Review
Pathology
Mohsen Karami Fath, Menooa Ebrahimi, Ehsan Nourbakhsh, Ahmad Zia Hazara, Ali Mirzaei, Saba Shafieyari, Azadeh Salehi, Mahsa Hoseinzadeh, Zahra Payandeh, Ghasem Barati
Summary: Cancer stem cells (CSCs) play a crucial role in tumor formation and resistance to therapy. Understanding the PI3K/Akt/mTOR signaling pathway in CSCs can provide insights into targeted therapy for drug-resistant tumors. While this pathway is well-known in tumor bulk, its functions in CSCs have not been fully explored.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Plant Sciences
Cuixia Liang, Yongjie Jiang, Lizhu Sun
Summary: The study showed that vitexin has inhibitory effects on the development of endometrial cancer and clarified its potential mechanism. Vitexin can inhibit cell proliferation, angiogenesis, and stemness capacity, and it also blocks tumor growth of endometrial cancer in vivo.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Cell & Tissue Engineering
Shuang Chen, Kang Li, Xinqi Zhong, Ganping Wang, Xiaocheng Wang, Maosheng Cheng, Jie Chen, Zhi Chen, Jianwen Chen, Caihua Zhang, Gan Xiong, Xiuyun Xu, Demeng Chen, Heping Li, Liang Peng
Summary: Our study demonstrates that Sox9-expressing cells promote lung tissue regeneration, with their ablation leading to severe radiation damage phenotypes. Through analysis of an online scRNA-Seq dataset, we found that the PI3K/AKT pathway is enriched in Sox9-expressing cells during lung epithelium regeneration.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Oncology
Hongyu Li, Boying Wang, Benquan Qi, Guojun Jiang, Min Qin, Meiling Yu
Summary: This study found that Cx32 regulates the expansion of liver cancer stem cells (LCSCs), and increased expression of Cx32 significantly inhibits the expansion of LCSCs, suggesting that Cx32 may be an optimal target for intervention of hepatocellular carcinoma (HCC).
Article
Biochemistry & Molecular Biology
Zongkui Wang, Peng Jiang, Fengjuan Liu, Xi Du, Li Ma, Shengliang Ye, Haijun Cao, Pan Sun, Na Su, Fangzhao Lin, Rong Zhang, Changqing Li
Summary: This study reveals that GDF11 negatively regulates neurogenesis by activating the ALK5-dependent PI3K-Akt signaling pathway in neural stem cells, inhibiting cell proliferation and migration while promoting differentiation and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Yi Cheng, Guiying Wang, Lianmei Zhao, Suli Dai, Jing Han, Xuhua Hu, Chaoxi Zhou, Feifei Wang, Hongqing Ma, Baokun Li, Zesong Meng
Summary: The study found that PPM can inhibit CRC cell proliferation, induce cell apoptosis, and promote G0/G1 cell cycle arrest. Additionally, PPM's effect may be related to the PI3K/AKT signaling pathway, with minimal impact on mouse functions and enhanced anticancer effects when combined with 5-FU.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Junwen Wang, Ziyi Wang, Limeng Dai, Xintong Zhu, Xingying Guan, Junyi Wang, Jia Li, Mao Zhang, Yun Bai, Hong Guo
Summary: The deficiency of Supt16 disrupts the self-renewal of human neural stem cells (hNSCs), leading to cell cycle arrest, impaired cell proliferation, and increased apoptosis. This provides a novel perspective to understand the causality between Supt16 heterozygous NSCs and neurodevelopmental disorders (NDDs) in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Peipei Xu, Xiongshi Lin, Xing Dong, Ying Liu, Zhichong Wang, Shuangyong Wang
Summary: This study discovered that trigeminal nerve-derived substance P (SP) can promote corneal epithelial homeostasis and wound healing closure, as well as enhance the proliferation and stemness of limbal stem cells (LSCs). Through in vivo and in vitro experiments and RNA sequencing analysis, the positive effects of SP on LSCs and its underlying mechanism were revealed. The findings showed that SP regulated LSCs functions by modulating the PI3K-AKT pathway, which may provide new insights into the regulation of LSCs' fate and stem cell therapy.
Article
Biochemistry & Molecular Biology
Ghmkin Hassan, Said M. Afify, Juan Du, Hend M. Nawara, Mona Sheta, Sadia Monzur, Maram H. Zahra, Hagar A. Abu Quora, Hager Mansour, Samah El-Ghlban, Ryo Uesaki, Akimasa Seno, Masaharu Seno
Summary: The MEK inhibitor AZD-6244 plays a critical role in the conversion of iPS cells into CSCs, with the converted cells maintaining self-renewal ability, stemness gene expression, and increased migration and invasion abilities.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Ji-Hye Park, Young-Heon Kim, Sehwan Shim, Areumnuri Kim, Hyosun Jang, Su-Jae Lee, Sunhoo Park, Songwon Seo, Won Il Jang, Seung Bum Lee, Min-Jung Kim
Summary: SOX2 plays a crucial role in maintaining colorectal cancer stem-like properties by regulating CD44 expression through the PI3K/AKT pathway, leading to enhanced resistance to radiation and metastatic potential. This highlights the potential of SOX2 as a therapeutic target in aggressive colorectal cancer.
Article
Environmental Sciences
Lulu Niu, Wenwen Li, Xin Chen, Xiaosan Su, Jingjing Dong, Quanyang Liao, Xuhong Zhou, Shaoqing Shi, Ruifen Sun
Summary: The active constituent 1-Monopalmitin (1-Mono) in Mougeotia nummuloides and Spirulina major inhibits the proliferation of lung cancer cells and induces apoptosis through the PI3K/Akt pathway. It also suppresses autophagy, and combining with autophagy inhibitor Chloroquine enhances its cytotoxicity.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Chemistry, Medicinal
Hui Shan, Xin Zhang, Yalu Mi, Jihui Jia, Bo Wang, Qing Yang
Summary: This study identifies eriodictyol as the most effective anti-gastric cancer flavonoid from Polygoni orientalis Fructus (POF) and investigates its potential targets in gastric cancer. Eriodictyol exhibits inhibitory effects on gastric cancer cell viability, suppresses colony formation, induces cell apoptosis, and inhibits tumor growth in vivo. Network pharmacology analysis suggests that the PI3K/AKT signaling pathway may be a potential target for eriodictyol in gastric cancer.
Article
Cell Biology
Han Dai, Wenjing Hu, Lianying Zhang, Feiyu Jiang, Xiongmin Mao, Gangyi Yang, Ling Li
Summary: Research showed that FGF21 was significantly downregulated in prostate cancer tissues and cell lines, and inhibited PCa cell proliferation and promoted apoptosis through facilitated autophagy.
CELL DEATH & DISEASE
(2021)
Review
Oncology
Huayi Li, Lorenzo Prever, Emilio Hirsch, Federico Gulluni
Summary: The PI3K signaling pathway is crucial in breast cancer and inhibitors targeting this pathway show promising activity, but resistance and adverse reactions limit their efficacy. Combination therapies and identifying suitable patient subpopulations are needed to enhance therapeutic benefit.
Article
Multidisciplinary Sciences
Jingjing Shang, Zhentang Yu, Chengwei Xiong, Junjie Zhang, Jinhong Gong, Changlin Yu, Yong Huang, Xindie Zhou
Summary: Osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) plays a crucial role in bone defect regeneration. Resistin, an adipose tissue-specific secretory factor, has diverse functions including metabolism, inflammation, cancer, and bone remodeling. However, the effects and mechanisms of resistin on BMSCs' osteogenic differentiation are still unclear.
Article
Orthopedics
Brendan C. Yi, Anirudh K. Gowd, Avinesh Agarwalla, Eric Chen, Nirav H. Amin, Gregory P. Nicholson, Anthony A. Romeo, Joseph N. Liu
Summary: This study examined the association between surgical complications and comorbidity indices in patients undergoing surgery for proximal humerus fractures, finding that both mFI-5 and mCCI were significantly associated with adverse events but had moderate predictive ability.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2021)
Article
Multidisciplinary Sciences
Donghoon Han, Si-Hyuck Kang, Chang-Hwan Yoon, Tae-Jin Youn, In-Ho Chae
Summary: This study investigated the efficacy of intracoronary administration of EDTA as an adjunctive treatment to reduce ischemia-reperfusion (IR) injury in a swine model. The results showed that EDTA significantly reduced infarct size, mitochondrial damage, and post-infarct remodeling. Further clinical studies are warranted to evaluate the efficacy of EDTA in patients with ST-segment elevation myocardial infarction.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Biomedical
Junsun Hwang, Sungwoong Jeon, Beomjoo Kim, Jin-young Kim, Chaewon Jin, Ara Yeon, Byung-Ju Yi, Chang-Hwan Yoon, Hun-Jun Park, Salvador Pane, Bradley J. Nelson, Hongsoo Choi
Summary: Robotic magnetic manipulation systems have potential benefits in medical fields for precise and selective manipulation of magnetically responsive instruments. This study presents a clinically translatable electromagnetically controllable microrobotic interventional system (ECMIS). Through preclinical and clinical studies, ECMIS demonstrates potential clinical effectiveness in real-time cardiovascular interventions.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Cardiac & Cardiovascular Systems
Jung-Joon Cha, Jong-Youn Kim, Hyoeun Kim, Young-Guk Ko, Donghoon Choi, Jae-Hwan Lee, Chang-Hwan Yoon, In-Ho Chae, Cheol Woong Yu, Seung Whan Lee, Sang-Rok Lee, Seung Hyuk Choi, Yoon Seok Koh, Pil-Ki Min
Summary: This study investigated the long-term outcomes of chronic limb threatening ischemia (CLTI) patients who underwent endovascular therapy (EVT). The results showed that age, end-stage renal disease (ESRD), Rutherford category 6, and suboptimal EVT were predictors of major amputation or death, while smoking provided protection. Low body mass index, ESRD, femoropopliteal lesion, Rutherford category 6, and suboptimal EVT were predictors of major adverse limb events (MALE). The highest hazard rates were observed within the first 6 months, followed by a decrease and then a rise after 3-4 years.
KOREAN CIRCULATION JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Chang-Hwan Yoon, Jihong Jang, Seung Ho Hur, Jun-Hee Lee, Seung Hwan Han, Soon-Jun Hong, Kiyuk Chang, In-Ho Chae
Summary: This study compared the safety and efficacy of the Osstem Cardiotec Centum stent with the Xience stent. The results showed that the Osstem Cardiotec Centum stent was non-inferior to the Xience stent in terms of efficacy and superior in terms of safety. Therefore, the Osstem Cardiotec Centum stent can be safely and effectively used in patients with coronary artery disease.
KOREAN CIRCULATION JOURNAL
(2022)
Article
Oncology
Seungkyung Kang, Miree Park, Jung Yeon Cho, Su Jin Ahn, Changhwan Yoon, Sang Gyun Kim, Soo-Jeong Cho
Summary: Estrogen and Helicobacter pylori together promote the progression of diffuse-type gastric cancer, particularly in young women. By regulating HOTAIR expression, estrogen and H. pylori enhance epithelial-mesenchymal transition and stemness phenotypes. These findings are of great importance for understanding the mechanisms of gastric cancer development and providing preventive and therapeutic strategies.
Article
Oncology
Mason D. Stillman, Nicole Kusche, Sabrina Toledano, Kimberly J. Hilfrank, Changhwan Yoon, Joel T. Gabre, Sheila D. Rustgi, Chin Hur, Fay Kastrinos, Sandra W. Ryeom, Sam S. Yoon
Summary: This study reviewed patients with CDH1 mutation who underwent PTG surgery and found that PTG can be performed safely at high-volume referral centers with good quality of life, although nutritional sequelae persist in some patients.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Chang-Hwan Yoon, Ju-Seung Kwun, Young Jin Choi, Jin Joo Park, Si-Hyuck Kang, Sun-Hwa Kim, Jung-Won Suh, Tae-Jin Youn, Myeong-Kon Kim, Kwang Soo Cha, Seung-Hwan Lee, Bum-Kee Hong, Seung-Woon Rha, Woong Chol Kang, Jae-Hwan Lee, Sang-Hyun Kim, In-Ho Chae
Summary: This study compared the long-term clinical outcomes of patients treated with ultrathin-strut biodegradable polymer sirolimus-eluting stents (BP-SES) and thick-strut biodegradable polymer biolimus-eluting stents (BP-BES). The results showed that the ultrathin-strut BP-SES had significantly lower target lesion failure rates and better outcomes compared to the thick-strut BP-BES.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Biochemistry & Molecular Biology
Alexander M. M. Minikes, Yu Song, Yan Feng, Changhwan Yoon, Sam S. S. Yoon, Xuejun Jiang
Summary: Gastric cancer, particularly the aggressive subtype diffuse-type gastric cancer (DGC), is difficult to detect and treat. In this study, it was found that DGC cells with loss-of-function mutation of E-cadherin are more sensitive to ferroptosis, a non-apoptotic, iron-dependent form of cell death. E-cadherin suppresses ferroptosis through activation of the Hippo pathway. Mutations in E-cadherin that reduce its homophilic binding capacity reverse its ability to suppress ferroptosis. Additionally, circulating DGC cells lacking E-cadherin have lower metastatic ability due to their susceptibility to ferroptosis. This study suggests E-cadherin as a biomarker for predicting ferroptosis sensitivity in DGC cells and guiding future therapeutic usage.
Article
Oncology
Changhwan Yoon, Jun Lu, Yukyung Jun, Yun-Suhk Suh, Bang-Jin Kim, Jacob E. Till, Jong Hyun Kim, Sara H. Keshavjee, Sandra Ryeom, Sam S. Yoon
Summary: Activation of KRAS in gastric cancer stem-like cells (CSCs) enhances secretion of pro-angiogenic factors, promoting tumor progression and metastasis.
Article
Cell Biology
Sung Joon Park, Hyun Jin Min, Changhwan Yoon, Seong Hee Kim, Jin Hyun Kim, Sei Young Lee
Summary: This study evaluated the role of integrin beta 1 (ITGB1) in perineural invasion, radioresistance, and tumor aggressiveness of oral squamous cell carcinoma (OSCC). It found that ITGB1 was overexpressed in radioresistant OSCC, especially in cancer stem cell-like cells. Inhibiting ITGB1 significantly reduced adhesion to neuronal cells, resistance to radiation, invasion and migration of radioresistant OSCC, as well as the expression of cancer stem cell markers and spheroid formations. These findings suggest that ITGB1 may be a promising therapeutic target for radioresistant OSCC.
CELLULAR SIGNALLING
(2023)
Article
Public, Environmental & Occupational Health
Changhwan Yoon, Jun Lu, Yukyung Jun, Yun-Suhk Suh, Bang-Jin Kim, Jacob E. Till, Jong Hyun Kim, Sara H. Keshavjee, Sandra Ryeom, Sam S. Yoon
Summary: This study reveals that KRAS activation in gastric cancer stem-like cells (CSCs) enhances the secretion of pro-angiogenic factors and promotes tumor progression and metastasis. Inhibition of KRAS significantly reduces the secretion of factors such as VEGF-A, which are important for tumor angiogenesis. Additionally, high expression of the gastric CSC marker CD44 is associated with expression of both KRAS and VEGF-A, and predicts worse overall survival in gastric cancer patients.
Article
Cardiac & Cardiovascular Systems
Ji Woong Roh, Sanghoon Shin, Young-Guk Ko, Nak-Hoon Son, Chul-Min Ahn, Pil-Ki Min, Jae-Hwan Lee, Chang-Hwan Yoon, Cheol Woong Yu, Seung Whan Lee, Sang-Rok Lee, Seung Hyuk Choi, In-Ho Chae, Donghoon Choi
Summary: This study investigated the long-term outcomes of iliac artery endovascular therapy (EVT) and analyzed the results according to TASC classifications. The study found that EVT achieved excellent technical success and 5-year TLR-free survival. However, patients with TASC D lesions had a lower TLR-free survival rate and a higher complication rate compared to other TASC groups.
KOREAN CIRCULATION JOURNAL
(2022)
Article
Peripheral Vascular Disease
Bong-Joon Kim, Kyoung-Im Cho, Hyuck Moon Kwon, Seung-Min Choi, Chang-Hwan Yoon, Sang Wook Lim, Seung-Jae Joo, Nam Ho Lee, Sang-Yup Lim, Seong-Hoon Lim, Hyo-Soo Kim
Summary: This study found that a telmisartan 40 mg/S-amlodipine 2.5 mg fixed-dose combination was more effective and tolerable than telmisartan 80 mg in patients with essential hypertension who did not respond to telmisartan 40 mg treatment.
CLINICAL HYPERTENSION
(2022)