Targeting soluble tumor necrosis factor as a potential intervention to lower risk for late-onset Alzheimer’s disease associated with obesity, metabolic syndrome, and type 2 diabetes

Targeting TNFR2 as a Novel Therapeutic Strategy for Alzheimer’s Disease

(2019) Natalia Ortí-Casañ et al.   Frontiers in Neuroscience

Circulating C1q/TNF-Related Protein 3, Omentin-1 and NGAL in Obese Patients with Type 2 Diabetes During Insulin Therapy

(2019) Katarzyna Komosinska-Vassev et al.   Journal of Clinical Medicine

Propionate enters GABAergic neurons, inhibits GABA transaminase, causes GABA accumulation and lethargy in a model of propionic acidemia

(2018) Cecilie Morland et al.   BIOCHEMICAL JOURNAL

Endogenous Murine Amyloid-β Peptide Assembles into Aggregates in the Aged C57BL/6J Mouse Suggesting These Animals as a Model to Study Pathogenesis of Amyloid-β Plaque Formation

(2018) Barbara Ahlemeyer et al.   JOURNAL OF ALZHEIMERS DISEASE

Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications

(2018) Geert Jan Biessels et al.   Nature Reviews Endocrinology

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

Suppressor of Cytokine Signaling 3: Emerging Role Linking Central Insulin Resistance and Alzheimer’s Disease

(2018) Lan Cao et al.   Frontiers in Neuroscience

Protective effect of extractive and biotechnological chondroitin in insulin amyloid and advanced glycation end product-induced toxicity

(2018) Clara Iannuzzi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

CNS inflammation and neurodegeneration

(2017) Tanuja Chitnis et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammatory mechanisms linking obesity and metabolic disease

(2017) Alan R. Saltiel et al.   JOURNAL OF CLINICAL INVESTIGATION

Global aetiology and epidemiology of type 2 diabetes mellitus and its complications

(2017) Yan Zheng et al.   Nature Reviews Endocrinology

Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice

(2017) Kathryn P. MacPherson et al.   NEUROBIOLOGY OF DISEASE

Lipocalin-2: A Master Mediator of Intestinal and Metabolic Inflammation

(2017) Alexander R. Moschen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Actors and Factors in the Resolution of Intestinal Inflammation: Lipid Mediators As a New Approach to Therapy in Inflammatory Bowel Diseases

(2017) Federica Ungaro et al.   Frontiers in Immunology

Gut-brain Axis: Role of Lipids in the Regulation of Inflammation, Pain and CNS Diseases

(2017) Roberto Russo et al.   CURRENT MEDICINAL CHEMISTRY

Branched-chain amino acids as biomarkers in diabetes

(2016) Pieter Giesbertz et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

The relationship between body weight and inflammation: Lesson from anti-TNF-α antibody therapy

(2016) Ilaria Peluso et al.   HUMAN IMMUNOLOGY

Non-alcoholic fatty liver disease induces signs of Alzheimer’s disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model

(2016) Do-Geun Kim et al.   Journal of Neuroinflammation

Association Between Tumor Necrosis Factor-α and Diabetic Peripheral Neuropathy in Patients with Type 2 Diabetes: a Meta-Analysis

(2016) Ze-Peng Mu et al.   MOLECULAR NEUROBIOLOGY

Purinergic receptors as potential therapeutic targets in Alzheimer's disease

(2016) Lucas T. Woods et al.   NEUROPHARMACOLOGY

Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration

(2016) Yun Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil Gelatinase-Associated Lipocalin Levels in Patients With Crohn Disease Undergoing Treatment With Infliximab

(2016) Davide Bolignano et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Regulation of Obesity-Related Insulin Resistance with Gut Anti-inflammatory Agents

(2015) Helen Luck et al.   Cell Metabolism

Protective effects of low molecular weight chondroitin sulfate on amyloid beta (Aβ)-induced damage in vitro and in vivo

(2015) Q. Zhang et al.   NEUROSCIENCE

Diverse functional roles of lipocalin-2 in the central nervous system

(2015) Mithilesh Kumar Jha et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegeneration

(2015) Gertjan van Dijk et al.   Frontiers in Neuroscience

Lipocalin 2 modulates the cellular response to amyloid beta

(2014) S D Mesquita et al.   CELL DEATH AND DIFFERENTIATION

Overexpression of Heparanase Lowers the Amyloid Burden in Amyloid-β Precursor Protein Transgenic Mice

(2014) Charlotte B. Jendresen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Implications of heparan sulfate and heparanase in neuroinflammation

(2014) Xiao Zhang et al.   MATRIX BIOLOGY

IL-1 Signaling in Obesity-Induced Hepatic Lipogenesis and Steatosis

(2014) Kimberly A. Negrin et al.   PLoS One

Lipocalin-2 is involved in emotional behaviors and cognitive function

(2014) Ana Ferreira   Frontiers in Cellular Neuroscience

Inactivation of SOCS3 in leptin receptor-expressing cells protects mice from diet-induced insulin resistance but does not prevent obesity

(2014) João A.B. Pedroso et al.   Molecular Metabolism

Tetrahydrobiopterin Has a Glucose-Lowering Effect by Suppressing Hepatic Gluconeogenesis in an Endothelial Nitric Oxide Synthase–Dependent Manner in Diabetic Mice

(2013) Abulizi Abudukadier et al.   DIABETES

Liver Lipocalin 2 Expression in Severely Obese Women With Non Alcoholic Fatty Liver Disease

(2013) T. Auguet et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Shared dysregulated pathways lead to Parkinson's disease and diabetes

(2013) Jose A. Santiago et al.   TRENDS IN MOLECULAR MEDICINE

Alterations in metabolic pathways and networks in Alzheimer’s disease

(2013) R Kaddurah-Daouk et al.   Translational Psychiatry

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

Inhibition of Hypothalamic Inflammation Reverses Diet-Induced Insulin Resistance in the Liver

(2012) M. Milanski et al.   DIABETES

Linking Inflammation to the Brain-Liver Axis

(2012) P. I. Mighiu et al.   DIABETES

Lipocalin 2: Novel component of proinflammatory signaling in Alzheimer's disease

(2012) Petrus J. W. Naudé et al.   FASEB JOURNAL

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Global metabolic profiling of animal and human tissues via UPLC-MS

(2012) Elizabeth J Want et al.   Nature Protocols

Anti-tumour necrosis factor alpha therapy improves insulin sensitivity in normal-weight but not in obese patients with rheumatoid arthritis

(2012) Antonios Stavropoulos-Kalinoglou et al.   ARTHRITIS RESEARCH & THERAPY

Metabolic Network of Nucleosides in the Brain

(2011) Piero L. Ipata et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Regulation of microglia effector functions by tumor necrosis factor signaling

(2011) Ashley S. Harms et al.   GLIA

Increased plasma levels of lipocalin 2 in mild cognitive impairment

(2011) Jihye Choi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Assessment of Social Interaction Behaviors

(2011) Oksana Kaidanovich-Beilin et al.   Jove-Journal of Visualized Experiments

Metabolomic changes in autopsy-confirmed Alzheimer's disease

(2010) Rima Kaddurah-Daouk et al.   Alzheimers & Dementia

Insulin resistance in rheumatoid arthritis: the impact of the anti-TNF-α therapy

(2010) Miguel A. Gonzalez-Gay et al.   Annals of the New York Academy of Sciences

Lipocalin-2 Deficiency Attenuates Insulin Resistance Associated With Aging and Obesity

(2010) I. K.M. Law et al.   DIABETES

Induction of Neutrophil Gelatinase-associated Lipocalin Expression by Co-stimulation with Interleukin-17 and Tumor Necrosis Factor-α Is Controlled by IκB-ζ but neither by C/EBP-β nor C/EBP-δ

(2010) Joachim R. Karlsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease

(2008) Melissa K McCoy et al.   Journal of Neuroinflammation

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

(2008) Aileen M. Moloney et al.   NEUROBIOLOGY OF AGING