Breast Cancer Stem-Like Cells Are Inhibited by Diosgenin, a Steroidal Saponin, by the Attenuation of the Wnt β-Catenin Signaling via the Wnt Antagonist Secreted Frizzled Related Protein-4

Wnt/ -Catenin Small-Molecule Inhibitor CWP232228 Preferentially Inhibits the Growth of Breast Cancer Stem-like Cells

(2015) G.-B. Jang et al.   CANCER RESEARCH

Secreted Frizzled-Related Protein 4 Inhibits Glioma Stem-Like Cells by Reversing Epithelial to Mesenchymal Transition, Inducing Apoptosis and Decreasing Cancer Stem Cell Properties

(2015) Bhuvanalakshmi G et al.   PLoS One

An aberrant nuclear localization of E-cadherin is a potent inhibitor of Wnt/β-catenin-elicited promotion of the cancer stem cell phenotype

(2015) Y-J Su et al.   Oncogenesis

Blockade of Wnt/β-catenin signaling suppresses breast cancer metastasis by inhibiting CSC-like phenotype

(2015) Gyu-Beom Jang et al.   Scientific Reports

Comparative analysis of diosgenin in Dioscorea species and related medicinal plants by UPLC-DAD-MS

(2014) Tao Yi et al.   BMC BIOCHEMISTRY

Cancer stem-like cells from head and neck cancers are chemosensitized by the Wnt antagonist, sFRP4, by inducing apoptosis, decreasing stemness, drug resistance and epithelial to mesenchymal transition

(2014) S Warrier et al.   CANCER GENE THERAPY

Wnt Antagonist, Secreted Frizzled-Related Protein 4 (sFRP4), Increases Chemotherapeutic Response of Glioma Stem-Like Cells

(2014) Sudha Warrier et al.   ONCOLOGY RESEARCH

Multifunctional Properties of Chicken Embryonic Prenatal Mesenchymal Stem Cells- Pluripotency, Plasticity, and Tumor Suppression

(2014) G Bhuvanalakshmi et al.   Stem Cell Reviews and Reports

Curcumin inhibits breast cancer stem cell migration by amplifying the E-cadherin/β-catenin negative feedback loop

(2014) Shravanti Mukherjee et al.   Stem Cell Research & Therapy

The Wnt signalling pathway is upregulated in an in vitro model of acquired tamoxifen resistant breast cancer

(2013) Yan Ni Loh et al.   BMC CANCER

sFRP1 Inhibits Epithelial–Mesenchymal Transition in A549 Human Lung Adenocarcinoma Cell Line

(2013) Jin Ren et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Silibinin inhibits β-catenin/ZEB1 signaling and suppresses bladder cancer metastasis via dual-blocking epithelial–mesenchymal transition and stemness

(2013) Kaijie Wu et al.   CELLULAR SIGNALLING

Tumor metastasis: moving new biological insights into the clinic

(2013) Liling Wan et al.   NATURE MEDICINE

Paracrine control of tissue regeneration and cell proliferation by Caspase-3

(2013) K Boland et al.   Cell Death & Disease

Diosgenin Induces Apoptosis in HepG2 Cells through Generation of Reactive Oxygen Species and Mitochondrial Pathway

(2012) Dae Sung Kim et al.   Evidence-based Complementary and Alternative Medicine

The Structural Basis of DKK-Mediated Inhibition of Wnt/LRP Signaling

(2012) J. Bao et al.   Science Signaling

CD24 enhances DNA damage-induced apoptosis by modulating NF-κB signaling in CD44-expressing breast cancer cells

(2011) Ji-hyun Ju et al.   CARCINOGENESIS

DNA-Damage Response in Tissue-Specific and Cancer Stem Cells

(2011) Cedric Blanpain et al.   Cell Stem Cell

Diosgenin, a Steroidal Saponin, Inhibits Migration and Invasion of Human Prostate Cancer PC-3 Cells by Reducing Matrix Metalloproteinases Expression

(2011) Pin-Shern Chen et al.   PLoS One

Secreted Frizzled-Related Protein 4

(2010) Ajit Muley et al.   AMERICAN JOURNAL OF PATHOLOGY

Fenugreek: A naturally occurring edible spice as an anticancer agent

(2010) Shabana Shabbeer et al.   CANCER BIOLOGY & THERAPY

Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells

(2010) Feng Li et al.   CANCER LETTERS

Diosgenin induces death receptor-5 through activation of p38 pathway and promotes TRAIL-induced apoptosis in colon cancer cells

(2010) C. Lepage et al.   CANCER LETTERS

Diosgenin, a Plant-Derived Sapogenin, Enhances Regulatory T-Cell Immunity in the Intestine of Mice with Food Allergy

(2010) Chung-Hsiung Huang et al.   JOURNAL OF NATURAL PRODUCTS

Targeting breast stem cells with the cancer preventive compounds curcumin and piperine

(2009) Madhuri Kakarala et al.   BREAST CANCER RESEARCH AND TREATMENT

Diosgenin targets Akt-mediated prosurvival signaling in human breast cancer cells

(2009) Sowmyalakshmi Srinivasan et al.   INTERNATIONAL JOURNAL OF CANCER

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

Regulation of Endothelial Cell Cytoskeletal Reorganization by a Secreted Frizzled-Related Protein-1 and Frizzled 4- and Frizzled 7-Dependent Pathway

(2007) Pascale Dufourcq et al.   AMERICAN JOURNAL OF PATHOLOGY