The role of caspases as executioners of apoptosis

The p53-caspase-2 axis in the cell cycle and DNA damage response

(2021) Yoon Lim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Caspase-14—From Biomolecular Basics to Clinical Approach. A Review of Available Data

(2021) Agnieszka Markiewicz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity

(2021) Junwei Hou et al.   MOLECULAR CELL

Dying cells fan the flames of inflammation

(2021) Kim Newton et al.   SCIENCE

Caspases in Cell Death, Inflammation, and Gasdermin-Induced Pyroptosis

(2020) Sannula Kesavardhana et al.   Annual Review of Immunology

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis

(2020) Kun Wang et al.   CELL

FLIP(L): the pseudo‐caspase

(2020) Peter Smyth et al.   FEBS Journal

Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

(2020) Min Zheng et al.   CELL

FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells

(2020) Robin Schwarzer et al.   IMMUNITY

A Switch in p53 Dynamics Marks Cells That Escape from DSB-Induced Cell Cycle Arrest

(2020) Michael Tsabar et al.   Cell Reports

The nuclear envelope: target and mediator of the apoptotic process

(2020) Liora Lindenboim et al.   Cell Death Discovery

Phosphorylation by Aurora B kinase regulates caspase-2 activity and function

(2020) Yoon Lim et al.   CELL DEATH AND DIFFERENTIATION

Integration of innate immune signaling by caspase-8 cleavage of N4BP1

(2020) Alexander D. Gitlin et al.   NATURE

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

(2020) Junwei Hou et al.   NATURE CELL BIOLOGY

Non-apoptotic roles of apoptotic proteases: new tricks for an old dog

(2020) Tin Tin Su   Open Biology

A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma

(2019) Mengjiao Wu et al.   EBioMedicine

Caspases in Cell Death, Inflammation, and Disease

(2019) Nina Van Opdenbosch et al.   IMMUNITY

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis

(2019) Kim Newton et al.   NATURE

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

(2019) Melanie Fritsch et al.   NATURE

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

(2019) Najoua Lalaoui et al.   NATURE

A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1

(2019) Panfeng Tao et al.   NATURE

GSDME mediates caspase-3-dependent pyroptosis in gastric cancer

(2018) Yubin Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

New insights into apoptosome structure and function

(2018) Loretta Dorstyn et al.   CELL DEATH AND DIFFERENTIATION

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Targeting BCL-2 regulated apoptosis in cancer

(2018) Kirsteen J. Campbell et al.   Open Biology

p53 accumulation following cytokinesis failure in the absence of caspase-2

(2018) Yoon Lim et al.   CELL DEATH AND DIFFERENTIATION

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis 

(2018) Bo Zhou et al.   CELL RESEARCH

The TNF Family of Ligands and Receptors: Communication Modules in the Immune System and Beyond

(2018) Catherine Dostert et al.   PHYSIOLOGICAL REVIEWS

The PIDDosome activates p53 in response to supernumerary centrosomes

(2017) Luca L. Fava et al.   GENES & DEVELOPMENT

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme

(2017) Yini Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein

(2017) Kinlin L. Chao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Post-translational Modification of Caspases: The Other Side of Apoptosis Regulation

(2017) Alexey V. Zamaraev et al.   TRENDS IN CELL BIOLOGY

Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate

(2016) Michelle A. Hughes et al.   MOLECULAR CELL

Caspase-2-mediated cell death is required for deleting aneuploid cells

(2016) S Dawar et al.   ONCOGENE

A near atomic structure of the active human apoptosome

(2016) Tat Cheung Cheng et al.   eLife

Structure of the apoptosome: mechanistic insights into activation of an initiator caspase fromDrosophila

(2015) Yuxuan Pang et al.   GENES & DEVELOPMENT

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Live to die another way: modes of programmed cell death and the signals emanating from dying cells

(2015) Yaron Fuchs et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

IAP gene deletion and conditional knockout models

(2015) John Silke et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Old, new and emerging functions of caspases

(2014) S Shalini et al.   CELL DEATH AND DIFFERENTIATION

Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure

(2014) K. Segawa et al.   SCIENCE

New roles for old enzymes: killer caspases as the engine of cell behavior changes

(2014) Patrick F. Connolly et al.   Frontiers in Physiology

Apoptosome and inflammasome: conserved machineries for caspase activation

(2014) Jijie Chai et al.   National Science Review

Developmentally programmed cell death in Drosophila

(2013) Donna Denton et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Caspase-2 as a tumour suppressor

(2013) J Puccini et al.   CELL DEATH AND DIFFERENTIATION

Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice

(2013) J. Puccini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase Substrates and Inhibitors

(2013) M. Poreba et al.   Cold Spring Harbor Perspectives in Biology

Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice

(2012) S Shalini et al.   CELL DEATH AND DIFFERENTIATION

IAPs limit activation of RIP kinases by TNF receptor 1 during development

(2012) Maryline Moulin et al.   EMBO JOURNAL

Apoptotic and Nonapoptotic Caspase Functions in Animal Development

(2012) M. Miura   Cold Spring Harbor Perspectives in Biology

Structural and Enzymatic Insights into Caspase-2 Protein Substrate Recognition and Catalysis

(2011) Yinyan Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop

(2011) Trudy G. Oliver et al.   MOLECULAR CELL

Structure of the Drosophila Apoptosome at 6.9 Å Resolution

(2011) Shujun Yuan et al.   STRUCTURE

Evaluation of recombinant caspase specificity by competitive substrates

(2009) Bistra Benkova et al.   ANALYTICAL BIOCHEMISTRY

Human Caspases: Activation, Specificity, and Regulation

(2009) Cristina Pop et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-2 activation in the absence of PIDDosome formation

(2009) Claudia Manzl et al.   JOURNAL OF CELL BIOLOGY

Death receptor signal transducers: nodes of coordination in immune signaling networks

(2009) Nicholas S Wilson et al.   NATURE IMMUNOLOGY

A tumor suppressor function for caspase-2

(2009) L. H. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of apoptosis in Drosophila

(2008) H Steller   CELL DEATH AND DIFFERENTIATION