Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition

Reducing Treatment Burden in AMD

(2020) Rajendra S. Apte   CELL

ClusterMap: Compare multiple Single Cell RNA-Seq datasets across different experimental conditions

(2019) Xin Gao et al.   BIOINFORMATICS

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

(2019) Rumani Singh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular Classification and Comparative Taxonomics of Foveal and Peripheral Cells in Primate Retina

(2019) Yi-Rong Peng et al.   CELL

VEGF in Signaling and Disease: Beyond Discovery and Development

(2019) Rajendra S. Apte et al.   CELL

Senolytic therapies for healthy longevity

(2019) Jan M. van Deursen   SCIENCE

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Prevalence and incidence of age-related macular degeneration in Europe: a systematic review and meta-analysis

(2019) Jeany Q Li et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Targeting senescent cells in translational medicine

(2019) Marta Paez‐Ribes et al.   EMBO Molecular Medicine

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

(2016) Yi Zhu et al.   AGING CELL

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Near-optimal probabilistic RNA-seq quantification

(2016) Nicolas L Bray et al.   NATURE BIOTECHNOLOGY

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo

(2016) Lluc Mosteiro et al.   SCIENCE

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

(2016) I. Tirosh et al.   SCIENCE

Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy

(2016) M. Oubaha et al.   Science Translational Medicine

Vascular Cell Senescence Contributes to Blood–Brain Barrier Breakdown

(2016) Yu Yamazaki et al.   STROKE

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

(2016) Reut Yosef et al.   Nature Communications

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

(2015) Evan Z. Macosko et al.   CELL

Microarray Analysis of Gene Expression in Fibrovascular Membranes Excised From Patients With Proliferative Diabetic Retinopathy

(2015) K. Ishikawa et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

ABT-199 (venetoclax) and BCL-2 inhibitors in clinical development

(2015) Shundong Cang et al.   Journal of Hematology & Oncology

P16INK4a Upregulation Mediated by SIX6 Defines Retinal Ganglion Cell Pathogenesis in Glaucoma

(2015) Dorota Skowronska-Krawczyk et al.   MOLECULAR CELL

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Growth of Geographic Atrophy in the Comparison of Age-related Macular Degeneration Treatments Trials

(2015) Juan E. Grunwald et al.   OPHTHALMOLOGY

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

BM-1197: A Novel and Specific Bcl-2/Bcl-xL Inhibitor Inducing Complete and Long-Lasting Tumor Regression In Vivo

(2014) Longchuan Bai et al.   PLoS One

The small-molecule compound BM-1197 inhibits the antiapoptotic regulators Bcl-2/Bcl-xL and triggers apoptotic cell death in human colorectal cancer cells

(2014) Lijun Ye et al.   TUMOR BIOLOGY

Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis

(2014) Wan Ling Wong et al.   Lancet Global Health

GSVA: gene set variation analysis for microarray and RNA-Seq data

(2013) Sonja Hänzelmann et al.   BMC BIOINFORMATICS

Impaired Cholesterol Efflux in Senescent Macrophages Promotes Age-Related Macular Degeneration

(2013) Abdoulaye Sene et al.   Cell Metabolism

Neuronal ER Stress Impedes Myeloid-Cell-Induced Vascular Regeneration through IRE1α Degradation of Netrin-1

(2013) François Binet et al.   Cell Metabolism

Ras pathway inhibition prevents neovascularization by repressing endothelial cell sprouting

(2013) Peter D. Westenskow et al.   JOURNAL OF CLINICAL INVESTIGATION

Retinopathy of prematurity

(2013) Ann Hellström et al.   LANCET

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

Risk of Geographic Atrophy in the Comparison of Age-related Macular Degeneration Treatments Trials

(2013) Juan E. Grunwald et al.   OPHTHALMOLOGY

Current Epidemiology of Diabetic Retinopathy and Diabetic Macular Edema

(2012) Jie Ding et al.   Current Diabetes Reports

RPE cell senescence: A key contributor to age-related macular degeneration

(2012) Michael R. Kozlowski   MEDICAL HYPOTHESES

Pathological neoangiogenesis depends on oxidative stress regulation by ATM

(2012) Yuji Okuno et al.   NATURE MEDICINE

Diabetic Retinopathy

(2012) David A. Antonetti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanisms and Management of Retinopathy of Prematurity

(2012) M. Elizabeth Hartnett et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A

(2011) J.-S. Joyal et al.   BLOOD

Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice

(2011) Yoko Fukushima et al.   JOURNAL OF CLINICAL INVESTIGATION

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of life

(2010) Przemyslaw Sapieha et al.   JOURNAL OF CLINICAL INVESTIGATION

Computer-aided quantification of retinal neovascularization

(2009) A. Stahl et al.   ANGIOGENESIS

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt

(2009) Steffen Durinck et al.   Nature Protocols

Energy limitation as a selective pressure on the evolution of sensory systems

(2008) J. E. Niven et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

INCIDENCE OF ENDOPHTHALMITIS RELATED TO INTRAVITREAL INJECTION OF BEVACIZUMAB AND RANIBIZUMAB

(2008) DAVID R. FINTAK et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES