Environmental Microbial Factors Determine the Pattern of Inflammatory Lesions in a Murine Model of Crohn’s Disease–Like Inflammation

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Intestinal epithelial Caspase-8 signaling is essential to prevent necroptosis during Salmonella Typhimurium induced enteritis

(2018) Manuela Hefele et al.   Mucosal Immunology

Bacterial Signaling at the Intestinal Epithelial Interface in Inflammation and Cancer

(2018) Olivia I. Coleman et al.   Frontiers in Immunology

IKKα controls ATG16L1 degradation to prevent ER stress during inflammation

(2017) Michaela A. Diamanti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Distinct Microbial Communities Trigger Colitis Development upon Intestinal Barrier Damage via Innate or Adaptive Immune Cells

(2017) Urmi Roy et al.   Cell Reports

Proteobacteria: A Common Factor in Human Diseases

(2017) G. Rizzatti et al.   Biomed Research International

NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions

(2016) Katerina Vlantis et al.   IMMUNITY

Analysis of factors contributing to variation in the C57BL/6J fecal microbiota across German animal facilities

(2016) Philipp Rausch et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis

(2016) Claudia Günther et al.   JOURNAL OF CLINICAL INVESTIGATION

Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study

(2016) Isabelle Cleynen et al.   LANCET

Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence

(2015) Monika Schaubeck et al.   GUT

The Intestinal Microbiota in Inflammatory Bowel Disease

(2015) Christoph Becker et al.   ILAR JOURNAL

Induction of Th17 cells by segmented filamentous bacteria in the murine intestine

(2015) Adam M. Farkas et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Spatial and temporal colonization dynamics of segmented filamentous bacteria is influenced by gender, age and experimental infection with Helicobacter hepaticus in Swiss Webster mice

(2015) Zhongming Ge et al.   MICROBES AND INFECTION

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Proteobacteria: microbial signature of dysbiosis in gut microbiota

(2015) Na-Ri Shin et al.   TRENDS IN BIOTECHNOLOGY

Mechanisms of Microbe–Host Interaction in Crohn’s Disease: Dysbiosis vs. Pathobiont Selection

(2015) Ludovica F. Buttó et al.   Frontiers in Immunology

Activation of Intestinal Epithelial Stat3 Orchestrates Tissue Defense during Gastrointestinal Infection

(2015) Nadine Wittkopf et al.   PLoS One

Caspase-8 controls the gut response to microbial challenges by Tnf-α-dependent and independent pathways

(2014) Claudia Günther et al.   GUT

Pleiotropic functions of TNF-  in the regulation of the intestinal epithelial response to inflammation

(2014) M. Leppkes et al.   INTERNATIONAL IMMUNOLOGY

Regulation and pathophysiological role of epithelial turnover in the gut

(2014) Claudia Günther et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Necroptosis Is Active in Children With Inflammatory Bowel Disease and Contributes to Heighten Intestinal Inflammation

(2013) Maria Pierdomenico et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Cellular FLICE-Like Inhibitory Protein Secures Intestinal Epithelial Cell Survival and Immune Homeostasis by Regulating Caspase-8

(2013) Nadine Wittkopf et al.   GASTROENTEROLOGY

Recent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammation

(2013) M Zaeem Cader et al.   GUT

The Mucin Muc2 Limits Pathogen Burdens and Epithelial Barrier Dysfunction during Salmonella enterica Serovar Typhimurium Colitis

(2013) Maryam Zarepour et al.   INFECTION AND IMMUNITY

Paneth cells as a site of origin for intestinal inflammation

(2013) Timon E. Adolph et al.   NATURE

Dysbiosis—A consequence of Paneth cell dysfunction

(2013) Nita H. Salzman et al.   SEMINARS IN IMMUNOLOGY

TNF-α-induced intestinal epithelial cell shedding: implications for intestinal barrier function

(2012) Alastair J.M. Watson et al.   Annals of the New York Academy of Sciences

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Apoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium

(2012) Claudia Günther et al.   GUT

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

Activation of epithelial STAT3 regulates intestinal homeostasis

(2011) Clemens Neufert et al.   CELL CYCLE

The Epithelial Barrier Is Maintained by In Vivo Tight Junction Expansion During Pathologic Intestinal Epithelial Shedding

(2011) Amanda M. Marchiando et al.   GASTROENTEROLOGY

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

(2011) Patrick-Simon Welz et al.   NATURE

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

(2011) William J. Kaiser et al.   NATURE

Functional complementation between FADD and RIP1 in embryos and lymphocytes

(2011) Haibing Zhang et al.   NATURE

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

Assessment of Tumor Development and Wound Healing Using Endoscopic Techniques in Mice

(2010) Markus F. Neurath et al.   GASTROENTEROLOGY

Paneth's disease

(2010) Jan Wehkamp et al.   Journal of Crohns & Colitis

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

Paneth cells and inflammation dance together in Crohn's disease

(2008) Arthur Kaser et al.   CELL RESEARCH

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS