E-type prostanoid receptor 4 drives resolution of intestinal inflammation by blocking epithelial necroptosis

A toolbox for imaging RIPK1, RIPK3, and MLKL in mouse and human cells

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SMAC mimetics and RIPK inhibitors as therapeutics for chronic inflammatory diseases

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WikiPathways: connecting communities

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Hobit- and Blimp-1-driven CD4+ tissue-resident memory T cells control chronic intestinal inflammation

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MLKL deficiency inhibits DSS-induced colitis independent of intestinal microbiota

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TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging

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Resolution of chronic inflammatory disease: universal and tissue-specific concepts

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PGE2 production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo

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COX-2–PGE2 Signaling Impairs Intestinal Epithelial Regeneration and Associates with TNF Inhibitor Responsiveness in Ulcerative Colitis

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Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency

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Inhibiting Interleukin 36 Receptor Signaling Reduces Fibrosis in Mice with Chronic Intestinal Inflammation

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Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface

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Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

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Soluble TNF-like weak inducer of apoptosis (TWEAK) enhances poly(I:C)-induced RIPK1-mediated necroptosis

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Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response

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NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8

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MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis

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Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis

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The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis

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PGE2 induced in and released by dying cells functions as an inhibitory DAMP

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Prostaglandin E2 constrains systemic inflammation through an innate lymphoid cell-IL-22 axis

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TAK1 regulates Paneth cell integrity partly through blocking necroptosis

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Blocking TWEAK-Fn14 interaction inhibits hematopoietic stem cell transplantation-induced intestinal cell death and reduces GVHD

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KAG-308, a newly-identified EP4-selective agonist shows efficacy for treating ulcerative colitis and can bring about lower risk of colorectal carcinogenesis by oral administration

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Strong Upregulation of AIM2 and IFI16 Inflammasomes in the Mucosa of Patients with Active Inflammatory Bowel Disease

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PhosphoPath: Visualization of Phosphosite-centric Dynamics in Temporal Molecular Networks

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Notch3 Pathway Alterations in Ovarian Cancer

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MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

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Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

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PTGER4 Expression-Modulating Polymorphisms in the 5p13.1 Region Predispose to Crohn's Disease and Affect NF-κB and XBP1 Binding Sites

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Inhibition of Proliferation and Induction of Apoptosis in Multiple Myeloma Cell Lines by CD137 Ligand Signaling

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Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

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Mucosal gene signatures to predict response to infliximab in patients with ulcerative colitis

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Effect of EP4 agonist (ONO-4819CD) for patients with mild to moderate ulcerative colitis refractory to 5-aminosalicylates: A randomized phase II, placebo-controlled trial

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