BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages

The many facets of macrophages in rheumatoid arthritis

(2019) Eleni Siouti et al.   BIOCHEMICAL PHARMACOLOGY

Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage

(2019) Stefan Uderhardt et al.   CELL

Locally renewing resident synovial macrophages provide a protective barrier for the joint

(2019) Stephan Culemann et al.   NATURE

The BH3-only protein BAD mediates TNFα cytotoxicity despite concurrent activation of IKK and NF-κB in septic shock

(2018) Jie Yan et al.   CELL RESEARCH

The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts

(2018) Marietta Armaka et al.   Nature Communications

BAD knockout provides metabolic seizure resistance in a genetic model of epilepsy with sudden unexplained death in epilepsy

(2017) Jeannine Foley et al.   EPILEPSIA

Immunopathogenesis of Rheumatoid Arthritis

(2017) Gary S. Firestein et al.   IMMUNITY

MicroRNA-155 contributes to enhanced resistance to apoptosis in monocytes from patients with rheumatoid arthritis

(2017) Megha Rajasekhar et al.   JOURNAL OF AUTOIMMUNITY

Tumor Necrosis Factor Alpha Promotes Osteoclast Formation Via PI3K/Akt Pathway-Mediated Blimp1 Expression Upregulation

(2017) LeCheng Wu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Transcription factor NFAT5 promotes macrophage survival in rheumatoid arthritis

(2017) Susanna Choi et al.   JOURNAL OF CLINICAL INVESTIGATION

Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization

(2017) Eleni Vergadi et al.   JOURNAL OF IMMUNOLOGY

Association of Increased F4/80high Macrophages With Suppression of Serum-Transfer Arthritis in Mice With Reduced FLIP in Myeloid Cells

(2017) Qi-Quan Huang et al.   Arthritis & Rheumatology

Macrophage heterogeneity in the context of rheumatoid arthritis

(2016) Irina A. Udalova et al.   Nature Reviews Rheumatology

Targeting of proangiogenic signalling pathways in chronic inflammation

(2015) Sander W. Tas et al.   Nature Reviews Rheumatology

Cytokines in rheumatoid arthritis — shaping the immunological landscape

(2015) Iain B. McInnes et al.   Nature Reviews Rheumatology

CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis

(2015) Masanori A. Murayama et al.   Nature Communications

Targeting proapoptotic protein BAD inhibits survival and self-renewal of cancer stem cells

(2014) K S R Sastry et al.   CELL DEATH AND DIFFERENTIATION

Platelet-derived Growth Factor-C (PDGF-C) Induces Anti-apoptotic Effects on Macrophages through Akt and Bad Phosphorylation

(2014) Dain Son et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inactivation of BAD by IKK Inhibits TNFα-Induced Apoptosis Independently of NF-κB Activation

(2013) Jie Yan et al.   CELL

IL-21-Producing Th Cells in Immunity and Autoimmunity

(2013) S. M. Liu et al.   JOURNAL OF IMMUNOLOGY

Immunogenicity of anti-TNF biologic therapies for rheumatoid arthritis

(2013) Pauline A. van Schouwenburg et al.   Nature Reviews Rheumatology

Deficiency of  -arrestin1 ameliorates collagen-induced arthritis with impaired TH17 cell differentiation

(2013) J. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intimal lining layer macrophages but not synovial sublining macrophages display an IL-10 polarized-like phenotype in chronic synovitis

(2012) Carmen A Ambarus et al.   ARTHRITIS RESEARCH & THERAPY

Treatment of arthritis by macrophage depletion and immunomodulation: Testing an apoptosis-mediated therapy in a humanized death receptor mouse model

(2011) Jun Li et al.   ARTHRITIS AND RHEUMATISM

A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis

(2011) Mourad Matmati et al.   NATURE GENETICS

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis

(2011) M. Kurowska-Stolarska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

(2011) W. Tang et al.   SCIENCE

Macrophages in Synovial Inflammation

(2011) Aisling Kennedy et al.   Frontiers in Immunology

Bim-Bcl-2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosis

(2010) John C. Scatizzi et al.   ARTHRITIS AND RHEUMATISM

The adaptor protein CIKS/ACT1 is necessary for collagen-induced arthritis, and it contributes to the production of collagen-specific antibody

(2010) Prapaporn Pisitkun et al.   ARTHRITIS AND RHEUMATISM

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism

(2010) Dimitra Zotos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+T cells

(2009) Oliver Dienz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Synovial Tissue Sublining CD68 Expression Is a Biomarker of Therapeutic Response in Rheumatoid Arthritis Clinical Trials: Consistency Across Centers

(2009) B. BRESNIHAN et al.   JOURNAL OF RHEUMATOLOGY

BAD: undertaker by night, candyman by day

(2009) N N Danial   ONCOGENE

Dual role of proapoptotic BAD in insulin secretion and beta cell survival

(2008) Nika N Danial et al.   NATURE MEDICINE

Protocol for the induction of arthritis in C57BL/6 mice

(2008) Julia J Inglis et al.   Nature Protocols