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Title
Necroptosis in development, inflammation and disease
Authors
Keywords
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Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 18, Issue 2, Pages 127-136
Publisher
Springer Nature
Online
2016-12-21
DOI
10.1038/nrm.2016.149
References
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Note: Only part of the references are listed.- RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury
- (2016) K Newton et al. CELL DEATH AND DIFFERENTIATION
- RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus
- (2016) Shoko Nogusa et al. Cell Host & Microbe
- NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions
- (2016) Katerina Vlantis et al. IMMUNITY
- The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis
- (2016) Silvia Alvarez-Diaz et al. IMMUNITY
- RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4
- (2016) Malek Najjar et al. IMMUNITY
- Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis
- (2016) Boris Strilic et al. NATURE
- Regulated necrosis: disease relevance and therapeutic opportunities
- (2016) Marcus Conrad et al. NATURE REVIEWS DRUG DISCOVERY
- RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS
- (2016) Yasushi Ito et al. SCIENCE
- Programmed necrosis in inflammation: Toward identification of the effector molecules
- (2016) D. Wallach et al. SCIENCE
- MLKL and FADD Are Critical for Suppressing Progressive Lymphoproliferative Disease and Activating the NLRP3 Inflammasome
- (2016) Xixi Zhang et al. Cell Reports
- NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis
- (2015) Vangelis Kondylis et al. CANCER CELL
- Necroptosis suppresses inflammation via termination of TNF- or LPS-induced cytokine and chemokine production
- (2015) C J Kearney et al. CELL DEATH AND DIFFERENTIATION
- Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis
- (2015) D A Rodriguez et al. CELL DEATH AND DIFFERENTIATION
- Herpes Simplex Virus Suppresses Necroptosis in Human Cells
- (2015) Hongyan Guo et al. Cell Host & Microbe
- RIP1/RIP3 Binding to HSV-1 ICP6 Initiates Necroptosis to Restrict Virus Propagation in Mice
- (2015) Zhe Huang et al. Cell Host & Microbe
- Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics
- (2015) Gi-Bang Koo et al. CELL RESEARCH
- Regulation of inflammasome activation
- (2015) Si Ming Man et al. IMMUNOLOGICAL REVIEWS
- Suppression of RIP3-dependent Necroptosis by Human Cytomegalovirus
- (2015) Shinya Omoto et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling
- (2015) Christina Antonopoulos et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A RIPK3–Caspase 8 Complex Mediates Atypical Pro–IL-1β Processing
- (2015) Kenta Moriwaki et al. JOURNAL OF IMMUNOLOGY
- NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling
- (2015) Yves Dondelinger et al. MOLECULAR CELL
- Ppm1b negatively regulates necroptosis through dephosphorylating Rip3
- (2015) Wanze Chen et al. NATURE CELL BIOLOGY
- The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis
- (2015) Michio Onizawa et al. NATURE IMMUNOLOGY
- Necrostatin-1 Ameliorates Intracerebral Hemorrhage-Induced Brain Injury in Mice Through Inhibiting RIP1/RIP3 Pathway
- (2015) Xingfen Su et al. NEUROCHEMICAL RESEARCH
- A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis
- (2015) Dianrong Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RIP3-mediated necrotic cell death accelerates systematic inflammation and mortality
- (2015) Lingjun Meng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury
- (2015) M Deutsch et al. Cell Death & Disease
- Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3
- (2015) Seokwon Kang et al. Nature Communications
- RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL
- (2015) Kate E. Lawlor et al. Nature Communications
- Activation of Necroptosis in Multiple Sclerosis
- (2015) Dimitry Ofengeim et al. Cell Reports
- Toxin-Induced Necroptosis Is a Major Mechanism of Staphylococcus aureus Lung Damage
- (2015) Kipyegon Kitur et al. PLoS Pathogens
- cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner
- (2014) W. W.-L. Wong et al. BLOOD
- RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction
- (2014) Mark Luedde et al. CARDIOVASCULAR RESEARCH
- RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis
- (2014) James A. Rickard et al. CELL
- RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3
- (2014) Christopher P. Dillon et al. CELL
- RIPK1- and RIPK3-induced cell death mode is determined by target availability
- (2014) W D Cook et al. CELL DEATH AND DIFFERENTIATION
- A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis
- (2014) J. Gautheron et al. EMBO Molecular Medicine
- Dysfunctional HIV-Specific CD8+ T Cell Proliferation Is Associated with Increased Caspase-8 Activity and Mediated by Necroptosis
- (2014) Gaurav D. Gaiha et al. IMMUNITY
- Mutation of a Self-Processing Site in Caspase-8 Compromises Its Apoptotic but Not Its Nonapoptotic Functions in Bacterial Artificial Chromosome-Transgenic Mice
- (2014) T.-B. Kang et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: RIPK1 Kinase Inactive Mice Are Viable and Protected from TNF-Induced Necroptosis In Vivo
- (2014) Apostolos Polykratis et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice
- (2014) S. B. Berger et al. JOURNAL OF IMMUNOLOGY
- RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity
- (2014) Pratyusha Mandal et al. MOLECULAR CELL
- Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3
- (2014) Huayi Wang et al. MOLECULAR CELL
- RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis
- (2014) Nozomi Takahashi et al. NATURE
- RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis
- (2014) Marius Dannappel et al. NATURE
- RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway
- (2014) Xiaqiong Wang et al. NATURE IMMUNOLOGY
- Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3
- (2014) M. Vieira et al. NEUROBIOLOGY OF DISEASE
- Necroptosis Takes Place in Human Immunodeficiency Virus Type-1 (HIV-1)-Infected CD4+ T Lymphocytes
- (2014) Ting Pan et al. PLoS One
- Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense
- (2014) X. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF- B and MAPK signaling
- (2014) N. H. Philip et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
- (2014) Joanne M. Hildebrand et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death
- (2014) D. Weng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition
- (2014) W. J. Kaiser et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis
- (2014) K. Newton et al. SCIENCE
- Necroptosis, in vivo detection in experimental disease models
- (2014) Sandrine Jouan-Lanhouet et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis
- (2014) Q Remijsen et al. Cell Death & Disease
- The B-RafV600E inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury
- (2014) J-X Li et al. Cell Death & Disease
- MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates
- (2014) Yves Dondelinger et al. Cell Reports
- XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation
- (2014) Monica Yabal et al. Cell Reports
- RIPK3-Mediated Necroptosis Promotes Donor Kidney Inflammatory Injury and Reduces Allograft Survival
- (2013) A. Lau et al. AMERICAN JOURNAL OF TRANSPLANTATION
- TNF Dually Mediates Resistance and Susceptibility to Mycobacteria via Mitochondrial Reactive Oxygen Species
- (2013) Francisco J. Roca et al. CELL
- Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death
- (2013) Xin Chen et al. CELL RESEARCH
- Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis
- (2013) Jianfeng Wu et al. CELL RESEARCH
- The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism
- (2013) James M. Murphy et al. IMMUNITY
- Diverse Sequence Determinants Control Human and Mouse Receptor Interacting Protein 3 (RIP3) and Mixed Lineage Kinase domain-Like (MLKL) Interaction in Necroptotic Signaling
- (2013) Wanze Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL
- (2013) William J. Kaiser et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Proapoptotic Chemotherapeutic Drugs Induce Noncanonical Processing and Release of IL-1 via Caspase-8 in Dendritic Cells
- (2013) C. Antonopoulos et al. JOURNAL OF IMMUNOLOGY
- RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3
- (2013) John R. Lukens et al. NATURE
- Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains
- (2013) Shan Li et al. NATURE
- A type III effector antagonizes death receptor signalling during bacterial gut infection
- (2013) Jaclyn S. Pearson et al. NATURE
- Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis
- (2013) Zhenyu Cai et al. NATURE CELL BIOLOGY
- Clostridium perfringens Beta-Toxin Induces Necrostatin-Inhibitable, Calpain-Dependent Necrosis in Primary Porcine Endothelial Cells
- (2013) Delphine Autheman et al. PLoS One
- CYLD Deubiquitinates RIP1 in the TNFα-Induced Necrosome to Facilitate Kinase Activation and Programmed Necrosis
- (2013) David M. Moquin et al. PLoS One
- Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury
- (2013) A. Linkermann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Widespread Mitochondrial Depletion via Mitophagy Does Not Compromise Necroptosis
- (2013) Stephen W.G. Tait et al. Cell Reports
- A Role of RIP3-Mediated Macrophage Necrosis in Atherosclerosis Development
- (2013) Juan Lin et al. Cell Reports
- Protective Roles for Caspase-8 and cFLIP in Adult Homeostasis
- (2013) Ricardo Weinlich et al. Cell Reports
- Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
- (2012) Liming Sun et al. CELL
- DAI/ZBP1/DLM-1 Complexes with RIP3 to Mediate Virus-Induced Programmed Necrosis that Is Targeted by Murine Cytomegalovirus vIRA
- (2012) Jason W. Upton et al. Cell Host & Microbe
- IAPs limit activation of RIP kinases by TNF receptor 1 during development
- (2012) Maryline Moulin et al. EMBO JOURNAL
- Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury
- (2012) Sanjoy Roychowdhury et al. HEPATOLOGY
- Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation
- (2012) James E. Vince et al. IMMUNITY
- Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome
- (2012) Tae-Bong Kang et al. IMMUNITY
- Intermediate Domain of Receptor-interacting Protein Kinase 1 (RIPK1) Determines Switch between Necroptosis and RIPK1 Kinase-dependent Apoptosis
- (2012) Linde Duprez et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Unknown
- (2012) Andreas Linkermann et al. MOLECULAR MEDICINE
- Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium
- (2012) Nirmal Robinson et al. NATURE IMMUNOLOGY
- Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration
- (2012) Y. Murakami et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis
- (2012) J. Zhao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A novel role for RIP1 kinase in mediating TNFα production
- (2012) D E Christofferson et al. Cell Death & Disease
- Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models
- (2012) N Takahashi et al. Cell Death & Disease
- Survival Function of the FADD-CASPASE-8-cFLIPL Complex
- (2012) Christopher P. Dillon et al. Cell Reports
- FLIPLinduces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity
- (2011) Cristina Pop et al. BIOCHEMICAL JOURNAL
- The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation
- (2011) Marion C. Bonnet et al. IMMUNITY
- RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome
- (2011) Linde Duprez et al. IMMUNITY
- RIG-I RNA Helicase Activation of IRF3 Transcription Factor Is Negatively Regulated by Caspase-8-Mediated Cleavage of the RIP1 Protein
- (2011) Akhil Rajput et al. IMMUNITY
- Mechanisms of necroptosis in T cells
- (2011) Irene L. Ch’en et al. JOURNAL OF EXPERIMENTAL MEDICINE
- cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms
- (2011) Maria Feoktistova et al. MOLECULAR CELL
- The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs
- (2011) Tencho Tenev et al. MOLECULAR CELL
- FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation
- (2011) Patrick-Simon Welz et al. NATURE
- Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis
- (2011) Claudia Günther et al. NATURE
- RIP3 mediates the embryonic lethality of caspase-8-deficient mice
- (2011) William J. Kaiser et al. NATURE
- Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis
- (2011) Andrew Oberst et al. NATURE
- Functional complementation between FADD and RIP1 in embryos and lymphocytes
- (2011) Haibing Zhang et al. NATURE
- Caspase 8 inhibits programmed necrosis by processing CYLD
- (2011) Marie Anne O’Donnell et al. NATURE CELL BIOLOGY
- Necrostatin-1 ameliorates symptoms in R6/2 transgenic mouse model of Huntington's disease
- (2011) S Zhu et al. Cell Death & Disease
- Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury
- (2010) Xingshun Xu et al. BRAIN RESEARCH
- Virus Inhibition of RIP3-Dependent Necrosis
- (2010) Jason W. Upton et al. Cell Host & Microbe
- Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation
- (2009) YoungSik Cho et al. CELL
- Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α
- (2009) Sudan He et al. CELL
- Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment
- (2009) Peter Geserick et al. JOURNAL OF CELL BIOLOGY
- RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis
- (2009) D.-W. Zhang et al. SCIENCE
- TNF-α Induces Two Distinct Caspase-8 Activation Pathways
- (2008) Lai Wang et al. CELL
- Cytomegalovirus M45 Cell Death Suppression Requires Receptor-interacting Protein (RIP) Homotypic Interaction Motif (RHIM)-dependent Interaction with RIP1
- (2008) Jason W. Upton et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Necrostatin-1 Reduces Histopathology and Improves Functional Outcome after Controlled Cortical Impact in Mice
- (2008) Zerong You et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Identification of RIP1 kinase as a specific cellular target of necrostatins
- (2008) Alexei Degterev et al. Nature Chemical Biology
- Antigen-mediated T cell expansion regulated by parallel pathways of death
- (2008) I. L. Ch'en et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells
- (2008) B. D. Bell et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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