Serine-70 phosphorylated Bcl-2 prevents oxidative stress-induced DNA damage by modulating the mitochondrial redox metabolism

Induction of apoptosis and ferroptosis by a tumor suppressing magnetic field through ROS-mediated DNA damage

(2020) Lin-Qing Yuan et al.   Aging-US

Multiple BCL2 mutations cooccurring with Gly101Val emerge in chronic lymphocytic leukemia progression on venetoclax

(2020) Piers Blombery et al.   BLOOD

Breaking through BCL-2 inhibition in CLL

(2020) Stephen J. F. Chong et al.   BLOOD

Visualizing and interpreting cancer genomics data via the Xena platform

(2020) Mary J. Goldman et al.   NATURE BIOTECHNOLOGY

Noncanonical Cell Fate Regulation by Bcl-2 Proteins

(2020) Stephen Jun Fei Chong et al.   TRENDS IN CELL BIOLOGY

A phase 1b/2 study of duvelisib in combination with FCR (DFCR) for frontline therapy for younger CLL patients

(2020) Matthew S. Davids et al.   LEUKEMIA

BH3 profiling discriminates on-target small molecule BH3 mimetics from putative mimetics

(2019) Mariana Villalobos-Ortiz et al.   CELL DEATH AND DIFFERENTIATION

A feedforward relationship between active Rac1 and phosphorylated Bcl-2 is critical for sustaining Bcl-2 phosphorylation and promoting cancer progression

(2019) Stephen Jun Fei Chong et al.   CANCER LETTERS

Ibrutinib plus fludarabine, cyclophosphamide, and rituximab as initial treatment for younger patients with chronic lymphocytic leukaemia: a single-arm, multicentre, phase 2 trial

(2019) Matthew S Davids et al.   Lancet Haematology

Reactive Oxygen Species and Oncoprotein Signaling-A Dangerous Liaison

(2018) Stephen Jun Fei Chong et al.   ANTIOXIDANTS & REDOX SIGNALING

Acquisition of the recurrent Gly101Val mutation in BCL2 confers resistance to venetoclax in patients with progressive chronic lymphocytic leukemia

(2018) Piers Blombery et al.   Cancer Discovery

Replication stress-induced endogenous DNA damage drives cellular senescence induced by a sub-lethal oxidative stress

(2017) Gireedhar Venkatachalam et al.   NUCLEIC ACIDS RESEARCH

RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome

(2017) Yingying Zhang et al.   Nature Communications

Activation of apoptosis signalling pathways by reactive oxygen species

(2016) Maureen Redza-Dutordoir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Targeted DNA damage at individual telomeres disrupts their integrity and triggers cell death

(2015) Luxi Sun et al.   NUCLEIC ACIDS RESEARCH

Overexpression of Bcl-2 induces STAT-3 activation via an increase in mitochondrial superoxide

(2015) Jia Kang et al.   Oncotarget

Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56  stabilizes its antiapoptotic activity

(2014) I. C. C. Low et al.   BLOOD

Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2

(2014) S. Tao et al.   CANCER RESEARCH

Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients

(2014) T. Z. Tan et al.   EMBO Molecular Medicine

The copper chelator ATN-224 induces caspase-independent cell death in diffuse large B cell lymphoma

(2014) KRISTY LEE et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Mitochondrial ROS and involvement of Bcl-2 as a mitochondrial ROS regulator

(2014) Stephen Jun Fei Chong et al.   MITOCHONDRION

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

OpenComet: An automated tool for comet assay image analysis

(2014) Benjamin M. Gyori et al.   Redox Biology

A Distinct Reactive Oxygen Species Profile Confers Chemoresistance in Glioma-Propagating Cells and Associates with Patient Survival Outcome

(2013) Lynnette Wei-Hsien Koh et al.   ANTIOXIDANTS & REDOX SIGNALING

Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies

(2013) J. J. Oaks et al.   BLOOD

The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignancies

(2013) Kristy Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sustained production of ROS triggers compensatory proliferation and is required for regeneration to proceed

(2013) Carole Gauron et al.   Scientific Reports

Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis

(2012) Sahar A. Saddoughi et al.   EMBO Molecular Medicine

Susceptibility to bystander DNA damage is influenced by replication and transcriptional activity

(2012) J. S. Dickey et al.   NUCLEIC ACIDS RESEARCH

Regulation of mitochondrial respiration and apoptosis through cell signaling: Cytochrome c oxidase and cytochrome c in ischemia/reperfusion injury and inflammation

(2011) Maik Hüttemann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The small GTPase Rac1 is a novel binding partner of Bcl-2 and stabilizes its antiapoptotic activity

(2011) R. Velaithan et al.   BLOOD

Manganese Superoxide Dismutase Is a p53-Regulated Gene That Switches Cancers between Early and Advanced Stages

(2011) S. K. Dhar et al.   CANCER RESEARCH

Functional relevance of the histone  H2Ax in the response to DNA damaging agents

(2011) I. Revet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A phase II study of 2-methoxyestradiol (2ME2) NanoCrystal® dispersion (NCD) in patients with taxane-refractory, metastatic castrate-resistant prostate cancer (CRPC)

(2010) Michael R. Harrison et al.   INVESTIGATIONAL NEW DRUGS

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of cytochrome c oxidase subunits Va and Vb in the regulation of cancer cell metabolism by Bcl-2

(2009) Z X Chen et al.   CELL DEATH AND DIFFERENTIATION

Phase I Trial of 2-Methoxyestradiol NanoCrystal Dispersion in Advanced Solid Malignancies

(2009) A. J. Tevaarwerk et al.   CLINICAL CANCER RESEARCH

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Phase I Study of Copper-Binding Agent ATN-224 in Patients with Advanced Solid Tumors

(2008) S. A. Lowndes et al.   CLINICAL CANCER RESEARCH

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL