Emricasan, a pan-caspase inhibitor, improves survival and portal hypertension in a murine model of common bile-duct ligation

Caspase inhibitors for the treatment of liver disease: friend or foe?

(2017) Benjamin L. Woolbright et al.   Expert Review of Gastroenterology & Hepatology

Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes

(2016) Petra Hirsova et al.   GASTROENTEROLOGY

Changes in Hospital Admissions and Mortality for Complications of Cirrhosis: Implications for Clinicians and Health Systems

(2016) Samuel B Ho et al.   Gut and Liver

Evolving insights in the pathophysiology of complications of cirrhosis: The farnesoid X receptor (FXR) to the rescue?

(2016) Wim Laleman et al.   HEPATOLOGY

Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood

(2016) Akiko Eguchi et al.   HEPATOLOGY

Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles

(2016) Vikas K. Verma et al.   JOURNAL OF HEPATOLOGY

Liver Bid suppression for treatment of fibrosis associated with non-alcoholic steatohepatitis

(2016) Akiko Eguchi et al.   JOURNAL OF HEPATOLOGY

Microparticles Release by Adipocytes Act as “Find-Me” Signals to Promote Macrophage Migration

(2015) Akiko Eguchi et al.   PLoS One

Differential regulation of inflammation and apoptosis in Fas-resistant hepatocyte-specific Bid-deficient mice

(2014) Milos Lazic et al.   JOURNAL OF HEPATOLOGY

The pan-caspase inhibitor Emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis

(2014) Fernando J. Barreyro et al.   LIVER INTERNATIONAL

Circulating Extracellular Vesicles with Specific Proteome and Liver MicroRNAs Are Potential Biomarkers for Liver Injury in Experimental Fatty Liver Disease

(2014) Davide Povero et al.   PLoS One

Lipid-Induced Toxicity Stimulates Hepatocytes to Release Angiogenic Microparticles That Require Vanin-1 for Uptake by Endothelial Cells

(2013) D. Povero et al.   Science Signaling

Abnormal Plasma Microparticles Impair Vasoconstrictor Responses in Patients With Cirrhosis

(2012) Pierre–Emmanuel Rautou et al.   GASTROENTEROLOGY

Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis

(2010) Quentin M. Anstee et al.   JOURNAL OF HEPATOLOGY

Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis

(2009) Rafal P. Witek et al.   HEPATOLOGY