Deletion of the BH3-only protein Noxa alters electrographic seizures but does not protect against hippocampal damage after status epilepticus in mice

Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury

(2016) B. D'Orsi et al.   JOURNAL OF NEUROSCIENCE

Comparison of short-term effects of midazolam and lorazepam in the intra-amygdala kainic acid model of status epilepticus in mice

(2015) Mairead Diviney et al.   EPILEPSY & BEHAVIOR

An interconnected hierarchical model of cell death regulation by the BCL-2 family

(2015) Hui-Chen Chen et al.   NATURE CELL BIOLOGY

Epilepsies associated with hippocampal sclerosis

(2014) Fernando Cendes et al.   ACTA NEUROPATHOLOGICA

Analysis of BH3-only proteins upregulated in response to oxygen/glucose deprivation in cortical neurons identifies Bmf but not Noxa as potential mediator of neuronal injury

(2014) S Pfeiffer et al.   Cell Death & Disease

CHOP regulates the p53–MDM2 axis and is required for neuronal survival after seizures

(2013) Tobias Engel et al.   BRAIN

Puma, but not noxa is essential for oligodendroglial cell death

(2013) Karin Hagemeier et al.   GLIA

How Does the Ketogenic Diet Work? Four Potential Mechanisms

(2013) Nika N. Danial et al.   JOURNAL OF CHILD NEUROLOGY

New avenues for anti-epileptic drug discovery and development

(2013) Wolfgang Löscher et al.   NATURE REVIEWS DRUG DISCOVERY

Bmf upregulation through the AMP-activated protein kinase pathway may protect the brain from seizure-induced cell death

(2013) C Moran et al.   Cell Death & Disease

NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1

(2012) A Craxton et al.   CELL DEATH AND DIFFERENTIATION

Differential DNA Methylation Patterns Define Status Epilepticus and Epileptic Tolerance

(2012) S. F. C. Miller-Delaney et al.   JOURNAL OF NEUROSCIENCE

BAD-Dependent Regulation of Fuel Metabolism and KATP Channel Activity Confers Resistance to Epileptic Seizures

(2012) Alfredo Giménez-Cassina et al.   NEURON

MiR-200c Regulates Noxa Expression and Sensitivity to Proteasomal Inhibitors

(2012) Mikael Lerner et al.   PLoS One

Apoptosis induced by overall metabolic stress converges on the Bcl-2 family proteins Noxa and Mcl-1

(2011) Felix M. Wensveen et al.   APOPTOSIS

Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice

(2011) Tobias Engel et al.   FASEB JOURNAL

The P2X7 receptor–pannexin-1 complex decreases muscarinic acetylcholine receptor–mediated seizure susceptibility in mice

(2011) Ji-Eun Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Oncogenic Ras-Induced Expression of Noxa and Beclin-1 Promotes Autophagic Cell Death and Limits Clonogenic Survival

(2011) Mohamed Elgendy et al.   MOLECULAR CELL

Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways

(2010) L Zhang et al.   CELL DEATH AND DIFFERENTIATION

BH3-only protein Bid is dispensable for seizure-induced neuronal death and the associated nuclear accumulation of apoptosis-inducing factor

(2010) Tobias Engel et al.   JOURNAL OF NEUROCHEMISTRY

The Proapoptotic Function of Noxa in Human Leukemia Cells Is Regulated by the Kinase Cdk5 and by Glucose

(2010) Xazmin H. Lowman et al.   MOLECULAR CELL

The BCL-2 Family Reunion

(2010) Jerry E. Chipuk et al.   MOLECULAR CELL

Loss of p53 results in protracted electrographic seizures and development of an aggravated epileptic phenotype following status epilepticus

(2010) T Engel et al.   Cell Death & Disease

Contrasting patterns of Bim induction and neuroprotection in Bim-deficient mice between hippocampus and neocortex after status epilepticus

(2009) B M Murphy et al.   CELL DEATH AND DIFFERENTIATION

Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapoptotic Puma

(2009) Tobias Engel et al.   FASEB JOURNAL

Noxa: at the tip of the balance between life and death

(2009) C Ploner et al.   ONCOGENE

Unilateral hippocampal CA3-predominant damage and short latency epileptogenesis after intra-amygdala microinjection of kainic acid in mice

(2008) Genshin Mouri et al.   BRAIN RESEARCH

In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute

(2008) E M Michalak et al.   CELL DEATH AND DIFFERENTIATION

Bmi1 regulates memory CD4 T cell survival via repression of theNoxagene

(2008) Masakatsu Yamashita et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY