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Targeting NF-κB–dependent alkaliptosis for the treatment of venetoclax-resistant acute myeloid leukemia cells

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Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein

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The circadian clock protects against ferroptosis-induced sterile inflammation

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Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers

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Tumor Cell–Derived IL1β Promotes Desmoplasia and Immune Suppression in Pancreatic Cancer

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ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity

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Role of oncogenic KRAS in the diagnosis, prognosis and treatment of pancreatic cancer

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Necroptosis in pancreatic cancer promotes cancer cell migration and invasion by release of CXCL5

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Regulatory T-cell Depletion Alters the Tumor Microenvironment and Accelerates Pancreatic Carcinogenesis

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Pancreatic ductal adenocarcinoma: Treatment hurdles, tumor microenvironment and immunotherapy

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Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death

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Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer

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Interplay between MTOR and GPX4 signaling modulates autophagy-dependent ferroptotic cancer cell death

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A Randomized Phase II Preoperative Study of Autophagy Inhibition with High-Dose Hydroxychloroquine and Gemcitabine/Nab-Paclitaxel in Pancreatic Cancer Patients

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A bioorthogonal system reveals antitumour immune function of pyroptosis

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Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

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The tumour microenvironment in pancreatic cancer — clinical challenges and opportunities

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Harnessing the potential of multimodal radiotherapy in prostate cancer

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The human tumor microbiome is composed of tumor type–specific intracellular bacteria

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Cysteine depletion induces pancreatic tumor ferroptosis in mice

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Golgi Acidification by NHE7 Regulates Cytosolic pH Homeostasis in Pancreatic Cancer Cells

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Aurora A kinase and its activator TPX2 are potential therapeutic targets in KRAS-induced pancreatic cancer

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(2020) Lorenzo Galluzzi et al.   Journal for ImmunoTherapy of Cancer

Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer

(2020) Luisa F. Escobar-Hoyos et al.   CANCER CELL

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Radiation causes tissue damage by dysregulating inflammasome–gasdermin D signaling in both host and transplanted cells

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(2020) Bao Chen Yang et al.   Molecular Therapy-Oncolytics

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(2020) Xin Chen et al.   Autophagy

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Challenges and Opportunities for Pancreatic Cancer Immunotherapy

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Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells

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CDK1/2/5 inhibition overcomes IFNG-mediated adaptive immune resistance in pancreatic cancer

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Regulation and modulation of antitumor immunity in pancreatic cancer

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KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors

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Regulation and function of autophagy in pancreatic cancer

(2020) Jingbo Li et al.   Autophagy

Pirin is a nuclear redox-sensitive modulator of autophagy-dependent ferroptosis

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Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway

(2020) Enyong Dai et al.   Nature Communications

Biological Functions of Autophagy Genes: A Disease Perspective

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Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

(2019) Rumani Singh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Toll-like receptor 2 and Toll-like receptor 4 exhibit distinct regulation of cancer cell stemness mediated by cell death-induced high-mobility group box 1

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CAFs and TGF-β Signaling Activation by Mast Cells Contribute to Resistance to Gemcitabine/Nabpaclitaxel in Pancreatic Cancer

(2019) Letizia Porcelli et al.   Cancers

A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity

(2019) Jennifer Yinuo Cao et al.   Cell Reports

Chaperone-mediated autophagy is involved in the execution of ferroptosis

(2019) Zheming Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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(2019) Eric A. Collisson et al.   Nature Reviews Gastroenterology & Hepatology

Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers

(2019) Conan G. Kinsey et al.   NATURE MEDICINE

MST1 Suppresses Pancreatic Cancer Progression via ROS-Induced Pyroptosis

(2019) Jiujie Cui et al.   MOLECULAR CANCER RESEARCH

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Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis

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CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

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ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

(2019) Bo Chu et al.   NATURE CELL BIOLOGY

Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance

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Genetic Ablation of the Cystine Transporter xCT in PDAC Cells Inhibits mTORC1, Growth, Survival, and Tumor Formation via Nutrient and Oxidative Stresses

(2019) Boutaina Daher et al.   CANCER RESEARCH

Tumor cell–intrinsic EPHA2 suppresses antitumor immunity by regulating PTGS2 (COX-2)

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Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling

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Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer

(2019) Talia Golan et al.   NEW ENGLAND JOURNAL OF MEDICINE

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

(2019) Yilong Zou et al.   Nature Communications

Oncogenic Kras induces Nix-mediated mitophagy to promote pancreatic cancer

(2019) Timothy J Humpton et al.   Cancer Discovery

DNA released from neutrophil extracellular traps (NETs) activates pancreatic stellate cells and enhances pancreatic tumor growth

(2019) Jennifer L. Miller-Ocuin et al.   OncoImmunology

Clockophagy is a novel selective autophagy process favoring ferroptosis

(2019) Minghua Yang et al.   Science Advances

Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes

(2019) Erick Riquelme et al.   CELL

Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11

(2019) Xueting Lang et al.   Cancer Discovery

ESCRT-III–dependent membrane repair blocks ferroptosis

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FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL

(2019) Berk Aykut et al.   NATURE

From state-of-the-art treatments to novel therapies for advanced-stage pancreatic cancer

(2019) Christopher Nevala-Plagemann et al.   Nature Reviews Clinical Oncology

Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism

(2019) Alex J. Bott et al.   Cell Reports

Assessing the Magnitude of Immunogenic Cell Death Following Chemotherapy and Irradiation Reveals a New Strategy to Treat Pancreatic Cancer

(2019) Jian Ye et al.   Cancer Immunology Research

NLRP3 Inflammasome Regulates Development of Systemic Inflammatory Response and Compensatory Anti-Inflammatory Response Syndromes in Mice With Acute Pancreatitis

(2019) Matthias Sendler et al.   GASTROENTEROLOGY

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

(2019) Vanessa A. N. Kraft et al.   ACS Central Science

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(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis

(2018) Rui Kang et al.   Cell Host & Microbe

JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice

(2018) Xinxin Song et al.   GASTROENTEROLOGY

JTC-801 exerts anti-proliferative effects in human osteosarcoma cells by inducing apoptosis

(2018) Chang-Jun Zheng et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Therapeutic developments in pancreatic cancer: current and future perspectives

(2018) John P. Neoptolemos et al.   Nature Reviews Gastroenterology & Hepatology

The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression

(2018) Smruti Pushalkar et al.   Cancer Discovery

p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells

(2018) Amy Tarangelo et al.   Cell Reports

TFAM is a novel mediator of immunogenic cancer cell death

(2018) Minghua Yang et al.   OncoImmunology

KRAS targeting antibody synergizes anti-cancer activity of gemcitabine against pancreatic cancer

(2018) Yeo Wool Kang et al.   CANCER LETTERS

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity

(2018) Xinxin Song et al.   CURRENT BIOLOGY

PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism

(2018) Changfeng Li et al.   DEVELOPMENTAL CELL

Antidiabetic adiponectin receptor agonist AdipoRon suppresses tumour growth of pancreatic cancer by inducing RIPK1/ERK-dependent necroptosis

(2018) Miho Akimoto et al.   Cell Death & Disease

A pharmacological probe identifies cystathionine β-synthase as a new negative regulator for ferroptosis

(2018) Li Wang et al.   Cell Death & Disease

Visualising the dynamics of live pancreatic microtumours self-organised through cell-in-cell invasion

(2018) Yukiko Miyatake et al.   Scientific Reports

Irisin inhibits pancreatic cancer cell growth via the AMPK-mTOR pathway

(2018) Jiayu Liu et al.   Scientific Reports

Quantitative single cell analysis uncovers the life/death decision in CD95 network

(2018) Jörn H. Buchbinder et al.   PLoS Computational Biology

Lipid storage and lipophagy regulates ferroptosis

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RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer

(2018) Wei Wang et al.   CANCER CELL

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(2018) Jake S. O’Donnell et al.   Nature Reviews Clinical Oncology

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma

(2017) Yangchun Xie et al.   GASTROENTEROLOGY

NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma

(2017) Donnele Daley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades

(2017) Sharan R. Srinivasan et al.   MOLECULAR CANCER RESEARCH

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

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(2017) Vasanthi S. Viswanathan et al.   NATURE

Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance

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(2017) Leore T. Geller et al.   SCIENCE

Nano-enabled pancreas cancer immunotherapy using immunogenic cell death and reversing immunosuppression

(2017) Jianqin Lu et al.   Nature Communications

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

Disrupting glutamine metabolic pathways to sensitize gemcitabine-resistant pancreatic cancer

(2017) Ru Chen et al.   Scientific Reports

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

(2017) Yangchun Xie et al.   Cell Reports

HSP90 is a promising target in gemcitabine and 5-fluorouracil resistant pancreatic cancer

(2016) Tarik Ghadban et al.   APOPTOSIS

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Identification of ACSL4 as a biomarker and contributor of ferroptosis

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NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer

(2016) Iok In Christine Chio et al.   CELL

Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation

(2016) Christopher J. Tape et al.   CELL

TGF-β Tumor Suppression through a Lethal EMT

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γδ T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell Activation

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GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

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An African-specific polymorphism in theTP53gene impairs p53 tumor suppressor function in a mouse model

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Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis

(2016) Xiaofang Sun et al.   HEPATOLOGY

The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression

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Pore-forming activity and structural autoinhibition of the gasdermin family

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Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

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Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

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(2016) Ricardo Weinlich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activation ofSAT1engages polyamine metabolism with p53-mediated ferroptotic responses

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Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

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Control of Apoptosis in Treatment and Biology of Pancreatic Cancer

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Glutaminolysis and Transferrin Regulate Ferroptosis

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Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

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(2015) Le Jiang et al.   NATURE

Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1

(2015) E. Vacchelli et al.   SCIENCE

Update on the management of pancreatic cancer: Surgery is not enough

(2015) Daniel Ansari et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer

(2015) A. J. Gunderson et al.   Cancer Discovery

Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia

(2015) K. E. Lee et al.   Cancer Discovery

Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction

(2015) Yi-Zhi Wang et al.   eLife

Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma

(2015) Tiansuo Zhao et al.   Oncotarget

Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling

(2014) Susann Weissmueller et al.   CELL

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

RIG-I-like helicases induce immunogenic cell death of pancreatic cancer cells and sensitize tumors toward killing by CD8+ T cells

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PRIMA-1, a mutant p53 reactivator, induces apoptosis and enhances chemotherapeutic cytotoxicity in pancreatic cancer cell lines

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Complementary Induction of Immunogenic Cell Death by Oncolytic Parvovirus H-1PV and Gemcitabine in Pancreatic Cancer

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Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis

(2014) K. Newton et al.   SCIENCE

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Pronecrotic mixed lineage kinase domain-like protein expression is a prognostic biomarker in patients with early-stage resected pancreatic adenocarcinoma

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PanIN-Specific Regulation of Wnt Signaling by HIF2  during Early Pancreatic Tumorigenesis

(2013) A. Criscimanna et al.   CANCER RESEARCH

A High-Fat Diet Activates Oncogenic Kras and COX2 to Induce Development of Pancreatic Ductal Adenocarcinoma in Mice

(2013) Bincy Philip et al.   GASTROENTEROLOGY

p53 status determines the role of autophagy in pancreatic tumour development

(2013) Mathias T. Rosenfeldt et al.   NATURE

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

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Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

(2013) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Strange attractors: DAMPs and autophagy link tumor cell death and immunity

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Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer

(2012) Lauren J. Bayne et al.   CANCER CELL

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

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Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies

(2012) Michael Steckel et al.   CELL RESEARCH

PAMPs and DAMPs: signal 0s that spur autophagy and immunity

(2012) Daolin Tang et al.   IMMUNOLOGICAL REVIEWS

Tumor-infiltrating DCs suppress nucleic acid–mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

(2012) Shigeki Chiba et al.   NATURE IMMUNOLOGY

A Central Role for RAF→MEK→ERK Signaling in the Genesis of Pancreatic Ductal Adenocarcinoma

(2012) Eric A. Collisson et al.   Cancer Discovery

Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer

(2011) Marina Lesina et al.   CANCER CELL

Human Tumor Cells Killed by Anthracyclines Induce a Tumor-Specific Immune Response

(2011) J. Fucikova et al.   CANCER RESEARCH

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(2011) Adam Lister et al.   Molecular Cancer

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(2011) Gina M. DeNicola et al.   NATURE

FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

(2011) Thierry Conroy et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

(2011) G. L. Beatty et al.   SCIENCE

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Radiosensitization and Stromal Imaging Response Correlates for the HIF-1 Inhibitor PX-478 Given with or without Chemotherapy in Pancreatic Cancer

(2010) D. L. Schwartz et al.   MOLECULAR CANCER THERAPEUTICS

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(2010) Guido Kroemer et al.   MOLECULAR CELL

Nuclear Factor (Erythroid-Derived 2)-Like 2 Regulates Drug Resistance in Pancreatic Cancer Cells

(2010) Young Bin Hong et al.   PANCREAS

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras

(2009) Catherine Carrière et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Synthetic Lethal Interaction between Oncogenic KRAS Dependency and STK33 Suppression in Human Cancer Cells

(2009) Claudia Scholl et al.   CELL

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

(2009) David A. Barbie et al.   NATURE

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

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Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

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