Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

(2011) William J. Kaiser et al.   NATURE

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

RIP Kinases at the Crossroads of Cell Death and Survival

(2009) Wim Declercq et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

The Death Effector Domains of Caspase-8 Induce Terminal Differentiation

(2009) Ainhoa Mielgo et al.   PLoS One

Mucosal Gene Expression of Antimicrobial Peptides in Inflammatory Bowel Disease Before and After First Infliximab Treatment

(2009) Ingrid Arijs et al.   PLoS One

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Non-apoptotic functions of caspase-8

(2008) Jonathan Maelfait et al.   BIOCHEMICAL PHARMACOLOGY

Death Effector Domain-Containing Proteins

(2008) M. Gudur Valmiki et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Barrier dysfunction due to distinct defensin deficiencies in small intestinal and colonic Crohn's disease

(2008) J Wehkamp et al.   Mucosal Immunology

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology