Nitidine chloride suppresses epithelial‐mesenchymal transition and stem cell‐like properties in glioblastoma by regulating JAK2/STAT3 signaling

CCL21/CCR7 interaction promotes EMT and enhances the stemness of OSCC via a JAK2/STAT3 signaling pathway

(2020) Yang Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The JAK2/STAT3/CCND2 Axis promotes colorectal Cancer stem cell persistence and radioresistance

(2019) So-Yeon Park et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

REX1 promotes EMT-induced cell metastasis by activating the JAK2/STAT3-signaling pathway by targeting SOCS1 in cervical cancer

(2019) Yu-Ting Zeng et al.   ONCOGENE

Repurposing Penfluridol in Combination with Temozolomide for the Treatment of Glioblastoma

(2019) Kim et al.   Cancers

Integrin α6 signaling induces STAT3-TET3-mediated hydroxymethylation of genes critical for maintenance of glioma stem cells

(2019) Andreas Herrmann et al.   ONCOGENE

3D bioprinted glioma cell-laden scaffolds enriching glioma stem cells via epithelial-mesenchymal transition

(2018) Xuanzhi Wang et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

Nitidine chloride suppresses epithelial-to-mesenchymal transition in osteosarcoma cell migration and invasion through Akt/GSK-3β/Snail signaling pathway

(2016) Zhenxiu Cheng et al.   ONCOLOGY REPORTS

Dysregulated JAK2 expression by TrkC promotes metastasis potential, and EMT program of metastatic breast cancer

(2016) Min Soo Kim et al.   Scientific Reports

STAT3polymorphisms may predict an unfavorable response to first-line platinum-based therapy for women with advanced serous epithelial ovarian cancer

(2015) Jennifer Permuth-Wey et al.   INTERNATIONAL JOURNAL OF CANCER

Bax-PGAM5L-Drp1 complex is required for intrinsic apoptosis execution

(2015) Wenjuan Xu et al.   Oncotarget

Novel Agent Nitidine Chloride Induces Erythroid Differentiation and Apoptosis in CML Cells through c-Myc-miRNAs Axis

(2015) Na Liu et al.   PLoS One

Nitidine chloride inhibits hepatic cancer growth via modulation of multiple signaling pathways

(2014) Jiumao Lin et al.   BMC CANCER

SOX2 promotes tumorigenicity and inhibits the differentiation of I-type neuroblastoma cells

(2014) SHAOBO YANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

SOX2 expression is an early event in a murine model of EGFR mutant lung cancer and promotes proliferation of a subset of EGFR mutant lung adenocarcinoma cell lines

(2014) Irem Dogan et al.   LUNG CANCER

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Increased SOX2 Gene Copy Number Is Associated with FGFR1 and PIK3CA Gene Gain in Non-Small Cell Lung Cancer and Predicts Improved Survival in Early Stage Disease

(2014) Luca Toschi et al.   PLoS One

Nitidine chloride induces apoptosis, cell cycle arrest, and synergistic cytotoxicity with doxorubicin in breast cancer cells

(2014) Mingjuan Sun et al.   TUMOR BIOLOGY

Data, information, knowledge and principle: back to metabolism in KEGG

(2013) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

The complex world of WNT receptor signalling

(2012) Christof Niehrs   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nitidine Chloride inhibits breast cancer cells migration and invasion by suppressing c-Src/FAK associated signaling pathway

(2011) Xinhua Pan et al.   CANCER LETTERS

The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors

(2011) Lauren L.C. Marotta et al.   JOURNAL OF CLINICAL INVESTIGATION

Mesenchymal stem cells enhance lung cancer initiation through activation of IL-6/JAK2/STAT3 pathway

(2011) Han-Shui Hsu et al.   LUNG CANCER

Inhibition of STAT3 Signaling Pathway by Nitidine Chloride Suppressed the Angiogenesis and Growth of Human Gastric Cancer

(2011) J. Chen et al.   MOLECULAR CANCER THERAPEUTICS

Conditional Activation of Bmi1 Expression Regulates Self-renewal, Apoptosis, and Differentiation of Neural Stem/Progenitor Cells In Vitro and In Vivo

(2011) Gokhan Yadirgi et al.   STEM CELLS

Epithelial plasticity, cancer stem cells and bone metastasis formation

(2010) Gabri van der Pluijm   BONE

Poised Lineage Specification in Multipotential Hematopoietic Stem and Progenitor Cells by the Polycomb Protein Bmi1

(2010) Hideyuki Oguro et al.   Cell Stem Cell

Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition

(2010) Melissa G. Mendez et al.   FASEB JOURNAL

Bmi1 is essential in Twist1-induced epithelial–mesenchymal transition

(2010) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY

Oncoprotein Bmi-1 Renders Apoptotic Resistance to Glioma Cells through Activation of the IKK-Nuclear Factor-κB Pathway

(2009) Jun Li et al.   AMERICAN JOURNAL OF PATHOLOGY

EMT, the cytoskeleton, and cancer cell invasion

(2009) Mahmut Yilmaz et al.   CANCER AND METASTASIS REVIEWS

Loss of E-Cadherin Promotes Metastasis via Multiple Downstream Transcriptional Pathways

(2008) T. T. Onder et al.   CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

The cell-cell adhesion molecule E-cadherin

(2008) F. van Roy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES