Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice

Microglial autophagy–associated phagocytosis is essential for recovery from neuroinflammation

(2020) Rasmus Berglund et al.   Science Immunology

Tumor necrosis factor receptor-2 (TNFR2): an overview of an emerging drug target

(2019) Juliane Medler et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

TNF-α induces autophagy through ERK1/2 pathway to regulate apoptosis in neonatal necrotizing enterocolitis model cells IEC-6

(2018) Yuhang Yuan et al.   CELL CYCLE

Selective Modulation of TNF–TNFRs Signaling: Insights for Multiple Sclerosis Treatment

(2018) Valentina Pegoretti et al.   Frontiers in Immunology

Multiple sclerosis as an adverse drug reaction: clues from the FDA Adverse Event Reporting System

(2018) Ippazio Cosimo Antonazzo et al.   Expert Opinion On Drug Safety

Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases

(2018) Junying Yuan et al.   NATURE REVIEWS NEUROSCIENCE

Tregs restrain dendritic cell autophagy to ameliorate autoimmunity

(2017) Themis Alissafi et al.   JOURNAL OF CLINICAL INVESTIGATION

Novel strategies to mimic transmembrane tumor necrosis factor-dependent activation of tumor necrosis factor receptor 2

(2017) Roman Fischer et al.   Scientific Reports

Opposing Functions of Microglial and Macrophagic TNFR2 in the Pathogenesis of Experimental Autoimmune Encephalomyelitis

(2017) Han Gao et al.   Cell Reports

Oligodendroglial TNFR2 Mediates Membrane TNF-Dependent Repair in Experimental Autoimmune Encephalomyelitis by Promoting Oligodendrocyte Differentiation and Remyelination

(2016) Pernille M. Madsen et al.   JOURNAL OF NEUROSCIENCE

Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration

(2016) Yun Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid mitochondrial dysfunction mediates TNF-alpha-induced neurotoxicity

(2015) Danielle N. Doll et al.   JOURNAL OF NEUROCHEMISTRY

Pathological mechanisms in progressive multiple sclerosis

(2015) Don H Mahad et al.   LANCET NEUROLOGY

TNF and its receptors in the CNS: The essential, the desirable and the deleterious effects

(2015) L. Probert   NEUROSCIENCE

The Role of Excitotoxic Programmed Necrosis in Acute Brain Injury

(2015) Denson G. Fujikawa   Computational and Structural Biotechnology Journal

Altered Expression of Oligodendrocyte and Neuronal Marker Genes Predicts the Clinical Onset of Autoimmune Encephalomyelitis and Indicates the Effectiveness of Multiple Sclerosis-Directed Therapeutics

(2014) M. Evangelidou et al.   JOURNAL OF IMMUNOLOGY

Central but not systemic administration of XPro1595 is therapeutic following moderate spinal cord injury in mice

(2014) Hans G Novrup et al.   Journal of Neuroinflammation

Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity

(2014) Gabriel Olmos et al.   MEDIATORS OF INFLAMMATION

Cellular and molecular neuropathology of the cuprizone mouse model: Clinical relevance for multiple sclerosis

(2014) Jelle Praet et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Regional regulation of glutamate signaling during cuprizone-induced demyelination in the brain

(2013) Abolfazl Azami Tameh et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium

(2013) Filip Van Hauwermeiren et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of NMDA Receptor Transport: A KIF17-Cargo Binding/Releasing Underlies Synaptic Plasticity and Memory In Vivo

(2012) X. Yin et al.   JOURNAL OF NEUROSCIENCE

IL-17-Induced Act1-Mediated Signaling Is Critical for Cuprizone-Induced Demyelination

(2012) Z. Kang et al.   JOURNAL OF NEUROSCIENCE

TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis

(2012) Adam P. Gregory et al.   NATURE

IκB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-κB in the central nervous system

(2011) Jenni Raasch et al.   BRAIN

Inhibition of soluble tumour necrosis factor is therapeutic in experimental autoimmune encephalomyelitis and promotes axon preservation and remyelination

(2011) Roberta Brambilla et al.   BRAIN

Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-κB

(2011) Era Taoufik et al.   BRAIN

A TNF Receptor 2 Selective Agonist Rescues Human Neurons from Oxidative Stress-Induced Cell Death

(2011) Roman Fischer et al.   PLoS One

Neuronal I B Kinase   Protects Mice from Autoimmune Encephalomyelitis by Mediating Neuroprotective and Immunosuppressive Effects in the Central Nervous System

(2009) M. Emmanouil et al.   JOURNAL OF IMMUNOLOGY

Tumor necrosis factor-α-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors

(2009) David Wheeler et al.   JOURNAL OF NEUROCHEMISTRY

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

(2009) Philip L De Jager et al.   NATURE GENETICS

Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

(2009) Fiona E. McAlpine et al.   NEUROBIOLOGY OF DISEASE

Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment

(2008) Meghan B. Azad et al.   ANTIOXIDANTS & REDOX SIGNALING

Rapid Tumor Necrosis Factor  -Induced Exocytosis of Glutamate Receptor 2-Lacking AMPA Receptors to Extrasynaptic Plasma Membrane Potentiates Excitotoxicity

(2008) D. Leonoudakis et al.   JOURNAL OF NEUROSCIENCE