Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis

Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus

(2015) Gregor Ebert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Birinapant, a Smac-Mimetic with Improved Tolerability for the Treatment of Solid Tumors and Hematological Malignancies

(2014) Stephen M. Condon et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synergistic Targeting of AML Stem/Progenitor Cells With IAP Antagonist Birinapant and Demethylating Agents

(2014) Bing Z. Carter et al.   JNCI-Journal of the National Cancer Institute

Birinapant (TL32711), a Bivalent SMAC Mimetic, Targets TRAF2-Associated cIAPs, Abrogates TNF-Induced NF- B Activation, and Is Active in Patient-Derived Xenograft Models

(2014) C. A. Benetatos et al.   MOLECULAR CANCER THERAPEUTICS

Inhibitors of apoptosis proteins (IAPs) are required for effective T-cell expansion/survival during antiviral immunity in mice

(2013) I. E. Gentle et al.   BLOOD

The Novel SMAC Mimetic Birinapant Exhibits Potent Activity against Human Melanoma Cells

(2013) C. Krepler et al.   CLINICAL CANCER RESEARCH

Smac-Mimetic-Induced Epithelial Cell Death Reduces the Growth of Renal Cysts

(2013) L. X. Fan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Blockade of Chronic Type I Interferon Signaling to Control Persistent LCMV Infection

(2013) E. B. Wilson et al.   SCIENCE

Persistent LCMV Infection Is Controlled by Blockade of Type I Interferon Signaling

(2013) J. R. Teijaro et al.   SCIENCE

T-cell responses in hepatitis B and C virus infection: similarities and differences

(2013) Julia Schmidt et al.   Emerging Microbes & Infections

Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-α-independent mechanism

(2012) Jennifer L. Allensworth et al.   BREAST CANCER RESEARCH AND TREATMENT

Kinetics of viral loads and risk of hepatitis B virus reactivation in hepatitis B core antibody-positive rheumatoid arthritis patients undergoing anti-tumour necrosis factor alpha therapy

(2011) J.-L. Lan et al.   ANNALS OF THE RHEUMATIC DISEASES

The regulation of TNF signalling: what a tangled web we weave

(2011) John Silke   CURRENT OPINION IN IMMUNOLOGY

IAP inhibitors enhance co-stimulation to promote tumor immunity

(2010) Michael Dougan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hepatitis B virus core antigen determines viral persistence in a C57BL/6 mouse model

(2010) Y.-J. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune effectors required for hepatitis B virus clearance

(2009) P. L. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

(2008) Lai Wang et al.   CELL