The Neutrophil’s Role During Health and Disease

The enigmatic neutrophil: what we do not know

(2018) Paul Kubes   CELL AND TISSUE RESEARCH

Neutrophil Extracellular Traps: The Biology of Chromatin Externalization

(2018) Gabriel Sollberger et al.   DEVELOPMENTAL CELL

Neutrophils recruited through high endothelial venules of the lymph nodes via PNAd intercept disseminatingStaphylococcus aureus

(2018) Ania Bogoslowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophils instruct homeostatic and pathological states in naive tissues

(2018) Maria Casanova-Acebes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

iNKT Cells Orchestrate a Switch from Inflammation to Resolution of Sterile Liver Injury

(2017) Pei Xiong Liew et al.   IMMUNITY

Splenic Ly6G high mature and Ly6G int immature neutrophils contribute to eradication of S. pneumoniae

(2017) Justin F. Deniset et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil myeloperoxidase diminishes the toxic effects and mortality induced by lipopolysaccharide

(2017) Laurent L. Reber et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors

(2017) Emma Lefrançais et al.   NATURE

Visualizing the function and fate of neutrophils in sterile injury and repair

(2017) Jing Wang et al.   SCIENCE

Transition from inflammation to proliferation: a critical step during wound healing

(2016) Ning Xu Landén et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Innate Immune Cell Trafficking and Function During Sterile Inflammation of the Liver

(2016) Braedon McDonald et al.   GASTROENTEROLOGY

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

PKM2 released by neutrophils at wound site facilitates early wound healing by promoting angiogenesis

(2016) Yinwei Zhang et al.   WOUND REPAIR AND REGENERATION

Neutrophil-Mediated Regulation of Innate and Adaptive Immunity: The Role of Myeloperoxidase

(2016) Dragana Odobasic et al.   Journal of Immunology Research

Role of Inhaled Nitric Oxide in the Management of Severe Acute Respiratory Distress Syndrome

(2016) Juliette Lucinda Hunt et al.   Frontiers in Pediatrics

Phagocytosis of apoptotic cells in homeostasis

(2015) Sanja Arandjelovic et al.   NATURE IMMUNOLOGY

Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature

(2015) Elzbieta Kolaczkowska et al.   Nature Communications

Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury

(2015) Philipp Kruger et al.   PLoS Pathogens

Timing and causes of death in septic shock

(2015) Fabrice Daviaud et al.   Annals of Intensive Care

Leukocyte recruitment in inflammation: basic concepts and new mechanistic insights based on new models and microscopic imaging technologies

(2014) Marion Leick et al.   CELL AND TISSUE RESEARCH

Molecular determinants of sterile inflammation

(2014) Hajime Kono et al.   CURRENT OPINION IN IMMUNOLOGY

The yin-yang of long pentraxin PTX3 in inflammation and immunity

(2014) Kenji Daigo et al.   IMMUNOLOGY LETTERS

Hemopoietic Cell Expression of the Chemokine Decoy Receptor D6 Is Dynamic and Regulated by GATA1

(2014) C. S. McKimmie et al.   JOURNAL OF IMMUNOLOGY

The Physiology of Leukocyte Recruitment: An In Vivo Perspective

(2014) B. Petri et al.   JOURNAL OF IMMUNOLOGY

Quantifying oral inflammatory load: oral neutrophil counts in periodontal health and disease

(2014) M. Landzberg et al.   JOURNAL OF PERIODONTAL RESEARCH

Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens

(2014) Nora Branzk et al.   NATURE IMMUNOLOGY

Neutrophils scan for activated platelets to initiate inflammation

(2014) Vinatha Sreeramkumar et al.   SCIENCE

Pulmonary retention of primed neutrophils: a novel protective host response, which is impaired in the acute respiratory distress syndrome

(2014) Charlotte Summers et al.   THORAX

Granule Protein Processing and Regulated Secretion in Neutrophils

(2014) Avinash Sheshachalam et al.   Frontiers in Immunology

The mercurial nature of neutrophils: still an enigma in ARDS?

(2013) Andrew E. Williams et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Multifaceted Functions of Neutrophils

(2013) Tanya N. Mayadas et al.   Annual Review of Pathology-Mechanisms of Disease

Neutrophils Recruited to Sites of Infection Protect from Virus Challenge by Releasing Neutrophil Extracellular Traps

(2013) Craig N. Jenne et al.   Cell Host & Microbe

Two Decades of Mortality Trends Among Patients With Severe Sepsis

(2013) Elizabeth K. Stevenson et al.   CRITICAL CARE MEDICINE

Therapeutic advantage of anti-VAP-1 over anti-α4 integrin antibody in concanavalin a-induced hepatitis

(2013) Woo-Yong Lee et al.   HEPATOLOGY

Imaging inflammatory leukocyte recruitment in kidney, lung and liver-challenges to the multi-step paradigm

(2013) Michael J Hickey et al.   IMMUNOLOGY AND CELL BIOLOGY

Neutrophil cell surface receptors and their intracellular signal transduction pathways

(2013) Krisztina Futosi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Nuclear Envelope Composition Determines the Ability of Neutrophil-type Cells to Passage through Micron-scale Constrictions

(2013) Amy C. Rowat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophil Transmigration: Emergence of an Adhesive Cascade within Venular Walls

(2013) Mathieu-Benoit Voisin et al.   Journal of Innate Immunity

Severe Sepsis and Septic Shock

(2013) Derek C. Angus et al.   NEW ENGLAND JOURNAL OF MEDICINE

Getting Leukocytes to the Site of Inflammation

(2013) W. A. Muller   VETERINARY PATHOLOGY

Animal models of sepsis

(2013) Mitchell P Fink   Virulence

Leukocyte adhesion deficiencies

(2012) Suhair Hanna et al.   Annals of the New York Academy of Sciences

Neutrophil Function: From Mechanisms to Disease

(2012) Borko Amulic et al.   Annual Review of Immunology

Leukocyte Rolling on P-Selectin: A Three-Dimensional Numerical Study of the Effect of Cytoplasmic Viscosity

(2012) Damir B. Khismatullin et al.   BIOPHYSICAL JOURNAL

VEGF-A recruits a proangiogenic MMP-9-delivering neutrophil subset that induces angiogenesis in transplanted hypoxic tissue

(2012) G. Christoffersson et al.   BLOOD

Intravascular Neutrophil Extracellular Traps Capture Bacteria from the Bloodstream during Sepsis

(2012) Braedon McDonald et al.   Cell Host & Microbe

Lessons from rare maladies

(2012) Estelle S. Harris et al.   CURRENT OPINION IN HEMATOLOGY

Neutrophil-active chemokines in in vivo imaging of neutrophil trafficking

(2012) Maria-Jesus Sanz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Neutrophils Transport Antigen from the Dermis to the Bone Marrow, Initiating a Source of Memory CD8+ T Cells

(2012) Darragh Duffy et al.   IMMUNITY

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4

(2012) Milena Schiraldi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CRTH2 Is A Critical Regulator of Neutrophil Migration and Resistance to Polymicrobial Sepsis

(2012) M. Ishii et al.   JOURNAL OF IMMUNOLOGY

Acquisition of Antigen-Presenting Functions by Neutrophils Isolated from Mice with Chronic Colitis

(2012) D. V. Ostanin et al.   JOURNAL OF IMMUNOLOGY

The Mammalian Actin-Binding Protein 1 Is Critical for Spreading and Intraluminal Crawling of Neutrophils under Flow Conditions

(2012) I. Hepper et al.   JOURNAL OF IMMUNOLOGY

T Lymphocyte Priming by Neutrophil Extracellular Traps Links Innate and Adaptive Immune Responses

(2012) K. Tillack et al.   JOURNAL OF IMMUNOLOGY

Human suppressive neutrophils CD16bright /CD62Ldim exhibit decreased adhesion

(2012) Vera M. Kamp et al.   JOURNAL OF LEUKOCYTE BIOLOGY

‘Slings’ enable neutrophil rolling at high shear

(2012) Prithu Sundd et al.   NATURE

Neutrophil infiltration during inflammation is regulated by PILRα via modulation of integrin activation

(2012) Jing Wang et al.   NATURE IMMUNOLOGY

Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases

(2012) Xiaowen Liu et al.   NATURE IMMUNOLOGY

The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss

(2012) Mehmet A Eskan et al.   NATURE IMMUNOLOGY

Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

(2012) Bryan G Yipp et al.   NATURE MEDICINE

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

(2012) Mona Saffarzadeh et al.   PLoS One

IL-17RA Signaling Reduces Inflammation and Mortality during Trypanosoma cruzi Infection by Recruiting Suppressive IL-10-Producing Neutrophils

(2012) Jimena Tosello Boari et al.   PLoS Pathogens

IL-1 family cytokines trigger sterile inflammatory disease

(2012) John R. Lukens et al.   Frontiers in Immunology

Regulation of Integrin Activation

(2011) Chungho Kim et al.   Annual Review of Cell and Developmental Biology

Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow

(2011) A. Zarbock et al.   BLOOD

Deuterium and neutrophil kinetics

(2011) K. W. Li et al.   BLOOD

Doubts concerning the recently reported human neutrophil lifespan of 5.4 days

(2011) P. S. Tofts et al.   BLOOD

Neutrophil survival and c-kit+-progenitor proliferation in Staphylococcus aureus-infected skin wounds promote resolution

(2011) M.-H. Kim et al.   BLOOD

Hospitalizations, costs, and outcomes of severe sepsis in the United States 2003 to 2007

(2011) Tara Lagu et al.   CRITICAL CARE MEDICINE

The Molecular Mechanisms of Glucocorticoids-Mediated Neutrophil Survival

(2011) Arash S. Saffar et al.   CURRENT DRUG TARGETS

Clinical and Genetic Features of Warts, Hypogammaglobulinemia, Infections and Myelokathexis (WHIM) Syndrome

(2011) L. Dotta et al.   CURRENT MOLECULAR MEDICINE

Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability

(2011) Dörte Schulte et al.   EMBO JOURNAL

Neuronal guidance molecule netrin-1 attenuates inflammatory cell trafficking during acute experimental colitis

(2011) Carol M Aherne et al.   GUT

Mouse neutrophils are professional antigen-presenting cells programmed to instruct Th1 and Th17 T-cell differentiation

(2011) D. S. Abi Abdallah et al.   INTERNATIONAL IMMUNOLOGY

Coordinate regulation of neutrophil homeostasis by liver X receptors in mice

(2011) Cynthia Hong et al.   JOURNAL OF CLINICAL INVESTIGATION

A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1

(2011) Janesh Pillay et al.   JOURNAL OF CLINICAL INVESTIGATION

Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils

(2011) Stephen J Galli et al.   NATURE IMMUNOLOGY

The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo

(2011) Abigail Woodfin et al.   NATURE IMMUNOLOGY

B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen

(2011) Irene Puga et al.   NATURE IMMUNOLOGY

GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice

(2011) Tibor Kempf et al.   NATURE MEDICINE

The neutrophil in vascular inflammation

(2011) Mia Phillipson et al.   NATURE MEDICINE

Neutrophils and Intravascular Immunity in the Liver during Infection and Sterile Inflammation

(2011) Braedon McDonald et al.   TOXICOLOGIC PATHOLOGY

Neutrophils cascading their way to inflammation

(2011) Christian D. Sadik et al.   TRENDS IN IMMUNOLOGY

Emerging mechanisms of neutrophil recruitment across endothelium

(2011) Marcie R. Williams et al.   TRENDS IN IMMUNOLOGY

Novel Lipid Mediators and Resolution Mechanisms in Acute Inflammation

(2010) Charles N. Serhan   AMERICAN JOURNAL OF PATHOLOGY

Management of sepsis in neutropenic patients: guidelines from the infectious diseases working party of the German Society of Hematology and Oncology

(2010) O. Penack et al.   ANNALS OF ONCOLOGY

NOX2 Complex–Derived ROS as Immune Regulators

(2010) Outi Sareila et al.   ANTIOXIDANTS & REDOX SIGNALING

Endothelial LSP1 is involved in endothelial dome formation, minimizing vascular permeability changes during neutrophil transmigration in vivo

(2010) B. Petri et al.   BLOOD

CCR7 is involved in the migration of neutrophils to lymph nodes

(2010) C. Beauvillain et al.   BLOOD

A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils

(2010) S. Massena et al.   BLOOD

In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days

(2010) J. Pillay et al.   BLOOD

Understanding the molecular mechanisms of the multifaceted IL-10-mediated anti-inflammatory response: Lessons from neutrophils

(2010) Flavia Bazzoni et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Neutrophils, from Marrow to Microbes

(2010) Niels Borregaard   IMMUNITY

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention

(2010) Michael J. Davies   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Proinflammatory Clearance of Apoptotic Neutrophils Induces an IL-12lowIL-10high Regulatory Phenotype in Macrophages

(2010) A. A. Filardy et al.   JOURNAL OF IMMUNOLOGY

A Novel Mechanism of Rapid Nuclear Neutrophil Extracellular Trap Formation in Response to Staphylococcus aureus

(2010) F. H. Pilsczek et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Apoptosis: Relevance to the Innate Immune Response and Inflammatory Disease

(2010) Sarah Fox et al.   Journal of Innate Immunity

Functional heterogeneity and differential priming of circulating neutrophils in human experimental endotoxemia

(2010) Janesh Pillay et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Chemokine-cleaving Streptococcus pyogenes protease SpyCEP is necessary and sufficient for bacterial dissemination within soft tissues and the respiratory tract

(2010) Prathiba Kurupati et al.   MOLECULAR MICROBIOLOGY

Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A

(2010) Carmela De Santo et al.   NATURE IMMUNOLOGY

Regulation of leukocyte recruitment by the long pentraxin PTX3

(2010) Livija Deban et al.   NATURE IMMUNOLOGY

An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells

(2010) Woo-Yong Lee et al.   NATURE IMMUNOLOGY

Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection

(2010) Jose C Alves-Filho et al.   NATURE MEDICINE

Stabilized imaging of immune surveillance in the mouse lung

(2010) Mark R Looney et al.   NATURE METHODS

Quantitative dynamic footprinting microscopy reveals mechanisms of neutrophil rolling

(2010) Prithu Sundd et al.   NATURE METHODS

The final steps of integrin activation: the end game

(2010) Sanford J. Shattil et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo two-photon imaging reveals monocyte-dependent neutrophil extravasation during pulmonary inflammation

(2010) D. Kreisel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

(2010) B. McDonald et al.   SCIENCE

Neutrophil kinetics in health and disease

(2010) Charlotte Summers et al.   TRENDS IN IMMUNOLOGY

Neutrophils: game changers in glomerulonephritis?

(2010) Tanya N. Mayadas et al.   TRENDS IN MOLECULAR MEDICINE

Role of nitric oxide in management of acute respiratory distress syndrome

(2009) AH Akmal et al.   Annals of Thoracic Medicine

The Ins and Outs of Leukocyte Integrin Signaling

(2009) Clare L. Abram et al.   Annual Review of Immunology

Junctional Adhesion Molecule-C Mediates Leukocyte Infiltration in Response to Ischemia Reperfusion Injury

(2009) Christoph Scheiermann et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1

(2009) A. Woodfin et al.   BLOOD

CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions

(2009) Kyle J. Eash et al.   BLOOD

Exploiting the Annexin A1 pathway for the development of novel anti-inflammatory therapeutics

(2009) Mauro Perretti et al.   BRITISH JOURNAL OF PHARMACOLOGY

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps

(2009) S Yousefi et al.   CELL DEATH AND DIFFERENTIATION

Effects of sepsis on neutrophil chemotaxis

(2009) Raju C Reddy et al.   CURRENT OPINION IN HEMATOLOGY

Coactivation of Syk Kinase and MyD88 Adaptor Protein Pathways by Bacteria Promotes Regulatory Properties of Neutrophils

(2009) Xiaoming Zhang et al.   IMMUNITY

Transcellular migration of leukocytes is mediated by the endothelial lateral border recycling compartment

(2009) Zahra Mamdouh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Vav1 Is Essential for Mechanotactic Crawling and Migration of Neutrophils out of the Inflamed Microvasculature

(2009) M. Phillipson et al.   JOURNAL OF IMMUNOLOGY

Selective Down-Regulation of Neutrophil Mac-1 in Endotoxemic Hepatic Microcirculation via IL-10

(2009) G. B. Menezes et al.   JOURNAL OF IMMUNOLOGY

Hypoxia-inducible factor–dependent induction of netrin-1 dampens inflammation caused by hypoxia

(2009) Peter Rosenberger et al.   NATURE IMMUNOLOGY

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis

(2009) J. C. Alves-Filho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans

(2009) Constantin F. Urban et al.   PLoS Pathogens

Sepsis-induced inhibition of neutrophil chemotaxis is mediated by activation of peroxisome proliferator-activated receptor- 

(2008) R. C. Reddy et al.   BLOOD

The phagocytes: neutrophils and monocytes

(2008) D. C. Dale et al.   BLOOD

Clinical implications ofELA2-,HAX1-, and G-CSF-receptor (CSF3R) mutations in severe congenital neutropenia

(2008) Cornelia Zeidler et al.   BRITISH JOURNAL OF HAEMATOLOGY

Pattern recognition receptors in the immune response against dying cells

(2008) Pascale Jeannin et al.   CURRENT OPINION IN IMMUNOLOGY

VEGF release by MMP-9 mediated heparan sulphate cleavage induces colorectal cancer angiogenesis

(2008) Lukas J.A.C. Hawinkels et al.   EUROPEAN JOURNAL OF CANCER

The role of the bone marrow in neutrophil clearance under homeostatic conditions in the mouse

(2008) Rebecca C. Furze et al.   FASEB JOURNAL

Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids

(2008) Braedon McDonald et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity

(2008) Monika Pruenster et al.   NATURE IMMUNOLOGY

PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils

(2008) Bryan Heit et al.   NATURE IMMUNOLOGY

Endothelial Domes Encapsulate Adherent Neutrophils and Minimize Increases in Vascular Permeability in Paracellular and Transcellular Emigration

(2008) Mia Phillipson et al.   PLoS One

Modelling pulmonary blood flow

(2008) Merryn H. Tawhai et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Del-1, an Endogenous Leukocyte-Endothelial Adhesion Inhibitor, Limits Inflammatory Cell Recruitment

(2008) E. Y. Choi et al.   SCIENCE

THE ROLE OF NEUTROPHILS IN SEVERE SEPSIS

(2008) José C. Alves-Filho et al.   SHOCK

Regulation of B-cell-activating factor (BAFF)/B lymphocyte stimulator (BLyS) expression in human neutrophils

(2007) Patrizia Scapini et al.   IMMUNOLOGY LETTERS