Oral administration of a non-absorbable plant cell-expressed recombinant anti-TNF fusion protein induces immunomodulatory effects and alleviates nonalcoholic steatohepatitis

Oral administration of non-absorbable delayed release 6-mercaptopurine is locally active in the gut, exerts a systemic immune effect and alleviates Crohn's disease with low rate of side effects: results of double blind Phase II clinical trial

(2015) E. Israeli et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Oral Administration of OKT3 MAb to Patients with NASH, Promotes Regulatory T-cell Induction, and Alleviates Insulin Resistance: Results of a Phase IIa Blinded Placebo-Controlled Trial

(2015) Gadi Lalazar et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Adipokines as Drug Targets in Diabetes and Underlying Disturbances

(2015) Vinícius Andrade-Oliveira et al.   Journal of Diabetes Research

Tu2029 A novel method for anti-TNF based-oral immunotherapy: Oral administration of a plant cell-expressed recombinant anti-TNF fusion protein for treating of Crohn's disease

(2014) Yoseph Shaaltiel et al.   GASTROENTEROLOGY

Oral anti-CD3 immunotherapy for HCV-nonresponders is safe, promotes regulatory T cells and decreases viral load and liver enzyme levels: results of a phase-2a placebo-controlled trial

(2014) W. Halota et al.   JOURNAL OF VIRAL HEPATITIS

CD8+ Treg Cells Associated with Decreasing Disease Activity after Intravenous Methylprednisolone Pulse Therapy in Lupus Nephritis with Heavy Proteinuria

(2014) Yi-Giien Tsai et al.   PLoS One

Mice Lacking Natural Killer T Cells Are More Susceptible to Metabolic Alterations following High Fat Diet Feeding

(2014) Brittany V. Martin-Murphy et al.   PLoS One

Regulatory T Cells as Immunotherapy

(2014) Benjamin D. Singer et al.   Frontiers in Immunology

Gut immune system and oral tolerance

(2013) Patricia Castro-Sánchez et al.   BRITISH JOURNAL OF NUTRITION

Immune Therapy for Nonalcoholic Steatohepatitis

(2013) Yaron Ilan   JOURNAL OF CLINICAL GASTROENTEROLOGY

Interplay between adipose tissue and blood vessels in obesity and vascular dysfunction

(2013) Ping Gu et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Anti-TNF-α therapy improves Treg and suppresses Teff in patients with rheumatoid arthritis

(2012) Zhuochun Huang et al.   CELLULAR IMMUNOLOGY

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

(2012) Jorge Henao-Mejia et al.   NATURE

The role of natural killer cells in autoimmune blistering diseases

(2011) L. R. Zakka et al.   AUTOIMMUNITY

NFκB-mediated metabolic inflammation in peripheral tissues versus central nervous system

(2011) Dongsheng Cai   CELL CYCLE

Oral administration of immunoglobulin G-enhanced colostrum alleviates insulin resistance and liver injury and is associated with alterations in natural killer T cells

(2011) T. Adar et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Gut-Liver Axis and Sensing Microbes

(2011) Gyongyi Szabo et al.   DIGESTIVE DISEASES

Oral tolerance

(2011) Howard L. Weiner et al.   IMMUNOLOGICAL REVIEWS

Association of tumor necrosis factor-α gene promoter polymorphism at sites -308 and -238 with non-alcoholic fatty liver disease: A meta-analysis

(2011) Ji-kai Wang et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Interplay between TNF and Regulatory T Cells in a TNF-Driven Murine Model of Arthritis

(2011) Jérôme Biton et al.   JOURNAL OF IMMUNOLOGY

Systematic review on the treatment of pentoxifylline in patients with non-alcoholic fatty liver disease

(2011) Wenjun Li et al.   Lipids in Health and Disease

Making sense of regulatory T cell suppressive function

(2011) Itay Shalev et al.   SEMINARS IN IMMUNOLOGY

Adverse Effects of Biological Agents in the Treatment of Psoriasis

(2010) Franco Rongioletti et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Adverse effects of biologics used for treating IBD

(2010) Andreas Stallmach et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

The Role of Cytokines in Non-Alcoholic Fatty Liver Disease

(2010) Herbert Tilg   DIGESTIVE DISEASES

Critical role of the liver in the induction of systemic inflammation in rats with preascitic cirrhosis

(2010) María Úbeda et al.   HEPATOLOGY

Mucosal Anti-CD3 Monoclonal Antibody Attenuates Collagen-Induced Arthritis That Is Associated with Induction of LAP+ Regulatory T Cells and Is Enhanced by Administration of an Emulsome-Based Th2-Skewing Adjuvant

(2010) H. Y. Wu et al.   JOURNAL OF IMMUNOLOGY

Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice

(2010) Y. Ilan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory T cells in obesity: the leptin connection

(2010) Giuseppe Matarese et al.   TRENDS IN MOLECULAR MEDICINE

ANTI-CD3 therapy expands the numbers of CD4+ and CD8+ treg cells and induces sustained amelioration of collagen-induced arthritis

(2009) Clare A. Notley et al.   ARTHRITIS AND RHEUMATISM

The Gut Mucosa as a Site for Induction of Regulatory T-Cells

(2009) Meir Mizrahi et al.   CURRENT PHARMACEUTICAL DESIGN

Oral tolerance: Can we make it work?

(2009) Yaron Ilan   HUMAN IMMUNOLOGY

Inflammation and endoplasmic reticulum stress in obesity and diabetes

(2009) G S Hotamisligil   INTERNATIONAL JOURNAL OF OBESITY

Oral Administration of OKT3 Monoclonal Antibody to Human Subjects Induces a Dose-Dependent Immunologic Effect in T Cells and Dendritic Cells

(2009) Yaron Ilan et al.   JOURNAL OF CLINICAL IMMUNOLOGY

The immunopathogenesis of alcoholic and nonalcoholic steatohepatitis: two triggers for one disease?

(2009) Luca Valenti et al.   Seminars in Immunopathology

TNF alpha Inhibition as Treatment Modality for Certain Rheumatologic and Gastrointestinal Diseases

(2009) Marcus Wiedmann et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Adalimumab Could Suppress the Activity of Non Alcoholic Steatohepatitis (NASH)

(2008) C Schramm et al.   ZEITSCHRIFT FUR GASTROENTEROLOGIE