Bergamottin Suppresses Metastasis of Lung Cancer Cells through Abrogation of Diverse Oncogenic Signaling Cascades and Epithelial-to-Mesenchymal Transition

Chemistry and health effects of furanocoumarins in grapefruit

(2017) Wei-Lun Hung et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Ginkgolic Acid C 17:1, Derived from Ginkgo biloba Leaves, Suppresses Constitutive and Inducible STAT3 Activation through Induction of PTEN and SHP-1 Tyrosine Phosphatase

(2017) Seung Baek et al.   MOLECULES

Nimbolide-Induced Oxidative Stress Abrogates STAT3 Signaling Cascade and Inhibits Tumor Growth in Transgenic Adenocarcinoma of Mouse Prostate Model

(2016) Jingwen Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Ginkgolic Acid Inhibits Invasion and Migration and TGF-β-Induced EMT of Lung Cancer Cells Through PI3K/Akt/mTOR Inactivation

(2016) Seung Ho Baek et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ascochlorin Enhances the Sensitivity of Doxorubicin Leading to the Reversal of Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma

(2016) Xiaoyun Dai et al.   MOLECULAR CANCER THERAPEUTICS

Simvastatin in combination with bergamottin potentiates TNF-induced apoptosis through modulation of NF-κB signalling pathway in human chronic myelogenous leukaemia

(2016) Sung-Moo Kim et al.   PHARMACEUTICAL BIOLOGY

Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1: Role in apoptosis induction and radiosensitization in head and neck tumor cells

(2016) Seung Ho Baek et al.   PHYTOMEDICINE

Embelin Inhibits Invasion and Migration of MDA-MB-231 Breast Cancer Cells by Suppression of CXC Chemokine Receptor 4, Matrix Metalloproteinases-9/2, and Epithelial-Mesenchymal Transition

(2016) Hanwool Lee et al.   PHYTOTHERAPY RESEARCH

Bioactive natural products in cancer prevention and therapy: Progress and promise

(2016) Anupam Bishayee et al.   SEMINARS IN CANCER BIOLOGY

Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds

(2016) Muthu K Shanmugam et al.   SEMINARS IN CANCER BIOLOGY

Exosome-Mediated Metastasis: From Epithelial–Mesenchymal Transition to Escape from Immunosurveillance

(2016) Nicholas Syn et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Effects of bergamot essential oil and its extractive fractions on SH-SY5Y human neuroblastoma cell growth

(2015) Michele Navarra et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Ascochlorin, an isoprenoid antibiotic inhibits growth and invasion of hepatocellular carcinoma by targeting STAT3 signaling cascade through the induction of PIAS3

(2015) Xiaoyun Dai et al.   Molecular Oncology

Brassinin Combined with Capsaicin Enhances Apoptotic and Anti-metastatic Effects in PC-3 Human Prostate Cancer Cells

(2015) Sung-Moo Kim et al.   PHYTOTHERAPY RESEARCH

Sustained proliferation in cancer: Mechanisms and novel therapeutic targets

(2015) Mark A. Feitelson et al.   SEMINARS IN CANCER BIOLOGY

Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?

(2015) Shikha Satendra Singh   WORLD JOURNAL OF GASTROENTEROLOGY

Natural Bioactives in Cancer Treatment and Prevention

(2015) Yih-Shou Hsieh et al.   Biomed Research International

Bergamottin, a natural furanocoumarin obtained from grapefruit juice induces chemosensitization and apoptosis through the inhibition of STAT3 signaling pathway in tumor cells

(2014) Sung-Moo Kim et al.   CANCER LETTERS

PI3K and cancer: lessons, challenges and opportunities

(2014) David A. Fruman et al.   NATURE REVIEWS DRUG DISCOVERY

Novel Medicines and Strategies in Cancer Treatment and Prevention

(2014) Chih-Hsin Tang et al.   Biomed Research International

Natural Bioactives and Phytochemicals Serve in Cancer Treatment and Prevention

(2013) Shun-Fa Yang et al.   Evidence-based Complementary and Alternative Medicine

Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway

(2013) Jiri Polivka et al.   PHARMACOLOGY & THERAPEUTICS

Signaling interplay between transforming growth factor-β receptor and PI3K/AKT pathways in cancer

(2013) Long Zhang et al.   TRENDS IN BIOCHEMICAL SCIENCES

Embelin inhibits growth and induces apoptosis through the suppression of Akt/mTOR/S6K1 signaling cascades

(2012) Seong Won Kim et al.   PROSTATE

Epithelial Mesenchymal Transition in Drug Resistance and Metastasis of Lung Cancer

(2012) Fariz Nurwidya et al.   Cancer Research and Treatment

Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways

(2011) Radhamani Kannaiyan et al.   APOPTOSIS

β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation

(2011) Kyung-Ran Park et al.   CANCER LETTERS

Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model

(2011) Muthu K. Shanmugam et al.   INTERNATIONAL JOURNAL OF CANCER

Targeting Cell Signaling and Apoptotic Pathways by Dietary Agents: Role in the Prevention and Treatment of Cancer

(2011) Muthu Shanmugam et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-κB activation in breast and pancreatic tumor cells

(2010) Angeline Wei Ling Chua et al.   BIOCHEMICAL PHARMACOLOGY

Cell and tissue interactions in carcinogenesis and metastasis and their clinical significance

(2010) David Tarin   SEMINARS IN CANCER BIOLOGY

TGF-β-induced epithelial to mesenchymal transition

(2009) Jian Xu et al.   CELL RESEARCH

Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease

(2009) Hervé Acloque et al.   JOURNAL OF CLINICAL INVESTIGATION

Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by bergamottin via the inhibition of protein kinase Cδ/p38 mitogen-activated protein kinase and JNK/nuclear factor-κB-dependent matrix metalloproteinase-9 expression

(2009) Yong Pil Hwang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Metastatic Cancer Cell

(2008) Marina Bacac et al.   Annual Review of Pathology-Mechanisms of Disease

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

(2008) Jing Yang et al.   DEVELOPMENTAL CELL