BCL‐2‐family protein tBID can act as a BAX‐like effector of apoptosis

Mitochondrial residence of the apoptosis inducer BAX is more important than BAX oligomerization in promoting membrane permeabilization

(2020) Tomomi Kuwana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Future Therapeutic Directions for Smac-Mimetics

(2020) Emma Morrish et al.   Cells

Separase-triggered apoptosis enforces minimal length of mitosis

(2020) Susanne Hellmuth et al.   NATURE

Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target

(2020) Sweta Iyer et al.   Cell Death & Disease

SMAC mimetics induce autophagy-dependent apoptosis of HIV-1-infected macrophages

(2020) Grant R. Campbell et al.   Cell Death & Disease

Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD

(2020) Rosalie Heilig et al.   Life Science Alliance

Necrostatin-1 and necroptosis inhibition: Pathophysiology and therapeutic implications

(2020) Liyuan Cao et al.   PHARMACOLOGICAL RESEARCH

The Mysteries around the BCL-2 Family Member BOK

(2020) Raed Shalaby et al.   Biomolecules

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

(2019) Rumani Singh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Quantitative analysis of super-resolved structures using ASAP

(2019) John S. H. Danial et al.   NATURE METHODS

Venetoclax and Obinutuzumab in Patients with CLL and Coexisting Conditions

(2019) Kirsten Fischer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Detection of tBid Oligomerization and Membrane Permeabilization by Graphene-Based Single-Molecule Surface-Induced Fluorescence Attenuation

(2019) Li Ma et al.   NANO LETTERS

BAX, BAK, and BOK: A Coming of Age for the BCL-2 Family Effector Proteins

(2019) Tudor Moldoveanu et al.   Cold Spring Harbor Perspectives in Biology

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

(2018) Kate McArthur et al.   SCIENCE

Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis

(2018) Joel S Riley et al.   EMBO JOURNAL

BFL1 modulates apoptosis at the membrane level through a bifunctional and multimodal mechanism showing key differences with BCLXL

(2018) Hector Flores-Romero et al.   CELL DEATH AND DIFFERENTIATION

The membrane activity of BOK involves formation of large, stable toroidal pores and is promoted by cBID

(2017) Yuniel Fernández-Marrero et al.   FEBS Journal

Iron and ferroptosis: A still ill-defined liaison

(2017) Sebastian Doll et al.   IUBMB LIFE

Gene editing and clonal isolation of human induced pluripotent stem cells using CRISPR/Cas9

(2017) Saniye Yumlu et al.   METHODS

Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation

(2017) Stephanie Bleicken et al.   Nature Communications

Bid-Induced Release of AIF/EndoG from Mitochondria Causes Apoptosis of Macrophages during Infection with Leptospira interrogans

(2017) Wei-Lin Hu et al.   Frontiers in Cellular and Infection Microbiology

Membrane insertion of the BAX core, but not latch domain, drives apoptotic pore formation

(2017) Hector Flores-Romero et al.   Scientific Reports

Assembling the puzzle: Oligomerization of α-pore forming proteins in membranes

(2016) Katia Cosentino et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

(2016) Fabien Llambi et al.   CELL

Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores

(2016) R. Salvador-Gallego et al.   EMBO JOURNAL

Bax assembles into large ring-like structures remodeling the mitochondrial outer membrane in apoptosis

(2016) L. Grosse et al.   EMBO JOURNAL

Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane

(2016) Katelyn L. O'Neill et al.   GENES & DEVELOPMENT

BH3-in-groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes

(2015) Z. Zhang et al.   EMBO JOURNAL

More Than a Pore: The Interplay of Pore-Forming Proteins and Lipid Membranes

(2015) Uris Ros et al.   JOURNAL OF MEMBRANE BIOLOGY

Lipid-Dependent Bimodal MCL1 Membrane Activity

(2014) Olatz Landeta et al.   ACS Chemical Biology

BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella

(2014) M. Andree et al.   EMBO JOURNAL

Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers

(2014) Jason M. Brouwer et al.   MOLECULAR CELL

Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis

(2013) Peter E. Czabotar et al.   CELL

Inhibitor of Apoptosis (IAP) Proteins-Modulators of Cell Death and Inflammation

(2013) J. Silke et al.   Cold Spring Harbor Perspectives in Biology

Three-dimensional structure of Bax-mediated pores in membrane bilayers

(2013) X-P Xu et al.   Cell Death & Disease

Dynamic Interaction of cBid with Detergents, Liposomes and Mitochondria

(2012) Stephanie Bleicken et al.   PLoS One

Bak Conformational Changes Induced by Ligand Binding: Insight into BH3 Domain Binding and Bak Homo-Oligomerization

(2012) Yuan-Ping Pang et al.   Scientific Reports

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

(2011) Haiming Dai et al.   JOURNAL OF CELL BIOLOGY

Bid and Bim Collaborate during Induction of T Cell Death in Persistent Infection

(2011) Frederick Masson et al.   JOURNAL OF IMMUNOLOGY

Pores Formed by Baxα5 Relax to a Smaller Size and Keep at Equilibrium

(2010) Gustavo Fuertes et al.   BIOPHYSICAL JOURNAL

Interaction of the alpha-helical H6 peptide from the pro-apoptotic protein tBid with cardiolipin

(2009) Patrice X. Petit et al.   FEBS Journal

Membrane promotes tBID interaction with BCLXL

(2009) Ana J García-Sáez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Bid: a Bax-like BH3 protein

(2009) L P Billen et al.   ONCOGENE

To Trigger Apoptosis, Bak Exposes Its BH3 Domain and Homodimerizes via BH3:Groove Interactions

(2008) Grant Dewson et al.   MOLECULAR CELL

Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax

(2008) J. I. Fletcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA