Caspase-2 impacts lung tumorigenesis and chemotherapy response in vivo

Identification of Distinct Basal and Luminal Subtypes of Muscle-Invasive Bladder Cancer with Different Sensitivities to Frontline Chemotherapy

(2014) Woonyoung Choi et al.   CANCER CELL

Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice

(2013) M J Parsons et al.   CELL DEATH AND DIFFERENTIATION

Caspase-2 as a tumour suppressor

(2013) J Puccini et al.   CELL DEATH AND DIFFERENTIATION

Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice

(2013) J. Puccini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53-Mediated Senescence Impairs the Apoptotic Response to Chemotherapy and Clinical Outcome in Breast Cancer

(2012) James G. Jackson et al.   CANCER CELL

PIDDosome-independent tumor suppression by Caspase-2

(2012) C Manzl et al.   CELL DEATH AND DIFFERENTIATION

Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability

(2012) L Dorstyn et al.   CELL DEATH AND DIFFERENTIATION

Tumor-suppressing Function of Caspase-2 Requires Catalytic Site Cys-320 and Site Ser-139 in Mice

(2012) Keqin Ren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PIDD Death-Domain Phosphorylation by ATM Controls Prodeath versus Prosurvival PIDDosome Signaling

(2012) Kiyohiro Ando et al.   MOLECULAR CELL

Caspase 2 is both required for p53-mediated apoptosis and downregulated by p53 in a p21-dependent manner

(2011) Nicole Baptiste-Okoh et al.   CELL CYCLE

Caspase-2: the orphan caspase

(2011) L Bouchier-Hayes et al.   CELL DEATH AND DIFFERENTIATION

Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop

(2011) Trudy G. Oliver et al.   MOLECULAR CELL

Somatic mutations of caspase-2 gene in gastric and colorectal cancers

(2011) Min Sung Kim et al.   PATHOLOGY RESEARCH AND PRACTICE

Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer

(2010) T. G. Oliver et al.   GENES & DEVELOPMENT

Diverse somatic mutation patterns and pathway alterations in human cancers

(2010) Zhengyan Kan et al.   NATURE

A tumor suppressor function for caspase-2

(2009) L. H. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The enigma of caspase-2: the laymen's view

(2008) G Krumschnabel et al.   CELL DEATH AND DIFFERENTIATION