Regulation of distinct caspase-8 functions in retinal ganglion cells and astroglia in experimental glaucoma

Transgenic inhibition of astroglial NF-κB restrains the neuroinflammatory and neurodegenerative outcomes of experimental mouse glaucoma

(2020) Xiangjun Yang et al.   Journal of Neuroinflammation

Inflammasome Activation Induces Pyroptosis in the Retina Exposed to Ocular Hypertension Injury

(2019) Alexey Pronin et al.   Frontiers in Molecular Neuroscience

Redundant and receptor-specific activities of TRADD, RIPK1 and FADD in death receptor signaling

(2019) Simone Füllsack et al.   Cell Death & Disease

Axon injury signaling and compartmentalized injury response in glaucoma

(2019) Stephanie B. Syc-Mazurek et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Cellular Specificity of NF-κB Function in the Nervous System

(2019) Erica C. Dresselhaus et al.   Frontiers in Immunology

A small peptide antagonist of the Fas receptor inhibits neuroinflammation and prevents axon degeneration and retinal ganglion cell death in an inducible mouse model of glaucoma

(2019) Anitha Krishnan et al.   Journal of Neuroinflammation

Neuroinflammation in glaucoma: A new opportunity

(2017) Pete A. Williams et al.   EXPERIMENTAL EYE RESEARCH

Caspase-8: regulating life and death

(2017) Bart Tummers et al.   IMMUNOLOGICAL REVIEWS

An Inflammatory Perspective on Necroptosis

(2017) Conor J. Kearney et al.   MOLECULAR CELL

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

BAX to basics: How the BCL2 gene family controls the death of retinal ganglion cells

(2017) Margaret E. Maes et al.   PROGRESS IN RETINAL AND EYE RESEARCH

The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain

(2017) Farraj Albalawi et al.   Frontiers in Cellular Neuroscience

JUN is important for ocular hypertension-induced retinal ganglion cell degeneration

(2017) Stephanie B Syc-Mazurek et al.   Cell Death & Disease

Poly-ubiquitination in TNFR1-mediated necroptosis

(2016) Yves Dondelinger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Bilateral neuroinflammatory processes in visual pathways induced by unilateral ocular hypertension in the rat

(2016) Anaïs Sapienza et al.   Journal of Neuroinflammation

Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death

(2016) Naomi H. Philip et al.   PLoS Pathogens

Novel Roles for Caspase-8 in IL-1β and Inflammasome Regulation

(2015) Prajwal Gurung et al.   AMERICAN JOURNAL OF PATHOLOGY

Necroptosis suppresses inflammation via termination of TNF- or LPS-induced cytokine and chemokine production

(2015) C J Kearney et al.   CELL DEATH AND DIFFERENTIATION

Caspase-8 functions as a key mediator of inflammation and pro-IL-1β processing via both canonical and non-canonical pathways

(2015) Tom P. Monie et al.   IMMUNOLOGICAL REVIEWS

FLIP the Switch: Regulation of Apoptosis and Necroptosis by cFLIP

(2015) Yuichi Tsuchiya et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-κB pathway in acute glaucoma

(2015) Wei Chi et al.   Journal of Neuroinflammation

Targeting caspase-6 and caspase-8 to promote neuronal survival following ischemic stroke

(2015) A P Shabanzadeh et al.   Cell Death & Disease

Tumor necrosis factor-alpha mediates activation of NF-κB and JNK signaling cascades in retinal ganglion cells and astrocytes in opposite ways

(2014) Galina Dvoriantchikova et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Cutting Edge: Endoplasmic Reticulum Stress Licenses Macrophages To Produce Mature IL-1  in Response to TLR4 Stimulation through a Caspase-8- and TRIF-Dependent Pathway

(2014) K. Shenderov et al.   JOURNAL OF IMMUNOLOGY

DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury

(2014) Kimberly A. Fernandes et al.   NEUROBIOLOGY OF DISEASE

Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1  production in acute glaucoma

(2014) W. Chi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functions of caspase 8: The identified and the mysterious

(2014) Guy S. Salvesen et al.   SEMINARS IN IMMUNOLOGY

The role of Müller glia and microglia in glaucoma

(2013) Roswitha Seitz et al.   CELL AND TISSUE RESEARCH

From Mechanosensitivity to Inflammatory Responses: New Players in the Pathology of Glaucoma

(2013) David Križaj et al.   CURRENT EYE RESEARCH

JUN regulates early transcriptional responses to axonal injury in retinal ganglion cells

(2013) Kimberly A. Fernandes et al.   EXPERIMENTAL EYE RESEARCH

Caspase Inhibitors Protect Neurons by Enabling Selective Necroptosis of Inflamed Microglia

(2013) Michael Fricker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury

(2013) T. A. Watkins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The FLIP Side of Life

(2013) J. Silke et al.   Science Signaling

Caspase blockade induces RIP3-mediated programmed necrosis in Toll-like receptor-activated microglia

(2013) S J Kim et al.   Cell Death & Disease

The flick of a switch: which death program to choose?

(2012) P Vandenabeele et al.   CELL DEATH AND DIFFERENTIATION

Immune regulation toward immunomodulation for neuroprotection in glaucoma

(2012) Gülgün Tezel   CURRENT OPINION IN PHARMACOLOGY

Proliferative versus apoptotic functions of caspase-8

(2011) Bram J. van Raam et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A Requirement for Nuclear Factor- B in Developmental and Plasticity-Associated Synaptogenesis

(2011) M. C. H. Boersma et al.   JOURNAL OF NEUROSCIENCE

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Caspase signalling controls microglia activation and neurotoxicity

(2011) Miguel A. Burguillos et al.   NATURE

Neuronal Deletion of Caspase 8 Protects against Brain Injury in Mouse Models of Controlled Cortical Impact and Kainic Acid-Induced Excitotoxicity

(2011) Maryla Krajewska et al.   PLoS One

Differential susceptibility to experimental glaucoma among 3 mouse strains using bead and viscoelastic injection

(2010) Frances E. Cone et al.   EXPERIMENTAL EYE RESEARCH

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment

(2009) Peter Geserick et al.   JOURNAL OF CELL BIOLOGY

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Mutational analyses of c-FLIPR, the only murine short FLIP isoform, reveal requirements for DISC recruitment

(2008) N Ueffing et al.   CELL DEATH AND DIFFERENTIATION

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology

JNK signaling in apoptosis

(2008) D N Dhanasekaran et al.   ONCOGENE