Fas/FasL mediates NF-κBp65/PUMA-modulated hepatocytes apoptosis via autophagy to drive liver fibrosis

The peripheral CB 1 receptor antagonist JD5037 attenuates liver fibrosis via a CB 1 receptor /β‐arrestin1/ Akt pathway

(2020) Siwei Tan et al.   BRITISH JOURNAL OF PHARMACOLOGY

miR-196b-5p-mediated downregulation of FAS promotes NSCLC progression by activating IL6-STAT3 signaling

(2020) Xiangjie Huang et al.   Cell Death & Disease

IL-6-driven FasL promotes NF-κBp65/PUMA-mediated apoptosis in portal hypertensive gastropathy

(2019) Siwei Tan et al.   Cell Death & Disease

Many Th Cell Subsets Have Fas Ligand–Dependent Cytotoxic Potential

(2018) Dmitri I. Kotov et al.   JOURNAL OF IMMUNOLOGY

Cell fate in antiviral response arises in the crosstalk of IRF, NF-κB and JAK/STAT pathways

(2018) Maciej Czerkies et al.   Nature Communications

β-Arrestin1 enhances liver fibrosis through autophagy-mediated Snail signaling

(2018) Siwei Tan et al.   FASEB JOURNAL

NS5ATP13 Promotes Liver Fibrogenesis Via Activation of Hepatic Stellate Cells

(2017) Yaru Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Proapoptotic PUMA targets stem-like breast cancer cells to suppress metastasis

(2017) Qi Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Thymic NF-κB-inducing kinase regulates CD4 + T cell-elicited liver injury and fibrosis in mice

(2017) Hong Shen et al.   JOURNAL OF HEPATOLOGY

CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response

(2017) Abdul S. Qadir et al.   Cell Reports

IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator receptor-interacting protein kinase 1

(2016) Christiane Koppe et al.   HEPATOLOGY

Hepatic expression of Sonic Hedgehog induces liver fibrosis and promotes hepatocarcinogenesis in a transgenic mouse model

(2016) Sook In Chung et al.   JOURNAL OF HEPATOLOGY

Out with the bad: Studying autophagy to fight infectious disease

(2016) Leah Shaffer   NATURE MEDICINE

Novel insights into the function and dynamics of extracellular matrix in liver fibrosis

(2015) Morten A. Karsdal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA

(2015) Wei Xie et al.   Autophagy

Antagonism between MCL-1 and PUMA governs stem/progenitor cell survival during hematopoietic recovery from stress

(2015) A. R. D. Delbridge et al.   BLOOD

Autophagy and apoptosis in liver injury

(2015) Kewei Wang   CELL CYCLE

An HNF1α-regulated feedback circuit modulates hepatic fibrogenesis via the crosstalk between hepatocytes and hepatic stellate cells

(2015) Hui Qian et al.   CELL RESEARCH

β-Arrestin-1 protects against endoplasmic reticulum stress/p53-upregulated modulator of apoptosis-mediated apoptosis via repressing p-p65/inducible nitric oxide synthase in portal hypertensive gastropathy

(2015) Siwei Tan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pathobiology of liver fibrosis: a translational success story

(2015) Youngmin A Lee et al.   GUT

Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation

(2015) Cristina Bárcena et al.   JOURNAL OF HEPATOLOGY

Autophagy-Related Deubiquitinating Enzymes Involved in Health and Disease

(2015) Fouzi Magraoui et al.   Cells

PUMA mediates ER stress-induced apoptosis in portal hypertensive gastropathy

(2014) S Tan et al.   Cell Death & Disease

Autophagy Controls the Kinetics and Extent of Mitochondrial Apoptosis by Regulating PUMA Levels

(2014) Jacqueline Thorburn et al.   Cell Reports

Mitochondria-mediated apoptosis in mammals

(2014) Shunbin Xiong et al.   Protein & Cell

Functions of autophagy in normal and diseased liver

(2013) Mark J. Czaja et al.   Autophagy

Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice

(2013) Jean-Philippe Pradere et al.   HEPATOLOGY

Hepatic stellate cells in liver development, regeneration, and cancer

(2013) Chunyue Yin et al.   JOURNAL OF CLINICAL INVESTIGATION

Evolving therapies for liver fibrosis

(2013) Detlef Schuppan et al.   JOURNAL OF CLINICAL INVESTIGATION

The complexity of NF-κB signaling in inflammation and cancer

(2013) Bastian Hoesel et al.   Molecular Cancer

The p53–PUMA axis suppresses iPSC generation

(2013) Yanxin Li et al.   Nature Communications

Conflicting Roles of Molecules in Hepatocarcinogenesis: Paradigm or Paradox

(2012) Gen-Sheng Feng   CANCER CELL

CD11b+Gr1+bone marrow cells ameliorate liver fibrosis by producing interleukin-10 in mice

(2012) Yang-Gun Suh et al.   HEPATOLOGY

CD95 death receptor and epidermal growth factor receptor (EGFR) in liver cell apoptosis and regeneration

(2011) Roland Reinehr et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Autophagy and disease: always two sides to a problem

(2011) Sunandini Sridhar et al.   JOURNAL OF PATHOLOGY

NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

(2011) Tom Luedde et al.   Nature Reviews Gastroenterology & Hepatology

PUMA cooperates with direct activator proteins to promote mitochondrial outer membrane permeabilization and apoptosis

(2010) Jerry E. Chipuk et al.   CELL CYCLE

Signals from dying hepatocytes trigger growth of liver progenitors

(2010) Y. Jung et al.   GUT

Human T cell microparticles circulate in blood of hepatitis patients and induce fibrolytic activation of hepatic stellate cells

(2010) Miroslaw Kornek et al.   HEPATOLOGY

Sorafenib Activates CD95 and Promotes Autophagy and Cell Death via Src Family Kinases in Gastrointestinal Tumor Cells

(2010) Margaret A. Park et al.   MOLECULAR CANCER THERAPEUTICS

BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program

(2010) D. Ren et al.   SCIENCE

Cell Apoptosis and Fas Gene Expression in Liver and Renal Tissues After Ischemia-Reperfusion Injury in Liver Transplantation

(2010) B. Li et al.   TRANSPLANTATION PROCEEDINGS

PUMA is directly activated by NF-κB and contributes to TNF-α-induced apoptosis

(2009) P Wang et al.   CELL DEATH AND DIFFERENTIATION

Downregulation of cyclooxygenase-1 is involved in gastric mucosal apoptosis via death signaling in portal hypertensive rats

(2009) Bin Wu et al.   CELL RESEARCH

Life and death by death receptors

(2009) Maria Eugenia Guicciardi et al.   FASEB JOURNAL

Hepatocyte-specific deletion of the antiapoptotic protein myeloid cell leukemia-1 triggers proliferation and hepatocarcinogenesis in mice

(2009) Achim Weber et al.   HEPATOLOGY

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

PUMA, a potent killer with or without p53

(2009) J Yu et al.   ONCOGENE

Fas-mediated autophagy requires JNK activation in HeLa cells

(2008) Yahong Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neurogenic Chronic Intestinal Pseudo-Obstruction: Antineuronal Antibody-Mediated Activation of Autophagy Via Fas

(2008) Roberto de Giorgio et al.   GASTROENTEROLOGY