The PIDDosome activates p53 in response to supernumerary centrosomes

Caspase-2 deficiency accelerates chemically induced liver cancer in mice

(2016) S Shalini et al.   CELL DEATH AND DIFFERENTIATION

A USP28–53BP1–p53–p21 signaling axis arrests growth after centrosome loss or prolonged mitosis

(2016) Bramwell G. Lambrus et al.   JOURNAL OF CELL BIOLOGY

53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration

(2016) Franz Meitinger et al.   JOURNAL OF CELL BIOLOGY

Chromosome missegregation during anaphase triggers p53 cell cycle arrest through histone H3.3 Ser31 phosphorylation

(2016) Edward H. Hinchcliffe et al.   NATURE CELL BIOLOGY

p53 protects against genome instability following centriole duplication failure

(2015) Bramwell G. Lambrus et al.   JOURNAL OF CELL BIOLOGY

Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis

(2015) Özdemirhan Serçin et al.   NATURE CELL BIOLOGY

Centrosome function and assembly in animal cells

(2015) Paul T. Conduit et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chronic centrosome amplification without tumorigenesis

(2015) Benjamin Vitre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epidermal development, growth control, and homeostasis in the face of centrosome amplification

(2015) Anita Kulukian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversible centriole depletion with an inhibitor of Polo-like kinase 4

(2015) Y. L. Wong et al.   SCIENCE

Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse

(2015) Paula A. Coelho et al.   Open Biology

Cytokinesis Failure Triggers Hippo Tumor Suppressor Pathway Activation

(2014) Neil J. Ganem et al.   CELL

HSF1 deficiency and impaired HSP90-dependent protein folding are hallmarks of aneuploid human cells

(2014) N. Donnelly et al.   EMBO JOURNAL

Oncogene-like induction of cellular invasion from centrosome amplification

(2014) Susana A. Godinho et al.   NATURE

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Metabolic control of cell death

(2014) D. R. Green et al.   SCIENCE

Spatial and temporal diversity in genomic instability processes defines lung cancer evolution

(2014) E. C. de Bruin et al.   SCIENCE

Tolerance of Whole-Genome Doubling Propagates Chromosomal Instability and Accelerates Cancer Genome Evolution

(2014) S. M. Dewhurst et al.   Cancer Discovery

Caspase-2 as a tumour suppressor

(2013) J Puccini et al.   CELL DEATH AND DIFFERENTIATION

p53 regulates a mitotic transcription program and determines ploidy in normal mouse liver

(2013) Svitlana Kurinna et al.   HEPATOLOGY

Caspase-2 at a glance

(2013) L. L. Fava et al.   JOURNAL OF CELL SCIENCE

Pan-cancer patterns of somatic copy number alteration

(2013) Travis I Zack et al.   NATURE GENETICS

Physiological significance of polyploidization in mammalian cells

(2013) Shusil K. Pandit et al.   TRENDS IN CELL BIOLOGY

Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome

(2013) C Manzl et al.   Cell Death & Disease

Polyploidization of Murine Mesenchymal Cells Is Associated with Suppression of the Long Noncoding RNA H19 and Reduced Tumorigenicity

(2012) O. Shoshani et al.   CANCER RESEARCH

PIDDosome-independent tumor suppression by Caspase-2

(2012) C Manzl et al.   CELL DEATH AND DIFFERENTIATION

The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle

(2012) A. J. Holland et al.   GENES & DEVELOPMENT

A Perspective on Mammalian Caspases as Positive and Negative Regulators of Inflammation

(2012) Seamus J. Martin et al.   MOLECULAR CELL

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

P53-induced protein with a death domain (PIDD): master of puppets?

(2012) F J Bock et al.   ONCOGENE

The Causes and Consequences of Polyploidy in Normal Development and Cancer

(2011) Teresa Davoli et al.   Annual Review of Cell and Developmental Biology

The conversion of centrioles to centrosomes: essential coupling of duplication with segregation

(2011) Won-Jing Wang et al.   JOURNAL OF CELL BIOLOGY

Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction

(2011) James D. Orth et al.   MOLECULAR BIOLOGY OF THE CELL

Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop

(2011) Trudy G. Oliver et al.   MOLECULAR CELL

Mitotic catastrophe: a mechanism for avoiding genomic instability

(2011) Ilio Vitale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations

(2011) A. Janssen et al.   SCIENCE

Prolonged Prometaphase Blocks Daughter Cell Proliferation Despite Normal Completion of Mitosis

(2010) Yumi Uetake et al.   CURRENT BIOLOGY

Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine

(2010) Stefano Santaguida et al.   JOURNAL OF CELL BIOLOGY

Proliferation of aneuploid human cells is limited by a p53-dependent mechanism

(2010) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

Caspase-2 activation in the absence of PIDDosome formation

(2009) Claudia Manzl et al.   JOURNAL OF CELL BIOLOGY

A mechanism linking extra centrosomes to chromosomal instability

(2009) Neil J. Ganem et al.   NATURE

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

(2009) Andrew J. Holland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Multipolar Spindle Pole Coalescence Is a Major Source of Kinetochore Mis-Attachment and Chromosome Mis-Segregation in Cancer Cells

(2009) William T. Silkworth et al.   PLoS One

Chk1 Suppresses a Caspase-2 Apoptotic Response to DNA Damage that Bypasses p53, Bcl-2, and Caspase-3

(2008) Samuel Sidi et al.   CELL

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes

(2008) M. Kwon et al.   GENES & DEVELOPMENT

Caspase-2 is required for cell death induced by cytoskeletal disruption

(2008) L H Ho et al.   ONCOGENE