Selective ablation of P53 in pancreatic beta cells fails to ameliorate glucose metabolism in genetic, dietary and pharmacological models of diabetes mellitus

SPARCLE, a p53-induced lncRNA, controls apoptosis after genotoxic stress by promoting PARP-1 cleavage

(2022) Karla F. Meza-Sosa et al.   MOLECULAR CELL

MDM2 binds and ubiquitinates PARP1 to enhance DNA replication fork progression

(2022) Celeste Giansanti et al.   Cell Reports

IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045

(2021) Hong Sun et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

(2020) Décio L. Eizirik et al.   Nature Reviews Endocrinology

Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis

(2020) Christian M. Cohrs et al.   Cell Reports

PARP1 Is Required for ATM-Mediated p53 Activation and p53-Mediated Gene Expression after Ionizing Radiation

(2020) Sabine Gajewski et al.   CHEMICAL RESEARCH IN TOXICOLOGY

ATM and P53 differentially regulate pancreatic beta cell survival in Ins1E cells

(2020) Celina Uhlemeyer et al.   PLoS One

The multiple mechanisms that regulate p53 activity and cell fate

(2019) Antonina Hafner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PARP-14 Promotes Survival of Mammalian α but Not β Pancreatic Cells Following Cytokine Treatment

(2019) Floriana D'Angeli et al.   Frontiers in Endocrinology

Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study

(2019) Oana P Zaharia et al.   Lancet Diabetes & Endocrinology

Animal models of obesity and diabetes mellitus

(2018) Maximilian Kleinert et al.   Nature Reviews Endocrinology

Transgenic Artifacts Caused by Passenger Human Growth Hormone

(2018) Geoffroy de Faudeur et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables

(2018) Emma Ahlqvist et al.   Lancet Diabetes & Endocrinology

Beta Cell DNA Damage Response Promotes Islet Inflammation in Type 1 Diabetes

(2018) Elad Horwitz et al.   DIABETES

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

QuPath: Open source software for digital pathology image analysis

(2017) Peter Bankhead et al.   Scientific Reports

The role of the p53 tumor suppressor in metabolism and diabetes

(2016) Che-Pei Kung et al.   JOURNAL OF ENDOCRINOLOGY

Identification of proliferative and mature β-cells in the islets of Langerhans

(2016) Erik Bader et al.   NATURE

ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes

(2016) Flora Brozzi et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms

(2015) Flora Brozzi et al.   DIABETOLOGIA

The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes

(2015) Bengt-Frederik Belgardt et al.   NATURE MEDICINE

Ins1 Cre knock-in mice for beta cell-specific gene recombination

(2014) Bernard Thorens et al.   DIABETOLOGIA

MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes

(2014) Amin Ardestani et al.   NATURE MEDICINE

PHLDA3 is a novel tumor suppressor of pancreatic neuroendocrine tumors

(2014) R. Ohki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic  -cell function in diabetes

(2014) A. Hoshino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Endothelial p53 Improves Metabolic Abnormalities Related to Dietary Obesity

(2014) Masataka Yokoyama et al.   Cell Reports

The MDM2 inhibitor Nutlin-3 attenuates streptozotocin-induced diabetes mellitus and increases serum level of IL-12p40

(2013) Paola Secchiero et al.   ACTA DIABETOLOGICA

Type 2 Diabetes and Congenital Hyperinsulinism Cause DNA Double-Strand Breaks and p53 Activity in β Cells

(2013) Sharona Tornovsky-Babeay et al.   Cell Metabolism

Predominance of β-Cell Neogenesis Rather Than Replication in Humans With an Impaired Glucose Tolerance and Newly Diagnosed Diabetes

(2013) S. Yoneda et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The use of animal models in diabetes research

(2012) Aileen JF King   BRITISH JOURNAL OF PHARMACOLOGY

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models

(2010) D. K. Broz et al.   CARCINOGENESIS

Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure

(2010) O. Kluth et al.   DIABETOLOGIA

Loss of Nix in Pdx1-deficient mice prevents apoptotic and necrotic β cell death and diabetes

(2010) Kei Fujimoto et al.   JOURNAL OF CLINICAL INVESTIGATION

Pdx1 and other factors that regulate pancreatic β-cell survival

(2009) K. Fujimoto et al.   DIABETES OBESITY & METABOLISM

Essential Role for DNA-PKcs in DNA Double-Strand Break Repair and Apoptosis in ATM-Deficient Lymphocytes

(2009) Elsa Callén et al.   MOLECULAR CELL

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress

(2009) Mira M. Sachdeva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes

(2008) Benbo Song et al.   JOURNAL OF CLINICAL INVESTIGATION