Metformin Suppresses Cancer Stem Cells through AMPK Activation and Inhibition of Protein Prenylation of the Mevalonate Pathway in Colorectal Cancer

Metformin exhibited anticancer activity by lowering cellular cholesterol content in breast cancer cells

(2019) Ankit Sharma et al.   PLoS One

Metastatic Colorectal Cancer: Prognostic And Predictive Factors

(2019) Anna Nappi et al.   CURRENT MEDICINAL CHEMISTRY

Effects of metformin on colorectal cancer stem cells depend on alterations in glutamine metabolism

(2018) Jae Hyun Kim et al.   Scientific Reports

Is cholesterol a mediator of cold-induced cancer?

(2016) Chandi C. Mandal et al.   TUMOR BIOLOGY

Metformin suppressed the proliferation of LoVo cells and induced a time-dependent metabolic and transcriptional alteration

(2015) Jiaojiao He et al.   Scientific Reports

Targeting cancer stem cells by curcumin and clinical applications

(2014) Yanyan Li et al.   CANCER LETTERS

Role of Oncogenic K-Ras in Cancer Stem Cell Activation by Aberrant Wnt/β-Catenin Signaling

(2014) Byoung-San Moon et al.   JNCI-Journal of the National Cancer Institute

Synergistic Simvastatin and Metformin Combination Chemotherapy for Osseous Metastatic Castration-Resistant Prostate Cancer

(2014) M. A. Babcook et al.   MOLECULAR CANCER THERAPEUTICS

IHC Profiler: An Open Source Plugin for the Quantitative Evaluation and Automated Scoring of Immunohistochemistry Images of Human Tissue Samples

(2014) Frency Varghese et al.   PLoS One

Chemopreventive drugs: Mechanismsviainhibition of cancer stem cells in colorectal cancer

(2014) Tae Il Kim   WORLD JOURNAL OF GASTROENTEROLOGY

Metformin-Induced Killing of Triple-Negative Breast Cancer Cells Is Mediated by Reduction in Fatty Acid Synthase via miRNA-193b

(2014) Reema S. Wahdan-Alaswad et al.   Hormones & Cancer

Metabolic roles of AMPK and metformin in cancer cells

(2013) Yeon Kyung Choi et al.   MOLECULES AND CELLS

Induction of the Stem-like Cell Regulator CD44 by Rho Kinase Inhibition Contributes to the Maintenance of Colon Cancer-Initiating Cells

(2012) H. Ohata et al.   CANCER RESEARCH

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

(2012) William A. Freed-Pastor et al.   CELL

Novel Aspects of Mevalonate Pathway Inhibitors as Antitumor Agents

(2012) M. Thurnher et al.   CLINICAL CANCER RESEARCH

Metformin use is associated with a decreased incidence of colorectal adenomas in diabetic patients with previous colorectal cancer

(2012) Jin Ha Lee et al.   DIGESTIVE AND LIVER DISEASE

Targeting tumor cell metabolism with statins

(2012) J W Clendening et al.   ONCOGENE

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

(2011) Yu Li et al.   Cell Metabolism

Metformin Amplifies Chemotherapy-Induced AMPK Activation and Antitumoral Growth

(2011) G. Z. Rocha et al.   CLINICAL CANCER RESEARCH

Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission

(2009) H. A. Hirsch et al.   CANCER RESEARCH

Rho GTPases in cancer cell biology

(2008) Francisco M. Vega et al.   FEBS LETTERS