Negative regulation of signal transducer and activator of transcription-3 signalling cascade by lupeol inhibits growth and induces apoptosis in hepatocellular carcinoma cells

Targeted therapy for hepatocellular carcinoma: novel agents on the horizon

(2015) Melchiorre Cervello et al.   Oncotarget

Garcinol, a Polyisoprenylated Benzophenone Modulates Multiple Proinflammatory Signaling Cascades Leading to the Suppression of Growth and Survival of Head and Neck Carcinoma

(2013) F. Li et al.   Cancer Prevention Research

HCMV Activates the IL-6-JAK-STAT3 Axis in HepG2 Cells and Primary Human Hepatocytes

(2013) Quentin Lepiller et al.   PLoS One

Celastrol Suppresses Growth and Induces Apoptosis of Human Hepatocellular Carcinoma through the Modulation of STAT3/JAK2 Signaling Cascade In Vitro and In Vivo

(2012) P. Rajendran et al.   Cancer Prevention Research

Signal Transducer and Activator of Transcription 3 in Liver Diseases: A Novel Therapeutic Target

(2012) Hua Wang et al.   International Journal of Biological Sciences

Hepatocellular carcinoma in non-alcoholic fatty liver disease: An emerging menace

(2012) György Baffy et al.   JOURNAL OF HEPATOLOGY

Telomerase directly regulates NF-κB-dependent transcription

(2012) Arkasubhra Ghosh et al.   NATURE CELL BIOLOGY

Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells

(2011) Radhamani Kannaiyan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

CD24+ Liver Tumor-Initiating Cells Drive Self-Renewal and Tumor Initiation through STAT3-Mediated NANOG Regulation

(2011) Terence Kin Wah Lee et al.   Cell Stem Cell

Lupeol, a Novel Androgen Receptor Inhibitor: Implications in Prostate Cancer Therapy

(2011) Hifzur Rahman Siddique et al.   CLINICAL CANCER RESEARCH

Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice

(2011) Muthu K. Shanmugam et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

STAT3 SIGNALING: Anticancer Strategies and Challenges

(2011) P. A. Johnston et al.   MOLECULAR INTERVENTIONS

γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent

(2010) Peramaiyan Rajendran et al.   BRITISH JOURNAL OF PHARMACOLOGY

Induction of apoptosis by lupeol in human epidermoid carcinoma A431 cells through regulation of mitochondrial, Akt/PKB and NF-kappaB signaling pathways

(2010) Sahdeo Prasad et al.   CANCER BIOLOGY & THERAPY

Specific targeting of Wnt/ -catenin signaling in human melanoma cells by a dietary triterpene lupeol

(2010) R. S. Tarapore et al.   CARCINOGENESIS

Hexamethylene Bisacetamide (HMBA) simultaneously targets AKT and MAPK pathway and represses NF-κB activity: Implications for cancer therapy

(2010) Anwesha Dey et al.   CELL CYCLE

Signal transducer and activator of transcription 3 inhibitors: a patent review

(2010) Brent DG Page et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Lupeol targets liver tumor-initiating cells through phosphatase and tensin homolog modulation

(2010) Terence Kin Wah Lee et al.   HEPATOLOGY

Beneficial health effects of lupeol triterpene: A review of preclinical studies

(2010) Hifzur Rahman Siddique et al.   LIFE SCIENCES

Sorafenib Induces Growth Arrest and Apoptosis of Human Glioblastoma Cells through the Dephosphorylation of Signal Transducers and Activators of Transcription 3

(2010) Fan Yang et al.   MOLECULAR CANCER THERAPEUTICS

Inflammation and Cancer: IL-6 and STAT3 Complete the Link

(2009) Jacqueline Bromberg et al.   CANCER CELL

Persistently Activated Stat3 Maintains Constitutive NF-κB Activity in Tumors

(2009) Heehyoung Lee et al.   CANCER CELL

Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer

(2009) Sergei I. Grivennikov et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Targeting STAT3 in cancer: how successful are we?

(2008) Peibin Yue et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Protein tyrosine phosphatases in the JAK/STAT pathway

(2008) Dan Xu   Frontiers in Bioscience-Landmark

siRNA targeting VEGF inhibits hepatocellular carcinoma growth and tumor angiogenesis in vivo

(2008) Esther Raskopf et al.   JOURNAL OF HEPATOLOGY

Natural Products as Leads to Potential Drugs: An Old Process or the New Hope for Drug Discovery?

(2008) David J. Newman   JOURNAL OF MEDICINAL CHEMISTRY