Long non-coding RNAs in the doxorubicin resistance of cancer cells

CRISPR-Cas13-Mediated Knockdown of lncRNA-GACAT3 Inhibited Cell Proliferation and Motility, and Induced Apoptosis by Increasing p21, Bax, and E-Cadherin Expression in Bladder Cancer

(2021) Zhongfu Zhang et al.   Frontiers in Molecular Biosciences

Single-cell long noncoding RNA (lncRNA) transcriptome implicates MALAT1 in triple-negative breast cancer (TNBC) resistance to neoadjuvant chemotherapy

(2021) Hibah Shaath et al.   Cell Death Discovery

Curcumin suppresses tumor growth of gemcitabine-resistant non-small cell lung cancer by regulating lncRNA-MEG3 and PTEN signaling

(2021) L. Gao et al.   Clinical & Translational Oncology

Exosomes in triple negative breast cancer: Garbage disposals or Trojan horses?

(2020) Chia Yin Goh et al.   CANCER LETTERS

Non-coding RNAs in GI cancers: from cancer hallmarks to clinical utility

(2020) Mihnea Paul Dragomir et al.   GUT

Exosome‐mediated transfer of long noncoding RNA H19 induces doxorubicin resistance in breast cancer

(2020) Xinxing Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA

(2020) Pan Wu et al.   Molecular Cancer

LncRNA PVT1 Enhances Proliferation and Cisplatin Resistance via Regulating miR-194-5p/HIF1a Axis in Oral Squamous Cell Carcinoma

(2020) Fang Wang et al.   OncoTargets and Therapy

FOXC2 Promotes Oxaliplatin Resistance by Inducing Epithelial-Mesenchymal Transition via MAPK/ERK Signaling in Colorectal Cancer

(2020) Yihong Chen et al.   OncoTargets and Therapy

HIF-1α or HOTTIP/CTCF promotes head and neck squamous cell carcinoma progression and drug resistance by targeting HOXA9

(2020) Qiang Sun et al.   Molecular Therapy-Nucleic Acids

The Emerging Role of Long Non-Coding RNAs in the Metastasis of Hepatocellular Carcinoma

(2020) Xuejiao Chen et al.   Biomolecules

Silencing of lncRNA XIST inhibits non-small cell lung cancer growth and promotes chemosensitivity to cisplatin

(2020) Xiaohui Xu et al.   Aging-US

LncRNA Sox2OT-V7 promotes doxorubicin-induced autophagy and chemoresistance in osteosarcoma via tumor-suppressive miR-142/miR-22

(2020) Kewei Zhu et al.   Aging-US

LncRNA TUG1 facilitates proliferation, invasion and stemness of ovarian cancer cell via miR ‐186‐5p/ ZEB1 axis

(2020) Fu‐Liang Zhan et al.   CELL BIOCHEMISTRY AND FUNCTION

The multifaceted role of reactive oxygen species in tumorigenesis

(2020) Anuradha Kirtonia et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

LncRNA LINP1 confers tamoxifen resistance and negatively regulated by ER signaling in breast cancer

(2020) Tingting Ma et al.   CELLULAR SIGNALLING

LncRNA XIST promotes chemoresistance of breast cancer cells to doxorubicin by sponging miR‐200c‐3p to upregulate ANLN

(2020) Min Zhang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Long non-coding RNAs regulate drug resistance in cancer

(2020) Kaisheng Liu et al.   Molecular Cancer

Autophagy-modulating phytochemicals in cancer therapeutics: Current evidences and future perspectives

(2020) Srimanta Patra et al.   SEMINARS IN CANCER BIOLOGY

TUG1 knockdown inhibits the tumorigenesis and progression of prostate cancer by regulating microRNA-496/Wnt/β-catenin pathway

(2020) Gang Li et al.   ANTI-CANCER DRUGS

Downregulation of lncRNA H19 sensitizes melanoma cells to cisplatin by regulating the miR-18b/IGF1 axis

(2020) Li-feng An et al.   ANTI-CANCER DRUGS

Exosomes as drug delivery vehicle and contributor of resistance to anticancer drugs

(2020) Mahendran Chinnappan et al.   CANCER LETTERS

TFAM depletion overcomes hepatocellular carcinoma resistance to doxorubicin and sorafenib through AMPK activation and mitochondrial dysfunction

(2020) Ying Zhu et al.   GENE

LINC00160 mediated paclitaxel‐And doxorubicin‐resistance in breast cancer cells by regulating TFF3 via transcription factor C/EBPβ

(2020) Huaiguo Wu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Non-coding RNAs shuttled via exosomes reshape the hypoxic tumor microenvironment

(2020) Wenyu Wang et al.   Journal of Hematology & Oncology

LncRNA KCNQ1OT1 is a key factor in the reversal effect of curcumin on cisplatin resistance in the colorectal cancer cells

(2020) Zhi-hai Zheng et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

MORC4 Promotes Chemoresistance of Luminal A/B Breast Cancer via STAT3-Mediated MID2 Upregulation

(2020) Jing Luo et al.   OncoTargets and Therapy

Low GAS5 expression may predict poor survival and cisplatin resistance in cervical cancer

(2020) Xingyu Fang et al.   Cell Death & Disease

Mechanistic Involvement of Long Non-Coding RNAs in Oncotherapeutics Resistance in Triple-Negative Breast Cancer

(2020) Samarth Kansara et al.   Cells

LncRNA NORAD accelerates the progression and doxorubicin resistance of neuroblastoma through up-regulating HDAC8 via sponging miR-144-3p

(2020) Baiqi Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

lncRNA- RP11-156p1.3, novel diagnostic and therapeutic targeting via CRISPR/Cas9 editing in hepatocellular carcinoma

(2020) Hebatalla Said Ali et al.   GENOMICS

Characterization of a novel HDAC/RXR/HtrA1 signaling axis as a novel target to overcome cisplatin resistance in human non-small cell lung cancer

(2020) Wenjing Wang et al.   Molecular Cancer

Targeting Hypoxia-Inducible Factor-1-Mediated Metastasis for Cancer Therapy

(2020) Zhaowu Ma et al.   ANTIOXIDANTS & REDOX SIGNALING

The implication of long non-coding RNAs in the diagnosis, pathogenesis and drug resistance of pancreatic ductal adenocarcinoma and their possible therapeutic potential

(2020) Gouri Pandya et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

A variant of H19 transcript regulates EMT and oral cancer progression

(2020) Wu Zhou et al.   ORAL DISEASES

lncRNA involvement in cancer stem cell function and epithelial-mesenchymal transitions

(2020) Evan M. McCabe et al.   SEMINARS IN CANCER BIOLOGY

The double-edged sword of H19 lncRNA: Insights into cancer therapy

(2020) Yun Wei Shermane Lim et al.   CANCER LETTERS

Exosomes and exosomal RNAs in breast cancer: A status update

(2020) Sreerenjini Lakshmi et al.   EUROPEAN JOURNAL OF CANCER

Ferroptosis is a type of autophagy-dependent cell death

(2019) Borong Zhou et al.   SEMINARS IN CANCER BIOLOGY

The expanding roles of long non-coding RNAs in the regulation of cancer stem cells

(2019) Zhaowu Ma et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Targeting autophagy using natural compounds for cancer prevention and therapy

(2019) Shuo Deng et al.   CANCER

LncRNA MALAT1 Promotes Lung Cancer Proliferation and Gefitinib Resistance by Acting as a miR-200a Sponge

(2019) Changjiang Feng et al.   ARCHIVOS DE BRONCONEUMOLOGIA

YY1 regulates cancer cell immune resistance by modulating PD-L1 expression

(2019) Emily Hays et al.   DRUG RESISTANCE UPDATES

Deregulation of lncRNA‐AC078883.3 and microRNA‐19a is involved in the development of chemoresistance to cisplatin via modulating signaling pathway of PTEN/AKT

(2019) Shijie Xing et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Extracellular vesicles-mediated intercellular communication: roles in the tumor microenvironment and anti-cancer drug resistance

(2019) Selma Maacha et al.   Molecular Cancer

Polydatin inhibits proliferation and promotes apoptosis of doxorubicin-resistant osteosarcoma through LncRNA TUG1 mediated suppression of Akt signaling

(2019) Tongzhou Hu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

GABARAPs and LC3s have opposite roles in regulating ULK1 for autophagy induction

(2019) Douglas S. Grunwald et al.   Autophagy

LncRNA LOXL1‐AS1/miR‐let‐7a‐5p/ EGFR ‐related pathway regulates the doxorubicin resistance of prostate cancer DU‐145 cells

(2019) Tianliang Bai et al.   IUBMB LIFE

Ursodeoxycholic acid and cancer: From chemoprevention to chemotherapy

(2019) Jean-François Goossens et al.   PHARMACOLOGY & THERAPEUTICS

Cycloastragenol can negate constitutive STAT3 activation and promote paclitaxel-induced apoptosis in human gastric cancer cells

(2019) Sun Tae Hwang et al.   PHYTOMEDICINE

Association of LncRNA MEG3 polymorphisms with efficacy of neoadjuvant chemotherapy in breast cancer

(2019) Battseren Bayarmaa et al.   BMC CANCER

NRF 2/ ABCB 1‐mediated efflux and PARP 1‐mediated dampening of DNA damage contribute to doxorubicin resistance in chronic hypoxic HepG2 cells

(2019) Xiangwen Xia et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Decrypting noncoding RNA interactions, structures, and functional networks

(2019) Muller Fabbri et al.   GENOME RESEARCH

LncRNA NEAT1 promotes autophagy via regulating miR‐204/ATG3 and enhanced cell resistance to sorafenib in hepatocellular carcinoma

(2019) Xinyu Li et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Insights into Biological Role of LncRNAs in Epithelial-Mesenchymal Transition

(2019) Jun-Ting Cheng et al.   Cells

RNA-binding protein ZFP36/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells

(2019) Zili Zhang et al.   Autophagy

β‐ LAP achone ameliorates doxorubicin‐induced cardiotoxicity via regulating autophagy and Nrf2 signalling pathways in mice

(2019) Saeed Nazari Soltan Ahmad et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

GX15–070 (Obatoclax), a Bcl-2 family proteins inhibitor engenders apoptosis and pro-survival autophagy and increases Chemosensitivity in neuroblastoma

(2019) Sonia Cournoyer et al.   BMC CANCER

IL-10 knockdown with siRNA enhances the efficacy of Doxorubicin chemotherapy in EBV-positive tumors by inducing lytic cycle via PI3K/p38 MAPK/NF-kB pathway

(2019) Li Gao et al.   CANCER LETTERS

The Role of Non-coding RNAs in Oncology

(2019) Frank J. Slack et al.   CELL

LncRNA PTCSC3 inhibits the proliferation, invasion and migration of cervical cancer cells via sponging miR‐574‐5p

(2019) Rui Tong et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

lncRNA UCA1 Increases Proliferation and Multidrug Resistance of Retinoblastoma Cells Through Downregulating miR-513a-5p

(2019) Lidong Yang et al.   DNA AND CELL BIOLOGY

Elevated serum lncRNA TUG1 levels are a potential diagnostic biomarker of multiple myeloma

(2019) Qingqing Yin et al.   EXPERIMENTAL HEMATOLOGY

CircPAN3 contributes to drug resistance in acute myeloid leukemia through regulation of autophagy

(2019) Jin Shang et al.   LEUKEMIA RESEARCH

Downregulation of LncRNA GAS5 promotes liver cancer proliferation and drug resistance by decreasing PTEN expression

(2019) Congren Wang et al.   MOLECULAR GENETICS AND GENOMICS

Mitochondria as multifaceted regulators of cell death

(2019) Florian J. Bock et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

At a glance: A history of autophagy and cancer

(2019) Xin Wen et al.   SEMINARS IN CANCER BIOLOGY

Upregulation of Long Noncoding RNA (lncRNA) X-Inactive Specific Transcript (XIST) is Associated with Cisplatin Resistance in Non-Small Cell Lung Cancer (NSCLC) by Downregulating MicroRNA-144-3p

(2019) Lin-Juan Tian et al.   MEDICAL SCIENCE MONITOR

CircRNAs and exosomes: a mysterious frontier for human cancer

(2019) Xuefei Shi et al.   Molecular Therapy-Nucleic Acids

LncRNA AFAP1-AS1 Supresses miR-139-5p and Promotes Cell Proliferation and Chemotherapy Resistance of Non-small Cell Lung Cancer by Competitively Upregulating RRM2

(2019) Na Huang et al.   Frontiers in Oncology

H19 lncRNA: Roles in tumorigenesis

(2019) Soudeh Ghafouri-Fard et al.   BIOMEDICINE & PHARMACOTHERAPY

EGFR-mediated autophagy in tumourigenesis and therapeutic resistance

(2019) Min Wu et al.   CANCER LETTERS

LncRNA NEAT1 promotes docetaxel resistance in prostate cancer by regulating ACSL4 via sponging miR-34a-5p and miR-204-5p

(2019) Xingkang Jiang et al.   CELLULAR SIGNALLING

Towards the overcoming of anticancer drug resistance mediated by p53 mutations

(2019) Xin Cao et al.   DRUG RESISTANCE UPDATES

LncRNA KCNQ1OT1 contributes to the progression and chemoresistance in acute myeloid leukemia by modulating Tspan3 through suppressing miR-193a-3p

(2019) Huifang Sun et al.   LIFE SCIENCES

LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer

(2019) Yun Wang et al.   Molecular Cancer

miR-137 alleviates doxorubicin resistance in breast cancer through inhibition of epithelial-mesenchymal transition by targeting DUSP4

(2019) Feiya Du et al.   Cell Death & Disease

LncRNA PTCSC3 affects drug resistance of anaplastic thyroid cancer through STAT3/INO80 pathway

(2018) Xiao-ming Wang et al.   CANCER BIOLOGY & THERAPY

Determinants and clinical implications of chromosomal instability in cancer

(2018) Laurent Sansregret et al.   Nature Reviews Clinical Oncology

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Doxorubicin induces an extensive transcriptional and metabolic rewiring in yeast cells

(2018) Hilal Taymaz-Nikerel et al.   Scientific Reports

The lncRNA BORG facilitates the survival and chemoresistance of triple-negative breast cancers

(2018) Alex J. Gooding et al.   ONCOGENE

Antisense lncRNA FOXF1-AS1 Promotes Migration and Invasion of Osteosarcoma Cells Through the FOXF1/MMP-2/-9 Pathway

(2017) Zhu Kun-Peng et al.   International Journal of Biological Sciences

LncRNA H19 is a major mediator of doxorubicin chemoresistance in breast cancer cells through a cullin4A-MDR1 pathway

(2017) Qiong-Ni Zhu et al.   Oncotarget

LncRNA plasmacytoma variant translocation 1 is an oncogene in bladder urothelial carcinoma

(2017) Zhongyuan Liu et al.   Oncotarget

A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma

(2017) Xiaoyun Dai et al.   Oncotarget

LncRNA FENDRR sensitizes doxorubicin-resistance of osteosarcoma cells through down-regulating ABCB1 and ABCC1

(2017) Zhu Kun-Peng et al.   Oncotarget

The lncRNA BORG Drives Breast Cancer Metastasis and Disease Recurrence

(2017) Alex J. Gooding et al.   Scientific Reports

ANLN is a prognostic biomarker independent of Ki-67 and essential for cell cycle progression in primary breast cancer

(2016) Kristina Magnusson et al.   BMC CANCER

Unique features of long non-coding RNA biogenesis and function

(2016) Jeffrey J. Quinn et al.   NATURE REVIEWS GENETICS

Long Non-Coding RNA (LncRNA) Urothelial Carcinoma Associated 1 (UCA1) Increases Multi-Drug Resistance of Gastric Cancer via Downregulating miR-27b

(2016) Qun Fang et al.   MEDICAL SCIENCE MONITOR

Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives

(2016) Pei Shi Ong et al.   Frontiers in Pharmacology

Isorhamnetin augments the anti-tumor effect of capeciatbine through the negative regulation of NF-κB signaling cascade in gastric cancer

(2015) Kanjoormana A. Manu et al.   CANCER LETTERS

PTCSC3 Is Involved in Papillary Thyroid Carcinoma Development by ModulatingS100A4Gene Expression

(2015) Jaroslaw Jendrzejewski et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The role of miR-125b-mitochondria-caspase-3 pathway in doxorubicin resistance and therapy in human breast cancer

(2015) Xiaohong Xie et al.   TUMOR BIOLOGY

Selective inhibition of HDAC8 decreases neuroblastoma growth in vitro and in vivo and enhances retinoic acid-mediated differentiation

(2015) I Rettig et al.   Cell Death & Disease

Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis

(2014) Sonia A. Melo et al.   CANCER CELL

NOTCH1 signaling promotes chemoresistance via regulating ABCC1 expression in prostate cancer stem cells

(2014) Cheng Liu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Therapeutic Strategies to Inhibit MYC

(2014) M. R. McKeown et al.   Cold Spring Harbor Perspectives in Medicine

SIRT1 and AMPK Mediate Hypoxia-Induced Resistance of Non-Small Cell Lung Cancers to Cisplatin and Doxorubicin

(2013) D. H. Shin et al.   CANCER RESEARCH

Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B-regulated gene products

(2013) Kanjoormana A. Manu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Long noncoding RNAs are rarely translated in two human cell lines

(2012) B. Banfai et al.   GENOME RESEARCH

The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression

(2012) T. Derrien et al.   GENOME RESEARCH

Collagen/β1 integrin signaling up-regulates the ABCC1/MRP-1 transporter in an ERK/MAPK-dependent manner

(2012) Mohammed-Amine El Azreq et al.   MOLECULAR BIOLOGY OF THE CELL

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

The polymorphism rs944289 predisposes to papillary thyroid carcinoma through a large intergenic noncoding RNA gene of tumor suppressor type

(2012) J. Jendrzejewski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A complex task? Direct modulation of transcription factors with small molecules

(2010) Angela N Koehler   CURRENT OPINION IN CHEMICAL BIOLOGY

The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein

(2010) Zhaohui Feng et al.   TRENDS IN CELL BIOLOGY

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

(2009) Mitchell Guttman et al.   NATURE

Histone Deacetylase 8 in Neuroblastoma Tumorigenesis

(2008) I. Oehme et al.   CLINICAL CANCER RESEARCH

Inhibition of transcription factors with small organic molecules

(2008) Thorsten Berg   CURRENT OPINION IN CHEMICAL BIOLOGY

ABC multidrug transporters: structure, function and role in chemoresistance

(2007) Frances J Sharom   PHARMACOGENOMICS