Article
Oncology
Yong-Zheng Yu, Qiang Mu, Qian Ren, Li-Juan Xie, Qi-Tang Wang, Cui-Ping Wang
Summary: miR-381-3p expression was significantly decreased in breast cancer tissues and cell lines. Overexpression of miR-381-3p inhibited breast cancer proliferation and invasion, while knockdown promoted cell proliferation and invasion. Mechanistically, miR-381-3p inhibits breast cancer progression and EMT by regulating the TGF-beta signaling via targeting Sox4 and Twist1.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Zhenqiang Sun, Bo Shao, Zaoqu Liu, Qin Dang, Yaxin Guo, Chen Chen, Yuying Guo, Zhuang Chen, Jinbo Liu, Shengyun Hu, Weitang Yuan, Quanbo Zhou
Summary: This study found that LINC01296 is highly expressed in NSCLC and CRC tissues, and is associated with poor prognosis. LINC01296 regulates invasion and metastasis of NSCLC and CRC by modulating the EMT process.
Article
Oncology
Yutong Fang, Qunchen Zhang, Chunfa Chen, Zexiao Chen, Rongji Zheng, Chuanghong She, Rendong Zhang, Jundong Wu
Summary: In this study, we identified epithelial-mesenchymal transition-associated target genes (ETGs) of miR-222-3p and comprehensively analyzed their roles in breast cancer. The results suggest that miR-222-3p may serve as a specific biomarker for basal-like breast cancer, and the ETGs may play a role in the development of breast cancer, serving as potential therapeutic targets.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Hao Wu, Juanjuan Qiu, Zhenru Wu, Tao He, Chen Zhou, Qing Lv
Summary: This study reveals that ADCY6 is expressed at low levels in breast cancer, leading to increased proliferation, invasion, and migration of breast cancer cells. The low expression of ADCY6 is attributed to the low demethylation of TET1, and the methylation of ADCY6 can be altered by TET1. Bioinformatics analysis shows that TET1 is regulated by miR-27a-3p and regulates the methylation of ADCY6, thereby affecting the EMT process of breast cancer cells and promoting the malignant biological behavior of breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Xiaowei Fu, Xueqiang Deng, Weidong Xiao, Bo Huang, Xuan Yi, Yeqing Zou
Summary: The study showed that downregulation of NEAT1 sensitized gemcitabine-resistant pancreatic cancer cells by mediating the expression of ZEB2 through sponging miR-506-3p. NEAT1 downregulation reversed the EMT process in pancreatic cancer cells, enhancing their sensitivity to gemcitabine. These findings provide novel insights into the function and molecular mechanism of NEAT1 and offer a new approach to improving chemotherapy effectiveness in pancreatic cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Oncology
Yuli Wang, Shuang Shi, Yunshan Wang, Xuhua Zhang, Xiaoyan Liu, Juan Li, Peilong Li, Lutao Du, Chuanxin Wang
Summary: The study revealed that miR-223-3p is overexpressed in breast cancer, associated with poor prognosis, promotes cell migration and invasion, and exerts its oncogenic role by targeting the tumor suppressor gene FBXW7 to promote invasion and metastasis in breast cancer.
Article
Cell Biology
Lee Armstrong, Colin E. Willoughby, Declan J. Mckenna
Summary: This study investigated the association between miR-143-3p and EMT in prostate cancer. The findings showed that miR-143-3p expression was significantly decreased in prostate cancer cells and it was associated with the EMT-associated gene AKT1. Further analysis suggested that miR-143-3p may serve as a predictor of disease recurrence in prostate cancer, making it a potential diagnostic and prognostic biomarker.
Article
Oncology
Guanghong Du, Xuelian Yu, Yun Chen, Wangting Cai
Summary: MiR-1-3p suppresses colorectal cancer cell proliferation and metastasis by regulating YWHAZ-mediated EMT, which may support a novel therapeutic strategy for CRC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Medicinal
Jia Yang, Gangdan Jiang, Kaiwen Ni, Liming Fan, Wang Tong, Junchao Yang
Summary: Emodin can attenuate pulmonary fibrosis and epithelial-mesenchymal transition (EMT) by regulating the c-MYC/miR-182-5p/ZEB2 axis, providing evidence for the application of Emodin in the treatment of pulmonary fibrosis.
PHYTOTHERAPY RESEARCH
(2023)
Article
Oncology
Heyang Xu, Qiusheng Lan, Yongliang Huang, Yang Zhang, Yujie Zeng, Pengwei Su, Ziqiang Chu, Wei Lai, Zhonghua Chu
Summary: MiR-203a-3p derived from hepatocyte exosomes plays a crucial role in promoting E-cadherin expression and inhibiting Src activity in colorectal cancer cells, leading to reduced invasion rate.
Article
Biochemistry & Molecular Biology
Mei-Chuan Kuo, Wei-An Chang, Ling-Yu Wu, Yi-Chun Tsai, Ya-Ling Hsu
Summary: Hypoxia-induced epithelial-to-mesenchymal transition (EMT) in proximal tubular epithelial cells (PTECs) is modulated by miR-545-3p-TNFSF10 interaction. TNFSF10 attenuates EMT induced by hypoxia in PTECs. These findings provide new insights into the unique regulation of miR-545-3p-TNFSF10 interaction and their potential therapeutic effect in kidney injury induced by hypoxia.
Article
Biochemistry & Molecular Biology
Moamen Masalha, Tal Meningher, Adi Mizrahi, Aviv Barzilai, Hilla Tabibian-Keissar, Devorah Gur-Wahnon, Iddo Z. Ben-Dov, Joshua Kapenhas, Jasmine Jacob-Hirsch, Raya Leibowitz, Yechezkel Sidi, Dror Avni
Summary: Cutaneous squamous cell carcinoma (CSCC) is a skin cancer that evolves from normal epidermis and is characterized by the disruption of cell-cell contacts and acquisition of a mesenchymal motile phenotype. The decreased expression of miR-199a-3p plays a crucial role in this process by targeting RAP2B and inhibiting the epithelial-to-mesenchymal transition (EMT). Inhibitors of RAP2B or FAK may be potential therapeutic agents for CSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Zhongjian Yu, Xiongjie Zhu, Ying Li, Min Liang, Meijun Liu, Zhile Liu, Lingyu Qin, Xiaoran Wu, Kunpeng Du, Lu Liu, Yong Wang, Yanfang Zheng
Summary: The study shows that in lung adenocarcinoma, circ-HMGA2 promotes cell metastasis through the miR-1236-3p/EMT axis, indicating that it could be a therapeutic target in LUAD.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Noriko Funato, Hiromi Yanagisawa
Summary: TBX1 regulates stem cell properties and epithelial differentiation by activating microRNAs, specifically miR-200 and miR-203, to inhibit their common targets BMI1 and ZEB2. The ablation of Tbx1 affects palatal epithelium differentiation and disrupts the expression of miR-200, miR-203, and their target genes. These findings have significant implications for understanding the mechanisms underlying tumors and cleft palate.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Xiaoxu Liu, Jing Wu, Bo Yang, Yuanyuan Zhao, Yafan Wang, Shuhong Pan, Suibing Miao, Xiaohua Wu
Summary: This study found that the hsa_circ_0005991/miR-30b-3p/Cdc42EP1 axis promotes the epithelial-mesenchymal transition process in endometriosis, providing a theoretical basis for the mechanism exploration and therapy of this disease.