Caspase-2 cleavage of tau reversibly impairs memory

Pathological Tau Disrupts Ongoing Network Activity

(2015) Noa Menkes-Caspi et al.   NEURON

A nonapoptotic role for CASP2/caspase 2

(2014) Meenakshi Tiwari et al.   Autophagy

Effect size of memory deficits in mice with adult-onset P301L tau expression

(2014) Holly C. Hunsberger et al.   BEHAVIOURAL BRAIN RESEARCH

Old, new and emerging functions of caspases

(2014) S Shalini et al.   CELL DEATH AND DIFFERENTIATION

Tau phosphorylation and tau mislocalization mediate soluble Aβ oligomer-induced AMPA glutamate receptor signaling deficits

(2014) Eric C. Miller et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neuronal activity regulates extracellular tau in vivo

(2014) Kaoru Yamada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A plasmonic chip for biomarker discovery and diagnosis of type 1 diabetes

(2014) Bo Zhang et al.   NATURE MEDICINE

Caspase-2 protects against oxidative stress in vivo

(2014) S Shalini et al.   ONCOGENE

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Noncanonical EF-hand motif strategically delays Ca2+ buffering to enhance cardiac performance

(2013) Wang Wang et al.   NATURE MEDICINE

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

(2013) Neil D. Rawlings et al.   NUCLEIC ACIDS RESEARCH

Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice

(2013) Julio Pozueta et al.   Nature Communications

Synaptic alterations in the rTg4510 mouse model of tauopathy

(2012) Katherine J. Kopeikina et al.   JOURNAL OF COMPARATIVE NEUROLOGY

IRE1  Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2

(2012) J.-P. Upton et al.   SCIENCE

Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease

(2011) Jeffrey B Carroll et al.   Molecular Neurodegeneration

Proteolytic processing of tau

(2010) Yipeng Wang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

A Caspase Cleaved Form of Tau Is Preferentially Degraded through the Autophagy Pathway

(2010) Philip J. Dolan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A  Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

(2010) H. Zempel et al.   JOURNAL OF NEUROSCIENCE

Caspase activation precedes and leads to tangles

(2010) Alix de Calignon et al.   NATURE

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs

(2009) A.B. Rocher et al.   EXPERIMENTAL NEUROLOGY

Tau pathophysiology in neurodegeneration: a tangled issue

(2009) Tara L. Spires-Jones et al.   TRENDS IN NEUROSCIENCES

Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

(2008) R. Dixit et al.   SCIENCE