Article
Biochemistry & Molecular Biology
Yu Jin, Yalin Kang, Minghuan Wang, Bili Wu, Beibei Su, Han Yin, Yang Tang, Qianxia Li, Wenjie Wei, Qi Mei, Guangyuan Hu, Veronika Lukacs-Kornek, Jian Li, Kongming Wu, Xianglin Yuan, Wei Wang
Summary: This study reveals that activated microglia in brain metastasis of non-small cell lung cancer play a crucial role in promoting tumor cell colonization through IL6/JAK2/STAT3 signaling pathway. Clinical samples and TCGA data support the significance of IL6 in brain metastasis process.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Oncology
Yiru Kong, Deng Shuangshuang, Xiaohua Liang, Xinli Zhou
Summary: This study elucidated the role and regulatory mechanism of RPS9 in non-small cell lung cancer (NSCLC), demonstrating that knockdown of RPS9 inhibits the progression of NSCLC via the inactivation of Stat3 and Erk signaling pathways.
Article
Pharmacology & Pharmacy
Dehua Yu, Simin Qi, Xiaoqing Guan, Wenkai Yu, Xuefei Yu, Maohua Cai, Qinglin Li, Weiyi Wang, Weidong Zhang, Jiang-Jiang Qin
Summary: In this study, the marine-derived natural product terphenyllin was identified to directly interact with STAT3 and exhibit potent anticancer efficacy against gastric cancer through inhibiting the STAT3 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Jiali Xu, Liren Zhang, Nana Li, Jingjing Dai, Ruizhi Zhang, Feifan Yao, Suiqing Zhou, Zifeng Wu, Huixuan Zhou, Ling Zhou, Qing Li, Xuehao Wang, Cunming Liu
Summary: Etomidate significantly inhibits the malignant progression of HCC cells through suppression of the JAK2/STAT3 signaling pathway.
Article
Biochemistry & Molecular Biology
Feng Zhou, Fanyun Zhu, Tianru Zhu, Zhucheng Zhao, Luyao Li, Shichong Lin, Haiyang Zhao, Lehe Yang, Chengguang Zhao, Liangxing Wang, Jifa Li, Xiaoying Huang
Summary: AT7519, a CDK inhibitor, exhibits great anti-tumor effects in lung cancer by blocking IL-6/STAT3 pathway and inhibiting cell proliferation and inducing apoptosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Tian-Jian Yu, Ying-Ying Liu, Xiao-Guang Li, Bi Lian, Xun-Xi Lu, Xi Jin, Zhi-Ming Shao, Xin Hu, Gen-Hong Di, Yi-Zhou Jiang
Summary: The study identifies PDSS1 as an essential gene for TNBC metastasis, with its expression correlated with poor survival in patients. Mechanistically, PDSS1 regulates TNBC metastasis by modulating CoQ10 levels and CAMK2A phosphorylation to induce STAT3 signaling. Inhibitors of STAT3 phosphorylation effectively block PDSS1-induced cell migration and invasion, highlighting PDSS1 as a potential therapeutic target in combating TNBC metastasis.
Article
Medicine, Research & Experimental
Feng Zhou, Ziyi Yuan, Yuyan Gong, Luyao Li, Yanmao Wang, Xian Wang, Chunbo Ma, Lehe Yang, Zhiguo Liu, Liangxing Wang, Haiyang Zhao, Chengguang Zhao, Xiaoying Huang
Summary: Lung cancer, especially non-small cell lung cancer (NSCLC), is a leading cause of cancer deaths worldwide. The metabolic enzyme MTHFD2, which is highly expressed in various tumors including lung cancer, plays a crucial role in NSCLC through its association with the ILK signaling pathway. Inhibition of MTHFD2 leads to suppression of cell growth, migration, invasion, and EMT, while the small-molecule compound C18 efficiently blocks the MTHFD2/ILK pathway and exhibits potential as a therapeutic strategy against NSCLC.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Hai-qing Luo, Yu-meng Huang, Jing Li, Xu-dong Tang, Ran Chen, Yan Wang, Jing Ren, Qiu-qin Dai, Liu-bo Lan, Jiang-yan Chen, Xiang-yong Li
Summary: Omega-3 has been proposed as a potential antitumor substance for suppressing the growth and metastasis of lung cancer cells. This study aimed to investigate the role of omega-3 in inhibiting invasion and metastasis of non-small cell lung cancer (NSCLC) by regulating the expression of CCL18. The results showed that the level of CCL18 was associated with the metastatic ability of NSCLC cells. Omega-3, specifically docosahexaenoic acid (DHA), effectively inhibited invasion and metastasis of NSCLC cells and downregulated the expression of metastasis- and EMT-related genes and the p-STAT3 signaling pathway. Moreover, DHA inhibited CCL18 expression in lung cancer cells, and overexpression of CCL18 reversed the inhibitory effects of DHA on metastasis and invasion of NSCLC cells. This study suggests that DHA inhibits NSCLC cell invasion and metastasis through targeted inhibition of the CCL18/STAT3 signaling pathway and EMT process.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Article
Environmental Sciences
Jingyun Fang, Huan Guan
Summary: This study investigated the effect of a gamma-secretase inhibitor in septic myocardial injury and revealed its mechanism. The results demonstrate that the gamma-secretase inhibitor alleviates septic myocardial injury via activating the JAK2/STAT3 signaling pathway. This research provides a novel therapeutic direction for septic myocardial injury.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Plant Sciences
Lehe Yang, Yulei Yao, Ying Bai, Dandan Zheng, Feng Zhou, Luye Chen, Wanle Hu, Youqun Xiang, Haiyang Zhao, Zhiguo Liu, Liangxing Wang, Xiaoying Huang, Chengguang Zhao
Summary: Corylin demonstrates potent anti-tumor activity in CRC by inhibiting the STAT3 signaling pathway, reducing cell viability, inducing apoptosis, and suppressing tumor growth. These findings support the potential of corylin as a unique STAT3 inhibitor in anti-tumor therapy.
Article
Microbiology
Guoli Hou, Zhao Lv, Wenzhi Liu, Shuting Xiong, Qiushi Zhang, Chun Li, Xiaodong Wang, Liang Hu, Chunhua Ding, Rui Song, Hongquan Wang, Yong-An Zhang, Tiaoyi Xiao, Junhua Li
Summary: Viral seasonality in the aquaculture industry is a significant scientific issue, but the temperature-dependent pathogenesis of aquatic viral diseases remains poorly understood. This study demonstrates that grass carp reovirus (GCRV) exploits the IL6-STAT3-HSP90 signaling to promote viral entry in a temperature-dependent manner. The interaction between GCRV's major capsid protein VP7 and HSP90 facilitates viral entry. Understanding the molecular mechanism behind temperature-dependent viral pathogenesis can guide the development of targeted preventives and therapeutics for aquaculture viral diseases.
Article
Chemistry, Medicinal
Dong-Ping Wang, Li-Hong Wu, Rui Li, Na He, Qian-Yue Zhang, Chen-Yang Zhao, Tao Jiang
Summary: The JAK/STAT3 signaling pathway is hyperactivated in many cancers, and inhibitors targeting this pathway have great potential for cancer treatment. In this study, we modified aldisine derivatives by introducing the isothiouronium group, which improved their antitumor activity. Through high-throughput screening, we identified compound 11c as a potent inhibitor of JAK/STAT3 activities. Further experiments showed that compound 11c effectively inhibited STAT3 activation and induced apoptosis in cancer cells. In an in vivo tumor xenograft experiment, compound 11c demonstrated significant antitumor effects.
Article
Medicine, Research & Experimental
Xiang Cao, Xin-Ming Chen, Wei-Zhang Xiao, Ben Li, Bo Zhang, Qiong Wu, Qun Xue
Summary: The study found PRDX5 to be highly expressed in non-small cell lung cancer tissues, and its demethylation status in the promoter region was related to the TNM stage. The binding of STAT3 to PRDX5 promoter region enhanced PRDX5 protein expression. PRDX5 promoted cell migration and invasion under oxidative stress conditions in NSCLC through activation of the Nrf2 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Chemistry, Medicinal
Ayyiliath M. Sajith, Kereyagalahally H. Narasimhamurthy, Muthu K. Shanmugam, Shobith Rangappa, S. Chandra Nayak, Arunachalam Chinnathambi, Tahani Awad Alahmadi, Sulaiman Ali Alharbi, K. R. Haridas, E. K. Reddy, B. Savitha, Chakrabhavi Dhananjaya Mohan, Kanchugarakoppal S. Rangappa
Summary: The synthesized compound MNK8 showed good cytotoxicity against hepatocellular carcinoma cells by suppressing phosphorylation of STAT3, inducing apoptotic effects, and reducing cell migration and invasion capabilities.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Review
Cell Biology
Jianbiao Zhou, Wee-Joo Chng
Summary: This article summarizes the role of STAT3 in multiple myeloma (MM), including its involvement in cell survival and proliferation, regulation of the tumor microenvironment, and induction of immunosuppression. The article also provides updates on different strategies for targeting STAT3 in MM, with a focus on JAK inhibitors currently undergoing clinical trials. Finally, the challenges and future directions of understanding STAT3 signaling and developing STAT3 inhibitors in MM are discussed.
Article
Environmental Sciences
Haiying Lu, Changlei Xia, Arunachalam Chinnathambi, Omaima Nasif, Mathiyazhagan Narayanan, Sabarathinam Shanmugam, Nguyen Thuy Lan Chi, Arivalagan Pugazhendhi, Ruangwong On-Uma, Kumchai Jutamas, Wongchai Anupong
Summary: The current study investigated the plant growth promoting (PGP) characteristics of multi-metal-tolerant Bacillus cereus and their positive effect on the physiology, biomolecule substance, and phytoremediation ability of Chrysopogon zizanioides in metal-contaminated soil.
Review
Biotechnology & Applied Microbiology
Milad Ashrafizadeh, Kiavash Hushmandi, Sepideh Mirzaei, Saied Bokaie, Ashkan Bigham, Pooyan Makvandi, Navid Rabiee, Vijay Kumar Thakur, Alan Prem Kumar, Esmaeel Sharifi, Rajender S. Varma, Amir Reza Aref, Marcin Wojnilowicz, Ali Zarrabi, Hassan Karimi-Maleh, Nicolas H. Voelcker, Ebrahim Mostafavi, Gorka Orive
Summary: Green chemistry has shown great promise in biomedical applications, particularly in cancer therapy. Chitosan-based nanoparticles (CS-NPs) serve as a promising carrier for anti-cancer drugs, overcoming drug resistance and enabling synergistic therapy. Various types of nanostructures can be modified with chitosan for efficient delivery of chemotherapeutic agents such as doxorubicin (DOX). The functionalization of CS-NPs with ligands and their pH-sensitive and redox-responsive characteristics further enhance their selectivity and drug release. Considering their high encapsulation efficiency and biocompatibility, significant progress is expected in the clinical translation of CS-NPs.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Energy & Fuels
Rajasree Shanmuganathan, Nguyen Thuy Lan Chi, Arunachalam Chinnathambi, Saleh H. Salmen, G. K. Jhanani, Beata Gavurova, Manigandan Sekar, Arivalagan Pugazhendhi, T. R. Praveenkumar
Summary: Extensive use of fossil fuels is the main cause of global warming. Biodiesel, as a promising alternative, can improve engine performance and reduce emissions when combined with nanoparticles and hydrogen. Among the blends tested, B20CH showed the lowest emissions.
Review
Biochemistry & Molecular Biology
Hardeep Singh Tuli, Prangya Rath, Abhishek Chauhan, Anuj Ranjan, Seema Ramniwas, Katrin Sak, Diwakar Aggarwal, Manoj Kumar, Kuldeep Dhama, E. Hui Clarissa Lee, Kenneth Chun-Yong Yap, Sharah Mae Capinpin, Alan Prem Kumar
Summary: Cucurbitacins, a group of highly oxidized tetracyclic triterpenoids found in cucumbers, have potential medical uses. They interact with various cellular targets to inhibit cancer cell growth through induction of apoptosis, cell-cycle arrest, anti-metastasis, and anti-angiogenesis. They may also be used in combination with other drugs to overcome treatment resistance in cancer cells. This study focuses on finding molecular targets for cucurbitacins in suppressing malignant processes.
Article
Biochemistry & Molecular Biology
Basappa Basappa, Lisha K. Poonacha, Zhang Xi, Divakar Vishwanath, Ji-Rui Yang, Omantheswara Nagaraja, Ananda Swamynayaka, Mahendra Madegowda, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Doddahosuru Mahadevappa Gurudatt, Vijay Pandey, Nanjundaswamy Shivananju, Kwang Seok Ahn, Gautam Sethi, Peter E. Lobie, Priya Babu Shubha
Summary: Small molecules are used to inhibit CDK enzymes in cancer treatment. Pyranopyrazoles were identified as CDK inhibitors synthesized by nano-zirconium dioxide via multicomponent reaction. The bioactive pyranopyrazoles target CDK1 in human breast cancer cells.
Article
Medicine, Research & Experimental
Na Young Kim, In Jin Ha, Jae-Young Um, Alan Prem Kumar, Gautam Sethi, Kwang Seok Ahn
Summary: This study found that LGA can effectively inhibit the proliferation, invasive ability, and migration of hepatocellular carcinoma cells, and reduce the occurrence of EMT by suppressing MnSOD expression. This has important implications for the development of novel anti-metastatic agents.
Review
Chemistry, Medicinal
Hui Li Ang, Chakrabhavi Dhananjaya Mohan, Muthu K. Shanmugam, Hin Chong Leong, Pooyan Makvandi, Kanchugarakoppal S. Rangappa, Anupam Bishyaee, Alan Prem Kumar, Gautam Sethi
Summary: Epithelial-mesenchymal transition (EMT) is a crucial process in which epithelial cells transform into mesenchymal cells, playing a significant role in tumor progression and resistance to therapy. Various factors, such as signaling pathways, transcriptional regulators, noncoding RNAs, and epigenetic alterations, are involved in the regulation of EMT. However, despite preclinical data, there is a lack of clinical translation in targeting EMT therapeutically. This review discusses the role of these factors in EMT regulation, the contribution of EMT to drug resistance, and potential therapeutic interventions using natural products and nano-formulations as EMT blockers.
MEDICINAL RESEARCH REVIEWS
(2023)
Review
Biotechnology & Applied Microbiology
Xin Yuan Lim, Sharah Mae Capinpin, Nagarjun Bolem, Aaron Song Chuan Foo, Wai-Cheong George Yip, Alan Prem Kumar, Daniel Boon Loong Teh
Summary: Glioblastoma multiforme (GBM) is an aggressive brain tumor with limited treatment options due to the difficulty of drugs crossing the blood-brain barrier (BBB) and tumor heterogeneity. Nanoparticle (NP) drug carriers have shown promise in targeting cells beyond the BBB. This review focuses on biomimetic NPs in GBM therapy and their potential in overcoming physiological and anatomical challenges.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Milad Ashrafizadeh, Wei Zhang, Rongjun Zou, Gautam Sethi, Daniel J. Klionsky, Xianbin Zhang
Summary: Pancreatic cancer is a serious gastrointestinal tract disease with a low 5-year survival rate. Genomic profile alterations and dysregulated biological mechanisms commonly occur in pancreatic cancer. Autophagy plays a crucial role in promoting the growth and metastasis of pancreatic cancer cells, as well as controlling their metabolism and drug resistance.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Chemistry, Medicinal
Bhagyalakshmi Nair, Jayaprakash K. Adithya, Gopika Chandrababu, P. K. Lakshmi, Joel Joy Koshy, Sreedharan Vilasini Manoj, D. B. Ambiliraj, Balachandran S. Vinod, Gautam Sethi, Lekshmi R. Nath
Summary: Keap1-Nrf2 is a crucial signaling cascade for promoting or preventing carcinogenesis. Nutraceuticals, as dietary agents with health benefits, show great potential as chemoprevention agents for cancer. This review systematically analyzes the role of 12 different nutraceuticals in modulating the Nrf2/Keap1 signaling mechanism. Although there is considerable preclinical evidence, further high-quality research is needed to validate the potential role of these nutraceuticals in Keap1-Nrf2 modulation.
PHYTOTHERAPY RESEARCH
(2023)
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Food Science & Technology
Mangala Hegde, Aviral Kumar, Sosmitha Girisa, Babu Santha Aswani, Ravichandran Vishwa, Gautam Sethi, Ajaikumar B. Kunnumakkara
Summary: Cancer is a complex disease with diverse characteristics and treatment responses. Overcoming the recurrence and resistance to therapy, as well as minimizing side effects, is crucial for improving the quality of life in cancer patients. This review explores the potential benefits of nanocurcumin, a nanotechnology-based formulation of the natural compound curcumin, in cancer treatment. Various types of curcumin nanoformulations are discussed, along with their anticancer activities and cellular mechanisms. The review also highlights the potential of nanocurcumin as a preventive or adjuvant therapy with conventional drugs.
Article
Oncology
Naveen Kumar, Gautam Sethi
Summary: Transformed cells acquire specific characteristics to become malignant. Telomerase, an enzyme complex, plays a significant role in maintaining telomere length. Its main component, TERT, interacts with various signaling molecules and promotes cancer hallmarks such as cell death resistance, sustained proliferation, angiogenesis activation, and metastasis. Understanding the role of telomerase in promoting cancer hallmarks is crucial for understanding the mechanism of cancer development and progression.