BAP1 forms a trimer with HMGB1 and HDAC1 that modulates gene × environment interaction with asbestos

BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation

(2021) Eric Conway et al.   MOLECULAR CELL

How asbestos and other fibers cause mesothelioma

(2020) Giovanni Gaudino et al.   Translational Lung Cancer Research

Nucleosomes effectively shield DNA from radiation damage in living cells

(2020) Francesca Brambilla et al.   NUCLEIC ACIDS RESEARCH

Biological Mechanisms and Clinical Significance of BAP1 Mutations in Human Cancer

(2020) Michele Carbone et al.   Cancer Discovery

Asbestos induces mesothelial cell transformation via HMGB1-driven autophagy

(2020) Jiaming Xue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mesothelioma: Scientific clues for prevention, diagnosis, and therapy

(2019) Michele Carbone et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Crosstalk between hepatitis B virus X and high-mobility group box 1 facilitates autophagy in hepatocytes

(2018) Sha Fu et al.   Molecular Oncology

BAP1 links metabolic regulation of ferroptosis to tumour suppression

(2018) Yilei Zhang et al.   NATURE CELL BIOLOGY

Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine

(2018) Michele Carbone et al.   CELL DEATH AND DIFFERENTIATION

A Subset of Mesotheliomas With Improved Survival Occurring in Carriers of BAP1 and Other Germline Mutations

(2018) Sandra Pastorino et al.   JOURNAL OF CLINICAL ONCOLOGY

High-mobility group box 1 protein orchestrates responses to tissue damage via inflammation, innate and adaptive immunity, and tissue repair

(2017) Marco E. Bianchi et al.   IMMUNOLOGICAL REVIEWS

BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation

(2017) Angela Bononi et al.   NATURE

HDOCK: a web server for protein–protein and protein–DNA/RNA docking based on a hybrid strategy

(2017) Yumeng Yan et al.   NUCLEIC ACIDS RESEARCH

HMGB1 targeting by ethyl pyruvate suppresses malignant phenotype of human mesothelioma

(2017) Laura Pellegrini et al.   Oncotarget

Protein Folding and Structure Prediction from the Ground Up II: AAWSEM for α/β Proteins

(2016) Mingchen Chen et al.   JOURNAL OF PHYSICAL CHEMISTRY B

High-density array-CGH with targeted NGS unmask multiple noncontiguous minute deletions on chromosome 3p21 in mesothelioma

(2016) Yoshie Yoshikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tuberous sclerosis complex

(2016) Elizabeth P. Henske et al.   Nature Reviews Disease Primers

Human malignant mesothelioma is recapitulated in immunocompetent BALB/c mice injected with murine AB cells

(2016) Rosanna Mezzapelle et al.   Scientific Reports

High Incidence of Somatic BAP1 Alterations in Sporadic Malignant Mesothelioma

(2015) Masaki Nasu et al.   Journal of Thoracic Oncology

Vorinostat in patients with advanced malignant pleural mesothelioma who have progressed on previous chemotherapy (VANTAGE-014): a phase 3, double-blind, randomised, placebo-controlled trial

(2015) Lee M Krug et al.   LANCET ONCOLOGY

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(2015) Hyong Choi et al.   MOLECULAR MEDICINE

Minimal asbestos exposure in germline BAP1 heterozygous mice is associated with deregulated inflammatory response and increased risk of mesothelioma

(2015) A Napolitano et al.   ONCOGENE

Aspirin delays mesothelioma growth by inhibiting HMGB1-mediated tumor progression

(2015) H Yang et al.   Cell Death & Disease

Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma

(2014) Tobias Bald et al.   NATURE

Release of Neuronal HMGB1 by Ethanol through Decreased HDAC Activity Activates Brain Neuroimmune Signaling

(2014) Jian Y. Zou et al.   PLoS One

Histone Deacetylase 1 and p300 Can Directly Associate with Chromatin and Compete for Binding in a Mutually Exclusive Manner

(2014) Xuehui Li et al.   PLoS One

JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation

(2014) B. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stabilization and targeting of INO80 to replication forks by BAP1 during normal DNA synthesis

(2014) Han-Sae Lee et al.   Nature Communications

Continuous Exposure to Chrysotile Asbestos Can Cause Transformation of Human Mesothelial Cells via HMGB1 and TNF-α Signaling

(2013) Fang Qi et al.   AMERICAN JOURNAL OF PATHOLOGY

Serum HMGB1 as a Diagnostic Marker for Malignant Peritoneal Mesothelioma

(2013) Chiharu Tabata et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair

(2013) H. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma

(2012) S. Jube et al.   CANCER RESEARCH

Serum high mobility group box-1 is a powerful diagnostic and prognostic biomarker for pancreatic ductal adenocarcinoma

(2012) Hye Won Chung et al.   CANCER SCIENCE

AWSEM-MD: Protein Structure Prediction Using Coarse-Grained Physical Potentials and Bioinformatically Based Local Structure Biasing

(2012) Aram Davtyan et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Novel role of PKR in inflammasome activation and HMGB1 release

(2012) Ben Lu et al.   NATURE

Diagnostic Significance of Serum HMGB1 in Colorectal Carcinomas

(2012) Hanna Lee et al.   PLoS One

HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

(2011) Ulf Andersson et al.   Annual Review of Immunology

Germline BAP1 mutations predispose to malignant mesothelioma

(2011) Joseph R Testa et al.   NATURE GENETICS

Erionite exposure in North Dakota and Turkish villages with mesothelioma

(2011) M. Carbone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High Mobility Group Box 1 Release from Hepatocytes during Ischemia and Reperfusion Injury Is Mediated by Decreased Histone Deacetylase Activity

(2010) John Evankovich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endogenous HMGB1 regulates autophagy

(2010) Daolin Tang et al.   JOURNAL OF CELL BIOLOGY

The Ubiquitin Carboxyl Hydrolase BAP1 Forms a Ternary Complex with YY1 and HCF-1 and Is a Critical Regulator of Gene Expression

(2010) H. Yu et al.   MOLECULAR AND CELLULAR BIOLOGY

Programmed necrosis induced by asbestos in human mesothelial cells causes high-mobility group box 1 protein release and resultant inflammation

(2010) Haining Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA