Old, new and emerging functions of caspases

Inflammaging: disturbed interplay between autophagy and inflammasomes

(2016) Antero Salminen et al.   Aging-US

A nonapoptotic role for CASP2/caspase 2

(2014) Meenakshi Tiwari et al.   Autophagy

A mitochondrial-associated link between an effector caspase and autophagic flux

(2014) Lindsay DeVorkin et al.   Autophagy

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

(2014) James A. Rickard et al.   CELL

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Caspase-8 as a Regulator of Tumor Cell Motility

(2014) R.P. Graf et al.   CURRENT MOLECULAR MEDICINE

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming

(2014) R. Allam et al.   EMBO REPORTS

Local Pruning of Dendrites and Spines by Caspase-3-Dependent and Proteasome-Limited Mechanisms

(2014) A. Erturk et al.   JOURNAL OF NEUROSCIENCE

Inefficient star formation in extremely metal poor galaxies

(2014) Yong Shi et al.   NATURE

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

(2014) Nozomi Takahashi et al.   NATURE

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

(2014) Marius Dannappel et al.   NATURE

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An unexpected role for caspase-2 in neuroblastoma

(2014) L Dorstyn et al.   Cell Death & Disease

Non-apoptotic functions of caspase-7 during osteogenesis

(2014) E Svandova et al.   Cell Death & Disease

Loss of caspase-2 accelerates age-dependent alterations in mitochondrial production of reactive oxygen species

(2013) Marisa Lopez-Cruzan et al.   BIOGERONTOLOGY

Control of Autophagic Cell Death by Caspase-10 in Multiple Myeloma

(2013) Laurence Lamy et al.   CANCER CELL

Th-MYCN Mice with Caspase-8 Deficiency Develop Advanced Neuroblastoma with Bone Marrow Metastasis

(2013) Tal Teitz et al.   CANCER RESEARCH

Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice

(2013) M J Parsons et al.   CELL DEATH AND DIFFERENTIATION

Caspase-7 participates in differentiation of cells forming dental hard tissues

(2013) Eva Matalova et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Caspase-6 as a novel early target in the treatment of Alzheimer's disease

(2013) Andrea C. LeBlanc   EUROPEAN JOURNAL OF NEUROSCIENCE

HuGE systematic review and meta-analysis demonstrate association of CASP-3 and CASP-7 genetic polymorphisms with cancer risk

(2013) S. Yan et al.   GENETICS AND MOLECULAR RESEARCH

Loss of caspase-8 in hepatocytes accelerates the onset of liver regeneration in mice through premature nuclear factor kappa B activation

(2013) Julia Freimuth et al.   HEPATOLOGY

Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death

(2013) Dimitry Ofengeim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice

(2013) J. Puccini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-3 Modulates Regenerative Response After Stroke

(2013) Wenying Fan et al.   STEM CELLS

Caspase Functions in Cell Death and Disease

(2013) D. R. McIlwain et al.   Cold Spring Harbor Perspectives in Biology

Dual role of the caspase enzymes in satellite cells from aged and young subjects

(2013) S Fulle et al.   Cell Death & Disease

Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome

(2013) C Manzl et al.   Cell Death & Disease

Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice

(2013) Julio Pozueta et al.   Nature Communications

Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death

(2012) Ozlem Oral et al.   APOPTOSIS

Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice

(2012) S Shalini et al.   CELL DEATH AND DIFFERENTIATION

Proteolysis of Ambra1 during apoptosis has a role in the inhibition of the autophagic pro-survival response

(2012) V Pagliarini et al.   CELL DEATH AND DIFFERENTIATION

PIDDosome-independent tumor suppression by Caspase-2

(2012) C Manzl et al.   CELL DEATH AND DIFFERENTIATION

Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability

(2012) L Dorstyn et al.   CELL DEATH AND DIFFERENTIATION

Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation

(2012) James E. Vince et al.   IMMUNITY

A Caspase Cascade Regulating Developmental Axon Degeneration

(2012) D. J. Simon et al.   JOURNAL OF NEUROSCIENCE

Innate immune responses to Chlamydia pneumoniae infection: role of TLRs, NLRs, and the inflammasome

(2012) Kenichi Shimada et al.   MICROBES AND INFECTION

Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology

(2012) Bradley T. Hyman et al.   NATURE REVIEWS NEUROSCIENCE

Cell death by autophagy: facts and apparent artefacts

(2011) D Denton et al.   CELL DEATH AND DIFFERENTIATION

Many stimuli pull the necrotic trigger, an overview

(2011) N Vanlangenakker et al.   CELL DEATH AND DIFFERENTIATION

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Somatic mutation of proapoptotic caspase-2 gene is rare in acute leukemias and common solid cancers

(2011) Min S. Kim et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Loss of Caspase-8 Protects Mice Against Inflammation-Related Hepatocarcinogenesis but Induces Non-Apoptotic Liver Injury

(2011) Christian Liedtke et al.   GASTROENTEROLOGY

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

Caspase-14 Is Required for Filaggrin Degradation to Natural Moisturizing Factors in the Skin

(2011) Esther Hoste et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs

(2011) Tencho Tenev et al.   MOLECULAR CELL

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Caspase 3–mediated stimulation of tumor cell repopulation during cancer radiotherapy

(2011) Qian Huang et al.   NATURE MEDICINE

The in vitro cleavage of the hAtg proteins by cell death proteases

(2010) Joanna M. Norman et al.   Autophagy

Caspase-8 as a therapeutic target in cancer

(2010) Dwayne G. Stupack   CANCER LETTERS

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization

(2010) Zheng Li et al.   CELL

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity

(2010) S. Ohsawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4

(2010) B. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apoptotic Cells Activate the "Phoenix Rising" Pathway to Promote Wound Healing and Tissue Regeneration

(2010) F. Li et al.   Science Signaling

Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis

(2010) Yushan Zhu et al.   Protein & Cell

The Enigmatic Roles of Caspases in Tumor Development

(2010) Richard Jäger et al.   Cancers

Atg4D at the interface between autophagy and apoptosis

(2009) Virginie M.S. Betin et al.   Autophagy

Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studies

(2009) Q. Lan et al.   BLOOD

Polymorphisms and Haplotypes in the Caspase-3, Caspase-7, and Caspase-8 Genes and Risk for Endometrial Cancer: A Population-Based, Case-Control Study in a Chinese Population

(2009) H.-L. Xu et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration

(2009) Wolfram Goessling et al.   CELL

Apoptotic Cells Provide an Unexpected Source of Wnt3 Signaling to Drive Hydra Head Regeneration

(2009) Simona Chera et al.   DEVELOPMENTAL CELL

Caspase-2 activation in the absence of PIDDosome formation

(2009) Claudia Manzl et al.   JOURNAL OF CELL BIOLOGY

Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease

(2009) Andrew Kovalenko et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Mutational analysis of CASP10 gene in acute leukaemias and multiple myelomas

(2009) Min Sung Kim et al.   PATHOLOGY

Mutational analysis of CASP10 gene in colon, breast, lung and hepatocellular carcinomas

(2009) Ji Eun Oh et al.   PATHOLOGY

A tumor suppressor function for caspase-2

(2009) L. H. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-mediated cleavage of ATG6/Beclin-1 links apoptosis to autophagy in HeLa cells

(2008) Dong-Hyung Cho et al.   CANCER LETTERS

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

Hematopoietic Stem Cell Responsiveness to Exogenous Signals Is Limited by Caspase-3

(2008) Viktor Janzen et al.   Cell Stem Cell

Caspase Activity Mediates the Differentiation of Embryonic Stem Cells

(2008) Jun Fujita et al.   Cell Stem Cell

CASP3 Polymorphisms and Risk of Squamous Cell Carcinoma of the Head and Neck

(2008) K. Chen et al.   CLINICAL CANCER RESEARCH

Distinct Mechanisms of Apoptosis-Induced Compensatory Proliferation in Proliferating and Differentiating Tissues in the Drosophila Eye

(2008) Yun Fan et al.   DEVELOPMENTAL CELL

Caspase polymorphisms and genetic susceptibility to multiple myeloma

(2008) H. Dean Hosgood et al.   HEMATOLOGICAL ONCOLOGY

A non-apoptotic role for caspase-9 in muscle differentiation

(2008) T. V. A. Murray et al.   JOURNAL OF CELL SCIENCE

Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8

(2008) Jonathan Maelfait et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Aging Impairs the Unfolded Protein Response to Sleep Deprivation and Leads to Proapoptotic Signaling

(2008) N. Naidoo et al.   JOURNAL OF NEUROSCIENCE

The Human Protein Atlas-a tool for pathology

(2008) F Pontén et al.   JOURNAL OF PATHOLOGY

Polymorphisms in the Caspase7 gene and the risk of lung cancer

(2008) Won Kee Lee et al.   LUNG CANCER

Identification of Novel Mammalian Caspases Reveals an Important Role of Gene Loss in Shaping the Human Caspase Repertoire

(2008) L. Eckhart et al.   MOLECULAR BIOLOGY AND EVOLUTION

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology

Identification of polymorphisms in theCaspase-3 gene and their association with lung cancer risk

(2007) Jin Sung Jang et al.   MOLECULAR CARCINOGENESIS