Journal
ONCOTARGET
Volume 8, Issue 7, Pages 11228-11238Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.14495
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Funding
- National Natural Science Foundation for Young Scholars of China [81501520]
- Natural Science Foundation of Chongqing Science Technology [cstc2015jcyjA10021]
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The acquisition of radioresistance by esophageal squamous carcinoma (ESC) cells during radiotherapy may lead to cancer recurrence and poor survival. Previous studies have demonstrated that ionizing radiation (IR) induces epithelial-mesenchymal transition (EMT) of ESC cells accompanied by increased migration, invasion, and radioresistance. However, the underlying molecular mechanisms of IR-induced EMT and radioresistance are not well established, hampering the development of potential solutions. To address this issue, we investigated the role of the IL-6/STAT3/TWIST signaling pathway in IR-induced EMT. We found not only the pathway was activated during IR-induced EMT but also STAT3 inhibition or Twist depletion reversed the EMT process and attenuated radioresistance. These results improve our understanding of the underlying mechanisms involved in IR-induced EMT and suggest potential interventions to prevent EMT-induced acquisition of radioresistance.
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