Caspase-8 promotes c-Rel–dependent inflammatory cytokine expression and resistance against Toxoplasma gondii

CNBP controls IL-12 gene transcription and Th1 immunity

(2018) Yongzhi Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation

(2018) Gianmaria Liccardi et al.   MOLECULAR CELL

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

RIPK1-dependent apoptosis bypasses pathogen blockade of innate signaling to promote immune defense

(2017) Lance W. Peterson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory “FADDosome” Complex upon TRAIL Stimulation

(2017) Conor M. Henry et al.   MOLECULAR CELL

EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation

(2017) Jaclyn S. Pearson et al.   Nature Microbiology

RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus

(2016) Shoko Nogusa et al.   Cell Host & Microbe

Cell-Extrinsic TNF Collaborates with TRIF Signaling To PromoteYersinia-Induced Apoptosis

(2016) Lance W. Peterson et al.   JOURNAL OF IMMUNOLOGY

Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate

(2016) Michelle A. Hughes et al.   MOLECULAR CELL

Molecular control of activation and priming in macrophages

(2016) Christopher K Glass et al.   NATURE IMMUNOLOGY

CYLD Proteolysis Protects Macrophages from TNF-Mediated Auto-necroptosis Induced by LPS and Licensed by Type I IFN

(2016) Diana Legarda et al.   Cell Reports

Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death

(2016) Naomi H. Philip et al.   PLoS Pathogens

Bone-Marrow-Resident NK Cells Prime Monocytes for Regulatory Function during Infection

(2015) Michael H. Askenase et al.   IMMUNITY

NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling

(2015) Yves Dondelinger et al.   MOLECULAR CELL

Caspase Functions in Cell Death and Disease: Figure 1.

(2015) David R. McIlwain et al.   Cold Spring Harbor Perspectives in Biology

Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3

(2015) Seokwon Kang et al.   Nature Communications

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming

(2014) R. Allam et al.   EMBO REPORTS

Use of Transgenic Parasites and Host Reporters To Dissect Events That Promote Interleukin-12 Production during Toxoplasmosis

(2014) David A. Christian et al.   INFECTION AND IMMUNITY

Mutation of a Self-Processing Site in Caspase-8 Compromises Its Apoptotic but Not Its Nonapoptotic Functions in Bacterial Artificial Chromosome-Transgenic Mice

(2014) T.-B. Kang et al.   JOURNAL OF IMMUNOLOGY

Caspase-8 Modulates Dectin-1 and Complement Receptor 3–Driven IL-1β Production in Response to β-Glucans and the Fungal Pathogen,Candida albicans

(2014) Sandhya Ganesan et al.   JOURNAL OF IMMUNOLOGY

FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes

(2014) P. Gurung et al.   JOURNAL OF IMMUNOLOGY

Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF- B and MAPK signaling

(2014) N. H. Philip et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death

(2014) D. Weng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRF5:RelA Interaction Targets Inflammatory Genes in Macrophages

(2014) David G. Saliba et al.   Cell Reports

Salmonella Infection Induces Recruitment of Caspase-8 to the Inflammasome To Modulate IL-1  Production

(2013) S. M. Man et al.   JOURNAL OF IMMUNOLOGY

A type III effector antagonizes death receptor signalling during bacterial gut infection

(2013) Jaclyn S. Pearson et al.   NATURE

CYLD Deubiquitinates RIP1 in the TNFα-Induced Necrosome to Facilitate Kinase Activation and Programmed Necrosis

(2013) David M. Moquin et al.   PLoS One

AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages

(2012) R Pierini et al.   CELL DEATH AND DIFFERENTIATION

A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death

(2012) Laura S. Dickens et al.   MOLECULAR CELL

Survival Function of the FADD-CASPASE-8-cFLIPL Complex

(2012) Christopher P. Dillon et al.   Cell Reports

FLIPLinduces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity

(2011) Cristina Pop et al.   BIOCHEMICAL JOURNAL

A Critical Role for SOCS3 in Innate Resistance to Toxoplasma gondii

(2011) Ryan J. Whitmarsh et al.   Cell Host & Microbe

CD8α+ Dendritic Cells Are the Critical Source of Interleukin-12 that Controls Acute Infection by Toxoplasma gondii Tachyzoites

(2011) Mona Mashayekhi et al.   IMMUNITY

Mechanisms of necroptosis in T cells

(2011) Irene L. Ch’en et al.   JOURNAL OF EXPERIMENTAL MEDICINE

cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms

(2011) Maria Feoktistova et al.   MOLECULAR CELL

The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs

(2011) Tencho Tenev et al.   MOLECULAR CELL

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

(2011) William J. Kaiser et al.   NATURE

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Caspase 8 inhibits programmed necrosis by processing CYLD

(2011) Marie Anne O’Donnell et al.   NATURE CELL BIOLOGY

Principles of dimer-specific gene regulation revealed by a comprehensive characterization of NF-κB family DNA binding

(2011) Trevor Siggers et al.   NATURE IMMUNOLOGY

Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway

(2011) S. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

(2011) J. V. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beyond the enhanceosome: cluster of novel  B sites downstream of the human IFN-  gene is essential for lipopolysaccharide-induced gene activation

(2010) F. G. Goh et al.   BLOOD

A Yersinia Effector Protein Promotes Virulence by Preventing Inflammasome Recognition of the Type III Secretion System

(2010) Igor E. Brodsky et al.   Cell Host & Microbe

Identification and Characterization of Enhancers Controlling the Inflammatory Gene Expression Program in Macrophages

(2010) Serena Ghisletti et al.   IMMUNITY

Role of the NF-κB transcription factor c-Rel in the generation of CD8+ T-cell responses to Toxoplasma gondii

(2010) Kimberly A. Jordan et al.   INTERNATIONAL IMMUNOLOGY

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL