Article
Oncology
Jian Zhou, Ningbo Xu, Boyang Liu, Chenyang Wang, Zhenyan He, Cameron Lenahan, Wenhui Tang, Huijun Zeng, Hongbo Guo
Summary: The study identified the important role of the XLOC/Sp1/PIK3R2/PI3K/AKT axis in GBM TMZ resistance. XLOC was found to regulate TMZ resistance, cell proliferation, and apoptosis in GBM.
Article
Oncology
Junhui Liu, Lun Gao, Xiaonan Zhu, Rongxin Geng, Xiang Tao, Haitao Xu, Zhibiao Chen
Summary: The study revealed that GSDMD expression was upregulated in glioma, significantly associated with WHO grade IV, IDH 1/2 wild-type, and mesenchymal subtypes, as well as shorter overall survival. GSDMD may participate in regulating macrophage infiltration and polarization, serving as a prognostic biomarker and TMZ-treatment response marker in glioma.
Article
Biochemistry & Molecular Biology
Ceyhan Hacioglu, Cengiz Tuncer
Summary: This study demonstrates that boric acid can enhance chemosensitivity in TMZ-resistant GBM cells by modulating the ferritinophagy pathway.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Tingting Ye, Rongrong Chen, Yu Zhou, Juan Zhang, Zhongqin Zhang, Hui Wei, Yan Xu, Yulan Wang, Yinlan Zhang
Summary: This study found that Sal A treatment can inhibit the malignant behaviors of glioma cells and improve the sensitivity of TMZ by inactivating the TAGLN2/PI3K/Akt pathway.
Article
Oncology
Yan Zou, Zi'xiang Liu, Yi'nan Zhou, Jing Wang, Qin'yi Xu, Xu'dong Zhao, Zeng'li Miao
Summary: Research has found that TRPC5 and P-gp are upregulated in TMZ-resistant glioblastoma cells, and downregulation of TRPC5 can inhibit P-gp expression and significantly reverse TMZ resistance; TRPC5-siRNA limited the tumor xenograft growth of TMZ-resistant cells in an athymic nude mouse model; in specimens from patients with recurrent glioblastoma, TRPC5 and P-gp are highly expressed.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Oncology
Deheng Li, Liangdong Li, Xin Chen, Wentao Yang, Yiqun Cao
Summary: A novel upregulated circRNA, circSERPINE2, was identified in glioblastoma, promoting tumor cell proliferation and progression by sponging miRNAs and enhancing the expression of the anti-apoptosis gene BCL2. This study reveals the biological function and mechanism of circSERPINE2 in glioblastoma progression, suggesting its potential as a therapeutic target.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Biochemistry & Molecular Biology
Xin Bu, Xuan Qu, Kai Guo, Xiangliang Meng, Xing Yang, Qike Huang, Wenjie Dou, Lin Feng, Xinxin Wei, Jiwei Gao, Wei Sun, Min Chao, Liying Han, Yaqin Hu, Liangliang Shen, Jian Zhang, Liang Wang
Summary: CD147 overexpression contributes to TMZ resistance in glioma cells through post-translational regulation of Nrf2 expression. Suppression of CD147 expression enhances the inhibitory effect of TMZ on cell survival by inhibiting GSK3 beta/beta-TrCP-dependent Nrf2 degradation and increasing Nrf2-mediated anti-oxidant gene expressions. Targeting CD147/Nrf2 axis may provide a new strategy for the treatment of TMZ resistant gliomas.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Qiongying Zhang, Ruichun Bi, Xiaodong Bao, Xiaohui Xu, Daoquan Fang, Lei Jiang
Summary: This study reveals that MYT1L gene plays a role in promoting migration and invasion of glioma cells. Through activation of the Notch signaling pathway, MYT1L enhances cell migration and invasion, while inhibition of MYT1L or blocking the Notch pathway suppresses these processes. These findings suggest that MYT1L could be a potential target for glioma treatment.
Article
Neurosciences
Yu-Hua Hu, Bao-Hua Jiao, Cheng-Ye Wang, Jian-Liang Wu
Summary: RIP2 is involved in TMZ resistance through the regulation of the NF-κB/MGMT signaling pathway. Interference with NF-κB or MGMT activity may be a novel strategy for treating RIP2-positive TMZ-resistant glioma.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Yan-Qing Fei, Ru-Ting Shi, Yang-Fan Zhou, Jin-Ze Wu, Zhi Song
Summary: Mannose inhibits glioma cell growth and enhances sensitivity to TMZ, possibly through the inhibition of MGMT and activation of the Wnt/beta-catenin pathway.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nanxi Shen, Wenzhi Lv, Shihui Li, Dong Liu, Yan Xie, Ju Zhang, Jiaxuan Zhang, Jingjing Jiang, Rifeng Jiang, Wenzhen Zhu
Summary: The use of multiparametric MRI radiomics can predict Notch signaling and correlate with biological characteristics in gliomas, providing a noninvasive method for prognostic evaluation and therapeutic intervention. The radiomics nomogram shows good diagnostic performance and calibration, confirming its clinical usefulness.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Cell Biology
Ke Gao, Tuo Wang, Yuan Qiao, Bo Cui
Summary: In this study, it was found that miR-30e-3p plays a critical role in glioma development by inhibiting cell growth and modulating drug sensitivity to TMZ through negative regulation of CNPY2. Overexpression of miR-30e-3p decreased proliferation and increased apoptosis of glioma cells treated with TMZ. Insights from this study suggest that miR-30e-3p/CNPY2 could potentially serve as a novel therapeutic target for improving glioma therapy.
Review
Pharmacology & Pharmacy
Yongguang Gao, Zhanda Fu, Junxia Guan, Xinhua Liu, Qing Zhang
Summary: Metabolic bone diseases are the third most common endocrine disorders, affecting over 500 million people worldwide. The Notch signaling pathway plays a crucial role in the development and regulation of bone metabolic diseases. Genetic mutations in Notch signaling genes can lead to various metabolic bone diseases. This review provides insights into the mechanisms and clinical manifestations of these diseases, aiming to raise awareness and offer new approaches for diagnosis and treatment of metabolic bone diseases.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Cell Biology
Aishun Guo, Guixia Fang, Zhenrong Lin, Shuishun Zheng, Zhijun Zhuang, Ruisheng Lin, Yanling Lin
Summary: This study found that IRAIN expression was down-regulated in glioma tissues. Low IRAIN expression was associated with larger tumor volume and higher pathological stages. Overexpression of IRAIN inhibited glioma cell proliferation, invasion, and migration, promoted apoptosis, and attenuated IGF-1R-PI3K-NF-kappa B expression and temozolomide resistance.
HISTOLOGY AND HISTOPATHOLOGY
(2022)
Article
Oncology
Yusheng Chen, Fengjin Ma, Zhe Zhang, Yang Guo, Hanwei Shen, Hang Chen
Summary: PVT1, a previously uncharacterized lncRNA, was found to be a critical regulator in glioma, involved in cell proliferation, cell motility, angiogenesis, and chemo-resistance. Elevated PVT1 expression was associated with aggressive progression of glioma, accompanied by PTEN and EGFR alterations. Functional analysis revealed that PVT1 inhibited the sensitivity of TMZ chemotherapy via the JAK/STAT signaling pathway.