GRIM‐19 repressed hypoxia‐induced invasion and EMT of colorectal cancer by repressing autophagy through inactivation of STAT3/HIF‐1α signaling axis

LncRNA CPS1-IT1 suppresses EMT and metastasis of colorectal cancer by inhibiting hypoxia-induced autophagy through inactivation of HIF-1α

(2018) Wei Zhang et al.   BIOCHIMIE

Antitumor activity of iNGR-GRIM-19 in colorectal cancer

(2017) Li Pang et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

SENP1/HIF-1α feedback loop modulates hypoxia-induced cell proliferation, invasion, and EMT in human osteosarcoma cells

(2017) Xiaowei Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Downregulation of AIF by HIF-1 contributes to hypoxia-induced epithelial–mesenchymal transition of colon cancer

(2016) Zhong Xiong et al.   CARCINOGENESIS

GRIM-19 inhibition induced autophagy through activation of ERK and HIF-1α not STAT3 in Hela cells

(2016) Xin Yue et al.   TUMOR BIOLOGY

The role of STAT3 in autophagy

(2015) Liangkun You et al.   Autophagy

GRIM-19 expression is a potent prognostic marker in colorectal cancer

(2015) Miao Hao et al.   HUMAN PATHOLOGY

Autophagy in colorectal cancer: An important switch from physiology to pathology

(2015) Florin Burada   World Journal of Gastrointestinal Oncology

Hypoxia-induced autophagy reduces radiosensitivity by the HIF-1α/miR-210/Bcl-2 pathway in colon cancer cells

(2014) YONG SUN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Upregulation of autophagy by hypoxia-inducible factor-1α promotes EMT and metastatic ability of CD133+ pancreatic cancer stem-like cells during intermittent hypoxia

(2014) HAITAO ZHU et al.   ONCOLOGY REPORTS

GRIM-19 opposes reprogramming of glioblastoma cell metabolism via HIF1α destabilization

(2013) Qian Liu et al.   CARCINOGENESIS

Autophagy and human diseases

(2013) Peidu Jiang et al.   CELL RESEARCH

Cancer stem cells, the epithelial to mesenchymal transition (EMT) and radioresistance: Potential role of hypoxia

(2012) Delphine Tamara Marie-Egyptienne et al.   CANCER LETTERS

Protein kinase Cɛ mediates Stat3Ser727 phosphorylation, Stat3-regulated gene expression and cell invasion in various human cancer cell lines through integration with MAPK cascade (RAF-1, MEK1/2 and ERK1/2)

(2010) M H Aziz et al.   ONCOGENE

The Double-Edged Sword of Autophagy Modulation in Cancer

(2009) E. White et al.   CLINICAL CANCER RESEARCH

Autophagy and metastasis: another double-edged sword

(2009) Candia M Kenific et al.   CURRENT OPINION IN CELL BIOLOGY

Role of hypoxia in the hallmarks of human cancer

(2009) Kai Ruan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

Redox mechanisms switch on hypoxia-dependent epithelial–mesenchymal transition in cancer cells

(2008) Stefania Cannito et al.   CARCINOGENESIS