Abrogation of STAT3 signaling cascade by zerumbone inhibits proliferation and induces apoptosis in renal cell carcinoma xenograft mouse model

Withaferin A inhibits JAK/STAT3 signaling and induces apoptosis of human renal carcinoma Caki cells

(2012) Hee Jung Um et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Key cell signaling pathways modulated by zerumbone: Role in the prevention and treatment of cancer

(2012) Remya Prasannan et al.   BIOCHEMICAL PHARMACOLOGY

Zerumbone causes Bax- and Bak-mediated apoptosis in human breast cancer cells and inhibits orthotopic xenograft growth in vivo

(2012) Anuradha Sehrawat et al.   BREAST CANCER RESEARCH AND TREATMENT

Expression and prognostic significance of Src family members in renal clear cell carcinoma

(2012) T Qayyum et al.   BRITISH JOURNAL OF CANCER

YB-1 suppression induces STAT3 proteolysis and sensitizes renal cancer to interferon-α

(2012) Ario Takeuchi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Celastrol Suppresses Growth and Induces Apoptosis of Human Hepatocellular Carcinoma through the Modulation of STAT3/JAK2 Signaling Cascade In Vitro and In Vivo

(2012) P. Rajendran et al.   Cancer Prevention Research

STAT3 Polymorphism Can Predict the Response to Interferon-α Therapy in Patients with Metastatic Renal Cell Carcinoma

(2012) Masatoshi Eto et al.   EUROPEAN UROLOGY

Zerumbone, a Southeast Asian Ginger Sesquiterpene, Induced Apoptosis of Pancreatic Carcinoma Cells through p53 Signaling Pathway

(2012) Songyan Zhang et al.   Evidence-based Complementary and Alternative Medicine

Zerumbone inhibits interleukin-6 and induces apoptosis and cell cycle arrest in ovarian and cervical cancer cells

(2012) Siddig Ibrahim Abdelwahab et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Successful Treatment of Renal Cell Carcinoma With Sorafenib After Effective but Hepatotoxic Sunitinib Exposure

(2012) Hans M. Westgeest et al.   JOURNAL OF CLINICAL ONCOLOGY

Novel Agents and Approaches for Advanced Renal Cell Carcinoma

(2012) Robert Figlin et al.   JOURNAL OF UROLOGY

Predictive models for the practical management of renal cell carcinoma

(2012) Lui Shiong Lee et al.   Nature Reviews Urology

Antiangiogenic and Antimetastatic Activity of JAK Inhibitor AZD1480

(2011) H. Xin et al.   CANCER RESEARCH

Simultaneous targeting of Src kinase and receptor tyrosine kinase results in synergistic inhibition of renal cell carcinoma proliferation and migration

(2011) Lanfang Bai et al.   INTERNATIONAL JOURNAL OF CANCER

γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent

(2010) Peramaiyan Rajendran et al.   BRITISH JOURNAL OF PHARMACOLOGY

Suppression of SOCS3 increases susceptibility of renal cell carcinoma to interferon-α

(2010) Shintaro Tomita et al.   CANCER SCIENCE

Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet)

(2010) Manal Mohamed Elhassan Taha et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Cytotoxicity against cholangiocarcinoma cell lines of zerumbone derivatives

(2010) Uraiwan Songsiang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Zerumbone induces apoptosis in T-acute lymphoblastic leukemia cells

(2010) Siddig Ibrahim Abdelwahab et al.   LEUKEMIA RESEARCH

Is Stat3 and/or p53 mRNA expression a prognostic marker for renal cell carcinoma?

(2009) Akinori Masuda et al.   BIOMEDICAL RESEARCH-TOKYO

Zerumbone Abolishes RANKL-Induced NF-κB Activation, Inhibits Osteoclastogenesis, and Suppresses Human Breast Cancer–Induced Bone Loss in Athymic Nude Mice

(2009) Bokyung Sung et al.   CANCER RESEARCH

Sunitinib Inhibition of Stat3 Induces Renal Cell Carcinoma Tumor Cell Apoptosis and Reduces Immunosuppressive Cells

(2009) H. Xin et al.   CANCER RESEARCH

Molecular Targeting Agents in Renal Cell Carcinoma: Present Strategies and Future Perspectives

(2008) Snezana Bjelogrlic et al.   CURRENT PHARMACEUTICAL DESIGN

Targeting STAT3 in cancer: how successful are we?

(2008) Peibin Yue et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Zerumbone, a tropical ginger sesquiterpene, inhibits colon and lung carcinogenesis in mice

(2008) Mihye Kim et al.   INTERNATIONAL JOURNAL OF CANCER