The TNFR1 Antagonist Atrosimab Is Therapeutic in Mouse Models of Acute and Chronic Inflammation

Evidence for tmTNF reverse signaling in vivo: Implications for an arginase-1-mediated therapeutic effect of TNF inhibitors during inflammation

(2021) Katy Diallo et al.   iScience

TNF-Receptor-1 inhibition reduces liver steatosis, hepatocellular injury and fibrosis in NAFLD mice

(2020) Franziska Wandrer et al.   Cell Death & Disease

Selective Targeting of TNF Receptors as a Novel Therapeutic Approach

(2020) Roman Fischer et al.   Frontiers in Cell and Developmental Biology

Tumor necrosis factor alpha receptor 1 deficiency in hepatocytes does not protect from non-alcoholic steatohepatitis, but attenuates insulin resistance in mice

(2020) Sena Bluemel et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Improved monovalent TNF receptor 1-selective inhibitor with novel heterodimerizing Fc

(2019) Fabian Richter et al.   mAbs

Exogenous activation of tumor necrosis factor receptor 2 promotes recovery from sensory and motor disease in a model of multiple sclerosis

(2019) Roman Fischer et al.   BRAIN BEHAVIOR AND IMMUNITY

Tumor Necrosis Factor (TNF) Receptor Expression Determines Keratinocyte Fate upon Stimulation with TNF-Like Weak Inducer of Apoptosis

(2019) Xuening Wang et al.   MEDIATORS OF INFLAMMATION

The role of lymphotoxin-α in rheumatoid arthritis

(2018) Tomohiro Hirose et al.   INFLAMMATION RESEARCH

Selective Activation of Tumor Necrosis Factor Receptor II Induces Antiinflammatory Responses and Alleviates Experimental Arthritis

(2018) Roman Fischer et al.   Arthritis & Rheumatology

Monovalent TNF receptor 1-selective antibody with improved affinity and neutralizing activity

(2018) Fabian Richter et al.   mAbs

Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis

(2018) Sarah K. Williams et al.   Scientific Reports

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

Transmembrane TNF-alpha reverse signaling leading to TGF-beta production is selectively activated by TNF targeting molecules: Therapeutic implications

(2017) Zsuzsa Szondy et al.   PHARMACOLOGICAL RESEARCH

TNFR1 inhibition with a Nanobody protects against EAE development in mice

(2017) Sophie Steeland et al.   Scientific Reports

Oligodendroglial TNFR2 Mediates Membrane TNF-Dependent Repair in Experimental Autoimmune Encephalomyelitis by Promoting Oligodendrocyte Differentiation and Remyelination

(2016) Pernille M. Madsen et al.   JOURNAL OF NEUROSCIENCE

Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration

(2016) Yun Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic review: predicting and optimising response to anti-TNF therapy in Crohn's disease - algorithm for practical management

(2015) N. S. Ding et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

TNF and its receptors in the CNS: The essential, the desirable and the deleterious effects

(2015) L. Probert   NEUROSCIENCE

Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF

(2015) Roman Fischer et al.   Oxidative Medicine and Cellular Longevity

ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development

(2014) Hayato Nakagawa et al.   CANCER CELL

Anti-TNF therapy: past, present and future

(2014) C. Monaco et al.   INTERNATIONAL IMMUNOLOGY

Generation and Characterization of Small Single Domain Antibodies Inhibiting Human Tumor Necrosis Factor Receptor 1

(2014) Sophie Steeland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antibody-Mediated Inhibition of TNFR1 Attenuates Disease in a Mouse Model of Multiple Sclerosis

(2014) Sarah K. Williams et al.   PLoS One

Efficacy and safety of pateclizumab (anti-lymphotoxin-α) compared to adalimumab in rheumatoid arthritis: a head-to-head phase 2 randomized controlled study (The ALTARA Study)

(2014) William P Kennedy et al.   ARTHRITIS RESEARCH & THERAPY

Astrocyte-specific activation of TNFR2 promotes oligodendrocyte maturation by secretion of leukemia inhibitory factor

(2013) Roman Fischer et al.   GLIA

Antagonistic TNF Receptor One-Specific Antibody (ATROSAB): Receptor Binding and In Vitro Bioactivity

(2013) Fabian Richter et al.   PLoS One

TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis

(2012) Adam P. Gregory et al.   NATURE

Inhibition of soluble tumour necrosis factor is therapeutic in experimental autoimmune encephalomyelitis and promotes axon preservation and remyelination

(2011) Roberta Brambilla et al.   BRAIN

Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-κB

(2011) Era Taoufik et al.   BRAIN

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

(2010) Eek Joong Park et al.   CELL

ATROSAB, a humanized antagonistic anti-tumor necrosis factor receptor one-specific antibody

(2010) Kirstin A. Zettlitz et al.   mAbs

Targeted depletion of lymphotoxin-α–expressing TH1 and TH17 cells inhibits autoimmune disease

(2009) Eugene Y Chiang et al.   NATURE MEDICINE

High levels of Lymphotoxin-Beta (LT-Beta) gene expression in rheumatoid arthritis synovium: clinical and cytokine correlations

(2008) Killian P. O’Rourke et al.   RHEUMATOLOGY INTERNATIONAL

Tumor necrosis factor antagonist mechanisms of action: A comprehensive review

(2007) Daniel Tracey et al.   PHARMACOLOGY & THERAPEUTICS