Tumor necrosis factor-α synthesis inhibitor 3,6′-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer’s disease

GLP-1 Receptor Stimulation Reduces Amyloid-β Peptide Accumulation and Cytotoxicity in Cellular and Animal Models of Alzheimer's Disease

(2017) Yazhou Li et al.   JOURNAL OF ALZHEIMERS DISEASE

Cyclooxygenase-1 null mice show reduced neuroinflammation in response to β-amyloid

(2016) Sang-Ho Choi et al.   Aging-US

Inflammatory Risk Factors and Pathologies Associated with Alzheimers Disease

(2012) M. Sastre et al.   Current Alzheimer Research

Deciphering the Physiology Underlying the Rapid Clinical Effects of Perispinal Etanercept in Alzheimers Disease

(2012) Edward Tobinick   Current Alzheimer Research

TNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation

(2012) Karim Belarbi et al.   Journal of Neuroinflammation

Ablation of TNF-RI/RII Expression in Alzheimer's Disease Mice Leads to an Unexpected Enhancement of Pathology

(2011) Sara L. Montgomery et al.   AMERICAN JOURNAL OF PATHOLOGY

Neuroinflammation and the plasticity-related immediate-early gene Arc

(2011) Susanna Rosi   BRAIN BEHAVIOR AND IMMUNITY

Chronic neuroinflammation impacts the recruitment of adult-born neurons into behaviorally relevant hippocampal networks

(2011) Karim Belarbi et al.   BRAIN BEHAVIOR AND IMMUNITY

Targeting TNF-Alpha to Elucidate and Ameliorate Neuroinflammation in Neurodegenerative Diseases

(2011) Kathryn A. Frankola et al.   CNS & Neurological Disorders-Drug Targets

Tumor necrosis factor-α synthesis inhibitor, 3,6′-dithiothalidomide, reverses behavioral impairments induced by minimal traumatic brain injury in mice

(2011) Renana Baratz et al.   JOURNAL OF NEUROCHEMISTRY

A role for tumor necrosis factor-α in ischemia and ischemic preconditioning

(2011) Orla Watters et al.   Journal of Neuroinflammation

Rivastigmine Lowers Aβ and Increases sAPPα Levels, Which Parallel Elevated Synaptic Markers and Metabolic Activity in Degenerating Primary Rat Neurons

(2011) Jason A. Bailey et al.   PLoS One

Arc in synaptic plasticity: from gene to behavior

(2011) Erica Korb et al.   TRENDS IN NEUROSCIENCES

Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction

(2010) Keigan M. Park et al.   CELLULAR SIGNALLING

Involvement of Rat Hippocampal Astrocytes in β-Amyloid-Induced Angiogenesis and Neuroinflammation

(2010) L. Fioravanzo et al.   Current Alzheimer Research

Probing the Biology of Alzheimer's Disease in Mice

(2010) Karen H. Ashe et al.   NEURON

Mechanisms of TNFα regulation in uveitis: Focus on RNA-binding proteins

(2010) Tarnjit K. Khera et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Accuracy of hippocampal network activity is disrupted by neuroinflammation: rescue by memantine

(2009) S. Rosi et al.   BRAIN

Tumour Necrosis Factor Modulation for Treatment of Alzheimerʼs Disease

(2009) Edward Tobinick   CNS DRUGS

Treatment with a C5aR Antagonist Decreases Pathology and Enhances Behavioral Performance in Murine Models of Alzheimer's Disease

(2009) M. I. Fonseca et al.   JOURNAL OF IMMUNOLOGY

A cellular model of inflammation for identifying TNF-α synthesis inhibitors

(2009) David Tweedie et al.   JOURNAL OF NEUROSCIENCE METHODS

Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

(2009) Fiona E. McAlpine et al.   NEUROBIOLOGY OF DISEASE

Chronic Neuron-Specific Tumor Necrosis Factor-Alpha Expression Enhances the Local Inflammatory Environment Ultimately Leading to Neuronal Death in 3xTg-AD Mice

(2008) Michelle C. Janelsins et al.   AMERICAN JOURNAL OF PATHOLOGY

Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence

(2008) Kotb Abdelmohsen et al.   BIOLOGICAL CHEMISTRY

Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model

(2008) Chiho Hirata-Fukae et al.   BRAIN RESEARCH

Pro-inflammatory Cytokines Modulate Glial Apolipoprotein E Secretion

(2008) Judes Poirier et al.   Current Alzheimer Research

Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease

(2008) Jing-Ji Jin et al.   Journal of Neuroinflammation

Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration

(2008) Edward L Tobinick et al.   Journal of Neuroinflammation

TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease

(2008) Melissa K McCoy et al.   Journal of Neuroinflammation

Targeting mRNA Stability Arrests Inflammatory Bone Loss

(2008) Chetan S Patil et al.   MOLECULAR THERAPY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

The brain expression of genes involved in inflammatory response, the ribosome and learning and memory is altered by centrally injected lipopolysaccharide in mice

(2008) R H Bonow et al.   PHARMACOGENOMICS JOURNAL

Tumor Necrosis Factor-α Modulates Survival, Proliferation, and Neuronal Differentiation in Neonatal Subventricular Zone Cell Cultures

(2008) Liliana Bernardino et al.   STEM CELLS

TNFα blockade in human diseases: An overview of efficacy and safety

(2007) Jan Lin et al.   CLINICAL IMMUNOLOGY

Neuroinflammation in Parkinson's Disease: Is there sufficient evidence for mechanism-based interventional therapy?

(2007) Malu et al.   Frontiers in Bioscience-Landmark