Caspase-8 modulates physiological and pathological angiogenesis during retina development

YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development

(2018) Filipa Neto et al.   eLife

NCK-dependent pericyte migration promotes pathological neovascularization in ischemic retinopathy

(2018) Alexandre Dubrac et al.   Nature Communications

RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation

(2018) Gianmaria Liccardi et al.   MOLECULAR CELL

RIPK1/RIPK3 promotes vascular permeability to allow tumor cell extravasation independent of its necroptotic function

(2017) Kay Hänggi et al.   Cell Death & Disease

Motor neurons control blood vessel patterning in the developing spinal cord

(2017) Patricia Himmels et al.   Nature Communications

Polarized actin and VE-cadherin dynamics regulate junctional remodelling and cell migration during sprouting angiogenesis

(2017) Jiahui Cao et al.   Nature Communications

Oncogenic p95HER2/611CTF primes human breast epithelial cells for metabolic stress-induced down-regulation of FLIP and activation of TRAIL-R/Caspase-8-dependent apoptosis

(2017) Rosa Martín-Pérez et al.   Oncotarget

CNS Macrophages Control Neurovascular Development via CD95L

(2017) Si Chen et al.   Cell Reports

Apoptosis regulates endothelial cell number and capillary vessel diameter but not vessel regression during retinal angiogenesis

(2016) Emma C. Watson et al.   DEVELOPMENT

Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate

(2016) Michelle A. Hughes et al.   MOLECULAR CELL

Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis

(2016) Boris Strilic et al.   NATURE

The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activation

(2016) E. J. Gordon et al.   Science Signaling

The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization

(2016) Feng Zhang et al.   Nature Communications

The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activation

(2016) E. J. Gordon et al.   Science Signaling

Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis

(2015) D A Rodriguez et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms of Vessel Pruning and Regression

(2015) Claudia Korn et al.   DEVELOPMENTAL CELL

Quantification of apoptosis and necroptosis at the single cell level by a combination of Imaging Flow Cytometry with classical Annexin V/propidium iodide staining

(2015) Sabine Pietkiewicz et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Pathophysiology and Mechanisms of Severe Retinopathy of Prematurity

(2015) M. Elizabeth Hartnett   OPHTHALMOLOGY

The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells

(2015) Soniya Savant et al.   Cell Reports

Dynamic Endothelial Cell Rearrangements Drive Developmental Vessel Regression

(2015) Claudio A. Franco et al.   PLOS BIOLOGY

Pro-apoptotic BIM is an essential initiator of physiological endothelial cell death independent of regulation by FOXO3

(2014) M N Koenig et al.   CELL DEATH AND DIFFERENTIATION

Endothelial cell-derived non-canonical Wnt ligands control vascular pruning in angiogenesis

(2014) C. Korn et al.   DEVELOPMENT

The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis

(2014) Katie Bentley et al.   NATURE CELL BIOLOGY

Cdh5/VE-cadherin Promotes Endothelial Cell Interface Elongation via Cortical Actin Polymerization during Angiogenic Sprouting

(2014) Loïc Sauteur et al.   Cell Reports

The impact of hypoxia on cell death pathways

(2013) Colin R. Lenihan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Retinopathy of prematurity

(2013) Ann Hellström et al.   LANCET

Blood Flow Changes Coincide with Cellular Rearrangements during Blood Vessel Pruning in Zebrafish Embryos

(2013) Eva Kochhan et al.   PLoS One

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Endothelial Cell–Specific FGD5 Involvement in Vascular Pruning Defines Neovessel Fate in Mice

(2012) Caroline Cheng et al.   CIRCULATION

VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd

(2012) Zuyue Sun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Visualization of gene expression in whole mouse retina by in situ hybridization

(2012) Michael B Powner et al.   Nature Protocols

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Caspase 8 inhibits programmed necrosis by processing CYLD

(2011) Marie Anne O’Donnell et al.   NATURE CELL BIOLOGY

p38 MAP kinase is necessary for melanoma-mediated regulation of VE-cadherin disassembly

(2010) Payal Khanna et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

ERG is required for the differentiation of embryonic stem cells along the endothelial lineage

(2010) Vesna Nikolova-Krstevski et al.   BMC DEVELOPMENTAL BIOLOGY

Bim is responsible for the inherent sensitivity of the developing retinal vasculature to hyperoxia

(2010) Shoujian Wang et al.   DEVELOPMENTAL BIOLOGY

Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of life

(2010) Przemyslaw Sapieha et al.   JOURNAL OF CLINICAL INVESTIGATION

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

(2010) Yingdi Wang et al.   NATURE

Inducible gene targeting in the neonatal vasculature and analysis of retinal angiogenesis in mice

(2010) Mara E Pitulescu et al.   Nature Protocols

Development of atopic dermatitis-like skin disease from the chronic loss of epidermal caspase-8

(2010) C. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-8 Is Involved in Neovascularization-Promoting Progenitor Cell Functions

(2009) Dörte Scharner et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Caspase-8 Association with the Focal Adhesion Complex Promotes Tumor Cell Migration and Metastasis

(2009) S. Barbero et al.   CANCER RESEARCH

Oxygen-induced retinopathy: a model for vascular pathology in the retina

(2009) A Scott et al.   EYE

Dynamic expression of epidermal caspase 8 simulates a wound healing response

(2009) Pedro Lee et al.   NATURE

Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis

(2009) Kip M Connor et al.   Nature Protocols

Modular control of endothelial sheet migration

(2008) P. Vitorino et al.   GENES & DEVELOPMENT

Identification of a Critical Tyrosine Residue in Caspase 8 That Promotes Cell Migration

(2008) Simone Barbero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vascular sprout formation entails tissue deformations and VE-cadherin-dependent cell-autonomous motility

(2007) Erica D. Perryn et al.   DEVELOPMENTAL BIOLOGY