XIAP Knockdown in Alcohol-Associated Liver Disease Models Exhibits Divergent in vitro and in vivo Phenotypes Owing to a Potential Zonal Inhibitory Role of SMAC

Hepatic stellate cell activation promotes alcohol-induced steatohepatitis through Igfbp3 and SerpinA12

(2020) Juan P. Arab et al.   JOURNAL OF HEPATOLOGY

Circulating extracellular vesicles carrying sphingolipid cargo for the diagnosis and dynamic risk profiling of alcoholic hepatitis

(2020) Tejasav S. Sehrawat et al.   HEPATOLOGY

The knowns and unknowns of treatment for alcoholic hepatitis

(2020) Tejasav S Sehrawat et al.   Lancet Gastroenterology & Hepatology

IRE1A Stimulates Hepatocyte-derived Extracellular Vesicles That Promote Inflammation in Mice With Steatohepatitis

(2020) Debanjali Dasgupta et al.   GASTROENTEROLOGY

A single cell atlas of the human liver tumor microenvironment

(2020) Hassan Massalha et al.   Molecular Systems Biology

Role of AGAP2 in the profibrogenic effects induced by TGFβ in LX-2 hepatic stellate cells

(2019) Amaia Navarro-Corcuera et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Alcohol-related liver disease: Areas of consensus, unmet needs and opportunities for further study

(2019) Mark Thursz et al.   JOURNAL OF HEPATOLOGY

An Open Label, Dose Escalation Study To Assess The Safety And Efficacy Of IL‐22 Agonist F‐652 In Patients With Alcoholic Hepatitis

(2019) Juan P. Arab et al.   HEPATOLOGY

Regulation of Cell Death and Immunity by XIAP

(2019) Philipp J. Jost et al.   Cold Spring Harbor Perspectives in Biology

ACG Clinical Guideline: Alcoholic Liver Disease

(2018) Ashwani K Singal et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

XIAP Regulation by MNK Links MAPK and NFκB Signaling to Determine an Aggressive Breast Cancer Phenotype

(2018) Myron K. Evans et al.   CANCER RESEARCH

ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth

(2018) George A. Ward et al.   MOLECULAR CANCER THERAPEUTICS

A New Role for the Mitochondrial Pro-apoptotic Protein SMAC/Diablo in Phospholipid Synthesis Associated with Tumorigenesis

(2018) Avijit Paul et al.   MOLECULAR THERAPY

Inhibitor of apoptosis proteins are required for effective fusion of autophagosomes with lysosomes

(2018) Sylwia Gradzka et al.   Cell Death & Disease

XIAP at the crossroads of cell death and inflammation

(2018) Domagoj Vucic   Oncotarget

A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl)-2-[(2R,5R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660)

(2018) Christopher N. Johnson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hepatocyte-Derived Lipotoxic Extracellular Vesicle Sphingosine 1-Phosphate Induces Macrophage Chemotaxis

(2018) Chieh-Yu Liao et al.   Frontiers in Immunology

Degradation of Bcl-2 by XIAP and ARTS Promotes Apoptosis

(2017) Natalia Edison et al.   Cell Reports

Targeting Inhibitor of Apoptosis Proteins Protects from Bleomycin-Induced Lung Fibrosis

(2016) Shanna L. Ashley et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles

(2016) Vikas K. Verma et al.   JOURNAL OF HEPATOLOGY

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

(2016) Gabriela Brumatti et al.   Science Translational Medicine

A mouse model of alcoholic liver fibrosis-associated acute kidney injury identifies key molecular pathways

(2016) Shinji Furuya et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Spatial reconstruction of single-cell gene expression data

(2015) Rahul Satija et al.   NATURE BIOTECHNOLOGY

Animals Models of Gastrointestinal and Liver Diseases. Animal models of alcohol-induced liver disease: pathophysiology, translational relevance, and challenges

(2014) Stephanie Mathews et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella

(2014) M. Andree et al.   EMBO JOURNAL

A Histologic Scoring System for Prognosis of Patients With Alcoholic Hepatitis

(2014) José Altamirano et al.   GASTROENTEROLOGY

XIAP variants in male Crohn's disease

(2014) Yvonne Zeissig et al.   GUT

Massively Parallel Single-Cell RNA-Seq for Marker-Free Decomposition of Tissues into Cell Types

(2014) D. A. Jaitin et al.   SCIENCE

Inhibitors of apoptosis (IAPs) regulate intestinal immunity and inflammatory bowel disease (IBD) inflammation

(2014) Jannie Pedersen et al.   TRENDS IN MOLECULAR MEDICINE

Triggering necroptosis in cisplatin and IAP antagonist-resistant ovarian carcinoma

(2014) K E McCabe et al.   Cell Death & Disease

X-linked inhibitor of apoptosis (XIAP) deficiency: The spectrum of presenting manifestations beyond hemophagocytic lymphohistiocytosis

(2013) C. Speckmann et al.   CLINICAL IMMUNOLOGY

Mouse model of chronic and binge ethanol feeding (the NIAAA model)

(2013) Adeline Bertola et al.   Nature Protocols

Rodent models of alcoholic liver disease: Of mice and men

(2012) Elizabeth Brandon-Warner et al.   ALCOHOL

Phase I Trial of AEG35156 an Antisense Oligonucleotide to XIAP Plus Gemcitabine in Patients With Metastatic Pancreatic Ductal Adenocarcinoma

(2012) Daruka Mahadevan et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins

(2012) H. H. J. Gerets et al.   CELL BIOLOGY AND TOXICOLOGY

XIAP Monoubiquitylates Groucho/TLE to Promote Canonical Wnt Signaling

(2012) Alison J. Hanson et al.   MOLECULAR CELL

Human X-linked variable immunodeficiency caused by a hypomorphic mutation in XIAP in association with a rare polymorphism in CD40LG

(2011) S. Rigaud et al.   BLOOD

Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets

(2011) Bin Gao et al.   GASTROENTEROLOGY

XIAP antisense oligonucleotide (AEG35156) achieves target knockdown and induces apoptosis preferentially in CD34+38− cells in a phase 1/2 study of patients with relapsed/refractory AML

(2010) Bing Z. Carter et al.   APOPTOSIS

XIAP deficiency: a unique primary immunodeficiency best classified as X-linked familial hemophagocytic lymphohistiocytosis and not as X-linked lymphoproliferative disease

(2010) R. A. Marsh et al.   BLOOD

Making a definitive diagnosis: Successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease

(2010) Elizabeth A Worthey et al.   GENETICS IN MEDICINE

Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-β signaling in hepatic stellate cells

(2010) Sheng Cao et al.   JOURNAL OF CLINICAL INVESTIGATION

XIAP as a ubiquitin ligase in cellular signaling

(2009) S Galbán et al.   CELL DEATH AND DIFFERENTIATION

Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: Role of CYP2E1 and TNF-α and activation of JNK and P38 MAP kinase

(2009) Xiaodong Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

A novel XIAP mutation in a Japanese boy with recurrent pancytopenia and splenomegaly

(2009) M. Zhao et al.   HAEMATOLOGICA

Phase I Trial of AEG35156 Administered as a 7-Day and 3-Day Continuous Intravenous Infusion in Patients With Advanced Refractory Cancer

(2009) Emma Dean et al.   JOURNAL OF CLINICAL ONCOLOGY

XIAP discriminates between type I and type II FAS-induced apoptosis

(2009) Philipp J. Jost et al.   NATURE

IAP-targeted therapies for cancer

(2008) E C LaCasse et al.   ONCOGENE