-α Receptor-Associated Death Domain Results from Ubiquitin-Dependent Degradation in Obstructive Renal Injury in Rats

(2009) Taro Misaki et al.   AMERICAN JOURNAL OF PATHOLOGY

Anti-Fas Gene Therapy Prevents Doxorubicin-Induced Acute Cardiotoxicity through Mechanisms Independent of Apoptosis

(2009) Shusaku Miyata et al.   AMERICAN JOURNAL OF PATHOLOGY

Deletion of Fas in the pancreatic β-cells leads to enhanced insulin secretion

(2009) Diana Choi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Signaling pathway via TNF-α/NF-κB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis

(2009) Michio Onizawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

TNF-α inhibition attenuates adverse myocardial remodeling in a rat model of volume overload

(2009) Lynetta J. Jobe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Silencing of Fas-associated Death Domain Protects Mice from Septic Lung Inflammation and Apoptosis

(2009) Naoyuki Matsuda et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Macrophage Tumor Necrosis Factor-α Induces Epithelial Expression of Granulocyte–Macrophage Colony-stimulating Factor

(2009) Lidija Cakarova et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Epithelial Ablation of Bcl-XLIncreases Sensitivity to Oxygen without Disrupting Lung Development

(2009) Rhonda J. Staversky et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Potential Role of Soluble TRAIL in Epithelial Injury in Children with Severe RSV Infection

(2009) Reinout A. Bem et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Can’t live without them, can live with them: roles of caspases during vital cellular processes

(2009) Yael Feinstein-Rotkopf et al.   APOPTOSIS

Caspase-8 Is Involved in Neovascularization-Promoting Progenitor Cell Functions

(2009) Dörte Scharner et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lack of X-Linked Inhibitor of Apoptosis Protein Leads to Increased Apoptosis and Tissue Loss Following Neonatal Brain Injury

(2009) Tim West et al.   ASN Neuro

Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival

(2009) M. Lamkanfi et al.   BLOOD

Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad

(2009) A. Frenzel et al.   BLOOD

FAS-L, IL-10, and double-negative CD4-CD8- TCR  / + T cells are reliable markers of autoimmune lymphoproliferative syndrome (ALPS) associated with FAS loss of function

(2009) A. Magerus-Chatinet et al.   BLOOD

TNF-α contributes to axonal sprouting and functional recovery following traumatic brain injury

(2009) Taku Oshima et al.   BRAIN RESEARCH

PUMA Suppresses Intestinal Tumorigenesis in Mice

(2009) W. Qiu et al.   CANCER RESEARCH

Involvement of cytochrome c oxidase subunits Va and Vb in the regulation of cancer cell metabolism by Bcl-2

(2009) Z X Chen et al.   CELL DEATH AND DIFFERENTIATION

Contrasting patterns of Bim induction and neuroprotection in Bim-deficient mice between hippocampus and neocortex after status epilepticus

(2009) B M Murphy et al.   CELL DEATH AND DIFFERENTIATION

Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis

(2009) E M Michalak et al.   CELL DEATH AND DIFFERENTIATION

Apaf-1-independent programmed cell death in mouse development

(2009) A Nagasaka et al.   CELL DEATH AND DIFFERENTIATION

Apoptosis and non-inflammatory phagocytosis can be induced by mitochondrial damage without caspases

(2009) M F van Delft et al.   CELL DEATH AND DIFFERENTIATION

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes

(2009) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Divergent Tumor Necrosis Factor Receptor–Related Remodeling Responses in Heart Failure

(2009) Tariq Hamid et al.   CIRCULATION

EARLY SUBCUTANEOUS ADMINISTRATION OF ETANERCEPT (ENBREL) PREVENTS FROM HYPEROXIA-INDUCED LUNG INJURY

(2009) Florian Guthmann et al.   EXPERIMENTAL LUNG RESEARCH

Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapoptotic Puma

(2009) Tobias Engel et al.   FASEB JOURNAL

BH3-only protein bid participates in the Bcl-2 network in healthy liver cells

(2009) Hayato Hikita et al.   HEPATOLOGY

Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liver

(2009) Hayato Hikita et al.   HEPATOLOGY

Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis

(2009) Rafal P. Witek et al.   HEPATOLOGY

Hepatocyte-specific deletion of the antiapoptotic protein myeloid cell leukemia-1 triggers proliferation and hepatocarcinogenesis in mice

(2009) Achim Weber et al.   HEPATOLOGY

Fatal Hepatitis Mediated by Tumor Necrosis Factor TNFα Requires Caspase-8 and Involves the BH3-Only Proteins Bid and Bim

(2009) Thomas Kaufmann et al.   IMMUNITY

The Many Roles of FAS Receptor Signaling in the Immune System

(2009) Andreas Strasser et al.   IMMUNITY

Roles of proinflammatory cytokines and the Fas/Fas ligand interaction in the pathogenesis of inflammatory myopathies

(2009) Masahiro Kondo et al.   IMMUNOLOGY

Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim sustains B lymphopoiesis in the absence of IL-7

(2009) N. D. Huntington et al.   INTERNATIONAL IMMUNOLOGY

Absence of caspase-3 protects against denervation-induced skeletal muscle atrophy

(2009) Pamela J. Plant et al.   JOURNAL OF APPLIED PHYSIOLOGY

The Death Domain of FADD Is Essential for Embryogenesis, Lymphocyte Development, and Proliferation

(2009) Hongxia Z. Imtiyaz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Absence of Caspase-3 Protects Pancreatic β-Cells from c-Myc-induced Apoptosis without Leading to Tumor Formation

(2009) Anna Radziszewska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis

(2009) G. Dewson et al.   JOURNAL OF CELL SCIENCE

Critical roles of Bim in T cell activation and T cell–mediated autoimmune inflammation in mice

(2009) Maciej W. Ludwinski et al.   JOURNAL OF CLINICAL INVESTIGATION

Non-viral systemic delivery of Fas siRNA suppresses cyclophosphamide-induced diabetes in NOD mice

(2009) Ji Hoon Jeong et al.   JOURNAL OF CONTROLLED RELEASE

Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice

(2009) Tetsuya Nomura et al.   JOURNAL OF CONTROLLED RELEASE

Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease

(2009) Andrew Kovalenko et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differential Role of the Fas/Fas Ligand Apoptotic Pathway in Inflammation and Lung Fibrosis Associated with Reovirus 1/L-Induced Bronchiolitis Obliterans Organizing Pneumonia and Acute Respiratory Distress Syndrome

(2009) A. D. Lopez et al.   JOURNAL OF IMMUNOLOGY

Mechanisms and Consequences of Ebolavirus-Induced Lymphocyte Apoptosis

(2009) Steven B. Bradfute et al.   JOURNAL OF IMMUNOLOGY

Cardioprotection against myocardial infarction with PTD-BIR3/RING, a XIAP mimicking protein

(2009) Richard Souktani et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Proapoptotic BH3-Only, Bcl-2 Family Member, Puma Is Critical for Acute Ethanol-Induced Neuronal Apoptosis

(2009) Arindam P. Ghosh et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Microglia Protect Neurons against Ischemia by Synthesis of Tumor Necrosis Factor

(2009) K. L. Lambertsen et al.   JOURNAL OF NEUROSCIENCE

A Nanomedicine Transports a Peptide Caspase-3 Inhibitor across the Blood-Brain Barrier and Provides Neuroprotection

(2009) H. Karatas et al.   JOURNAL OF NEUROSCIENCE

Effect of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand on the Reduction of Joint Inflammation in Experimental Rheumatoid Arthritis

(2009) C.-H. Jin et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Prevention of lung ischemia–reperfusion injury by short hairpin RNA–mediated caspase-3 gene silencing

(2009) Yong-Xing Zhang et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Proteome-wide Substrate Analysis Indicates Substrate Exclusion as a Mechanism to Generate Caspase-7VersusCaspase-3 Specificity

(2009) Dieter Demon et al.   MOLECULAR & CELLULAR PROTEOMICS

Functional Cooperation of the Proapoptotic Bcl2 Family Proteins Bmf and Bim In Vivo

(2009) A. Hubner et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeted disruption of Bcl-xLin mouse keratinocytes inhibits both UVB- and chemically induced skin carcinogenesis

(2009) Dae Joon Kim et al.   MOLECULAR CARCINOGENESIS

Bak Activation for Apoptosis Involves Oligomerization of Dimers via Their α6 Helices

(2009) Grant Dewson et al.   MOLECULAR CELL

Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis

(2009) Hyungjin Kim et al.   MOLECULAR CELL

The Fas–FADD death domain complex structure unravels signalling by receptor clustering

(2009) Fiona L. Scott et al.   NATURE

XIAP discriminates between type I and type II FAS-induced apoptosis

(2009) Philipp J. Jost et al.   NATURE

Membrane-bound Fas ligand only is essential for Fas-induced apoptosis

(2009) Lorraine A. O’ Reilly et al.   NATURE

Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development

(2009) Stephen Malin et al.   NATURE IMMUNOLOGY

Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

(2009) Fiona E. McAlpine et al.   NEUROBIOLOGY OF DISEASE

TNF-α receptor 1 deficiency reduces antigen-presenting capacity of Schwann cells and ameliorates experimental autoimmune neuritis in mice

(2009) Xi-Jing Mao et al.   NEUROSCIENCE LETTERS

BH3-only proteins and their roles in programmed cell death

(2009) M Giam et al.   ONCOGENE

MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family

(2009) L J Beverly et al.   ONCOGENE

Absence of p55 TNF Receptor Reduces Atherosclerosis, but Has No Major Effect on Angiotensin II Induced Aneurysms in LDL Receptor Deficient Mice

(2009) Sofia Xanthoulea et al.   PLoS One

A tumor suppressor function for caspase-2

(2009) L. H. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 Controls Radiation-Induced Gastrointestinal Syndrome in Mice Independent of Apoptosis

(2009) D. G. Kirsch et al.   SCIENCE

BIM siRNA DECREASES LYMPHOCYTE APOPTOSIS AND IMPROVES SURVIVAL IN SEPSIS

(2009) Steven J. Schwulst et al.   SHOCK

RECOMBINANT HUMAN SOLUBLE TUMOR NECROSIS FACTOR-ALPHA RECEPTOR FUSION PROTEIN PARTLY ATTENUATES VENTILATOR-INDUCED LUNG INJURY

(2009) Esther K. Wolthuis et al.   SHOCK

Neuroprotection Against Hypoxic-Ischemic Brain Injury by Inhibiting the Apoptotic Protease Activating Factor-1 Pathway

(2009) Yanqin Gao et al.   STROKE

Pretreatment With the Tumor Nerosis Factor-α Blocker Etanercept Attenuated Ischemia-Reperfusion Renal Injury

(2009) D.E. Choi et al.   TRANSPLANTATION PROCEEDINGS

Caspase-3 Is Enriched in Postsynaptic Densities and Increased in Alzheimer's Disease

(2008) Natalia Louneva et al.   AMERICAN JOURNAL OF PATHOLOGY

The Fas System Confers Protection against Alveolar Disruption in Hyperoxia-Exposed Newborn Mice

(2008) Quanfu Mao et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A critical role for Fas/CD-95 dependent signaling pathways in the pathogenesis of hyperoxia-induced brain injury

(2008) Mark Dzietko et al.   ANNALS OF NEUROLOGY

Blockade of the Fas/Fas ligand interaction suppresses hepatocyte apoptosis in ischemia-reperfusion rat liver

(2008) Hiroo Nakajima et al.   APOPTOSIS

Brief Report: Increased Apoptosis in Advanced Atherosclerotic Lesions of Apoe −/− Mice Lacking Macrophage Bcl-2

(2008) Edward Thorp et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

TNFα is required for cholestasis-induced liver fibrosis in the mouse

(2008) Erwin Gäbele et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The mitochondrial p53 pathway

(2008) Angelina V. Vaseva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

TNF-α and IL-6 signals from the bone marrow derived cells are necessary for normal murine liver regeneration

(2008) Kaori Sudo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A Role for TNF Receptor Type II in Leukocyte Infiltration into the Lung during Experimental Idiopathic Pneumonia Syndrome

(2008) Gerhard C. Hildebrandt et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils

(2008) S. A. Didichenko et al.   BLOOD

Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function

(2008) D. A. Steimer et al.   BLOOD

p55 Tumour necrosis factor receptor in bone marrow-derived cells promotes atherosclerosis development in low-density lipoprotein receptor knock-out mice

(2008) Sofia Xanthoulea et al.   CARDIOVASCULAR RESEARCH

Caspase-8 deficiency facilitates cellular transformation in vitro

(2008) Y Krelin et al.   CELL DEATH AND DIFFERENTIATION

In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute

(2008) E M Michalak et al.   CELL DEATH AND DIFFERENTIATION

PUMA Regulates Intestinal Progenitor Cell Radiosensitivity and Gastrointestinal Syndrome

(2008) Wei Qiu et al.   Cell Stem Cell

Proapoptotic BH3-Only Protein Bid Is Essential For Death Receptor-Induced Apoptosis of Pancreatic  -Cells

(2008) M. D. McKenzie et al.   DIABETES

Overexpression of Mcl-1 Attenuates Liver Injury and Fibrosis in the Bile Duct–Ligated Mouse

(2008) Alisan Kahraman et al.   DIGESTIVE DISEASES AND SCIENCES

Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Inhibits Experimental Autoimmune Thyroiditis by the Expansion of CD4+CD25+Regulatory T Cells

(2008) Su He Wang et al.   ENDOCRINOLOGY

Involvement of mitochondrial signaling pathways in the mechanism of Fas-mediated apoptosis after spinal cord injury

(2008) Wen Ru Yu et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

TNF-α deficiency accelerates renal tubular interstitial fibrosis in the late stage of ureteral obstruction

(2008) Yoshifumi Morimoto et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

TRAIL mediates liver injury by the innate immune system in the bile duct-ligated mouse

(2008) Alisan Kahraman et al.   HEPATOLOGY

Knockout of myeloid cell leukemia-1 induces liver damage and increases apoptosis susceptibility of murine hepatocytes

(2008) Binje Vick et al.   HEPATOLOGY

Apoptosis Regulators Fas and Bim Cooperate in Shutdown of Chronic Immune Responses and Prevention of Autoimmunity

(2008) Peter D. Hughes et al.   IMMUNITY

Sequence Analysis of BIRC4/XIAP in Male Patients with Common Variable Immunodeficiency

(2008) Ulrich Salzer et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

TRAIL-R deficiency in mice enhances lymph node metastasis without affecting primary tumor development

(2008) Anne Grosse-Wilde et al.   JOURNAL OF CLINICAL INVESTIGATION

TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis

(2008) Niklas Finnberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates γ irradiation–induced thymic lymphoma development

(2008) Verena Labi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Loss of BH3-only Protein Bim Inhibits Apoptosis of Hemopoietic Cells in the Fetal Liver and Male Germ Cells but Not Neuronal Cells in Bcl-x-deficient Mice

(2008) Rizwan S. Akhtar et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

c-Flip overexpression reduces cardiac hypertrophy in response to pressure overload

(2008) Claudia Giampietri et al.   JOURNAL OF HYPERTENSION

Increased X-linked inhibitor of apoptosis protein (XIAP) expression exacerbates experimental autoimmune encephalomyelitis (EAE)

(2008) Craig S. Moore et al.   JOURNAL OF NEUROIMMUNOLOGY

Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration

(2008) Edward L Tobinick et al.   Journal of Neuroinflammation

The Proapoptotic BCL-2 Homology Domain 3-Only Protein Bim Is Not Critical for Acute Excitotoxic Cell Death

(2008) Panos Theofilas et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Developing Postmitotic Mammalian Neurons In Vivo Lacking Apaf-1 Undergo Programmed Cell Death by a Caspase-Independent, Nonapoptotic Pathway Involving Autophagy

(2008) R. W. Oppenheim et al.   JOURNAL OF NEUROSCIENCE

Misplacement of Purkinje Cells during Postnatal Development in Bax Knock-Out Mice: A Novel Role for Programmed Cell Death in the Nervous System?

(2008) A-r. Jung et al.   JOURNAL OF NEUROSCIENCE

Mcl-1 Is a Key Regulator of Apoptosis during CNS Development and after DNA Damage

(2008) N. Arbour et al.   JOURNAL OF NEUROSCIENCE

Lack of Pathology in a Triple Transgenic Mouse Model of Alzheimer's Disease after Overexpression of the Anti-Apoptotic Protein Bcl-2

(2008) T. T. Rohn et al.   JOURNAL OF NEUROSCIENCE

TNF-α receptor 1 deficiency enhances kainic acid–induced hippocampal injury in mice

(2008) Ming-Ou Lu et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Disruption of Bax Protein Prevents Neuronal Cell Death but Produces Cognitive Impairment in Mice following Traumatic Brain Injury

(2008) Roya Tehranian et al.   JOURNAL OF NEUROTRAUMA

A critical role for TRAIL in resolution of granulomatous experimental autoimmune thyroiditis

(2008) Y Fang et al.   JOURNAL OF PATHOLOGY

Cardiac-Targeted Expression of Soluble Fas Attenuates Doxorubicin-Induced Cardiotoxicity in Mice

(2008) J. Niu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Caspase-3 Gene Deletion Prolongs Survival in Polycystic Kidney Disease

(2008) Y. Tao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Death Ligand TRAIL in Diabetic Nephropathy

(2008) C. Lorz et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA

(2008) Sarah Camargos et al.   LANCET NEUROLOGY

Selection against PUMA Gene Expression in Myc-Driven B-Cell Lymphomagenesis

(2008) S. P. Garrison et al.   MOLECULAR AND CELLULAR BIOLOGY

BAX activation is initiated at a novel interaction site

(2008) Evripidis Gavathiotis et al.   NATURE

The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors

(2008) Yelena L Pobezinskaya et al.   NATURE IMMUNOLOGY

Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses

(2008) Maria A Ermolaeva et al.   NATURE IMMUNOLOGY

A tumor necrosis factor-α–mediated pathway promoting autosomal dominant polycystic kidney disease

(2008) Xiaogang Li et al.   NATURE MEDICINE

Fas-associated factor 1 and Parkinson's disease

(2008) Ranjita Betarbet et al.   NEUROBIOLOGY OF DISEASE

Screening, identification, and functional analysis of three novel missense mutations in the TRADD gene in children with ALL and ALPS

(2008) M.J. Dechant et al.   PEDIATRIC BLOOD & CANCER

In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas

(2008) K. D. Mason et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease

(2008) K. Takeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNF receptor I sensitizes neurons to erythropoietin- and VEGF-mediated neuroprotection after ischemic and excitotoxic injury

(2008) E. Taoufik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigen-mediated T cell expansion regulated by parallel pathways of death

(2008) I. L. Ch'en et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells

(2008) B. D. Bell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors

(2008) N.-J. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BH3-only protein Puma contributes to death of antigen-specific T cells during shutdown of an immune response to acute viral infection

(2008) S. F. Fischer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Executioner caspase-3 and caspase-7 are functionally distinct proteases

(2008) J. G. Walsh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase inhibitor zVAD.fmk reduces infarct size after myocardial ischaemia and reperfusion in rats but not in mice

(2008) Jan Mersmann et al.   RESUSCITATION

Viral Control of Mitochondrial Apoptosis

(2008) Lorenzo Galluzzi et al.   PLoS Pathogens

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY