Article
Medicine, Research & Experimental
Aihua Wu, Daoquan Fang, Yangyang Liu, Xiaomeng Shi, Zuyue Zhong, Baojian Zhou, Lechi Ye, Xuecheng Sun, Lei Jiang
Summary: This study investigates the role of Trx-1 nuclear translocation in the development of colorectal cancer (CRC). The research reveals that nuclear translocation of Trx-1 is induced by IL-6 and is closely associated with STAT3 activation, lymph node metastasis, and distant metastasis in human CRC. Inhibiting Trx-1 nuclear translocation could potentially be a therapeutic target for the treatment of CRC and colitis-associated cancer (CAC).
Article
Medicine, Research & Experimental
Minmin Xu, Li Ren, Jinhua Fan, Lu Huang, Liming Zhou, Xuegang Li, Xiaoli Ye
Summary: Berberine was found to inhibit proliferation, induce apoptosis and cell cycle arrest of gastric cancer cells, as well as suppress migration and invasion. In addition, it was shown to modulate signaling pathways related to IL-6/JAK2/STAT3, providing a theoretical basis for its use in gastric cancer prevention.
Article
Cell Biology
Xuedi Gao, Wenfang Bao, Jin Bai, Kailing Fan, Li Li, Yandong Li
Summary: UHMK1 is frequently upregulated in colorectal cancer and its high expression predicts poor prognosis. Knockdown of UHMK1 inhibits CRC cell proliferation and increases sensitivity to oxaliplatin, while overexpression of UHMK1 promotes CRC cell growth and oxaliplatin resistance. UHMK1 interacts with STAT3 and enhances its activity in regulating gene transcription, thus affecting IL6/STAT3 signaling.
CELL DEATH & DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Antonios N. Gargalionis, Kostas A. Papavassiliou, Athanasios G. Papavassiliou
Summary: STAT3 plays a critical role in the development of colorectal cancer by enhancing tumor cell proliferation and growth through inflammatory mechanisms. However, the mechanisms underlying the role of STAT3 in tumor immunity are not fully understood, and STAT3 inhibitors have not yet been widely used in clinical practice.
Article
Cell Biology
Beiping Zhong, Bing Cheng, Xiaoming Huang, Qian Xiao, Zhitong Niu, Yu-feng Chen, Qiang Yu, Wenyu Wang, Xiao-Jian Wu
Summary: Cancer-associated fibroblasts (CAFs) play a crucial role in colorectal cancer (CRC) metastasis by inducing the expression of Leucine Rich Alpha-2-Glycoprotein 1 (LRG1), which promotes CRC migration and invasion through epithelial-mesenchymal transition (EMT). The CAFs-mediated IL-6-STAT3-LRG1 axis is responsible for the up-regulation of LRG1 in CRC, and higher LRG1 expression predicts poor clinical outcomes, especially distant metastasis free survival in CRC patients.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Yi Shou, Changjie Yue, Qi Wang, Jingchong Liu, Jiaju Xu, Qi Miao, Di Liu, Hongmei Yang, Yuenan Liu, Xiaoping Zhang
Summary: Renal cell carcinoma (RCC) is difficult to diagnose early and prone to metastasis. Sunitinib is the recommended first-line drug for advanced RCC, but adaptive resistance is a major challenge. In this study, circPTPN12 was found to be highly expressed in RCC tissues and associated with poorer clinical outcomes. CircPTPN12 promoted RCC cell proliferation, migration, invasion, and resistance to sunitinib. Mechanistically, circPTPN12 formed a complex with hnRNPM and enhanced its ability to stabilize IL-6 mRNA, activating the STAT3 signaling pathway. This study identifies circPTPN12/hnRNPM/IL-6/STAT3 axis as a promising therapeutic target for relieving sunitinib resistance in RCC.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Bhesh Raj Sharma, Rajendra Karki, Balamurugan Sundaram, Yaqiu Wang, Peter Vogel, Thirumala-Devi Kanneganti
Summary: This study found that IRF9 plays an oncogenic role in CRC, and its loss reduces tumorigenesis. IRF9 promotes the activation of the pro-oncogenic STAT3 signaling pathway in the colon by promoting the release of IL-6. These findings provide new therapeutic strategies for the treatment of CRC.
Article
Biochemistry & Molecular Biology
Sun-Ae Park, Young Ju Seo, Lee Kyung Kim, Hee Jung Kim, Kee Dong Yoon, Tae-Hwe Heo
Summary: The study found that Butea monosperma, a traditional Indian medicine, has potent anti-IL-6 activity and can be used for the treatment of ovarian cancer. It inhibits IL-6 signaling pathway, suppresses cell proliferation, migration, and invasion, induces cell cycle arrest and apoptosis, and significantly inhibits the growth of ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jihye Yoo, Darong Kim, Jiyoung Park, Young-Kook Kim, Hea-Young Park Choo, Hyun Ae Woo
Summary: Development of small molecule inhibitors for inflammatory cytokines is a promising strategy for treating inflammatory diseases like rheumatoid arthritis. The synthesized compounds demonstrated significant inhibitory activity on interleukins and their signaling pathways, showing potential for further development as small molecule inhibitors for RA.
Review
Oncology
Bei Huang, Xiaoling Lang, Xihong Li
Summary: This article focuses on the role of interleukin-6 (IL-6) in liver cancer, breast cancer, colorectal cancer, gastric cancer, lung cancer, pancreatic cancer and ovarian cancer, as well as its relationship with the JAK2/STAT3 signaling pathway.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medical Laboratory Technology
Eman H. Yousef, Nada F. Abo El-Magd, Amal M. El Gayar
Summary: This study evaluates the ability of norcantharidin (NCTD) to improve the efficacy of sorafenib (Sora) in hepatocellular carcinoma (HCC). The results show that NCTD enhances the activity of Sora against HCC and potentiates Sora-induced oxidative stress, tumor immunity reactivation, and attenuation of angiogenesis and metastasis. NCTD also suppresses drug resistance and stemness, and boosts Sora's antiproliferative and apoptotic activities.
TRANSLATIONAL RESEARCH
(2023)
Article
Oncology
Tsunenori Yamamoto, Ryouichi Tsunedomi, Masao Nakajima, Nobuaki Suzuki, Shin Yoshida, Shinobu Tomochika, Ming Xu, Yuki Nakagami, Hiroto Matsui, Yukio Tokumitsu, Yoshitaro Shindo, Yusaku Watanabe, Michihisa Iida, Shigeru Takeda, Shoichi Hazama, Tsuyoshi Tanabe, Tatsuya Ioka, Yoshinobu Hoshii, Akifumi Kiyota, Hitoshi Takizawa, Yutaka Kawakami, Tomio Ueno, Hiroaki Nagano
Summary: This study investigated the relationship between an immunosuppressive state and patient prognosis in colorectal cancer (CRC) by evaluating the levels of interleukin (IL)-6 in both the systemic and tumor microenvironment. The results showed that elevated serum IL-6 levels were associated with elevated stromal IL-6 levels and a poor prognosis for CRC patients. In addition, tumor-infiltrating immune cells expressing IL-6 were primarily composed of myeloid cells and rarely lymphoid cells.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Athina Dritsoula, Laura Dowsett, Camilla Pilotti, Marie N. O'Connor, Stephen E. Moss, John Greenwood
Summary: This study investigates the role of IL-6 in defective angiogenesis mediated by LRG1. The results show that IL-6 activates LRG1 transcription through STAT3 phosphorylation, resulting in vascular destabilization. This finding is important for understanding the role of IL-6 in COVID-19 patients.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Medicinal
Xiu-Qiao Zhou, Xiao-Mei Mao, Rui Fan, Si-Yang Li, Jin Shang, Tong Zhang, Rui-Han Li, Hui-Qi Li, Yang Hui, Wen-Hao Chen, Zhan-Xiang Wang, Dong-Yan Shen
Summary: TBB, a compound extracted from Wedelia trilobata flowers, exhibits significant anti-tumor effects on HCC cells, inhibiting cell growth, inducing apoptosis, arresting cell cycle, and regulating protein expression levels. It effectively suppresses tumor growth in xenograft models without causing overt toxicity to healthy tissues.
PHYTOTHERAPY RESEARCH
(2021)
Article
Chemistry, Medicinal
Yaxian Wang, Xipeng Sun, Quanjun Yang, Cheng Guo
Summary: The main features of cancer cachexia include skeletal muscle atrophy, which significantly reduces the quality of life of patients. Current clinical treatment mainly focuses on nutritional therapy and physical exercise, while medication only improves appetite. In this study, the researchers found that cucurbitacin IIb (CuIIb) can ameliorate muscle wasting in cancer cachexia by preventing the upregulation of muscle atrophy related proteins and regulating the IL-6/STAT3/FoxO pathway.
PHYTOTHERAPY RESEARCH
(2023)
Article
Oncology
Jiazhang Wei, Jiaxiang Ye, Yue Luo, Jingjin Weng, Qian He, Fei Liu, Min Li, Yan Lin, Yongqiang Li, Zhe Zhang, Shenhong Qu, Jinyan Zhang
Article
Gastroenterology & Hepatology
Rong-yun Mai, Jie Zeng, Hua-ze Lu, Rong Liang, Yan Lin, Xue-min Piao, Xing Gao, Guo-bin Wu, Fei-xiang Wu, Liang Ma, Bang-de Xiang, Le-qun Li, Jia-zhou Ye
Summary: The combination of APRI and sFLR showed significantly greater predictive accuracy for severe PHLF in HCC patients compared to using CP grade, MELD, APRI, or sFLR alone.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Surgery
Rong-yun Mai, Hua-ze Lu, Tao Bai, Rong Liang, Yan Lin, Liang Ma, Bang-de Xiang, Guo-bin Wu, Le-qun Li, Jia-zhou Ye
Article
Genetics & Heredity
Ziyu Liu, Yan Lin, Xing Gao, Rongyun Mai, Xuemin Piao, Jiazhou Ye, Rong Liang
FRONTIERS IN GENETICS
(2020)
Article
Oncology
Rong Liang, Jinyan Zhang, Zhihui Liu, Ziyu Liu, Qian Li, Xiaoling Luo, Yongqiang Li, Jiazhou Ye, Yan Lin
Summary: RBM8A is abnormally overexpressed in hepatocellular carcinoma (HCC) and is involved in the development of drug resistance. It has the ability to regulate tumor-related signaling pathways, particularly through its interaction with histone deacetylase 9 (HDAC9). These findings suggest that RBM8A and its related pathways could serve as potential markers of oxaliplatin resistance and therapeutic targets in HCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Min Luo, Yao Xiong, Yan Lin, Rong Liang, Yongqiang Li, Lianying Ge
Summary: The study found that HHLA2 is highly expressed in HCC tissues compared to para-carcinoma liver tissues, indicating its significant role in HCC development and progression. Due to its high expression, HHLA2 may serve as a potential prognostic biomarker for HCC.
MEDICAL SCIENCE MONITOR
(2021)
Article
Oncology
Rong-yun Mai, Jie Zeng, Wei-da Meng, Hua-ze Lu, Rong Liang, Yan Lin, Guo-bin Wu, Le-qun Li, Liang Ma, Jia-zhou Ye, Tao Bai
Summary: The study found that an artificial neural network model can predict PHER for HCC patients more accurately, aiding in determining postoperative treatment and monitoring.
Review
Oncology
Jiazhou Ye, Xiaomin She, Ziyu Liu, Ziqin He, Xing Gao, Lu Lu, Rong Liang, Yan Lin
Summary: EIF4A3 plays a crucial role in post-transcriptional gene regulation and maintains the expression of important proteins, but its overexpression is associated with tumorigenesis in various cancers. Further research is needed to elucidate its functions, mechanisms, and potential clinical applications, providing new insights and opportunities for cancer diagnosis and treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Min Luo, Yan Lin, Rong Liang, Yongqiang Li, Lianying Ge
Summary: Higher levels of HHLA2 in HCC are associated with advanced clinical cancer stage, multiple tumors, poor tumor differentiation, microvascular invasion, and hepatic capsule invasion. High levels of HHLA2 are correlated significantly with density of TILs, but not with PD-L1 levels. High HHLA2 levels are associated with worse prognosis.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Oncology
Yan Lin, Lei Wei, Beiquan Hu, Jinyan Zhang, Jiazhang Wei, Zhongrun Qian, Donghua Zou
Summary: The study revealed that RBM8A is up-regulated in GBM tissues and its higher expression is correlated with worse prognosis. RBM8A may promote GBM cell proliferation and migration by activating the Notch/STAT3 pathway, suggesting it as a potential therapeutic target for GBM treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yue Luo, Jiaxiang Ye, Yayan Deng, Yujuan Huang, Xue Liu, Qian He, Yong Chen, Qiuyun Li, Yan Lin, Rong Liang, Yongqiang Li, Jiazhang Wei, Jinyan Zhang
Summary: The miRNA-185-5p/STIM1 axis regulates the invasiveness of nasopharyngeal carcinoma (NPC) cell lines by affecting EGFR activation, making it a potential therapeutic target. Additionally, knocking down STIM1 inhibits migration ability and locoregional lymphatic invasion of NPC cells.
Article
Oncology
Jiazhou Ye, Yan Lin, Xing Gao, Lu Lu, Xi Huang, Shilin Huang, Tao Bai, Guobin Wu, Xiaoling Luo, Yongqiang Li, Rong Liang
Summary: Bioinformatics tools were used to identify prognosis-related molecular subtypes and biomarkers of hepatocellular carcinoma (HCC). Differential expression analysis of four datasets identified 3330 overlapping differentially expressed genes (DEGs) in the same direction in all four datasets. Those genes were involved in the cell cycle, FOXO signaling pathway, as well as complement and coagulation cascades. Based on non-negative matrix decomposition, two molecular subtypes of HCC with different prognoses were identified, with subtype C2 showing better overall survival than subtype C1. Cox regression and Kaplan-Meier analysis showed that 217 of the overlapping DEGs were closely associated with HCC prognosis. The subset of those genes showing an area under the curve >0.80 was used to construct random survival forest and least absolute shrinkage and selection operator models, which identified seven feature genes (SORBS2, DHRS1, SLC16A2, RCL1, IGFALS, GNA14, and FANCI) that may be involved in HCC occurrence and prognosis. Based on the feature genes, risk score and recurrence models were constructed, while a univariate Cox model identified FANCI as a key gene involved mainly in the cell cycle, DNA replication, and mismatch repair. Further analysis showed that FANCI had two mutation sites and that its gene may undergo methylation. Single-sample gene set enrichment analysis showed that Th2 and T helper cells are significantly upregulated in HCC patients compared to controls. Our results identify FANCI as a potential prognostic biomarker for HCC.
Article
Oncology
Xing Gao, Cheng Lu, Ziyu Liu, Yan Lin, Julu Huang, Lu Lu, Shuanghang Li, Xi Huang, Minchao Tang, Shilin Huang, Ziqin He, Xiaomin She, Rong Liang, Jiazhou Ye
Summary: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. Sorafenib, a first-line chemotherapeutic drug, is the standard therapy for advanced HCC. However, the development of drug resistance limits its efficacy. This study aimed to identify the mechanisms underlying sorafenib resistance and found that the RBM38-GAS5 signaling pathway is involved.
Review
Oncology
Xue Liu, Yayan Deng, Yujuan Huang, Jiaxiang Ye, Sifang Xie, Qian He, Yong Chen, Yan Lin, Rong Liang, Jiazhang Wei, Yongqiang Li, Jinyan Zhang
Summary: Genomic instability plays a crucial role in driving the evolution of malignancies, enhancing tumor cells' ability to adapt to the tumor microenvironment. Nasopharyngeal carcinoma progression is driven by genomic instability and persistent EBV infection, highlighting the importance of understanding and targeting genomic instability for effective treatment strategies.
