Article
Cell Biology
Shujun Zhang, Juan Li, Huiru Gao, Yao Tong, Peilong Li, Yunshan Wang, Lutao Du, Chuanxin Wang
Summary: Long non-coding RNAs (lncRNAs) have shown potential as prognostic markers in esophageal squamous cell carcinoma (ESCC), with a developed model effectively predicting patient prognosis. Additionally, lncRNA-based classification revealed associations with race and Barrett's esophagus in ESCC patients. Furthermore, the upregulated lncRNA AC007128.1 was identified to be associated with poor prognosis and was found to promote epithelial-mesenchymal transition (EMT) in ESCC cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pathology
Yanxin Dong, Boshi Fan, Mingyang Li, Jiale Zhang, Shun Xie, Shouyin Dia, Qingge Jia, Taiqian Gong
Summary: Tescalcin (TESC) is upregulated in esophageal squamous carcinoma (ESCC) and is associated with poor prognosis, tumor infiltration, staging, and lymph node metastasis. TESC promotes proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) progression in ESCC, as well as activates the AKT pathway. TESC may serve as a prognostic factor and provide a new therapeutic strategy for ESCC.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Medicine, Research & Experimental
Xingyu Du, Xueyuan Zhang, Jing Dong, Naiyi Zou, Dong Guo, Weinan Yao, Xiaobin Wang, Shuguang Li, Chunyang Song, Ke Yan, Wenbin Shen, Shuchai Zhu
Summary: High expression of plasma exosomal HMGB1 is associated with an adverse radiotherapy response in ESCC patients. IR-induced exosomal HMGB1 enhances the radioresistance of ESCC cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Xiao-Ya Sun, Hao-Zheng Li, Da-Fei Xie, Shan-Shan Gao, Xin Huang, Hua Guan, Chen-Jun Bai, Ping-Kun Zhou
Summary: This study identified LPAR5 as an important upstream regulator of radiation-induced EMT, modulating the ERK/Snail pathway. Overexpression of LPAR5 promoted EMT and migration of cancer cells, and increased expression of LPAR5 was significantly associated with radiation-induced EMT and radioresistance.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Huiru Yang, Zhen Wei, Yifan Song, Kexin Du, Nannan Yin, Hong Lu, Bingbing Li, Lili Hou, Panfei Xing, Liang Chen, Chaojie Wang, Songqiang Xie
Summary: This study found that NUAK1 is highly expressed in esophageal squamous cell carcinoma (ESCC) and is associated with tumor invasion depth, lymph node metastasis, and poor prognosis. Moreover, NUAK1 promotes the migration and invasion of ESCC cells by activating the JNK/c-Jun/Slug signaling pathway.
CANCER CELL INTERNATIONAL
(2023)
Article
Oncology
Jing Dong, Xueyuan Zhang, Xingyu Du, Naiyi Zou, Wenbin Shen, Ming Ma, Yaojie Wang, Shuchai Zhu
Summary: The study found that overexpression of HMGB1 promotes migration, proliferation, and radioresistance of esophageal squamous cell carcinoma cells, and mitigates cell cycle arrest induced by irradiation at the G0/G1 phase. Negative expression of HMGB1 is associated with 10-year survival in ESCC patients.
Article
Oncology
Zhihua Shi, Tao Jiang, Bingji Cao, Xusheng Sun, JunFeng Liu
Summary: CAF-derived exosomal LINC01410 promotes metastasis and EMT in ESCC cells by sponging miR-122-5p and increasing PKM2 levels.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Oncology
Lixia Wang, Chuanlai Yang, Man Chu, Zhi-wei Wang, Boxin Xue
Summary: The study investigated the molecular mechanisms underlying radioresistance in bladder cancer, revealing elevated Cdc20 expression in IR cells and its role in governing IR-mediated EMT by regulating FoxO1 degradation. Therefore, inhibiting Cdc20 or activating FoxO1 may be potential strategies to overcome radioresistance in bladder cancer.
Review
Oncology
Hongfang Zhang, Jingxing Si, Jing Yue, Shenglin Ma
Summary: ESCC, a lethal malignancy with high aggressive potential, is resistant to radiotherapy mainly due to the influence of factors like CAFs, cancer stemness, and non-coding RNAs. Studying the mechanisms of resistance and reversal strategies can lead to the development of new intervention approaches.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Genetics & Heredity
Xiuying Chen, Li Yu, Junyang Zhou, Ji Ren, Shan Wang, Yujie Tan, Yan Ding
Summary: In esophageal squamous cell carcinoma, both NFE2L2 and SQSTM1 (p62) are upregulated and promote tumor progression and epithelial-mesenchymal transition (EMT) through autophagy activity. Inhibiting both proteins simultaneously can reverse the migration and EMT characteristics of the tumor, suggesting that targeting both proteins may be a viable treatment option for esophageal squamous cell carcinoma.
Article
Cell Biology
Reihaneh Alsadat Mahmoudian, Maryam Lotfi Gharaie, Mohammad Reza Abbaszadegan, Ali Alasti, Mohammad Mahdi Forghanifard, Atena Mansouri, Mehran Gholamin
Summary: This study investigated the expression of MMP-13, TWIST1, and CD44 in ESCC and found significant correlations with clinical features, such as tumor progression and invasion. The results suggest that the TWIST1-CD44-MMP-13 axis may be involved in tumor aggressiveness and could serve as diagnostic markers and therapeutic targets in ESCC.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Xueyuan Zhang, Naiyi Zou, Wenzhao Deng, Chunyang Song, Ke Yan, Wenbin Shen, Shuchai Zhu
Summary: This study found that down-regulation of HMGB1 can promote the radiosensitivity of esophageal cancer cells through regulating the PI3K/Akt/ATM pathway, leading to improved prognosis for patients.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Oncology
Yan Zhao, Jiajia Gao, Xiufeng Xie, Peng Nan, Fang Liu, Yulin Sun, Xiaohang Zhao
Summary: The study demonstrated that BACH1 is overexpressed in ESCC tissues, associated with poor prognosis. BACH1 enhances migration and invasion in ESCC, promotes EMT and angiogenesis, and may serve as a promising therapeutic target or molecular marker in ESCC.
Review
Biochemistry & Molecular Biology
Lingbo An, Mingyang Li, Qingge Jia
Summary: Esophageal squamous cell carcinoma (ESCC) is a common cause of cancer-related mortality, especially in China. Radiotherapy (RT) is commonly used for treatment, but it can induce radioresistance and promote tumor invasion and metastasis. Understanding the mechanisms of radioresistance can lead to more effective strategies for ESCC therapy. This article summarizes the possible mechanisms of radioresistance and compares current strategies to reverse it.
Article
Biotechnology & Applied Microbiology
Da Yao, Shengcheng Lin, Size Chen, Zhe Wang
Summary: This study demonstrates that circHIPK3 is highly expressed in esophageal squamous cell carcinoma (ESCC) and is associated with a poor prognosis. It functions as an oncogene by acting as a sponge for microRNA-124 (miR-124) and promoting the expression of serine/threonine kinase 3 (AKT3), leading to enhanced cell proliferation and migration in ESCC. Targeting the circHIPK3-AKT3 axis may have therapeutic potential for ESCC patients.