Article
Ophthalmology
Chung-Ling Liang, Ku-Chung Chen, Edward Hsi, Jui-Yu Lin, Chien-Yuan Chen, Jung-Kai Tseng, Suh-Hang H. Juo
Summary: This study investigated the role of miR-328-3p in controlling myopia. The results showed that anti-miR-328-3p could reduce the expression of fibromodulin and collagen1A1 in myopic eyes, and it exerted its effects by regulating the expression of TGF-beta 1 and phosphorylation levels of p38-MAPK and JNK. Additionally, retinoic acid was found to up-regulate the expression of miR-328-3p. Animal studies demonstrated that anti-miR-328-3p effectively suppressed axial elongation. The toxicity study showed that anti-miR-328-3p had no adverse effects.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jiancong Lu, Junhong Lin, Yu Zhou, Kai Ye, Changquan Fang
Summary: In NSCLC, the majority of patients have lung adenocarcinoma (LA) with varying survival rates. PYCR1 gene and miR-328-3p are associated with cancer development, with miR-328-3p targeting PYCR1 to suppress LA cell malignancy by inhibiting cell proliferation and migration while promoting apoptosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Oncology
Matthew G. Davey, Sean O. Hynes, Michael J. Kerin, Nicola Miller, Aoife J. Lowery
Summary: In breast cancer development, the expression of Ki-67 is a valuable indicator for prognosis and treatment decision making. The advent of molecular medicine has transformed breast cancer management by recognizing the heterogeneity of the disease and using a combination of factors for substratification and personalization of treatment modalities. Routine evaluation of Ki-67 as a proliferation marker in breast cancer patients has limitations, but promising strategies are being explored to enhance its utility in future oncology.
Article
Oncology
Jing Li, Yinmou Li, Hong Cheng
Summary: This study indicates that the silencing of circ-RPPH1 can suppress the malignant phenotypes and glycolysis of breast cancer cells through the miR-328-3p/HMGA2 axis, thereby impeding the progression of breast cancer.
CLINICAL BREAST CANCER
(2022)
Article
Biotechnology & Applied Microbiology
Dong Zhang, Xiao-Jie Yang, Qi-Dong Luo, Li Xue, Tie Chong
Summary: The study revealed that p53 activates miR-519d-3p to suppress the expression of E2F1 and CD147, thereby inhibiting the growth and metastasis of prostate cancer.
CANCER GENE THERAPY
(2022)
Article
Medicine, Research & Experimental
Behzad Mansoori, Pascal H. G. Duijf, Ali Mohammadi, Elham Safarzadeh, Henrik J. Ditzel, Morten F. Gjerstorff, William Chi-Shing Cho, Behzad Baradaran
Summary: miR-142-3p directly targets the HMGA2 gene in breast cancer cells, leading to apoptosis, cell cycle arrest, and inhibition of cancer stem cell properties. This study provides evidence for miR-142-3p as a potential therapeutic target for breast cancer treatment, highlighting its role in regulating oncogenesis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Li Zhang, Mengyi Shen, Dingyi Zhang, Xin He, Qinglin Du, Nian Liu, Xiaohua Huang
Summary: A nomogram based on dual-sequence MRI radiomic features and clinical characteristics was developed to assess Ki-67 expression in breast cancer. It showed improved prediction efficiency compared to single-sequence models and clinical models.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Oncology
Z. M. Bai, X. F. Li, Y. Yang, Y. F. Yang, D. R. Lv, L. L. Tang
Summary: The study elucidated that propofol inhibits gastric cancer proliferation by suppressing the STAT3 pathway via up-regulating hsa-miR-328-3p.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2021)
Article
Cell Biology
Tsu-Yang Chao, Theresa Kordass, Wolfram Osen, Stefan B. Eichmueller
Summary: The miRNAs miR-134-3p and miR-224-3p were found to directly interact with the SOX9 gene and inhibit its expression in breast cancer cells. These two miRNAs were down-regulated in breast cancer tissues, suggesting their potential role as tumor suppressors in breast cancer progression.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yasemin Kayadibi, Burak Kocak, Nese Ucar, Yesim Namdar Akan, Pelin Akbas, Sibel Bektas
Summary: This study aimed to investigate the value of MRI-based radiomics in predicting Ki-67 expression of breast cancer. The results showed that the combination of ADC map-based selected radiomic features and a generalized linear model could be a promising non-invasive method to determine the Ki-67 expression level of breast cancer.
ACADEMIC RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tao Jiang, Wenyan Jiang, Shijie Chang, Hongbo Wang, Shuxian Niu, Zhibin Yue, Huazhe Yang, Xiaoyu Wang, Nannan Zhao, Siqi Fang, Yahong Luo, Xiran Jiang
Summary: This study aimed to evaluate the Ki-67 level in digital breast tomosynthesis (DBT) images of breast cancer patients using a subregional radiomics approach. Results showed that radiomics features extracted from the inner subregion had higher accuracy compared to the whole tumor region or marginal subregion.
Article
Health Care Sciences & Services
Paola Fuso, Mariantonietta Di Salvatore, Concetta Santonocito, Donatella Guarino, Chiara Autilio, Antonino Mule, Damiano Arciuolo, Antonina Rinninella, Flavio Mignone, Matteo Ramundo, Brunella Di Stefano, Armando Orlandi, Ettore Capoluongo, Nicola Nicolotti, Gianluca Franceschini, Alejandro Martin Sanchez, Giampaolo Tortora, Giovanni Scambia, Carlo Barone, Alessandra Cassano
Summary: The up-regulation of miRNAs let-7a-5p, mirR-100-5p, miR-101-3p, and miR-199a-3p is associated with better event-free survival and overall survival in breast cancer patients, regardless of breast cancer subtypes.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, Research & Experimental
Xiaodan Wang, Suibing Miao, Linqi Lu, Jingchuan Yuan, Shuhong Pan, Xiaohua Wu
Summary: Successful embryo implantation requires a competent embryo, a receptive endometrium, and synchronized communication between them. In this study, it was found that miR-519d-3p expression in the spent embryo culture medium (SCM) can be used as a biomarker for predicting pregnancy outcomes. It was also demonstrated that miR-519d-3p can negatively regulate embryo implantation by targeting HIF1 alpha.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Oncology
Reiko Mitsueda, Hiroko Toda, Yoshiaki Shinden, Kosuke Fukuda, Ryutaro Yasudome, Mayuko Kato, Naoko Kikkawa, Takao Ohtsuka, Akihiro Nakajo, Naohiko Seki
Summary: Accumulating evidence indicates that the miR-30 family plays a critical role in various human cancers, acting as either tumor suppressors or oncogenes. The downregulation of miR-30c-1-3p and miR-30c-2-3p in cancer tissues is associated with worse prognosis in breast cancer (BrCa) patients, and overexpression of these miRNAs inhibits cancer cell aggressiveness, suggesting their tumor-suppressor function in BrCa cells. Furthermore, TRIP13 is identified as a direct target of these two miRNAs and its inactivation attenuates BrCa cell aggressiveness and prevents malignant transformation. Understanding the molecular networks controlled by miRNAs, including passenger strands, may lead to the identification of diagnostic markers and therapeutic targets for BrCa.
Article
Multidisciplinary Sciences
Dan Zhao, Kerui Wu, Sambad Sharma, Fei Xing, Shih-Ying Wu, Abhishek Tyagi, Ravindra Deshpande, Ravi Singh, Martin Wabitsch, Yin-Yuan Mo, Kounosuke Watabe
Summary: This study reveals that miR-1304-3p is highly upregulated in African American breast cancer patients and its expression is associated with poor progression-free survival. miR-1304 promotes tumor progression by activating cancer-associated adipocytes that release lipids and enhance cancer cell growth. The anti-adipogenic gene GATA2 is identified as the target of miR-1304-3p. Additionally, a single nucleotide polymorphism (SNP) in the miR-1304 stem-loop region shows a significant difference in frequency between African and Caucasian American groups, influencing the maturation of miR-1304-3p.
NATURE COMMUNICATIONS
(2022)
Article
Gastroenterology & Hepatology
Cheng Kong, Lei Liang, Guang Liu, Lutao Du, Yongzhi Yang, Jianqiang Liu, Debing Shi, Xinxiang Li, Yanlei Ma
Summary: This study investigated the interactions between gut microbiome, metabolites, and microbial enzymes in early-onset colorectal cancer (EO-CRC) patients. The results showed distinct associations between microbiome and metabolome in EO-CRC compared to late-onset CRC (LO-CRC). The study identified potential biomarkers for EO-CRC and achieved a powerful classification performance for distinguishing EO-CRC from controls. This research provides valuable insights into the pathogenesis of EO-CRC and highlights the potential of microbiome-derived biomarkers for non-invasive detection.
Article
Engineering, Civil
Haoran Chen, Xuedong Yan, Xiaobing Liu, Tao Ma
Summary: With the rapid development of internet technologies and shared mobility services, online ridesharing services have become popular worldwide. This study compares the operational performance of two major online ridesharing modes, ridesplitting and carpooling, using actual operating data provided by DiDi Chuxing. The findings indicate that ridesplitting has lower fuel-saving and distance-saving ratios compared to carpooling, and online ridesharing is not considered fuel-saving in terms of transportation system's fuel economy.
Article
Information Science & Library Science
Pengzhen Yin, Chuang Wang, Liang Liang
Summary: This study examines the antecedents (i.e. characteristics of MICT) and outcomes (i.e. employee affective and cognitive well-being) of routine MICT use in the remote work context. The findings show that routine MICT use increases employee affective well-being, such as job satisfaction, and mitigates cognitive well-being issues, such as technology overload. The study also highlights the mediation effects of routine MICT use on the relationship between its characteristics and employee well-being.
INFORMATION TECHNOLOGY & PEOPLE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Liyun Zheng, Chun Yang, Liang Liang, Shengxiang Rao, Yongming Dai, Mengsu Zeng
Summary: This study aimed to explore the feasibility of pancreatic imaging at 5 T and evaluate the practical improvement of T2-weighted MRI and diffusion-weighted imaging (DWI) at 5 T as compared with 3 T. The results showed that imaging at 5 T provided higher image quality ratings and SNR compared to 3 T for both T2-weighted and DWI images. However, there were no significant differences in the mean ADC values and CV of ADC between 3 T and 5 T measurements.
Article
Chemistry, Organic
Mao-Lin Yang, Hao-Ran Chen, Long Zhao, Ming-Wu Ding
Summary: A new efficient synthesis method for the preparation of 6,12-dihydro-5H-quinazolino[3,2-a]quinazolin-5-ones has been developed. This method involves sequential Ugi/Staudinger/aza-Wittig/addition/nucleophilic acyl substitution reactions and provides a domino and effective strategy for the preparation of various substituted quinazolino[3,2-a]quinazolin-5-ones under mild reaction conditions.
SYNTHESIS-STUTTGART
(2023)
Article
Automation & Control Systems
Huiming Li, Hao Chen, Xiangke Wang
Summary: This paper investigates the problem of collision-free leader-follower formation generation and tracking of multiple fixed-wing unmanned aerial vehicles (UAVs). A novel control law based on physicomimetics approach is proposed to integrate formation generation, formation tracking, and collision avoidance. The artificial forces driven by control laws imitating physical forces are used to achieve desired collaborative behaviors and obstacle avoidance naturally. Speed constraints are also considered and modified using a saturation function. Numerical simulations and experiments are provided to verify the effectiveness of the proposed control scheme.
ASIAN JOURNAL OF CONTROL
(2023)
Article
Engineering, Environmental
Long Liang, Chunmin Zhang, Shaolei Zhao, Baozhong Liu, Limin Wang, Fei Liang
Summary: Designing efficient catalysts is a crucial challenge for practical applications of high-capacity hydride in fuel-cell-based hydrogen economy. In this study, platinum-functionalized Ti3C2 material with an accordion-like structure, interlayer, and surface-dispersed nanoparticles was synthesized. The catalyst, Ti3C2@Pt, reduced the initial dehydrogenation temperature of high-density hydride AlH3 by 50% to 62 °C, comparable to commercial AlH3. Moreover, it exhibited high hydrogen supplying performance and retention ratio, achieving 9.3 wt% and 98% respectively, surpassing previously reported catalysts. The exceptional dehydrogenation performance of the material makes it a practical candidate for mobile device applications with the aid of high-efficiency catalysts.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Qiang Liu, Youjin Gong, Boyu Liu, Shunshun Xiong, Hui-Min Wen, Xiaolin Wang
Summary: In this study, an ultra-microporous alkyl Cu-based MOF-11 was developed for highly selective adsorption of xenon. The unique pore system of MOF-11 not only enables strong binding affinity with xenon, but also allows for dense packing of xenon molecules. MOF-11 demonstrates record-high xenon storage density, uptake, and selectivity, making it a promising candidate for xenon separation and capture.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Rheumatology
Haoran Chen, Huarui Liu, Wenting Lyu, Yin Liu, Mei Huang, Yingwei Zhang, Yuying Qiu, Yonglong Xiao, Hourong Cai, Jinghong Dai
Summary: This study retrospectively analyzed the clinical characteristics and risk factors of clinical recurrence in interstitial lung disease related to antisynthetase syndrome (ARS-ILD). Recurrence of ARS-ILD was common during medication intensity reduction, and age, lactate dehydrogenase (LDH), medication tapering duration, and discontinuation were identified as risk factors for recurrence.
CLINICAL RHEUMATOLOGY
(2023)
Article
Automation & Control Systems
Yuanmao Ye, Yongbin Zhang, Xiaolin Wang, Ka-Wai Eric Cheng
Summary: This article presents a new type of step-up multilevel inverter (MLI) using a front-side quasi-Z-source unit, which effectively limits the charging current variation and enhances the total voltage gain.
IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS
(2023)
Article
Engineering, Electrical & Electronic
Yuanmao Ye, Minhao Chen, Xiaolin Wang, Lingling Cao
Summary: This article introduces a new boost-type common-ground photovoltaic (PV) inverter, which solves the problems of inrush charging current, input current quality, and boost capability by inserting a quasi-Z-source (qZS) unit into an SC-based common-ground inverter, and is experimentally verified.
INTERNATIONAL JOURNAL OF ELECTRICAL POWER & ENERGY SYSTEMS
(2023)
Article
Engineering, Electrical & Electronic
Jianqiang Luo, Fei Teng, Siqi Bu, Zhongda Chu, Ning Tong, Anbo Meng, Ling Yang, Xiaolin Wang
Summary: This paper proposes a solution to address the traditional operational constraint issue in power systems considering converter-driven stability and elaborates on a power sensitivity-based power dispatch method to enhance stability margin and update operational constraint solutions.
INTERNATIONAL JOURNAL OF ELECTRICAL POWER & ENERGY SYSTEMS
(2023)
Review
Chemistry, Multidisciplinary
Hui-Ying Tan, Jiali Wang, Sheng-Chih Lin, Tsung-Rong Kuo, Hao Ming Chen
Summary: Single-atom catalysts (SACs) are promising electrocatalysts for energy conversion and storage due to their efficient atom utilization and unique electronic properties. The local coordination structures of single metal centers play a significant role in catalytic performances, and understanding the dynamic changes of SACs during reactions is crucial for improving catalytic activity.
ADVANCED MATERIALS INTERFACES
(2023)
Article
Gastroenterology & Hepatology
Xiaoduan Zhuang, Shaoheng Zhang, Guiquan Chen, Zongqi Luo, Huiqin Hu, Wenfeng Huang, Yu Guo, Yongwen Ouyang, Liang Peng, Qing Qing, Huiting Chen, Bingsheng Li, Jie Chen, Xinying Wang
Summary: This study aimed to explore the unsatisfactory histologically complete resection (CR) rate of small rectal neuroendocrine tumors (RNETs) and its associated risk factors and clinical outcomes. The study found that polypectomy, a central depression, and treatment in the early period were risk factors for incomplete resection (IR). Further analysis revealed that an atypical hyperemic appearance and treatment in the early period were significant predisposing factors for inappropriate choice of polypectomy.
GASTROENTEROLOGY REPORT
(2023)
Article
Automation & Control Systems
Zhongjing Yu, Gangyi Zhang, Jingyu Chen, Haoran Chen, Duo Zhang, Qinli Yang, Junming Shao
Summary: This paper proposes a noise-resistant graph embedding method, called NGE, which leverages subspace clustering information to capture community structure and reinforce the relationship between topology and attributes. Experimental results demonstrate the superiority of this method in tasks such as community detection, link prediction, and node classification.
IEEE TRANSACTIONS ON CYBERNETICS
(2023)