Caspase‐8 in endothelial cells maintains gut homeostasis and prevents small bowel inflammation in mice

FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure

(2021) Alejandra González-Loyola et al.   Science Advances

Single-Cell Transcriptome Atlas of Murine Endothelial Cells

(2020) Joanna Kalucka et al.   CELL

FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells

(2020) Robin Schwarzer et al.   IMMUNITY

A necroptotic-independent function of MLKL in regulating endothelial cell adhesion molecule expression

(2020) Jialin Dai et al.   Cell Death & Disease

Intestinal Flora and Disease Mutually Shape the Regional Immune System in the Intestinal Tract

(2020) Bolun Zhou et al.   Frontiers in Immunology

The Lymphatic Vasculature in the 21st Century: Novel Functional Roles in Homeostasis and Disease

(2020) Guillermo Oliver et al.   CELL

Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi

(2020) Seon Pyo Hong et al.   Nature Communications

TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity

(2019) Hisamichi Naito et al.   DEVELOPMENTAL CELL

Gut microbiota regulates lacteal integrity by inducing VEGF‐C in intestinal villus macrophages

(2019) Sang Heon Suh et al.   EMBO REPORTS

Compartmentalized gut lymph node drainage dictates adaptive immune responses

(2019) Daria Esterházy et al.   NATURE

Interferon lambda Promotes Paneth Cell Death via STAT1 Signaling in Mice and is Increased in Inflamed Ileal Tissues of Patients with Crohn’s Disease

(2019) Claudia Günther et al.   GASTROENTEROLOGY

Environmental Microbial Factors Determine the Pattern of Inflammatory Lesions in a Murine Model of Crohn’s Disease–Like Inflammation

(2019) Iris Stolzer et al.   INFLAMMATORY BOWEL DISEASES

Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2

(2019) Evan Bolyen et al.   NATURE BIOTECHNOLOGY

Caspase-8 modulates physiological and pathological angiogenesis during retina development

(2019) Nathalie Tisch et al.   JOURNAL OF CLINICAL INVESTIGATION

A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease

(2019) Qingdong Guan   Journal of Immunology Research

Caspase-8 deficiency in mouse embryos triggers chronic RIPK1-dependent activation of inflammatory genes, independently of RIPK3

(2018) Tae-Bong Kang et al.   CELL DEATH AND DIFFERENTIATION

Distinct roles of VE‐cadherin for development and maintenance of specific lymph vessel beds

(2018) René Hägerling et al.   EMBO JOURNAL

Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency

(2018) Anna S. Lehle et al.   GASTROENTEROLOGY

PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools

(2018) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

Regionalized Development and Maintenance of the Intestinal Adaptive Immune Landscape

(2017) William W. Agace et al.   IMMUNITY

Microbial Ecology along the Gastrointestinal Tract

(2017) Ethan T. Hillman et al.   MICROBES AND ENVIRONMENTS

Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory “FADDosome” Complex upon TRAIL Stimulation

(2017) Conor M. Henry et al.   MOLECULAR CELL

Intestinal lymphatic vasculature: structure, mechanisms and functions

(2017) Jeremiah Bernier-Latmani et al.   Nature Reviews Gastroenterology & Hepatology

Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology

(2017) Hellmut G. Augustin et al.   SCIENCE

Dextran sodium sulfate colitis murine model: An indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis

(2017) Derrick D Eichele et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The molecular basis of endothelial cell plasticity

(2017) Elisabetta Dejana et al.   Nature Communications

NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions

(2016) Katerina Vlantis et al.   IMMUNITY

Angiocrine functions of organ-specific endothelial cells

(2016) Shahin Rafii et al.   NATURE

DADA2: High-resolution sample inference from Illumina amplicon data

(2016) Benjamin J Callahan et al.   NATURE METHODS

High-resolution 3D analysis of mouse small-intestinal stroma

(2016) Jeremiah Bernier-Latmani et al.   Nature Protocols

Microbiota of the Small Intestine Is Selectively Engulfed by Phagocytes of the Lamina Propria and Peyer’s Patches

(2016) Masatoshi Morikawa et al.   PLoS One

DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport

(2015) Jeremiah Bernier-Latmani et al.   JOURNAL OF CLINICAL INVESTIGATION

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

A gut-vascular barrier controls the systemic dissemination of bacteria

(2015) Ilaria Spadoni et al.   SCIENCE

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

(2014) Marius Dannappel et al.   NATURE

Heterogeneity across the murine small and large intestine

(2014) Rowann Bowcutt   WORLD JOURNAL OF GASTROENTEROLOGY

Necroptosis Is Active in Children With Inflammatory Bowel Disease and Contributes to Heighten Intestinal Inflammation

(2013) Maria Pierdomenico et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Conditional ablation of LYVE-1+ cells unveils defensive roles of lymphatic vessels in intestine and lymph nodes

(2013) J. Y. Jang et al.   BLOOD

Molecular Signatures of Tissue-Specific Microvascular Endothelial Cell Heterogeneity in Organ Maintenance and Regeneration

(2013) Daniel J. Nolan et al.   DEVELOPMENTAL CELL

Cellular FLICE-Like Inhibitory Protein Secures Intestinal Epithelial Cell Survival and Immune Homeostasis by Regulating Caspase-8

(2013) Nadine Wittkopf et al.   GASTROENTEROLOGY

Protective Roles for Caspase-8 and cFLIP in Adult Homeostasis

(2013) Ricardo Weinlich et al.   Cell Reports

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

The role of neutrophils during intestinal inflammation

(2012) B M Fournier et al.   Mucosal Immunology

Tissue factor and PAR1 promote microbiota-induced intestinal vascular remodelling

(2012) Christoph Reinhardt et al.   NATURE

The SILVA ribosomal RNA gene database project: improved data processing and web-based tools

(2012) Christian Quast et al.   NUCLEIC ACIDS RESEARCH

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Survival Function of the FADD-CASPASE-8-cFLIPL Complex

(2012) Christopher P. Dillon et al.   Cell Reports

Epithelial barrier: an interface for the cross-communication between gut flora and immune system

(2011) Yoshiyuki Goto et al.   IMMUNOLOGICAL REVIEWS

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

(2011) Patrick-Simon Welz et al.   NATURE

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

(2010) Yingdi Wang et al.   NATURE

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Efficient, inducible Cre-recombinase activation in vascular endothelium

(2008) Suzanne Claxton et al.   GENESIS