STAT3-EMT axis in tumors: Modulation of cancer metastasis, stemness and therapy response
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Title
STAT3-EMT axis in tumors: Modulation of cancer metastasis, stemness and therapy response
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Keywords
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Journal
PHARMACOLOGICAL RESEARCH
Volume 182, Issue -, Pages 106311
Publisher
Elsevier BV
Online
2022-06-16
DOI
10.1016/j.phrs.2022.106311
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- Oncogenic Activities Of UBE2S Mediated By VHL/HIF-1α/STAT3 Signal Via The Ubiquitin-Proteasome System In PDAC
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- Niclosamide reverses adipocyte induced epithelial-mesenchymal transition in breast cancer cells via suppression of the interleukin-6/STAT3 signalling axis
- (2019) Jones Gyamfi et al. Scientific Reports
- Dietary Flavonoids Luteolin and Quercetin Inhibit Migration and Invasion of Squamous Carcinoma through Reduction of Src/Stat3/S100A7 Signaling
- (2019) Jhen-Jia Fan et al. Antioxidants
- Knockdown of PYCR1 inhibits proliferation, drug resistance and EMT in colorectal cancer cells by regulating STAT3-Mediated p38 MAPK and NF-κB signalling pathway
- (2019) Kun Yan et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- IL6/STAT3 Signaling Orchestrates Premetastatic Niche Formation and Immunosuppressive Traits in Lung
- (2019) Bo Jing et al. CANCER RESEARCH
- mir-21-5p inhibits the progression of human chondrosarcoma by regulating CCR7/STAT3/NF-κB pathway
- (2019) Guosong Li et al. CONNECTIVE TISSUE RESEARCH
- Telmisartan inhibits oxalate and calcium oxalate crystal-induced epithelial-mesenchymal transformation via PPAR-γ-AKT/STAT3/p38 MAPK-Snail pathway
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- Farnesol abrogates epithelial to mesenchymal transition process through regulating Akt/mTOR pathway
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- Cinobufagin Suppresses The Characteristics Of Osteosarcoma Cancer Cells By Inhibiting The IL-6-OPN-STAT3 Pathway
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- Downregulation of Rab17 promotes cell proliferation and invasion in non‐small cell lung cancer through STAT3/HIF‐1α/VEGF signaling
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- The IκB Kinase Inhibitor ACHP Targets the STAT3 Signaling Pathway in Human Non-Small Cell Lung Carcinoma Cells
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- Interleukin-23 promotes the migration and invasion of gastric cancer cells by inducing epithelial-to-mesenchymal transition via the STAT3 pathway
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- Huaier Granule extract inhibit the proliferation and metastasis of lung cancer cells through down-regulation of MTDH, JAK2/STAT3 and MAPK signaling pathways
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- α-Hederin inhibits interleukin 6-induced epithelial-to-mesenchymal transition associated with disruption of JAK2/STAT3 signaling in colon cancer cells
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- Overexpression of ALK4 inhibits cell proliferation and migration through the inactivation of JAK/STAT3 signaling pathway in glioma
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- Abnormally expressed JunB transactivated by IL-6/STAT3 signaling promotes uveal melanoma aggressiveness via epithelial–mesenchymal transition
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- Exosome biogenesis, bioactivities and functions as new delivery systems of natural compounds
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- Arsenic trioxide attenuates STAT-3 activity and epithelial-mesenchymal transition through induction of SHP-1 in gastric cancer cells
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- Pim-3 enhances melanoma cell migration and invasion by promoting STAT3 phosphorylation
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- miR-200c inhibits TGF-β-induced-EMT to restore trastuzumab sensitivity by targeting ZEB1 and ZEB2 in gastric cancer
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- Formononetin-induced oxidative stress abrogates the activation of STAT3/5 signaling axis and suppresses the tumor growth in multiple myeloma preclinical model
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- Triple negative breast cancer in Asia: An insider’s view
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- microRNA-30d mediated breast cancer invasion, migration, and EMT by targeting KLF11 and activating STAT3 pathway
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- YM155 decreases radiation-induced invasion and reverses epithelial–mesenchymal transition by targeting STAT3 in glioblastoma
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- RAC1-GTP promotes epithelial-mesenchymal transition and invasion of colorectal cancer by activation of STAT3
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- Bergamottin Suppresses Metastasis of Lung Cancer Cells through Abrogation of Diverse Oncogenic Signaling Cascades and Epithelial-to-Mesenchymal Transition
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- Targeting activator protein 1 signaling pathway by bioactive natural agents: Possible therapeutic strategy for cancer prevention and intervention
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- M2-polarized tumor-associated macrophages facilitated migration and epithelial-mesenchymal transition of HCC cells via the TLR4/STAT3 signaling pathway
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- G3BP1 promotes tumor progression and metastasis through IL-6/G3BP1/STAT3 signaling axis in renal cell carcinomas
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- Human colorectal cancer-derived mesenchymal stem cells promote colorectal cancer progression through IL-6/JAK2/STAT3 signaling
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- Pro-Apoptotic and Anti-Cancer Properties of Diosgenin: A Comprehensive and Critical Review
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- Targeting S1PR1/STAT3 loop abrogates desmoplasia and chemosensitizes pancreatic cancer to gemcitabine
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- TGF-β-induced STAT3 overexpression promotes human head and neck squamous cell carcinoma invasion and metastasis through malat1/miR-30a interactions
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- Annexin A2 overexpression associates with colorectal cancer invasiveness and TGF-ß induced epithelial mesenchymal transition via Src/ANXA2/STAT3
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- The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies
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- Role of tumor-derived exosomes in cancer metastasis
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- A DHX9-lncRNA-MDM2 interaction regulates cell invasion and angiogenesis of cervical cancer
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- SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression
- (2018) Jinfang Zhang et al. DEVELOPMENTAL CELL
- GRIM‐19 repressed hypoxia‐induced invasion and EMT of colorectal cancer by repressing autophagy through inactivation of STAT3/HIF‐1α signaling axis
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- CircRNAs and cancer: Biomarkers and master regulators
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- Thymoquinone Inhibits Bone Metastasis of Breast Cancer Cells Through Abrogation of the CXCR4 Signaling Axis
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- Stemness, Pluripotentiality, and Wnt Antagonism: sFRP4, a Wnt antagonist Mediates Pluripotency and Stemness in Glioblastoma
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- The STAT3/Slug Axis Enhances Radiation-Induced Tumor Invasion and Cancer Stem-like Properties in Radioresistant Glioblastoma
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- Overexpression of Indoleamine 2,3-Dioxygenase 1 Promotes Epithelial-Mesenchymal Transition by Activation of the IL-6/STAT3/PD-L1 Pathway in Bladder Cancer
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- Icariin exerts inhibitory effects on the growth and metastasis of KYSE70 human esophageal carcinoma cells via PI3K/AKT and STAT3 pathways
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- Long non-coding RNA CCAT1 promotes metastasis and poor prognosis in epithelial ovarian cancer
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- MiR-93-5p inhibits the EMT of breast cancer cells via targeting MKL-1 and STAT3
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- Antagonistic Effects of p53 and HIF1A on microRNA-34a Regulation of PPP1R11 and STAT3 and Hypoxia-induced Epithelial to Mesenchymal Transition in Colorectal Cancer Cells
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- Tanshinone IIA Inhibits Epithelial-Mesenchymal Transition in Bladder Cancer Cells via Modulation of STAT3-CCL2 Signaling
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- miR-345 inhibits tumor metastasis and EMT by targeting IRF1-mediated mTOR/STAT3/AKT pathway in hepatocellular carcinoma
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- Wanted DEAD/H or Alive: Helicases Winding Up in Cancers
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- Jak Stat signaling and cancer: Opportunities, benefits and side effects of targeted inhibition
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- PPARγ Ligand–induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers
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- EMT, CSCs, and drug resistance: the mechanistic link and clinical implications
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- OS10.3 Randomized Phase 3 Study Evaluating the Efficacy and Safety of Nivolumab vs Bevacizumab in Patients With Recurrent Glioblastoma: CheckMate 143
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- miR520c blocks EMT progression of human breast cancer cells by repressing STAT3
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- Irisin reverses the IL-6 induced epithelial-mesenchymal transition in osteosarcoma cell migration and invasion through the STAT3/Snail signaling pathway
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- Basic Transcription Factor 3 Is Required for Proliferation and Epithelial‐Mesenchymal Transition via Regulation of FOXM1 and JAK2/STAT3 Signaling in Gastric Cancer
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- TMPRSS4 Upregulates TWIST1 Expression through STAT3 Activation to Induce Prostate Cancer Cell Migration
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- Quercetin inhibits epithelial–mesenchymal transition, decreases invasiveness and metastasis, and reverses IL-6 induced epithelial–mesenchymal transition, expression of MMP by inhibiting STAT3 signaling in pancreatic cancer cells
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- MicroRNA-216a inhibits the metastasis of gastric cancer cells by targeting JAK2/STAT3-mediated EMT process
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- Chemotherapy-mediated miR-29b expression inhibits the invasion and angiogenesis of cervical cancer
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- ING5 knockdown enhances migration and invasion of lung cancer cells by inducing EMT via EGFR/PI3K/Akt and IL-6/STAT3 signaling pathways
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- IL-6/STAT3/TWIST inhibition reverses ionizing radiation-induced EMT and radioresistance in esophageal squamous carcinoma
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- IL-6 secreted by cancer-associated fibroblasts promotes epithelial-mesenchymal transition and metastasis of gastric cancer via JAK2/STAT3 signaling pathway
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- Wanted DEAD/H or Alive: Helicases Winding Up in Cancers
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- Breast Cancer Stem-Like Cells Are Inhibited by Diosgenin, a Steroidal Saponin, by the Attenuation of the Wnt β-Catenin Signaling via the Wnt Antagonist Secreted Frizzled Related Protein-4
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- Potential role of targeted therapies in the treatment of triple-negative breast cancer
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- Annexins A2 and A8 in endothelial cell exocytosis and the control of vascular homeostasis
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- Epithelial-mesenchymal transition in tissue repair and fibrosis
- (2016) Rivka C. Stone et al. CELL AND TISSUE RESEARCH
- WSTF promotes proliferation and invasion of lung cancer cells by inducing EMT via PI3K/Akt and IL-6/STAT3 signaling pathways
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- IL-6/STAT3 Plays a Regulatory Role in the Interaction Between Pancreatic Stellate Cells and Cancer Cells
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- Inhibition of STAT3 enhances the radiosensitizing effect of temozolomide in glioblastoma cells in vitro and in vivo
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- Fractionated irradiation-induced EMT-like phenotype conferred radioresistance in esophageal squamous cell carcinoma
- (2016) Hongfang Zhang et al. JOURNAL OF RADIATION RESEARCH
- Ascochlorin Enhances the Sensitivity of Doxorubicin Leading to the Reversal of Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma
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- The biogenesis and emerging roles of circular RNAs
- (2016) Ling-Ling Chen NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Upregulation of MEK5 by Stat3 promotes breast cancer cell invasion and metastasis
- (2016) Fang Liu et al. ONCOLOGY REPORTS
- Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1: Role in apoptosis induction and radiosensitization in head and neck tumor cells
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- Potential of neem ( Azadirachta indica L.) for prevention and treatment of oncologic diseases
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- IGF/STAT3/NANOG/Slug Signaling Axis Simultaneously Controls Epithelial-Mesenchymal Transition and Stemness Maintenance in Colorectal Cancer
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- NANOG regulates epithelial-mesenchymal transition and chemoresistance through activation of the STAT3 pathway in epithelial ovarian cancer
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- Interleukin-32α inactivates JAK2/STAT3 signaling and reverses interleukin-6-induced epithelial–mesenchymal transition, invasion, and metastasis in pancreatic cancer cells
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- Gankyrin promotes epithelial-mesenchymal transition and metastasis in NSCLC through forming a closed circle with IL-6/ STAT3 and TGF-β/SMAD3 signaling pathway
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- ANXA1 inhibits miRNA-196a in a negative feedback loop through NF-kB and c-Myc to reduce breast cancer proliferation
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- Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives
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- Structure and Functional Characterization of the Conserved JAK Interaction Region in the Intrinsically Disordered N-Terminus of SOCS5
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- Farnesol inhibits tumor growth and enhances the anticancer effects of bortezomib in multiple myeloma xenograft mouse model through the modulation of STAT3 signaling pathway
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- Isorhamnetin augments the anti-tumor effect of capeciatbine through the negative regulation of NF-κB signaling cascade in gastric cancer
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- Persistent activation of STAT3 by PIM2-driven positive feedback loop for epithelial-mesenchymal transition in breast cancer
- (2015) Nizam Uddin et al. CANCER SCIENCE
- Rindopepimut vaccine and bevacizumab combination therapy: improving survival rates in relapsed glioblastoma patients?
- (2015) Martha R Neagu et al. Immunotherapy
- Ascochlorin, an isoprenoid antibiotic inhibits growth and invasion of hepatocellular carcinoma by targeting STAT3 signaling cascade through the induction of PIAS3
- (2015) Xiaoyun Dai et al. Molecular Oncology
- Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis
- (2015) Sara Lovisa et al. NATURE MEDICINE
- STAT3 integrates cooperative Ras and TGF-β signals that induce Snail expression
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- Cytoplasmic p27 promotes epithelial–mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation
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- Primary malignant lymphoma of the uterus and broad ligament: a case report and review of literature
- (2015) Bao-An Chen et al. OncoTargets and Therapy
- Luteolin decreases invasiveness, deactivates STAT3 signaling, and reverses interleukin-6 induced epithelial–mesenchymal transition and matrix metalloproteinase secretion of pancreatic cancer cells
- (2015) Xince Huang et al. OncoTargets and Therapy
- Inhibition of ERRα suppresses epithelial mesenchymal transition of triple negative breast cancer cells by directly targeting fibronectin
- (2015) Ying-Min Wu et al. Oncotarget
- MiR-125a suppresses tumor growth, invasion and metastasis in cervical cancer by targeting STAT3
- (2015) Zhongyi Fan et al. Oncotarget
- Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel
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- Anxa2 binds to STAT3 and promotes epithelial to mesenchymal transition in breast cancer cells
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- Acquisition of resistance to trastuzumab in gastric cancer cells is associated with activation of IL-6/STAT3/Jagged-1/Notch positive feedback loop
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- Multiple regulation pathways and pivotal biological functions of STAT3 in cancer
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- Negative regulation of signal transducer and activator of transcription-3 signalling cascade by lupeol inhibits growth and induces apoptosis in hepatocellular carcinoma cells
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- Bergamottin, a natural furanocoumarin obtained from grapefruit juice induces chemosensitization and apoptosis through the inhibition of STAT3 signaling pathway in tumor cells
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- Immunotherapy for Primary Brain Tumors: No Longer a Matter of Privilege
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- Effect of the STAT3 inhibitor STX-0119 on the proliferation of a temozolomide-resistant glioblastoma cell line
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- Development of a Novel Azaspirane That Targets the Janus Kinase-Signal Transducer and Activator of Transcription (STAT) Pathway in Hepatocellular Carcinomain Vitroandin Vivo
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- Decreased Amyloid-β Pathologies by Intracerebral Loading of Glycosphingolipid-enriched Exosomes in Alzheimer Model Mice
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- Vaccine therapies for patients with glioblastoma
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- Overexpression of ANXA2 predicts adverse outcomes of patients with malignant tumors: a systematic review and meta-analysis
- (2014) Xinyu Liu et al. MEDICAL ONCOLOGY
- RRAD Promotes EGFR-Mediated STAT3 Activation and Induces Temozolomide Resistance of Malignant Glioblastoma
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- Abrogation of STAT3 signaling cascade by zerumbone inhibits proliferation and induces apoptosis in renal cell carcinoma xenograft mouse model
- (2014) Muthu K. Shanmugam et al. MOLECULAR CARCINOGENESIS
- Sphingolipid metabolites in inflammatory disease
- (2014) Michael Maceyka et al. NATURE
- Detecting and characterizing circular RNAs
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- Molecular mechanisms of epithelial–mesenchymal transition
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- A phase II trial of everolimus, temozolomide, and radiotherapy in patients with newly diagnosed glioblastoma: NCCTG N057K
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- A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma
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- Bevacizumab plus Radiotherapy–Temozolomide for Newly Diagnosed Glioblastoma
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- A ROS/STAT3/HIF-1α signaling cascade mediates EGF-induced TWIST1 expression and prostate cancer cell invasion
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- Cancer Associated Fibroblasts express pro-inflammatory factors in human breast and ovarian tumors
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- STAT3 mediates TGF-β1-induced TWIST1 expression and prostate cancer invasion
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- Capillarisin inhibits constitutive and inducible STAT3 activation through induction of SHP-1 and SHP-2 tyrosine phosphatases
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- Garcinol, a Polyisoprenylated Benzophenone Modulates Multiple Proinflammatory Signaling Cascades Leading to the Suppression of Growth and Survival of Head and Neck Carcinoma
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- Targeting the androgen receptor with siRNA promotes prostate cancer metastasis through enhanced macrophage recruitment via CCL2/CCR2-induced STAT3 activation
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- Annexin A2 Regulates β1 Integrin Internalization and Intestinal Epithelial Cell Migration
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- The epigenetics of epithelial-mesenchymal plasticity in cancer
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- Stat3-coordinated Lin-28–let-7–HMGA2 and miR-200–ZEB1 circuits initiate and maintain oncostatin M-driven epithelial–mesenchymal transition
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- Cancer Stem Cells: Current Status and Evolving Complexities
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- Targeting EGF receptor variant III: tumor-specific peptide vaccination for malignant gliomas
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- HBx-dependent activation of twist mediates STAT3 control of epithelium-mesenchymal transition of liver cells
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- Ursolic Acid Inhibits the Initiation, Progression of Prostate Cancer and Prolongs the Survival of TRAMP Mice by Modulating Pro-Inflammatory Pathways
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- Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts
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- Extracellular and intracellular sphingosine-1-phosphate in cancer
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- The role of the N-terminal domain in dimerization and nucleocytoplasmic shuttling of latent STAT3
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- p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2
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- The effects and mechanisms of blockage of STAT3 signaling pathway on IL-6 inducing EMT in human pancreatic cancer cells in vitro
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- Hyperactive EGF receptor, Jaks and Stat3 signaling promote enhanced colony-forming ability, motility and migration of cisplatin-resistant ovarian cancer cells
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- E-Cadherin loss associated with EMT promotes radioresistance in human tumor cells
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- Signalling pathways in vasculogenic mimicry
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- Bcl-XL and STAT3 mediate malignant actions of γ-irradiation in lung cancer cells
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- EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
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- Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis
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- TGF-β-induced epithelial to mesenchymal transition
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- Polo-like kinase inhibitors: an emerging opportunity for cancer therapeutics
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- Crystal structure of unphosphorylated STAT3 core fragment
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- Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial–mesenchymal transition in ovarian carcinomas
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- Inhibition of STAT3Tyr705 Phosphorylation by Smad4 Suppresses Transforming Growth Factor -Mediated Invasion and Metastasis in Pancreatic Cancer Cells
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- The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
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- Epidermal growth factor-induced ovarian carcinoma cell migration is associated with JAK2/STAT3 signals and changes in the abundance and localization of α6β1 integrin
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