Review
Pharmacology & Pharmacy
Jian-Yu Chen, Xiao-Yun Tian, Shan-Shan Wei, Ying-Jie Yang, Shan Deng, Chun-Jie Jiao, Can-Jian Wang, Ke-Dan Chu, Xue-Qin Ma, Wei Xu
Summary: JAK/STAT signaling pathways play a critical role in regulating various biological processes and their abnormal activation is associated with disease progression. FDA-approved JAK/STAT inhibitors, such as tofacitinib and baricitinib, have shown promising results in rheumatology treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
John E. La Marca, Lee F. Willoughby, Kirsten Allan, Marta Portela, Pei Kee Goh, Tony Tiganis, Helena E. Richardson
Summary: This passage discusses the importance of maintaining tissue homeostasis by eliminating aberrant cells for organism survival, and the role of cell competition in this process. The study identifies the protein tyrosine phosphatase 61F (PTP61F) as playing a key role in the initiation and progression of epithelial cancers, affecting cell competition, cell polarity, and tumor aggressiveness through regulation of signaling pathways. PTP61F acts as a tumor suppressor in both autonomous and non-cell-autonomous ways to ensure cellular fitness and reduce tumorigenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Malgorzata Galecka, Janusz Szemraj, Kuan-Pin Su, Angelos Halaris, Michael Maes, Aleksandra Skiba, Piotr Galecki, Katarzyna Blizniewska-Kowalska
Summary: This study found that there is increased expression of JAK3 and decreased expression of STAT1 in depressed patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Oncology
Boheng Li, Qin Wan, Zhubo Li, Wee-Joo Chng
Summary: Janus kinases (JAKs) are transmembrane receptors that play a role in lymphoid cancer pathogenesis by mediating gene expression through the JAK/STAT pathway. JAK abnormalities can lead to over-activation of the JAK/STAT pathway and the nuclear role of JAK tyrosine kinases. Anti-JAK therapeutics have been developed to effectively target lymphoid cancer cells.
Article
Cell Biology
Bhawana Maurya, Satya Surabhi, Rituparna Das, Pranjali Pandey, Ashim Mukherjee, Mousumi Mutsuddi
Summary: Mahe, an RNA helicase, regulates Notch signaling and neuronal development in Drosophila. The study demonstrates that Mahe can promote apoptosis by modulating the JAK/STAT pathway components. Through transcriptome profiling and RNA immunoprecipitation experiments, the study reveals the regulatory mechanism of Mahe on the JAK/STAT pathway.
CELL DEATH & DISEASE
(2021)
Review
Pharmacology & Pharmacy
Qianqian Yin, Longyun Wang, Haiyang Yu, Daquan Chen, Wenwei Zhu, Changgang Sun
Summary: The JAK-STAT signaling pathway is closely related to cell proliferation, apoptosis, differentiation, and inflammatory response, essential for inhibiting inflammation, initiating innate immunity, and coordinating adaptive immune mechanisms. Various plant polyphenol compounds play a role in suppressing abnormal activation in the JAK-STAT pathway, showing significant effects in anti-inflammatory, antitumor, and cardiovascular disease control.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Yanhua Luo, Tahir Ali, Zizhen Liu, Ruyan Gao, Axiang Li, Canyu Yang, Li Ling, Liufang He, Shupeng Li
Summary: EPO has antidepressant potential by inhibiting inflammatory response and regulating JAK2/STAT5 signaling.
Review
Biochemistry & Molecular Biology
Hyunjung Park, Sangjik Lee, Jaehun Lee, Hyuk Moon, Simon Weonsang Ro
Summary: This review highlights the importance of the JAK/STAT pathway in hepatocellular carcinoma (HCC) and its association with factors such as chronic inflammation and cirrhosis. It also summarizes recent advancements in targeting the JAK/STAT pathway for HCC treatment, emphasizing the potential of this pathway as a promising avenue for therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Nagendra Awasthi, Clifford Liongue, Alister C. Ward
Summary: STAT proteins, an important family of evolutionarily conserved transcription factors, play key roles in blood and immune cell development and function. In addition to their classical role in transcriptional activation, STAT proteins also have non-canonical functions such as transcriptional repression and roles outside the nucleus. This review presents a revised framework for understanding the diverse functional modalities of STAT proteins.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Xiaoyi Hu, Jing Li, Maorong Fu, Xia Zhao, Wei Wang
Summary: The JAK/STAT signaling pathway is a crucial cellular signal transduction pathway, associated with various cancers and autoimmune diseases. Researchers discussed the composition, activation, and regulation of this pathway, as well as its role in diseases.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Oncology
Alexander Ou, Martina Ott, Dexing Fang, Amy B. Heimberger
Summary: Glioblastoma is a highly refractory and deadly human malignancy, with the dysregulated JAK/STAT signaling pathway playing a key role in tumorigenesis and resistance to therapy, influencing functions such as proliferation, anti-apoptosis, angiogenesis, stem cell maintenance, and immune suppression. Current understanding of JAK/STAT signaling in glioblastoma highlights the need for targeted inhibition and future research directions in the field.
Review
Pharmacology & Pharmacy
Qiuyu Pang, Lu You, Xiangmin Meng, Yumeng Li, Tian Deng, Deyong Li, Bingmei Zhu
Summary: The JAK/STAT signaling pathway plays a crucial role in cell growth, differentiation, immune response, and hematopoietic system development. It has been found to have regulatory functions in various cardiovascular diseases, such as myocardial ischemia-reperfusion injury, acute myocardial infarction, hypertension, myocarditis, heart failure, angiogenesis, and fibrosis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Spandana Rajendra Kopalli, Venkata Prakash Annamneedi, Sushruta Koppula
Summary: Atopic dermatitis (AD) is a chronic inflammatory skin disease caused by dysregulation of cytokines and other immune mediators. The JAK/STAT pathway plays a crucial role in AD pathogenesis, and its dysregulation can lead to inflammation and pruritus. SOCS proteins negatively regulate the immune-related inflammatory responses mediated by the JAK/STAT pathway. Natural product-derived biomolecules targeting JAK/STAT/SOCS signaling have shown potential in treating AD and other inflammatory disorders.
Article
Medicine, Research & Experimental
Yuqian Chang, Pan Kang, Tingting Cui, Weinan Guo, Weigang Zhang, Pengran Du, Xiuli Yi, Sen Guo, Tianwen Gao, Chunying Li, Shuli Li
Summary: T-96, extracted from Tripterygium wilfordii Hook F, has been found to have anti-inflammatory and immunosuppressive properties. It can effectively inhibit the activation and infiltration of CD8(+) T cells in the skin, making it a potential therapeutic option for vitiligo.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Lena Jakob, Tony Andreas Mueller, Michael Rassner, Helen Kleinfelder, Pia Veratti, Jan Mitschke, Cornelius Miething, Robert A. J. Oostendorp, Dietmar Pfeifer, Miguel Waterhouse, Justus Duyster
Summary: The IL-6 family cytokine Oncostatin M (OSM) has various effects on cell development, growth, hematopoiesis, inflammation, and cancer. It can have both proliferative and antiproliferative effects depending on the target cell, with mechanisms involving OSM receptors and signaling pathways. Studies in murine cells show that OSM affects proliferation in stromal and fibroblast cell lines by activating JAK-STAT, PI3K-AKT, and MAPK-ERK pathways through OSMR, offering new insights into proliferation regulation by mOSM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Milad Ashrafizadeh, Ali Zarrabi, Hassan Karimi-Maleh, Afshin Taheriazam, Sepideh Mirzaei, Mehrdad Hashemi, Kiavash Hushmandi, Pooyan Makvandi, Ehsan Nazarzadeh Zare, Esmaeel Sharifi, Arul Goel, Lingzhi Wang, Jun Ren, Yavuz Nuri Ertas, Alan Prem Kumar, Yuzhuo Wang, Navid Rabiee, Gautam Sethi, Zhaowu Ma
Summary: Nanomedicine has great potential in the treatment of bladder cancer, including improving drug efficacy, regulating gene expression, providing photodynamic and photothermal therapy, remodeling tumor microenvironment and infiltration of immune cells, timely diagnosis, and targeted therapy for bladder cancer.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Akshay Ravish, Rashmi Shivakumar, Zhang Xi, Min Hee Yang, Ji-Rui Yang, Ananda Swamynayaka, Omantheswara Nagaraja, Mahendra Madegowda, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Vijay Pandey, Gautam Sethi, Kwang Seok Ahn, Peter E. E. Lobie, Basappa Basappa
Summary: This study explored the design of imidazopyridine-tethered pyrazolines as a de novo drug strategy for inhibiting STAT3 phosphorylation in human BC cells. Compound 3f with 2,3-dichlorophenyl substitution was recognized among the tested series as a lead structure that inhibited the viability of MCF-7 cells. It effectively inhibited STAT3 phosphorylation in MCF-7 and T47D cells, indicating that these structures may be an alternative synthon to target STAT3 signaling in BC.
BIOENGINEERING-BASEL
(2023)
Review
Biotechnology & Applied Microbiology
Puttasiddaiah Rachitha, Krupashree Krishnaswamy, Renal Antoinette Lazar, Vijai Kumar Gupta, Baskaran Stephen Inbaraj, Vinay Basavegowda Raghavendra, Minaxi Sharma, Kandi Sridhar
Summary: The ayurvedic herb Emblica officinalis has great therapeutic and nutritional importance. It is used in Indian medicine for treating various illnesses and has been found to have hepatoprotective, immunomodulatory, antimicrobial, radioprotective, and hyperlipidemic effects. Nanoencapsulation technology can enhance the therapeutic activities and bioaccessibility of Emblica officinalis.
BIOENGINEERING-BASEL
(2023)
Correction
Chemistry, Medicinal
Elina Khatoon, Mangala Hegde, Aviral Kumar, Uzini Devi Daimary, Gautam Sethi, Anupam Bishayee, Ajaikumar B. Kunnumakkara
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Oncology
Mangala Hegde, Nikunj Naliyadhara, Jyothsna Unnikrishnan, Mohammed S. Alqahtani, Mohamed Abbas, Sosmitha Girisa, Gautam Sethi, Ajaikumar B. Kunnumakkara
Summary: Metastasis is the main cause of cancer-related deaths, and despite advancements in treatment methods, it remains difficult to treat. Nanotechnology has shown promising applications in the diagnosis and treatment of metastatic cancer, with nanoparticles demonstrating the ability to target specific cells within metastatic regions. This review summarizes the current state of nanotechnology in the field and discusses its potential in various imaging techniques and combination therapies.
Article
Biochemistry & Molecular Biology
Illia V. V. Kapitanov, Surya M. M. Sudheer, Toshikee Yadav, Kallol K. K. Ghosh, Nicholas Gathergood, Vijai K. K. Gupta, Yevgen Karpichev
Summary: The solubilization capacity of sustainable phenylalanine-derived surface-active ionic liquids (SAILs) towards polycyclic aromatic hydrocarbons (PAHs) was evaluated and compared with a conventional cationic surfactant, CTABr. The SAILs showed increased solubilization capacity with longer alkyl chain length, comparable to CTABr for certain SAIL types. The phenylalanine-derived SAILs also had the advantage of enzymatically cleaving ester and amide bonds under mild conditions for in situ separation of PAHs.
Article
Biochemistry & Molecular Biology
Na Young Kim, Divakar Vishwanath, Zhang Xi, Omantheswara Nagaraja, Ananda Swamynayaka, Keshav Kumar Harish, Shreeja Basappa, Mahendra Madegowda, Vijay Pandey, Gautam Sethi, Peter E. Lobie, Kwang Seok Ahn, Basappa Basappa
Summary: A JNK-targeting compound has been developed for HER2-positive breast cancer, which selectively inhibits cell proliferation and induces DNA damage and apoptosis. Further studies showed that the compound could interact with JNK and enhance its phosphorylation. These findings contribute to the development of new JNK-targeting compounds for HER2-positive breast cancer.
Article
Chemistry, Medicinal
Naisarg Gamit, Manasi Patil, Soumya B. Sundrappa, S. Mohana Sundaram, Gautam Sethi, Arun Dharmarajan, Sudha Warrier
Summary: A reliable and efficient in vitro model using amniotic membrane-derived mesenchymal stem cells (AM-MSCs) has been developed for screening drugs for Alzheimer's disease (AD). This model can assess the neuroprotective ability of different drugs and quickly test a large number of potential compounds. The study found that the novel drugs probucol and NMJ-2 have protective effects against neurodegeneration.
DRUG DEVELOPMENT RESEARCH
(2023)
Article
Chemistry, Medicinal
Rajaghatta N. Suresh, Young Y. Jung, Chakrabhavi D. Mohan, Shalini V. Gowda, Kachigere B. Harsha, Kempegowda Mantelingu, Gautam Sethi, Kwang S. Ahn, Kanchugarakoppal S. Rangappa
Summary: In this study, new compounds called DTI were synthesized and found to exhibit selective cytotoxicity against gastric cancer cells. The cytotoxic effect was achieved by inhibiting the phosphorylation of STAT3 and STAT5, which are transcription factors involved in cancer development. Further investigation revealed that the inhibition of STAT proteins was mediated through the suppression of upstream kinases such as JAK1, JAK2, and Src. The involvement of tyrosine phosphatase and negative regulator PTP & epsilon;C in the DTI-induced STATs inhibition was also demonstrated. Overall, triazolyl-indolo-quinoxaline compounds like DTI show promise as inhibitors of the STAT3/STAT5 pathway in gastric cancer cells.
DRUG DEVELOPMENT RESEARCH
(2023)
Article
Green & Sustainable Science & Technology
Alireza Shafizadeh, Hossein Shahbeik, Mohammad Hossein Nadian, Vijai Kumar Gupta, Abdul-Sattar Nizami, Su Shiung Lam, Wanxi Peng, Junting Pan, Meisam Tabatabaei, Mortaza Aghbashlo
Summary: This study develops a machine learning-based research framework for modeling, understanding, and optimizing the catalytic steam reforming of volatile matter compounds. Chemical/ textural analyses are used to obtain input features, and ensemble machine learning provides the best prediction performance for toluene conversion and product distribution. The framework can expedite the search for optimal catalyst characteristics and reaction conditions.
JOURNAL OF CLEANER PRODUCTION
(2023)
Review
Green & Sustainable Science & Technology
Hossein Shahbeik, Alireza Shafizadeh, Vijai Kumar Gupta, Su Shiung Lam, Hajar Rastegari, Wanxi Peng, Junting Pan, Meisam Tabatabaei, Mortaza Aghbashlo
Summary: The unfavorable properties of biomass pyrolysis bio-oil require physical/thermochemical methods to enhance its quality. Nanotechnology offers potential solutions to overcome the drawbacks of conventional catalysts used in bio-oil upgrading. This article provides a comprehensive overview of the application of nanocatalysts in bio-oil upgrading, including their mechanisms and effects on important operating parameters. Nanocatalysts have been shown to yield higher bio-oil quality and have advantages over bulk catalysts. However, more research and development are needed before nanocatalysts can be fully realized in practical applications.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Green & Sustainable Science & Technology
Yadong Yang, Lila Yazdani, Mortaza Aghbashlo, Vijai Kumar Gupta, Junting Pan, Meisam Tabatabaei, Ahmad Rajaei
Summary: This study aimed to increase the commercial value of shrimp shell waste by using chitosan extracted from these wastes as a food emulsion stabilizer. The findings showed that the stabilizer developed from shrimp shell waste is suitable for stabilizing emulsions containing more polar oils with less degree of unsaturation.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Biochemistry & Molecular Biology
Divakar Vishwanath, Zhang Xi, Akshay Ravish, Arunkumar Mohan, Shreeja Basappa, Niranjan Pattehalli Krishnamurthy, Santosh L. Gaonkar, Vijay Pandey, Peter E. Lobie, Basappa Basappa
Summary: Based on our study, we identified two new compounds, 5h and 6l, that can inhibit the proliferation of human breast cancer cells and have the potential to be developed as new drugs for cancer treatment.
Article
Chemistry, Physical
Akshay Ravish, Tejaswini P. Siddappa, Zhang Xi, Divakar Vishwanath, Arunkumar Mohan, Shreeja Basappa, Niranjan Pattehalli Krishnamurthy, Peter E. Lobie, Vijay Pandey, Basappa Basappa
Summary: Researchers have synthesized novel drug-like compounds using electrochemical and conventional methods and demonstrated their ability to inhibit the growth of breast cancer cells. Further analysis revealed that these compounds can target VEGFR-2, thereby inhibiting angiogenesis signaling.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.